Transcript Slide 1

G3 Workshop
North America
Leadership Conference
March 3, 2006
This material has been prepared by Pharmanex to be used in
conjunction with general educational events and activities only.
Alterations or modifications of this presentation without the express
approval of Pharmanex is prohibited.
Mark R. Bartlett Ph.D.
Sr. Director, Pharmanex
New Product Development
Science &
Tradition
MSNBC.com
Spartan diet may slow aging
NIH launches study to test practicality
By Rob Stein
The Washington Post
As the rest of the nation has been supersizing, a small cadre of Americans
such as Francesca Skelton have been radically downsizing their diets — not to
slim down their physiques but to slow down the hands of time.
Skelton is an adherent to the theory that "caloric restriction" can hold back the
aging process by fundamentally altering basic metabolic functions in ways
that protect the body from decaying as quickly.
So for years, the District grandmother and others like her have been eating
often radical diets carefully calibrated to slash calories they consume each day
while still providing their bodies with the nutrients they need.
Mean Age of Death .
82
80
Green Tea and Longevity
Green Tea
Consumption
78
76
74
72
70
68
66
(Cups/Day)
3 or less
4 to 9
over 10
Men
Women
Prospective, 11-year cohort study of 8,552 subjects in Yoshimi,
Japan, 1986-1997. From: H. Fujiki et al., Ann. N.Y.Acad.Sci.,
928:274, 2001; used with author’s permission
Aging Symptoms
Antioxidants Addresses the Root
Cause of Aging:
DNA Damage
• DNA (DeoxyriboNucleic Acid) is your
genetic blueprint
• DNA enables healthy cell renewal into old
age
Most Vulnerable to free radicals…
Free Radical Sources
• Environmental pollution (smog, ozone, NO2)
• Radiation exposure:
– sunlight (UV-light), X-rays, etc.
• Smoking:
– 10,000,000,000,000,000 free radicals/cigarette!
• Eating and Breathing:
metabolism in your mitochondria
Mitochondria – The Energy
Furnaces of the body
Free Radicals
SOD
CAT
MSNBC.com
• Starve Your Way to Health
It works for mice and fruit flies, but can
ultra-low-calorie diets extend the life of
humans?
•
•
By Jerry Adler and Anne Underwood
Newsweek
• Jan. 19 issue - If the world is divided into people who live to eat and those
who eat to live, perhaps there ought to be a third category for Brian
Delaney. At 5 feet 11 inches and 139 pounds, Delaney, 40, is really, really
thin. Thin, and hungry. He limits his calories to 1,800 a day, in part by
eating just two meals, except when he has a dinner date, in which case
that's the only meal he eats. After 10 years on this regimen—actually, he
started out at 1,400 calories a day, less than half of what the average
American male consumes—he still experiences "the same pit in my
stomach" every afternoon, but now finds it "easier to deal with."
Especially when he thinks of all the diseases he's avoiding. If Brian
Delaney is right, he may well have the last laugh on the rest of humanity ...
sometime in the 22d century.
Aging so far…
• DNA damage
• Cell membrane damage
• Uncontrolled free radical leakage
from Mitochondria
The most common link?
Free Radicals
Antioxidant Health Benefits
Journal of the American Medical Association
“… low levels of the antioxidant vitamins (vitamins A, E, and C)
may increase risk for several chronic diseases. Most people do
not consume an optimal amount of all vitamins by diet alone.”
“It appears prudent for all adults to take vitamin
supplements.”
Robert H. Fletcher, MD, MSc; Kathleen M. Fairfield, MD, DrPH, Harvard University
Journal of the American Medical Association 2002; 287: 3127-3129
3 years ago…
Pharmanex began Searching
the World for Superfruits
– R&D evaluated hundreds of fruits for…
• Extraordinary antioxidant power
– Measurable (Scanner)
– Protect cells, (DNA, Membranes)
– Enhance internal antioxidant
production
Fruit Phytonutrients
• At least 1,000 phytochemicals identified
with cell protective effects
• Very few (25) studied
• Fruits and vegetables – more than meets
the eye
• We don’t eat enough fruits and vegetables
Families of Antioxidants
• Vitamin E: 8 natural forms
Families of Antioxidants
• Vitamin E: 8 natural forms
• Vitamin C:
Families of Antioxidants
• Vitamin E: 8 natural forms
• Vitamin C
• (Metallo-enzyme cofactors)
– Selenium, Zinc, Manganese, Copper
Enzyme Protein
Zinc
Families of Antioxidants
• Vitamin E: 8 natural forms
• Vitamin C: 500 mg
• (Metallo-enzyme cofactors)
– Selenium, Zinc, Manganese
• Flavonoids:
–Catechins,
–polyphenols etc
Families of Antioxidants
• Vitamin E: 8 natural forms
• Vitamin C
• (Metallo-enzyme cofactors)
– Selenium, Zinc, Manganese
• Flavonoids:
– Catechins, polyphenols etc
• Carotenoids:
– Β-carotene, lutein, lycopene, α-carotene
Your Antioxidant Network
More than just One…
• Vitamin E: 8 natural forms
• Vitamin C
• Metallo-enzymes (cofactors)
– SOD, Catalase, Glutathione per.
– Selenium, Zn, Mn, Cu
• Flavonoids:
– Catechins, polyphenols etc
• Carotenoids:
– Β-carotene, lutein, lycopene, α-carotene
Pharmanex
Research Centers
were involved…
1.Provo R&D Center
2.Shanghai R&D Center
3.Beijing R&D Center
years of searching
–Almost all failed Selection
criteria
–All but Four (g+3) very special
fruits
3 Pharmanex Research Centers
3 Years of Searching and R&D
3 +1 Superfruits
1. Gâc fruit (Chinese Bitter Cucumber)
2. Chinese Lycium (Wolfberry)
3. Cili fruit
4. Siberian Pineapple (Seabuckthorn)
Gâc - “Fruit From Heaven”
• Indigenous to Southern Asia
Bangladesh, Burma, Cambodia,
China, India, Japan, Laos, Malaysia,
Philippines, Thailand, and Vietnam
• Traditionally used internally
and externally*
Topical: wound healing
Internally: eye health, and to promote
growth in children*
*These statements have not been evaluated by the Food and Drug Administration. This
product is not intended to diagnose, treat, cure, or prevent any disease.
Antioxidants in Gâc Pulp
• Extraordinarily rich in antioxidants, esp.
lycopene, beta-carotene, vitamin E
• Unique fatty acids → Lipocarotenes™
Fruit flesh
Pulp
(mesocarp)
(aril)
Seeds
Gac Fruit Lycopene Content
2500
2227
2000
1500
70 x more
than tomatoes!
1000
500
0
31
Tomato
54
41
Watermelon
Guava
mcg/g wet weight
Ishida et al., J Agric Food Chem 52:274, 2004
Gac aril
Gac Fruit Beta-Carotene Content
800
718
700
600
500
10 x more
than carrots!
400
300
200
100
48
79
76
0
Spinach
Carrot
Sw.Potato
mcg/g wet weight
Ishida et al., J Agric Food Chem 52:274, 2004
Gac aril
1000
900
800
700
600
500
400
300
200
100
0
Zeaxanthin in Chinese
Lycium Fruit
800
40 x more than
yellow corn!
18
Yellow Corn
mcg/g wet weight
Ch.Lycium
Vitamin C in Cili Fruit
2500
2500
2000
1500
60 x more
than oranges!
1000
500
0
30
Mandarin
mg/100g wet weight
45
Orange
71
Kiwi
Cili
Antioxidant protection
Vitamin C
Carotenoid protection
Betacarotene
Carotenoid protection
Betacarotene
Lutein
Carotenoid
protection
Betacarotene
Lutein
Lycopene
Antioxidant protection
Betacarotene
Lutein
Lycopene
Vitamin C
Carotenoids and DNA damage (2006)
Carotenoids
•
•
•
•
First line of defense antioxidants*
Protect cell membranes*
Protect DNA*
Enhance communication in cell
membranes*
• Found in a diet rich in fruits and
vegetables
• Indicator of overall antioxidant health*
*These statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure, or prevent any disease.
Carotenoids Predict Antioxidant Status
• Recent paper published in the Journal of Nutrition
– Carotenoids (blood) are indicator of total antioxidant status
– Carotenoids interact with the antioxidant network
– Vitamin E (blood) is not a good indicator of antioxidant status
Raman Spectroscopy
Intense monochromatic light (one color only) interacts with
molecules that have vibrational energy (e.g., carotenoids)
and gets scattered at a higher wavelength (color).
Sir C. V. Raman, Nobel Prize in Physics, 1930
Carotenoid molecules shift blue laser light color to green:
from 473 nm to 510 nm
Pharmanex BioPhotonic Scanner
• Measures skin carotenoids –an
indication of your personal
antioxidant protection
• Easy & non-invasive
• Scientifically and clinically
validated
• Gold standard
Measure antioxidant effect of g3 in your own
body!
Bioavailability
Relative risk
Effect of tomato food products on prostate health risk
1.10
tomato juice
1.00
0.90
tomato fruits
0.80
pizza
tomato sauce
0.70
0.60
0
1
2
Servings
3
from Giovanucci et al. J. of Natl. Canc. Inst. 87, 1767 (1995)
g3 Increased Antioxidant Network
Antioxidant Network Score
Scores ~9,500 in 8 Weeks
50,000
1
2
3
4
5
6
7
8
9
10
11
40,000
30,000
20,000
10,000
Week 0
Week 8
Noni & Xango vs. g3
Antioxidant Score
10,000
Tahitian Noni
XanGo
8,000
6,000
4,000
2,000
0
Week 0
Week 2
Week 4
Week 6
Week 8
Other
Ingredients
Chinese Lycium
(Wolfberry; Lycium chinense)
2000 years TCM history in China
• Longevity, wellness, vision
• Cellular rejuvenation:* protects DNA*
– antioxidant (SOD, GPX)
Cili Fruit
(Rosa roxburghii)
• Cardiovascular, antioxidant benefits:*
– ↓ oxLDL, increases SOD*
• Addresses symptoms of Aging*
*Theses statements have not been evaluated by the Food and Drug Administration. This
product is not intended to diagnose, treat, cure, or prevent any disease.
Is Catalytically Active
g3 activates SOD and Catalase*
– the body's catalytic antioxidant system
– antioxidant protection inside the cell, where it is
needed the most
SOD: Superoxide Dismutase
– most important antioxidant enzyme
– requires copper, zinc & manganese (LifePak)
*Theses statements have not been evaluated by the Food and Drug Administration. This
product is not intended to diagnose, treat, cure, or prevent any disease.
Vulnerable to Oxidation
Betacarotene
Lutein
Lycopene
Vitamin C
Internal Antioxidants
SOD
Catalase
SOD
CAT
The Measurable Difference
You have the 3 most powerful tools of the entire
nutritional supplement industry worldwide:
lifepak nano: The best multi-nutrient supplement.
 : The best functional fruit juice.
BioPhotonic SCANNER: The best consumer test
for antioxidant nutrition.
Key Business Takeaways
• G3™ supports your body’s antioxidant network*
• Lipocarotenes™ naturally increase absorption of
antioxidants*
• SCS Certified ~ 9,500 increase in 8 weeks
• 6 times more powerful than Noni or Xango™*
• Proprietary and patent pending
*Theses statements have not been evaluated by the Food and Drug Administration. This
product is not intended to diagnose, treat, cure, or prevent any disease.
More Information
Presentations
www.pharmanexusa.com
Leadership Conference link
My Office  Marketing Tools
Product Resources
www.pharmanexusa.com
www.pharmanexscanner.com
Product Support
E-Mail: [email protected]
Phone: 1-800-487-1000