Transcript Title and contents - Rijksuniversiteit Groningen

Hemodynamic stability during hemodialysis
A role for vasopressin?
Esmée M. Ettema
Esmée M. Ettema
Hemodynamic stability during hemodialysis: a role for vasopressin?
Dissertation University of Groningen, the Netherlands
The studies presented in this thesis were supported by the Dutch Kidney Foundation and
the Jan Kornelis de Cock foundation.
Financial support by the Dutch Kidney Foundation, the University of Groningen, University
Medical Center Groningen, the Graduate School for Drug Exploration (GUIDE), Dialysis Center Groningen and Amgen B.V. for the publication of this thesis is gratefully acknowledged.
Cover design by Sjors Kroes
Lay-out by Joop van Dijken, www.optimaaldesign.nl
Printed by Gildeprint Drukkerijen, Enschede
ISBN 978-90-367-9138-0 (printed version)
ISBN 978-90-367-9139-7 (digital version)
© E.M. Ettema 2016
All rights reserved. No part of this publication may be reproduced, copied, modified,
stored in a retrieval system or transmitted without the prior permission in writing from the
author.
Hemodynamic stability during hemodialysis
A role for vasopressin?
Proefschrift
ter verkrijging van de graad van doctor aan de
Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. E. Sterken
en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op
woensdag 2 november 2016 om 12:45 uur
door
Esmée Marlien Ettema
geboren op 23 maart 1988
te Groningen
Promotores
Prof. dr. C.A.J.M. Gaillard
Prof. dr. R.T. Gansevoort
Copromotor
Dr. C.F.M. Franssen
Beoordelingscommissie
Prof. dr. I.P. Kema
Prof. dr. R. Zietse
Prof. dr. D. Schneditz
Paranimfen
Mr. L.E. Ettema
Dr. J.H. Bielderman
Contents
Chapter 1
Introduction
9
Chapter 2
Dialysis hypotension: a role for inadequate increase in arginine vasopressin levels? A systematic literature review
and meta-analysis
Am J Nephrol 2014; 39: 100-109
27
Chapter 3
Chapter 4
Chapter 5
Chapter 6
Chapter 7
Chapter 8
Vasopressin release is enhanced by the Hemocontrol biofeedback system and could contribute to better
haemodynamic stability during haemodialysis
Nephrol Dial Transplant 2012; 27:3263-3270
73
Effect of plasma sodium concentration on blood pressure regulators during hemodialysis: A randomized crossover study
Submitted
93
Changes in plasma copeptin levels during hemodialysis: are the physiological stimuli active in hemodialysis patients?
PLoS One 2015; 10: e01127116
121
Comparison of ex vivo stability of copeptin and vasopressin
Accepted for publication in Clin Chem Lab Med
139
The effect of renal function and hemodialysis treatment on
plasma vasopressin and copeptin levels
Submitted
159
Summary, general discussion and future perspectives 183
Nederlandse Samenvatting 199
Dankwoord 209
About the author 217