Acute Respiratory Distress Syndrome It’s so shocking, I can’t breathe! Heidi Ditmyer DVM University of Tennessee College of Veterinary Medicine Department of Pathobiology Tifton 2008 Presented at SEVPAC.

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Transcript Acute Respiratory Distress Syndrome It’s so shocking, I can’t breathe! Heidi Ditmyer DVM University of Tennessee College of Veterinary Medicine Department of Pathobiology Tifton 2008 Presented at SEVPAC.

Acute Respiratory Distress
Syndrome
It’s so shocking, I can’t breathe!
Heidi Ditmyer DVM
University of Tennessee
College of Veterinary Medicine
Department of Pathobiology
Tifton 2008
Presented at SEVPAC 2008 –
Permission granted for use on
SEVPAC website only
Signalment


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Juvenile Female Spayed Yorkshire Terrier
Presented to rDVM after chewing electric
cord
rDVM treated with Oxygen and diuretics
Presented at SEVPAC 2008 –
Permission granted for use on
SEVPAC website only
Case 07-796

Referred to UT

Ventilator

Febrile

Died 24 hours post arrival
Presented at SEVPAC 2008 –
Permission granted for use on
SEVPAC website only
Gross Findings
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Glossal and gingival ulceration

Bilateral interstitial pneumonia

Congenital portosystemic shunt
Presented at SEVPAC 2008 –
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SEVPAC website only
Glossal ulceration
Presented at SEVPAC 2008 –
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Presented at SEVPAC 2008 –
Permission granted for use on
SEVPAC website only
Presented at SEVPAC 2008 –
Permission granted for use on
SEVPAC website only
Histology and etiology

Fibrinous interstitial pneumonia

Multiple possibilities

Consistent with Acute Respiratory Distress
Syndrome
Presented at SEVPAC 2008 –
Permission granted for use on
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Acute Respiratory Distress
Syndrome (ARDS)
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Acute onset
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Bilateral/diffuse pulmonary changes
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Hypoxemia
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No evidence of left atrial hypertension
Presented at SEVPAC 2008 –
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ARDS
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
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Secondary inflammatory response
Macrophages  cytokines  enzymes 
free radicals  diffuse alveolar and
endothelial damage
Differential diagnosis for any animal with
non-cardiogenic pulmonary edema and
appropriate risk factors
Presented at SEVPAC 2008 –
Permission granted for use on
SEVPAC website only
Conclusion

Limited lung response regardless of trigger

Overzealous inflammatory response

Pathophysiology not entirely understood

Considered as differential diagnosis
Presented at SEVPAC 2008 –
Permission granted for use on
SEVPAC website only
Acknowledgements

Dr Kim Newkirk

UT histology staff
Presented at SEVPAC 2008 –
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SEVPAC website only
Thank you
www.k9station.com
Questions?
Presented at SEVPAC 2008 –
Permission granted for use on
SEVPAC website only