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Understanding Nutrition Jenny Engemann Manager, Global Product Support Pharmanex R & D Nutrition: Outside In & Inside Out The same nutrients that promote health and longevity also help maintain our skin’s youthful appearance Suboptimal nutrition may result in... Fatigue, loss of appetite, depression, poor concentration Dry, pale, scaly, oily, wrinkled skin Nutrition: Outside In & Inside Out Key to a healthy diet = variety and moderation Balanced intake of carbohydrates, protein, and fat Optimal intake of essential vitamins & minerals Broad range of antioxidants to support antioxidant defense system including antioxidant-rich fruits and vegetables Essential fatty acids - fish, flaxseed, fish oil supplements Water Common Nutrient Deficiencies Vitamins A and E Bone minerals calcium and magnesium, and vitamin D Trace minerals iron—particularly for women-- copper, chromium, and zinc B vitamins - thiamin, riboflavin, vitamin B6, folate, vitamin B12 JAMA, 19 June 2002 “Most people do not consume an optimal amount of all vitamins by diet alone. Pending strong evidence of effectiveness from randomized trials, it appears prudent for all adults to take vitamin supplements.” Robert H. Fletcher, MD, MSc; Kathleen M. Fairfield, MD, DrPH, Harvard University. Journal of the American Medical Association 2002; 287: 3127-3129 Optimum Supplementation Ensures RDA levels + Considers typical dietary intakes + Optimum nutrient levels for long-term health + Non-essential, beneficial nutrients Why Use Supplements? To prevent nutrient deficiencies and provide optimal levels of nutrients Vitamin C (Scurvy) – 4-5 oranges weekly to prevent tooth loss from scurvy – dozen oranges a day for effective antioxidant activity Vitamin E – 100- 400 IU daily for antioxidant – high sources only available in fatty food - obesity B-vitamins – Folic acid and neural tube defects Why Use Supplements? To provide consistent intake of all essential nutrients and ultimately improve general well-being, e.g., physical and mental performance • Additional reasons you may need to supplement your diet: – – – – – – food processing methods smoking tobacco food allergies stress prescription & over-the-counter medicines illness LifePak® is a comprehensive nutritional supplementation program delivering the optimal amounts of all essential vitamins, antioxidants, minerals, and trace elements, as well as beneficial phytonutrients. LifePak® - 5 Formulas in 1 High potency antioxidant formula with vitamins C & E Potent blend of carotenoids and flavonoids, including green tea catechins, citrus bioflavonoids, and beta-carotene Comprehensive bone nutrition with calcium, magnesium, vitamin D and vitamin K Supports healthy immune function Complete trace element supplement Promotes cardiovascular health Antioxidants & Free Radicals Free Radicals Normal metabolism, stress, sun exposure, smoking, environment Antioxidants are stable compounds that combine with and neutralize the highly reactive free radicals that otherwise can damage the cells throughout our bodies Smoking 30000 25000 n = 1047 20000 n = 39 n = 10 17600 17591 19890 n = 58 15000 n = 16 n = 32 13056 13030 11593 10000 p < 0.01 5000 0 NonSmokers Smokers (all) Unpublished data, Pharmanex 2002 Past Smokers < 1/day 1-5/day > 5/day Antioxidant Defense System A comprehensive profile of antioxidants must work together in synergy to afford effective protection from free radical damage Vitamin E Vitamin C Mineral cofactors (selenium, zinc, copper, manganese) Alpha-Lipoic Acid Carotenoids (beta-carotene, lutein, and lycopene) Flavonoids (green tea catechins, bioflavonoids, grape seed extract, quercetin) Two Scientific Studies Proving LifePak’s Antioxidant Effects 65 60 Protection of LDL against free radicals 8 7 6 Placebo LifePak p < 0.001 (means +/- SD) 5 PL MVMS p < 0.001 (means +/- SD) Vitamin E 6.248 4 3 3.429 3.305 3.477 2 55 1 0 50 Baseline 1200 45 1000 43.4 40 Endpoint 50.9 42.1 42 800 600 35 PL MVMS (means +/- SD) p < 0.001 b-Carotene 716 400 200 30 331 335 299 0 Start After 6 Weeks Baseline Smidt CR, Seidehamel RJ, Devaraj S, Jialal I. The Effects of a Nutritionally Complete Dietary Supplement (LifePak®) on Antioxidant Status and LDL-Oxidation in Healthy Non-Smokers. FASEB 1999;13(4):A546. Endpoint Essential Fatty Acids Balance intake of essential fatty acids (more omega-3, less omega-6). EFAs have numerous health benefits, including helping restore damaged skin, and maintaining moist and smooth skin. Double-blind study in The Lancet found omega-3s may address symptoms associated with certain problem skin conditions. Omega-3s found in fish, flaxseed, and certain food supplements. Bittiner SB, et al. Lancet. Feb1988;1(8582):378-80. Kojima T, et al. Dermatologica. 1991;182(4):225-30. Nourish your Body Internally & Externally Nu Skin Personal Care Balanced Diet fruits, vegetables, essential nutrients, water Food Supplements Pharmanex Supplements LifePak Optimum Omega OptiProtect, Tegreen, or Optimum C