Transcript Product Development

The Measurable Difference
Prepared for U.S. Aim High Conferences, 2004
What is LifePak®?
A comprehensive nutritional
wellness program delivering the
optimum amounts of all essential
and generally beneficial nutrients
for long-term health and wellbeing.*
*These statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure or prevent any disease.
Comprehensive & Convenient
Better than these 7 popular
supplements together.
>
Multi
Vitamin
Multi
Carotenes
Vitamin E
300 IU
Chromium
200 mcg
Vitamin C Calcium &
500 mg Magnesium
Multi
Flavonoid
®
LifePak
Health Benefits
Optimum supplementation for general well-being*
1. Addresses nutrient deficiencies*
2. Cardiovascular benefits*
3. Complete bone nutrition*
4. Promotes healthy immune function*
5. Supports normal blood sugar metabolism*
6. Protects against the symptoms of aging*
7. Raises your antioxidant defense*
*These statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure or prevent any disease.
Zi
n
c
80
Percent of Adults Not Meeting RDA
n
90
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6
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12
C
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The Need to Supplement
Males
Females
70
60
50
40
30
20
10
0
A Landmark Endorsement
Journal of the American Medical Association
June 2002
“… low levels of the antioxidant vitamins (vitamins A, E, and C)
may increase risk for several chronic diseases. Most people do
not consume an optimal amount of all vitamins by diet alone.”
“It appears prudent for all adults to take vitamin
supplements.”
Robert H. Fletcher, MD, MSc; Kathleen M. Fairfield, MD, DrPH, Harvard University
Journal of the American Medical Association 2002; 287: 3127-3129
Free Radicals & Antioxidants
Free Radicals
• Highly reactive, short-lived molecules
• Damage cells and genetic material (DNA)
• 70,000 free radical attacks on DNA every day in a cell
• Aging process
• Implicated in most health conditions
• Many different types of free radicals
Sources of Free Radicals
• Metabolism in your mitochondria
• Environmental pollution (smog, ozone, NO2)
• Radiation exposure:
– sunlight (UV-light), X-rays, etc.
• Smoking:
– 10,000,000,000,000,000 free radicals/cigarette!
Free Radicals & Antioxidants
Antioxidants fight free radicals
• Slow down aging process & improve health:
• over 30,000 research studies on antioxidant health benefits
• affecting over 50 health conditions, including cardiovascular
function, eye health, CNS health, skin health, etc.
• Many antioxidants work together:
“Antioxidant Defense System”
• Relies on a steady supply of dietary antioxidants
LifePak® 40+ Antioxidants
•
•
•
•
All 8 forms of natural vitamin E: 300 IU
Buffered vitamin C: 500 mg
Selenium, Copper, Zinc, Manganese
6 Carotenoids:
– as found in 5-10 fruits & vegetables per day
• Over 20 Flavonoids:
– 6 Catechins, Quercetin, naringenin, hesperidin,
3 Soy isoflavones, Over 10 grape seed polyphenols
• Alpha-Lipoic Acid: 30-50 mg
®
LifePak Science
is Measurable
• First to show antioxidant and
cardiovascular benefits in doubleblind studies*
• 200,000+ published studies on
LifePak’s antioxidants
• Nearly 800,000 published studies on
all LifePak ingredients
*These statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure or prevent any disease.
LifePak® Clinical Study
Antioxidant and Cardiovascular Health*
1200
1000
Placebo
LifePak
p < 0.001
800
600
Beta-carotene
65
60
716
p < 0.001
Placebo
LifePak
55
50
400
50.9
45
200
331
335
43.4
299
40
0
Baseline
Endpoint
6
5
LDL Protection*
Baseline
Placebo
LifePak
Vitamin E
3.429
Endpoint
p < 0.001
6.248
4
3
42
30
8
7
35
42.1
3.305
Smidt CR, Seidehamel RJ, Devaraj S, Jialal I.
FASEB Journal Vol.13 No.4, p.A546, March
1999.
3.477
2
1
0
Baseline
Endpoint
*These statements have not been evaluated by the Food and Drug
Administration. This product is not intended to diagnose, treat, cure or prevent
any disease.
LifePak® Antioxidant Capacity (ORAC)
Jan 2003
3500
3000
2500
2000
1500
1000
500
Li
fe
Pa
k
LM
-E
M
LM
-D
M
M
-2
M
LM
-C
M
LM
-B
M
LM
-A
M
M
M
-1
0
Pharmanex® BioPhotonic Scanner
• LifePak® augments the entire
antioxidant defense system*
• The effect can easily be
demonstrated using the
BioPhotonic Scanner
• Clinical studies identify link
between scores and healthy diet
and lifestyle
*This statement has not been evaluated by the Food and Drug Administration. This
product is not intended to diagnose, treat, cure or prevent any disease.
Function and Structure of Carotenoids
Lycopene
-carotene
-carotene
Zeaxanthin
•
•
•
•
•
•
uptake through the diet
safe vitamin A sources (a- & b-carotene)
antioxidants (1O2 quenchers)
promote immune function (b-carotene)
protect cellular DNA (lycopene)
protect macular region of retina (lutein)
Lutein
Biological Functions of Carotenoids
Bright beaks in birds signal health
of the immune system
Color of the beak is signal female
zebra finches consider when
selecting a mate; clear now that a
male's carotenoid levels, and
therefore attractiveness, are linked to
the effectiveness of his immune
function.
Zebra finch
Source: Pennisi, E. 2003. Colorful males flaunt their health. Science 300: 29-30
What is a Spectrometer?
Spectrometer
An instrument that separates light signals into
different frequencies, producing a spectrum
What is Raman Spectroscopy?
“Raman” effect
A scattering of electromagnetic radiation through a
transparent medium in which light changes in frequency
(color)
Raman
Laser scattered light
light
Vibronic Energy
Levels
Excited Carotenoid molecules shift blue laser light color
from blue to green
Scanner Science is Measurable
•
•
•
•
National Institutes of Health and Office of Dietary Supplements
New York Academy of Sciences
Oxygen Club of California
FASEB/American Physiological Society - Oct 2003 and April
2004
• Gordon Research Conference
• Review paper pending publication in Current Topics in
Nutraceutical Research
Demographic Study - Sep 2002
120
90th
75th
100
95
99th
th
Mean: 19,072
SD: 8,828
1,375 Subjects
50th
25th
10th
5th
1
Percentile Rankings:
1st
4,500
5th
8,500
10th 10,500
25th 13,500
50th 17,500
75th 22,500
90th 30,500
95th 36,500
99th 48,000
st
60
40
20
BDS Categories
79000
76000
73000
70000
67000
64000
61000
58000
55000
52000
49000
46000
43000
40000
37000
34000
31000
28000
25000
22000
19000
16000
13000
10000
7000
4000
0
1000
Frequency
80
Demographic Study
Raman Intensity, Counts
25000
23997
25377
20000
19669
15000
16827
p < 0.01
p < 0.01
10000
5000
n = 534
n = 649
n = 137
n = 30
2 to 3
4 to 5
6 or More
0
1 or Less
Reported Daily Fruit & Vegetable Servings
35000
30000
Raman Intensity, Counts .
1,375-Subject Study
Results show that Skin Carotenoid
Signal:
• Is not influenced by Age, gender or
skin pigmentation (race/ethnicity)
• Is high in people who eat more fruits
& vegetables
• Is high in people who take LifePak*
• Is low in people who smoke or have
oxidative stress (free radical
damage)
.
30000
28848
25000
25717
p < 0.01
20000
p < 0.01
20193
17888
15000
10000
5000
n = 800
n = 192
n = 89
n = 59
None
Irregular
One/Day
Two/Day
0
*These statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure or prevent any disease.
Reported LifePak Usage
Clinical Study - Sep 2002
LifePak®  Scanner Score*
40000
Raman Intensity, Counts .
35000
p = 0.23
30000
32175
p < 0.01
28924
25991
25000
p < 0.001
20000
18828
15000
10000
0
4
8
Time (Weeks)
*This statement has not been evaluated by the Food and Drug Administration. This
product is not intended to diagnose, treat, cure or prevent any disease.
12
Body Fat - Inverse Correlation
30000
Raman Intensity (mean)
25000
20000
15000
10000
5000
0
Normal
(N = 131,122 scans)
Overweight
Obese
Body Mass Index (BMI)
Morbidly Obese
Antioxidant Status and Weight Loss
1. Overweight and obesity are associated with decreased
antioxidant protection.
2. Dieting causes stress to the body, generating more
free radicals, which may result in decreased
antioxidant protection.
Conclusion
Overweight individuals and anyone on a diet should
increase antioxidant protection through diet and
supplementation.
Carotenoid Correlation Study
June 2003
60,000
Raman Intensity Counts
50,000
40,000
30,000
20,000
r = 0.78 p < 0.001
10,000
0
0.0
1.0
2.0
3.0
Total Serum Carotenoids (mg/ml)
Pending publication, FASEB April 2004
4.0
Scan Values in Asians
28,000


26,000

24,000
22,000

20,000

LifePak 2/day
LifePak 1/day
no Lifepak
Singapore study - Dec 2003
Thailand study - Jan 2004
Same data relationship as U.S.
study (diet, supplements, body
fat, lifestyle)
25,000 average with 82% of
participants taking LifePak®
LifePak® users (2/day) scored
25% higher than non-LP users*
*This statement has not been evaluated by the Food and Drug Administration. This
product is not intended to diagnose, treat, cure or prevent any disease.
Internal data on file.
Summary of Scanner Research
 Data from 300,000 scans and Asian studies correlate with
original demographic study of 1,300 participants
 Known risk factors that induce oxidative stress reduce
scanner score
 Healthy diets improves score
 Long-term LifePak® supplementation improves score*
 Score is related to lean body mass & body fat
 Desirable score is the blue zone, the higher the better
*This statement has not been evaluated by the Food and Drug Administration. This
product is not intended to diagnose, treat, cure or prevent any disease.
Media Coverage in 2003
Self Magazine April 03
Elle Magazine Sep 03
Ms. Fitness Magazine Oct 03
NBC Today in LA
KNXV ABC News
Phoenix AZ News 3
WHDH-TV NBC Boston MA
WHAS 11 News Louisville KY
News All Morning New York
KUTV News Salt Lake City
NewsChannel 4 Columbus OH
CNBC Asia - Singapore
How DoesThe
Measuring
Skin
Carotenoids
Questions
Predict Antioxidant Status?
The Antioxidant Network
NAD(P)
THIOL
cycle
ROOH
ROH
VITAMIN E
cycle
ROO•
RO•
PUFA
VITAMIN C
cycle
+
NAD(P)H + H
Lipid–water
interface
O2– and other radicals
Carotenoids
+
Metabolism, strenuous exercise,
cigarette smoke, pollution
What Does
“25,000”
Mean?
The
Questions
• Serum equivalent ~ 1 mcg/ml (+ 10%, 95% CI)
1000 units ~ 0.04 mcg/ml
• ~ 5 servings fruits/veg. per day
30000
• 2-3 fruits/veg.
• Scan 19,000
• 0.7 mcg/ml serum
25377
23997
Skin Carotenoid Score
Average Diet
25000
20000
19669
15000
16827
p < 0.01
p < 0.01
10000
5000
n = 534
n = 649
n = 137
n = 30
1 or Less
2 to 3
4 to 5
6 or More
0
Fruit & Vegetable Servings
How Can I Improve My Score?
50,000
• Moderate fruit/veg. intake
SCS = 20,000
40,000
• Irregular supplement use
• Smoker
• High body fat
30,000
20,000
High
Moderate to High
Moderate
Low
en
et
ic
s
G
Fa
t
B
od
y
e
st
yl
Li
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D
ie
Su
t
pp
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m
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ts
10,000
How CanThe
I Improve
My Score?
Questions
50,000
• Take LifePak® 2x/day
• Improve diet
40,000
• Quit smoking
30,000
• Lose weight
20,000
High
Moderate to High
Moderate
Low
en
et
ic
s
G
Fa
t
B
od
y
e
st
yl
Li
fe
D
ie
Su
t
pp
le
m
en
ts
10,000
SCS = 42,000
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