Transcript Effects of inhaled corticosteroids on clinical and pathological

Cover Page
The handle http://hdl.handle.net/1887/44522 holds various files of this Leiden University
dissertation.
Author: Kunz, L.I.Z.
Title: Effects of inhaled corticosteroids on clinical and pathological outcomes in COPD Insights from the GLUCOLD study
Issue Date: 2016-11-30
Effects of inhaled corticosteroids
on clinical and pathological outcomes in COPD
Insights from the GLUCOLD study
ISBN/EAN 9789462334366
© L.I.Z. Kunz, Leiden, The Netherlands 2016
Cover: Ilse Schrauwers, isontwerp.nl
Printed by: Gildeprint - Enschede
The studies in this thesis were financially supported by grants from the Netherlands Organization for
Scientific Research (NWO), Netherlands Lung Foundation (Longfonds, previously Netherlands Asthma
Foundation), GlaxoSmithKline (GSK The Netherlands), Leiden University Medical Center (LUMC) and
University Medical Center Groningen (UMCG).
All rights reserved. No part of this publication may be reproduced or transmitted in any form without
written permission of the author.
The publication of this thesis was financially supported by:
Netherlands Lung Foundation (Longfonds), Stichting Astma Bestrijding (SAB)
Effects of inhaled corticosteroids
on clinical and pathological outcomes in COPD
Insights from the GLUCOLD study
Proefschrift
ter verkrijging van de graad van Doctor aan de Universiteit Leiden,
op gezag van Rector Magnificus prof. mr. C.J.J.M. Stolker,
volgens besluit van het College voor Promoties
te verdedigen op woensdag 30 november 2016
klokke 10.00 uur
door
Lisette Irene Zophia Kunz
geboren te Voorburg
op 30 oktober 1978
Promotores
Prof. Dr. P.S. Hiemstra
Prof. Dr. P.J. Sterk (Academisch Medisch Centrum)
Prof. Dr. D.S. Postma (Universitair Medisch Centrum Groningen)
Overige leden
Prof. Dr. C. Taube
Prof. Dr. E.F.M. Wouters (Universitair Medisch Centrum Maastricht)
Prof. Dr. Y.F. Heijdra (Radboud Universiteit Nijmegen)
Dr. K. Grünberg (Radboud Universiteit Nijmegen)
The studies in this thesis were financially supported by grants from the Netherlands Organization for
Scientific Research (NWO), Dutch Lung Foundation (Longfonds) GlaxoSmithKline of The Netherlands,
Leiden University Medical Center (LUMC) and University Medical Center Groningen (UMCG).
Als we wisten wat we deden, heette het geen onderzoek
Albert Einstein (1879-1955)
Voor mijn ouders
Contents
Chapter 1 General introduction
10
Chapter 2
Smoking status and anti-inflammatory macrophages in bronchoalveolar lavage and induced sputum in COPD
60
Chapter 3 Regulation of YKL-40 Expression by Corticosteroids: Effect on Pro-inflammatory Macrophages in vitro and its modulation in
COPD in vivo
82
Chapter 4
Inhaled steroids modulate extracellular matrix composition in bronchial biopsies of COPD patients: a randomized, controlled trial
104
Chapter 5 Relapse in FEV1-Decline after Steroid Withdrawal in Chronic Obstructive Pulmonary Disease
124
Chapter 6
Airway inflammation in COPD after Withdrawal of Inhaled Corticosteroids
Chapter 7
Summary and general discussion
140
Chapter 8 Nederlandse samenvatting
Appendix
Curriculum vitae
Dankwoord
Bibliography
The GLUCOLD study group
182
158
198
199
202
204