Transcript Glycolysis Glucose Pyruvate Lactate

Glycolysis
Glucose
10 steps
Pyruvate
3 regulated steps
No O2
Lactate
Energy (ATP) and metabolites
Eric Niederhoffer
SIU-SOM
Pathway Overview

What does glycolysis do for us?
Glycogen
•Input to Glycogen, PPP
PPP
Glc
HK (reg)
G6P •Process Glc (Frc) monomers
F6P
PFK-1 (reg)
F16BP
DHAP + G3P •Form 3-C metabolites
G3P DH
NADH
1,3-BPG
PGK
ATP
3-PG
•Generate ATP and NADH
2-PG
PEP
PK (reg)
ATP
•Regenerate
NAD+
LDH
Lactate
Pyr
TCA
•Input to TCA cycle
Regulation
Epinephrine (cardiac muscle)
AC
cAMP
Glc
HK
PKA (inactive)
ATP
PKA (active)
G6P
PFK-2 (active)
F6P
PFK-1
F16BP
DHAP + G3P
1,3-BPG
3-PG
2-PG
PEP
PK
Pyr
F26BP
PFK-2 (inactive)