Transcript Immunotherapy for human cancer

Cover Page
The handle http://hdl.handle.net/1887/44515 holds various files of this Leiden University
dissertation.
Author: Kelderman, S.
Title: Immunotherapy for human cancer : from bedside to bench and back
Issue Date: 2016-11-30
Immunotherapy for human cancer
From bedside to bench and back
Sander Kelderman
Cover design: Lay-out and printing: “Diverging roads” by Tomasz Ahrends
Gildeprint, Enschede
ISBN: 978-90-9029972-3.
The research described in this thesis was performed at the Division of Immunology at the
Netherlands Cancer Institute – Antoni van Leeuwenhoek Hospital (NKI-AVL).
The printing of this thesis was financially supported by the NKI-AVL.
© 2016 by S. Kelderman, Amsterdam, The Netherlands
Immunotherapy for human cancer
From bedside to bench and back
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden
op gezag van Rector Magnificus prof. mr. C.J.J.M. Stolker,
volgens besluit van het College voor Promoties
te verdedigen op woensdag 30 november 2016
klokke 13.45 uur
door
Sander Kelderman
geboren te Heemskerk
in 1986
Prof. dr. Ton N.M. Schumacher (promotor)
Prof. dr. Christian U. Blank (co-promotor)
Leden promotiecommissie:
Prof. dr. Sjoerd H. van der Burg
Prof. dr. John B.A.G. Haanen
Dr. Mirjam H.M. Heemskerk
Prof. dr. Jannie Borst (Universiteit van Amsterdam)
Prof dr. Gemma G. Kenter (Vrije Universiteit)
To all cancer patients and their families
who decide to participate in clinical trials
and donate tissue for scientific research
TABLE OF CONTENTS
Chapter 1
Scope of the thesis
Chapter 2
Lactate dehydrogenase as a selection criterion for ipilimumab treatment in metastatic melanoma
Cancer Immunology Immunotherapy, 2014
19
Chapter 3
Ipilimumab in pretreated metastastic uveal melanoma patients. Results of the Dutch Working group on Immunotherapy of Oncology
(WIN-O).
Acta Oncologica, 2013
39
Chapter 4
Mismatch repair-deficient cancers are targets for anti-PD-1 therapy Cancer Cell, 2015
49
Chapter 5
Acquired and intrinsic resistance in cancer immunotherapy
Molecular Oncology, 2014
55
Chapter 6
Tumor antigens in human cancer control
Biochimica et Biophysica Acta, 2016
71
Chapter 7
Antigen-specific TIL therapy for melanoma: A flexible platform for personalized cancer immunotherapy
European Journal of Immunology, 2016
89
Chapter 8
Neo-antigen enriched TIL therapy mediates superior tumor control in a xenograft model of human melanoma
Manuscript submitted
111
Chapter 9
Reconstructing tumor-reactivity of single cytotoxic T lymphocytes in human cancer
Manuscript in preparation
137
Chapter 10
Preclinical assessment of the potential of tumor-infiltrating lymphocyte (TIL) therapy in epithelial ovarian cancer
Manuscript in preparation
153
Chapter 11
Discussion: The futures challenges in cancer immunotherapy
163
Chapter 12Addendum

English summary

Nederlandse samenvatting

Dankwoord

Curriculum Vitae

List of publications
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