Transcript 14122-Thesis Hanane El Bannoudi-Insidework-20161020

Cover Page
The handle http://hdl.handle.net/1887/44487 holds various files of this Leiden University
dissertation
Author: El Bannoudi, Hanane
Title: Immune regulation by CD49b+ CD4+ T cells & modulation of B cell responses
Issue Date: 2016-11-29
Immune regulation by CD49b
CD49b+ CD4+ T cells
& modulation of B cell responses
Hanane El Bannoudi
Immune regulation by CD49b+ CD4+ T cells & modulation of B cell responses
Hanane El Bannoudi
Painting used for the cover: Aouatif El Ghalbzouri
Layout: Hanane El Bannoudi
Printing: Ridderprint BV, the Netherlands
Layout cover: Ridderprint BV, the Netherlands
ISBN: 978-94-6299-465-2
©2016 Hanane El Bannoudi
The research leading to the results presented in this thesis has received funding from
The European Community’s Seventh Framework Programme FP7, Centre for Medical
Systems Biology (CMSB), Dutch Arthritis Foundation, programme Masterswitch, the
Netherlands Organisation for Scientific Research (a Vici grant) and the Innovative
Medicines Initiative-funded project BeTheCure. Thank you.
Leiden University Medical Center, Leiden University has financially contributed to the
printing of this thesis.
Immune regulation by CD49b+ CD4+ T cells
& modulation of B cell responses
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden,
op gezag van Rector Magnificus prof.mr. C.J.J.M. Stolker,
volgens besluit van het College voor Promoties
te verdedigen op dinsdag 29 november 2016
Klokke 16:15 uur
Door
Hanane El Bannoudi
Geboren te Marokko in 1978
Promotores
Prof.dr. R.E.M. Toes
Prof.dr. T.W.J. Huizinga
Promotiecommissie
Prof. dr. F. A. Ossendorp
Prof. dr. C. van Kooten
Prof. dr. P.H.A. Quax
Prof. dr. J. Kuiper
Dr. L. M. van Duivenvoorde (AMC)
Dr. A. Ioan-Fascinay
Contents
Chapter 1
Introduction
Chapter 2
Bridging auto-antibodies and arthritis: the role of Fc receptors
37
Part I
Modulation of B cell responses
57
Chapter 3
Abatacept decreases disease activity in a absence of CD4+T cells
in a collagen induced arthritis model
59
Chapter 4
Anti-cyclic citrullinated peptide antibodies are a collection of
anti-citrullinated protein antibodies and contain overlapping and
non-overlapping reactivities
79
Chapter 5
CD28 expressing B cells and ACPA+ plasmablasts/-cells in
Rheumatoid Arthritis patients
95
Part II
Immune regulation by CD49b+CD4+ T cells
109
Chapter 6
DX5+CD4+ T cells modulate CD4+ T cell response via inhibition of
IL-12 production by DCs
111
Chapter 7
Antigen specificity of CD49b+CD4+ T cells
129
Chapter 8
Summary & discussion
149
Chapter 9
Nederlandse samenvatting
169
Addendum
7
177
List of publications
179
Curriculum Vitae
181
Acknowledgment
183