Transcript Title and contents

second
messengers
in cancer.
cyclic amp meets
ß-catenin in tumor
progression
cover & lay out — duwo media. groningen
printed by — Ipskamp printing. enschede
printed on fsc certified paper
© 2016 by sepp reinier jansen
all rights reserved. no part of this publication may
be reproduced or transmitted in any form or by
any means, electronic or mechanical, by print or
otherwise, without persmission in writing from the
author, or, when appropiate, from the publishers of
the publications.
Seco
ond messe
m
enger
rs in canc
cer
cyclic AMP me
eets β-ca
atenin in
n tumor p
progress
sion
Pro
oefschrift
ft
ter verkrrijging van de
d graad vaan doctor aaan de
Rijksuniveersiteit Gron
ningen
op gezag
g
van dee
recto
or magnificcus prof. drr. E. Sterken
n
en volgens besluit van
n het Collegge voor Prom
moties.
De open
nbare verded
diging zal p
plaatsvinden op
maan
ndag 24 oktober 2016 o
om 12.45 uu
ur
Door
Sepp Re
einier Ja
ansen
geboren
g
op 18 novemb
ber 1986
te Zwolle
promotores
prof. dr. M. Schmidt
prof. dr. R. Gosens
assessment committee
prof. dr. M. Smit
prof. dr. F.A. Kruyt
prof. dr. A. Tengholm
4
5
index.
8 — 25
chapter 1.
General introduction
26 — 8 5
chapter 2.
Paving the Rho in cancer: Rho GTPases and beyond in metastasis
and angiogenesis
86 — 11 3
chapter 3.
Prostaglandin E2 promotes MYCN non-amplified neuroblastoma
cell survival via ß-catenin stabilization
114 — 14 3
chapter 4.
Epac1 links prostaglandin E2 to ß-catenin-dependent
transcription during epithelial-to-mesenchymal transition
14 4 — 1 61
chapter 5.
Epac2 regulates hypoxia-induced gene transcription
and ß-catenin/TCF transcription
6
162 — 171
chapter 6.
Inhibition of Epac2 and ß-catenin reinforce all-trans retinoic acid-induced
differentiation of neuroblastoma cells
1 8 0 — 20 0
chapter 7
General discussion
20 1 — 20 8
nederlandse samenvatting
20 9
list of publications.
210 — 215
acknowledgements.
216 — 217
curriculum vitea.
2 1 8 — 2 20
abbreviations.
7