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Curriculum Vitae
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Principal areas of expertise
EDUCATION AND
TRAINING
Prof. Mauro Krampera
Section of Hematology, Department of Medicine, University of Verona, Italy
Policlinico ‘G.B. Rossi’, P.le L.A. Scuro 10, 37134 Verona, Italy
+39-045-8124420 / 8124173
+39-045-8027488
[email protected]
http://www.dm.univr.it/?ent=persona&id=1163 , www.stemcellreslab-verona.it
Italian
February 24,1967
M
Hematology (Italian SSD MED/15), with particular focus on diagnostic and clinical
approach to hematological diseases and on stem cell biology and clinical
application
July 16, 1992:
Oct. 21, 1996:
Jan. 12, 2001:
2000-2001:
Oct. 18, 2007:
Nov. 13-14 2007:
Jan. 28, 2008:
Sept. 4, 2015
M.D. graduation at the University School of Medicine in Verona
(Italy). Title of the graduation thesis: "Intensive cyclic chemotherapy
in chronic myelogenous leukemia"
Specialization in Hematology, University of Verona (Italy). Title of
the Specialization thesis: “Immunophenotypic detection of minimal
residual disease in acute T-lymphoblastic leukemia”
Ph.D. in Experimental Hematology at the University of Milan (Italy).
Title of the Ph.D thesis: “Immunophenotypic detection of minimal
residual disease in acute T-lymphoblastic leukemia: G.I.M.E.M.A.
(Italian Group for the study of Adult Malignant Hematological
Diseases) multicentric study”
Academic Visitor and Research Associate at the Departments of
Hematology (Prof. J.M. Goldman) and Immunology (Prof. R.
Lechler) Imperial College School of Medicine, Hammersmith
Hospital, London, U.K. with a research project about the immune
regulation by mesenchymal stem cells in allogeneic bone marrow
transplantation.
Certification by the Italian Agency of Drug (AIFA) of Qualified
Person in authorized centres for the preparation of cell therapy
products (articolo 52 del D.L. 24 aprile 2006 n. 219)
AIFA Course in collaboration with ISS (Istituto Superiore di Sanità)
and CNT (Centro Nazionale Trapianti) for the use of cell therapy
products.
Courses on “Procedures in GMP rooms” e “GMP rooms cleaning”,
organized by Società A.M. Instruments Srl., Policlinico “G.B. Rossi”,
Verona.
Course “A Joint Basic Training Session for Quality Assurance &
Quality Control on Advanced Therapies”, organized by the
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International Society for Cellular Therapy (ISCT) in Seville (ESP).
WORK EXPERIENCE
Main activities and
responsabilities
Jan. 2, 2017:
Full Professor of Hematology, Department of Medicine, Section of
Hematology, University of Verona (Italy).
Jan. 29, 2015: Appointment of Full Professor of Hematology (art. 16 L. 240/2010).
Nov. 1, 2014:
Associate Professor of Hematology at the Department of Medicine,
Section of Hematology, University of Verona (Italy).
Dec. 3, 2013:
Appointment of Associate Professor of Hematology (art. 16 L. 240/2010)
1998-Oct. 2014: Assistant Professor and Consultant at the Department of Medicine,
Section of Hematology, University of Verona (Italy).
1998-present:
Acquisition of broad professional experience and competence, with
continuous clinical activity (including night and day on-call-service and
consultancy in other Hospital Units) and direct responsibility for patient
management, in all the services of the Section of Hematology, University
of Verona, including Inpatient Ward, Bone Marrow Transplant Unit
(whose he was Responsible for Quality Assurance), Outpatient Service
(Clinic and Hospital Day), and Laboratory of Hematological Diagnostics.
In particular, he has specific competences for diagnosis, treatment,
management of complications and follow-up of hematological patients
undergoing chemotherapy and autologous or allogeneic stem cell
transplantation.
2004-2013:
Member of the Faculty Council, at the Faculty of Medicine, University of
Verona.
2004-present:
collaboration with Dr. Luc Sensebé (Etablissement Francais du Sang
Centre Atlantique, Tours - Toulouse, France) to design protocols of
human mesenchymal stem cells for clinical use according to the rules of
GMP (Good Manufacturing Practice). Co-founder, with Dr. Sensebé, and
member of the European Consortium CASCADE (Cultivated Adult Stem
Cells for Damaged Epithelia), financed in 2008 by the 7TH Framework
Programme on Research, Technological Development and
Demonstration of European Commission.
2005-2006:
Member of the MIUR (Italian Ministry of University and Scientific
Research) 60% Commission for research fund assignment at the Faculty
of Medicine, University of Verona.
2005-present:
Coordinator of the Stem Cell Research Laboratory, Section of
Hematologiy, University of Verona, Italy (www.stemcellreslab-verona.it)
2005-present:
Coordinator and teacher of the PhD Course on ‘Biology and Clinical
Application of Stem Cells’, University of Verona, until 2013 belonging to
the PhD School of Translational Biomedical Sciences, Doctorate of
Oncological Pathology and Stem Cells, and since 2013 belonging to the
PhD School of Clinical and Experimental Biomedical Sciences.
2006-2013:
Member of the Research and Development Commission of the Faculty
of Medicine, University of Verona.
2006-2013:
Delegate of the Chancellor of the University of Verona inside the CORIT
(Consortium for the Research on Organ Transplantation)
2007-present:
Member of the Commission for Good Use of Blood, Azienda
Ospedaliera di Verona
2008-present:
Co-founder with Dr. Pierre Layrolle (INSERM, Nantes, France) and
member of the European Consortium REBORNE (Regenerating Bone
defects using New biomedical Engineering approaches), financed in
2009 by the 7TH Framework Programme on Research, Technological
Development and Demonstration of European Commission.
2010-present:
Assignement of High Qualification in ‘Biological and clinical integrated
approach to stem cell use in regenerative medicine’ by Azienda
Ospedaliera Universitaria Integrata (University Hospital) of Verona
2010-present:
Appointment by A.I.F.A. (Agenzia Italiana del Farmaco) of European
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2010-present:
2010-present:
2011-present:
2013-present:
2013-present:
2013-present:
Jan. 13, 2015:
2015-present:
2015-present:
2015-present:
2016-present:
2016-present:
Expert for Advanced Therapies inside EMA (European Medicines
Agency)
Appointment of Production Manager of the Cell Factory, Policlinico 'G.B.
Rossi', Verona
Responsible for Thrombocytemia Italian Registry (RIT) at the Section of
Hematology of Verona
Member of the Mesenchymal Stromal Cell (MSC) Committee of the
International Society for Cellular Therapy (ISCT)
Member of the Mesenchymal Stromal Cell (MSC) Ruler Working Group,
coordinated by Prof. Armand Keating (University of Toronto, Canada)
Institutional Representative of University of Verona inside APRE
(Agency for Promotion of European Research).
Member of the Commission for the final evaluation of the Doctorate
degree at the School of Oncology and Oncological Surgery, University of
Padua, Italy.
Nomination as external examiner for a Doctoral Thesis in the
Department of Biology, Faculty of Science and Engineering, National
University of Ireland Maynooth.
Responsible for the Laboratory of hematological flow-cytometric
diagnostics of the Section of Hematology, Azienda Ospedaliera
Universitaria Integrata (AOUI) Verona.
Member of the Study Group of the Italian Society of Diabetology (SID)
“Regenerative Medicine in diabetes” (Coordinator Prof. Lorenzo
Piemonti) at the Diabetes Research Institute, San Raffaele Hospital,
Milan, Italy.
Responsible for the Specialized Regional Center “Center for the
Translational Research in Regenerative and Immune Regulatory Cell
Therapy with Mesenchymal Stromal Cells (CRT-STAMI-RIM)” - prot. n.
25687 May 29th, 2015 by General Director of the Azienda Ospedaliera
Universitaria (AOUI) Verona, trasmitted to Veneto Region - “Sezione
Attuazione Programmazione Sanitaria”.
Teaching Coordinator for Blood diseases (SSD MED/15) for the
Department of Medicine, University of Verona, Italy.
Member of the Evaluation Expert Group (GEV) of the National Agency
for University and Reasearch Evaluation (ANVUR).
SCIENTIFIC ACTIVITY (Technical Skills and Competence):
The scientific activity is currently carried out at the Department of Medicine, Section of
Hematology, University of Verona (headed by Prof. Giovanni Pizzolo until September
2014, then by Prof. Achille Ambrosetti) and, from October 2000 to October 2001, it was
carried out at the Departments of Hematology (Prof. John M. Goldman) and Immunology
(Prof. Robert Lechler), Imperial College School of Medicine, Hammersmith Hospital in
London. At present he is the Coordinator of both the Stem Cell Research Laboratory and
the Laboratory of hematological flow-cytometric diagnostics of the Section of Hematology,
University of Verona. Main fields of interest:
1. immunophenotypic and functional characterization and sorting of lymphoid subsets in
peripheral blood and normal hemato-lymphopoietic tissues and in a number of malignant
and non-malignant conditions
2. immunophenotypic characterization of acute and chronic leukemias
3. clinical application of flow-cytometric monitoring of minimal residual disease (MRD) in
acute leukemia patients; he coordinated the use of this approach also in an Italian
multicentre study (GIMEMA LAL0496)
4. biology and clinical application of adult stem cells, including:
a) mesenchymal stromal cells: investigation of their differentiation potential and of their
role in regenerative medicine, transplant-related immune reactions following allogeneic
bone marrow transplantation, tumor-specific immune responses and stromal support to
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hematological and nonhematological malignancies;
b) hematopoietic stem cells: in vitro expansion and in vivo transplantation;
c) leukemia stem cells: study of the mechanisms of leukemia self-renewal, with particular
interest in the role of the Notch and Wnt pathways in the stromal support to acute and
chronic leukemia development, as potential targets for new drug development;
d) neural stem cells: study of in vivo niches of neurogenesis;
e) cardiac stem cells: study of the mechanisms of regeneration of infarcted myocardium;
f) epithelial stem cells: study of the mechanism of wound healing and epithelial
regeneration.
Scientific referee for many years for many scientific journals in the field of clinical
and experimental hematology, laboratory diagnostics, cell biology, clinical and
experimental immunology, transplantation, cell therapy and regenerative medicine
based on adult stem cells. For some of these journals the revision activity is carried out
very frequently (Blood, Leukemia, Haematologica, Stem Cells, Stem Cells and
Development, Cytotherapy, Plos One, Oncotarget).
Chronologically:
- British Journal of Haematology (2002-present)
- Haematologica (2004-present)
- Stem Cells and Development (2005-present)
- Biomaterials (2005-present)
- Bone (2006-present)
- Cytometry. Part B, Clinical Cytometry (2006-present)
- Chinese Journal of Clinical Rehabilitative Tissue Engineering Research (CRTER) (2006present)
- Stem Cells (2007-present)
- Leukemia & Lymphoma (2007-present)
- International Journal of Laboratory Hematology (2007-present)
- Journal of Clinical Rehabilitative Tissue Engineering Research (2007-present)
- Human Molecular Genetics (2007-present)
- Cell Proliferation (2007-present)
- Journal of Orthopaedic Research (2007-present)
- Annals of Hematology (2007-present)
- BioMedCentral Immunology (2007-present)
- Regenerative Medicine (2007-present)
- Expert Opinion on Biological Therapy (EOBT) (2008-present)
- Cell Biology International (2008-present)
- Cancer Letters (2008-present)
- Cytotherapy (2008-present)
- Cell Biology International (2008-present)
- Cells Tissues Organs (2009-present)
- Tissue Engineering (2009-present)
- Experimental Hematology (2009-present)
- Trends in Molecular Medicine (2009-present)
- Journal of Cellular and Molecular Medicine (2009-present)
- Eur J Immunol (2009-present)
- Cell &Tissue Research (2009-present)
- Leukemia (2010-present)
- PlosOne (2011-present)
- Acta Diabetologica (2011-present)
- Blood Transfusion (2011-present)
- Transplant Immunology (2011-present)
- Journal of Healthcare Engineering (2011-present)
- Journal of Immunological Methods (2011-present)
- Expert Opinion On Therapeutic Targets (2011-present)
- Blood (2011-present)
- FEBS J (2011-present)
- Mol Medicine (2011-present)
- Critical Reviews in Oncology/Hematology (2011-present)
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- Biotechnology and Molecular Biology Reviews (2012-present)
- Neurological Research (2012-present)
- Journal of Translational Medicine (2012-present)
- American Society of Hematology (ASH) meeting (2012-present)
- BMC Medicine (2012-present)
- Journal of Biomedicine and Biotechnology (2012-present)
- Reproductive BioMedicine Online (2012-present)
- Current Medicinal Chemistry (2012-present)
- Cancer Cell International (2012-present)
- Journal of Neuroscience Methods (2012-present)
- Stem Cell Research & Therapy (2013-present)
- Journal of Regenerative Medicine & Tissue Engineering (2013-present)
- Endocrine - International Journal of Basic and Clinical Endocrinology (2013-present)
- Biotechnology Progress (2013-present)
- Journal of Preventive Medicine (2013-present)
- Immunology Letters (2014-present)
- Journal of Cellular Physiology (2014-present)
- International Journal of Molecular Sciences (2014-present)
- Journal of Hematology & Oncology (2014-present)
- Expert Review of Clinical Immunology (2015-present)
- Stem Cells International (2015-present)
- Worldwide Cancer Research (formerly known as AICR) (2015-present)
- Peertechz Journal of Biomedical Engineering (2015-present)
- Future Neurology (2015-present)
- Cell and Gene Therapy Insights (2015-present)
- Journal of Biomaterials Applications (2015-present)
- FEBS Letters (2015-present)
- Oncotarget (2015-present)
- Human Molecular Genetics (2015-present)
- Cellular & Molecular Immunology (2015-present)
- Immunotherapy (2015-present)
- Cellular Physiology and Biochemistry (2015-present)
- Stem Cell Research & Therapy (2015-present)
- Stem Cells Translational Medicine (2016-present)
- Gene (2016-presente)
- Theranostic (2016-presente)
Project referee for:
- National Medical Research Council of Singapore
- Swiss National Science Foundation
- Medical Research Council (MRC), London, UK
- National Science Centre (Narodowe Centrum Nauki - NCN), Poland
- Multiple Sclerosis Society Grant Round U.K.
- Health and Social Services sector, The Research Council, Sultanate of Oman
- BRAIN-be - Belgian Research Action through Interdisciplinary Networks
- Etablissement Francais du Sang Centre Atlantique (EFS), France
- Research council of Oman
- Israel Science Foundation
- Leukaemia & Lymphoma Research
- Dutch Kidney Foundation
- Italian Ministry of Instruction, University and Research (MIUR) – Reprise - ResearchItaly
Guest Editor for Stem Cells International journal on topic of "Mesenchymal Stem Cell
Biodistribution, Migration, and Homing in Vivo" (2012)
Member of the Editorial Board of Stem Cells and Development journal (2012-present).
Affiliation to scientific societies:
1993 - present: Member of the Italian Society of Hematology (SIE)
1993 - present: Member of the Italian Society of Experimental Hematology (SIES)
2010 - present: Member of the Directive Board of the Italian Society for Clinical and
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Experimental Cytometry (S.I.Ci.C.S.)
2011 - present: Member of the MSC Committee of the International Society for Cellular
Therapy (ISCT)
2013 - present: Member of the American Society of Hematology (ASH)
2014 – present: Member of the Directive Board of the Italian Society of Experimental
Hematology (SIES)
December 2016 – present: Vice-President of the Italian Society of Experimental
Hematology (SIES).
Patents:
Patent n. TO2010U000026, deposited on 23rd February 2010, entitled: "Device for cell
culture", then converted into national (n. 272134) and international patent
(PCT/IB2011/000365) - International and European Patent: WO2011104612 (A2). Date:
09/01/2011 DEVICE FOR CELL CULTURE AND ANALYSIS.
Teaching activity:
COURSES:
1998-present:
1999-2000:
2001-present:
2002-present:
2004-present:
2003-present:
2005-present:
2013:
2015-present:
tutor in the Course of Hematology, Faculty of Medicine, University of
Verona
Course of “Immunological principles and methods” at the Specialization
School of Hematology, University of Verona (Italy)
Course of “Bone Marrow Transplantation” at the Specialization School of
Hematology, University of Verona (Italy)
Course of “Bone marrow and hemopoietic stem cell transplantation” at
the Faculty of Medicine, University of Verona (Italy)
Course of “Immunophenotypic analysis of normal hemopoiesis and
blood diseases” at the Faculty of Medicine, University of Verona (Italy)
Course of "Blood diseases" in the integrated course of "Oncology and
Blood diseases", Degree in Biomedical Laboratory Techniques at the
Faculty of Medicine, University of Verona (Italy), Teaching Pole of
Rovereto (Italy)
Coordinator and teacher of the PhD Course on ‘Biology and Clinical
Application of Stem Cells’, University of Verona, until 2013 belonging to
the PhD School of Translational Biomedical Sciences, Doctorate of
Oncological Pathology and Stem Cells, and since 2013 belonging to the
PhD School of Clinical and Experimental Biomedical Sciences.
Course on “Mesenchymal stromal cells” at the Master in “Hematopoietic
Stem Cells and Regenerative Medicine”, University of Parma (Italy)
Course on “Stem Cells Biology”, Degree in Molecular and Medical
Biotechnology, University of Verona (Italy).
1998-present: Supervisor or Co-supervisor in:
- 3 theses of the Faculty of Medicine (University of Verona, Italy)
- 2 theses of the Faculty of Nurse Sciences (University of Verona, Italy)
- 3 theses of the Faculty of Biomedical Laboratory Techniques (University of Verona, Italy)
- 1 thesis of Degree in Drug Biotechnology, Faculty of Drug Sciences (University of Milan,
Italy)
- 1 thesis of Degree in Applied Biomolecular Sciences (class LM-6), Faculty of Matematic,
Physic and Natural Sciences (University of Perugia, Italy)
- 4 theses of Degree in Bioinformatics and Medical Biotechnologies (LM9), Faculty of
Biotechnologies (University of Verona, Italy)
- 6 theses of Post Graduated Medical School of Hematology (University of Verona, Italy)
- 2 theses in Master of Immunology (Department of Immunology, Imperial College School
of Medicine, Hammersmith Hospital di Londra)
- 17 PhD theses of the Doctorate course of Stem Cell Biology and Clinical Applications
(University of Verona, Italy).
- 3 PhD theses of the Doctorate course of Experimental Hematology (University of Milan,
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Italy).
CONFERENCES AND CHAIRMANSHIP AT ITALIAN CONGRESSES AND SCIENTIFIC
EVENTS:
Sept. 15, 2002: Invited speaker at the 7th National Congress of the Italian Society of
Experimental Hematology, Modena (Italy), about 'Flow cytometry for minimal residual
disease detection in acute lymphoblastic leukemia'
Feb. 24, 2003: Invited speaker at the Ph.D Course of Biotechnologies Applied to Biomedical
Sciences, University of Verona (Italy), about 'Immunoregulatory effect on T cells mediated
by mesenchymal stem cells'
March 10, 2003: Invited speaker at the Specialization School of Hematology, University of
Perugia (Italy), about 'Immunophenotypic detection of minimal residual disease in acute
leukemias'
July 07, 2003: Invited speaker at the Department of Internal Medicine, Laboratory of
Immunology (Prof. S. Romagnani), University of Florence (Italy), about 'Mesenchymal stem
cells: an alternative pathway to modulate T-cell activation'
Nov. 28, 2003: Invited speaker at the course 'Updates in Hematology', organized by the
National Academy of Medicine, about 'Immunophenotype in Hematology', Verona, Ospedale
Civile Maggiore, Italy.
Oct. 10, 2004: Invited speaker at the course 'Stem cell biology', organized by the
Transfusional Centre, Azienda Ospedaliera di Verona, about 'Clinical applications of stem
cells in regenerative medicine', Verona, Ospedale Civile Maggiore, Italy.
Nov. 26, 2004: Invited speaker at the course 'Updates in Hematology', organized by the
National Academy of Medicine, about 'Immunophenotype in multiple myeloma', Verona,
Ospedale Civile Maggiore, Italy.
June 24, 2005: Invited speaker at the PhD course in Molecular and Cellular Biology and
Pathology, about ‘Regenerative and immunosoppressive potential of mesenchymal stem
cells’, Section of General Pathology, University of Verona, Italy.
Nov. 14, 2005: Invited speaker at the course ‘Acute leukemia: diagnostic-therapeutic
algorithm’, Vicenza, Hotel Boscolo De La Ville, Italy.
Jan. 20, 2006: Invited speaker at the 8th Meeting on Multiple Sclerosis, about ‘Regenerative
and immunoregulatory effects of mesenchymal stem cells’ Agriturismo Prati a Salti,
Buonconvento (Siena), Italy
March 15, 2006: Invited speaker at the 4th National Congress of the Italian Society of
Clinical and Experimental Cytometry, about ‘Minimal Residual Disease in Acute Lymphoid
Leukemia’, Rome (Italy), Università Tor Vergata.
Dec. 15, 2006: Invited speaker at the Workshop ‘Acute Lymphoblastic Leukemia’, about
‘Minimal residual disease: the role of flow-cytometry‘, Treviso (Italy), Presidio Ospedaliero
Ca’ Foncello.
Feb. 13, 2007: Invited speaker at the 1st Educational and training course for laboratory
technicians about research with animal models, University of Verona (Italy), about
‘Mesenchymal stem cells for regenerative medicine and immune regulation’,
Interdepartmental centre for experimental use of small-sized animals (C.I.R.S.A.L.),
University of Verona, Italy.
May 24-25, 2007: Organizer, chairman and speaker about ‘Mesenchymal stem cells and
immune effectors’ at the International Workshop on Mesenchymal Stem Cells for
Regenerative Medicine and Immune Regulation, Policlinico ‘G.B. Rossi’, Verona, Italy.
July 12, 2007: Scientific Responsible and speaker at the Round Table ‘Essential
Thrombocytemia: clinical and therapeutical management” – Verona, Hotel Boscolo Leon
d’Oro.
June 5, 2008: Chairman at the meeting of the Italian Society of Experimental Hematology
‘Discutiamone insieme SIES’ about ‘Mesenchymal stem cells’ – Firenze, Hotel Montebello
Splendid.
Sept. 24, 2008: Chairman and invited speaker about ‘Role of mesenchymal cell population
in cancer development’ at the National Congress of the Italian Society of Experimental
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Hematology (SIES) - Session ‘Mesenchymal stem cells’ - Bari, Italy
Sept. 26, 2008: Invited speaker at 38th Nation Congress of Transfusional Medicine, about
“Clinical applications of stem cells” - Session “Cell Therapy and Regenerative Medicine”–
Rimini, Italy.
Oct. 10, 2008: Scientific Responsible and speaker at the ECM Course ‘Essential
Thrombocytemia: clinical and therapeutical management” – Verona, Hotel Boscolo Leon
d’Oro.
Nov. 17, 2008: Chairman and invited speaker about ‘Biology and clinical application of
mesenchymal stem cells’ - Meeting FITOT (Fondazione per l’Incremento dei Trapianti
d’Organo e di Tessuti) – Verona, Italy.
Nov. 20, 2008: Invited speaker about ‘Role of stromal cells in the devolopment of cancer’,
Meeting LURM – University of Verona, Italy.
April 21, 2009: Invited speaker about ‘Mesenchymal Stem Cells and adipose tissue’, 1st
Italian Mesenchymal Stem Cell Meeting, Milan, Italy
May 6, 2009: Invited speaker about ‘Minimal residual disease in T-cell acute lymphoblastic
leukemia: flow-cytometry today’, 6th SICiCS (Società Italiana di Citometria Clinica e
Sperimentale) National Congress, Catania, Italy.
May 20, 2009: Co-organizer and Chairman at the Workshop ‘Neurogenesis and Neural
Differentiation of Stem Cells’, Verona, Italy.
June 22, 2009: Invited speaker about ‘Mesenchymal stem cells’ – Dipartimento di Medicina
Oncologica, Laboratorio di Ematologia – Trapianto di Midollo Osseo, Fondazione IRCCS,
Istituto Nazionale dei Tumori, Milan, Italy.
July 10, 2009: Invited speaker about ‘Engineered mesenchymal stem cells for anti-cancer
therapy’ at the Meeting on Stem Cells in Onco-hematology: Biology Clinical Applications,
Centro Studi Lorenzon – Treviso, Italy
Sept. 30, 2009: Invited speaker about ‘Mesenchymal stem cells: production and
standardization” at the XIV National Congress of the Italian Society of Emapheresis and Cell
Manipulation (SIdEM) - Palazzo dei Congressi di Pisa, Italy
Oct. 10, 2009: Invited speaker about ‘Methodological approach to stem cell research’ –
Workshop on “Stem cells: present, myths and perspectives” – Congresso AMMI, Gran
Guardia, Verona, Italy
Oct. 23, 2009: Invited speaker about ‘Mesenchymal stem cells in allogeneic hematopoietic
stem cell transplantation’ - Workshop on ‘Stem cells: safe therapeutical potential’, Brescia,
Italy
Oct. 29, 2009: Invited speaker about ‘Stem cells and spinal cord injury: a feasible wedding?’
– Unità Spinale Ospedale Sacro Cuore Negrar (VR), Italy
Nov. 2, 2009: Invited speaker about ‘Biology and functional characterization of
hematopoietic stem cells’ – Stage on ‘Autologous stem cell transplantation’, Pesaro, Italy.
Feb. 25, 2010: Invited speaker about ‘Hematopoietic stem cells in hematopoiesis and nonhematopoietic regeneration” – Divisione Universitaria di Ematologia e Terapie Cellulari,
Università di Torino, Italia.
March 26, 2010: Invited speaker about ‘Leptomeningeal stem cells in spinal cord injury’ –
Politecnico di Torino, Italy
April 20, 2010: Invited speaker about ‘Biology and functional characterization of
hematopoietic stem cells’ – Excellence Center DENOTHE, University of Florence, Italy.
Sept. 7, 2010: Invited speaker about ‘The importance of clinical trials in European research
projects: CASCADE e REBORNE, two examples of successful projects.” – National Day of
presentation of 2011 Health call of the 7th Framework Programme on Research,
Technological Development and Demonstration – University of Verona, Policlinico G.B.
Rossi.
Sept. 17, 2010: Invited speaker about ‘Immunophenotypic monitoring of minimal residual
disease in adult acute lymphoblastic leukemia’ – 25th Congress of the Gruppo Piemontese
Marcatori Immunologici (GPMI) – Centro Restauro Reggia di Venaria - Torino, Italy
Sept. 23, 2010: Co-organizer, chairman and speaker about ‘Minimal residual disease in
acute lymphoblastic leukemia: flow-cytometric protocols and clinical application’ – 7th
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National Congress of the Italian Society for Clinical and Experimental Cytometry
(S.I.Ci.C.S.) – Rimini, Italy
Oct. 16, 2010: Invited speaker about ‘Biology and functions of hematopoietic stem cells’ –
Workshop on “Cord blood donation: the role of Obstetrician’ – Hotel Leopardi, Verona, Italy
Nov. 12, 2010: Invited speaker about ‘Hematopoietic stem cell characterization’ –
Hematopatology Meeting– Aula Magna Policlinico “G.B. Rossi”, Verona, Italy
June 27, 2011: Invited speaker about ‘Immune regulatory properties of mesenchymal stem
cells’ - Laboratory of Cell Biology and Advanced Cancer Therapies Dpt. Oncology,
Hematology and Respiratory Diseases University Hospital of Modena and Reggio Emilia,
Modena (Italy).
Sept. 30, 2011: Organizer and Chairman of the Educational ‘Immunophenotypic
characterization of stem cells’ – Aula Magna Policlinico “G.B. Rossi”, Verona, Italy.
Oct. 21, 2011: Invited speaker about ‘GMP facility realization inside the Academic/Hospital
context: Verona experience’ - Workshop on ‘Advanced cell therapies amongst rules,
research and clinic: an update on the state-of-the-art’ - Vicenza, Italy
Nov. 8, 2011: Invited speaker about ‘Stem Cells and Adipose Tissue’ – XV National
Congress of the Italian Society of Hemapheresis and Cell Manipulation (SIdEM), Torino,
Italy
Nov. 12, 2011: Invited speaker about ‘Leukemia stem cells: the past’ – Meeting ‘2001-2011:
What has changed in Hematology’ – Treviso, Italy.
Nov. 15, 2011: Invited speaker about ‘Minimal residual disease in acute lymphoblastic
leukemia’ –S.I.Ci.C.S. Meeting (Italian Society for Clinical and Experimental Cytometry)
“Flow-cytometry in the clinical decisional process of laboratory medicine” – Parma, Italy.
Feb. 2-4, 2012: Invited speaker about ‘Regenerative Medicine’ - 5st Post-ASH 2012
Educational Meeting - Milano, Italy.
Feb. 10-11, 2012: Invited speaker about ‘Stem cells: biology, certainties and perspectives’ Studying blood towards personalized medicine - Giorgio de Sandre’s (1926-2002) heritage –
Verona, Italy
Oct. 02, 2012: Chairman at the SIMeL-SICiCS Pre-Congress Course “Flow-cytometry in the
clinical decisional process of laboratory medicine”, 26° Congresso Nazionale della Società
Italiana di Medicina di Laboratorio (SIMeL), Salerno 2-5 ottobre 2012.
Nov. 05, 2012: Chairmen at SIBioC-SICiCS Pre-Congress Course “Flow-cytometry in the
clinical decisional process: minimal residual disease”, 44° Congresso Nazionale della
Società Italiana di Biochimica Clinica e Biologia Molecolare Clinica (SIBioC), Salerno 2-5
ottobre 2012.
Feb. 14-16, 2013: Invited speaker about ‘Regenerative Medicine’ - “Post-Atlanta 2012 Educational Meeting – News from the American Society of Hematology (ASH) Annual
Meeting” – Bologna, Italy.
May 17, 2013: Invited speaker about “Mesenchymal stem cells: what and where they are,
and how they can be used for cell therapy” – Specialization Course in Hematology,
University of Brescia, Italy.
Oct. 8, 2013: Invited speaker about “Standardized approach to the assessment of
mesenchymal stromal cell immune regulatory properties” – 3rd Workshop AIEOP
(Associazione Italiana Ematologia Oncologica Pediatrica) in Lab, IRCCS Policlinico S.
Matteo, Pavia, Italy.
Oct. 20-23, 2013: Member of the Organizing Committe of the 44th National Congress of the
Italian Society of Hematology (SIE) - Verona, Italy.
Nov. 14, 2013: Co-organizer and Chairman of the Joint Session SIES-SCR “Bone Marrow
stem cells and microenvironment” – 4th National Workshop of the Italian Society of
Experimental Hematology (SIES) – Translational Hematology, Bologna, Italy.
Feb. 7, 2014: Chairman and Speaker at the Session “Trasfusional and Regenerative
Medicine” of the Post - New Orleans 2013 – News from the Meeting of the American Society
of Hematology (ASH), Neaples, Italy.
March 20-21, 2014: Invited speaker about “Comparison of mesenchymal stromal cells
(MSC) from different tissues" at the Fifth Meeting of the Mesenchymal Stem Cells in Solid
9
Organ Transplantation (MiSOT) group, Bergamo, Italy, organized by IRCCS - Istituto di
Ricerche Farmacologiche Mario Negri di Milano.
October 15, 2014: Invited speaker about “Stromal support to hematological malignancies”
at the XIII National Congress of the Italian Society of Experimental Hematology (SIES) –
October 15-17, 2014, Rimini, Italy.
Nov. 14, 2014: Invited speaker about “Mesenchymal stromal cells: from biology to
standardisation” at the 5th International Satellite Symposium AICC-GISM – November 14,
2014, Verona, Italy.
Feb. 13, 2015: Chairman at the Session “Trasfusional Medicine and Cell Therapies” of the
Post - San Francisco 2014 – News from the Meeting of the American Society of
Hematology (ASH), Verona, Italy.
April 10, 2015: Invited speaker about “Mesenchymal stromal cells in regenerative and
immune regulatory medicine” at the National Meeting ANBI (National Association of Italian
Biotechnologists) on “Regenerative medicine in Italy: great advances and false miths” –
Polo Scientifico “Fabio Ferrari”, Povo (TN), Italia.
May 13, 2015: Invited speaker about “Mesenchymal stromal cells: identification, production
and therapeutical use” at the 14th Advanced Training Course on “Circulating rare cells” Collegio Ghislieri, Pavia, Italy.
May 22, 2015: Invited speaker about Mesenchymal stromal cells for GvHD treatment” at
Inter-regional Meeting SIE (Italian Society of Hematology, Delegazione Triveneto) on “Cell
therapies in Hematology” – Udine, Italy.
Oct. 29, 2015: Co-organizer and Chairman at the Session “Notch and Wnt Systems in
hematological malignancies”, 5th Educational Workshop of the Italian Society of
Experimental Hematology (SIES) - Pisa, Italy, October 29-30, 2015.
Nov. 21, 2015: Chairman at the Session “Non only CAR-T cells” at the Workshop “New
frontiers in the treatment of oncological and hematological malignancies” – Treviso,
November 20-21, 2015.
Nov. 26, 2015: Invited speaker about “Stem Cells in Regenerative and Immune Regulatory
Medicine” at the Workshop – “Transplants in Verona”, Scuola Medica Ospedaliera, AOUI
Verona.
March 11, 2016: Invited speaker about “What stem cells are for” at UniStem Day – Aula
Magna - Policlinico, University of Verona, Italy.
April 21, 2016: Chairman at the “Discutiamone Insieme” Meeting of the Italian Society of
Experimental Hematology (SIES) about “Precision Medicine in lymphoproliferative
disorders: new targets, new molecules and new resistance” - Florence, Italy.
May 26, 2016: Invited speaker about “Mesenchymal cells: from characterization to clinical
applications” – 42nd National Congress of Transfusional Medicine (SIMTI) - Bologna, Italy,
May 25-28, 2016.
Oct. 3, 2016: Invited speaker about “Reconstruction of scaphoid bone defects by using
autologous ex-vivo expanded mesenchymal stromal cells” at the Workshop “Advanced
Therapies: update on clinical trials and biological drug production” – University of Milan.
Oct. 11, 2016: Chairman at the Session “Cytopenias” at the 7th Edition of the “Giornate
Ematologiche Vicentine” – Vicenza (Italy), October 10-12, 2016.
Oct. 19, 2016: Co-organizer and Chairman at the Istitutional Session C
“Microenvironmental intercellular communication” al XIV National Congress of the Italian
Society of Experimental Hematology (SIES) – October 19-21, 2016, Rimini, Italy.
Nov. 7, 2016: Invited speaker about “Mesenchymal stromal cells (MSCs): from
characterization to clinical application” a “In House Meetings 2016/2017” – University of
Verona, Policlinico G.B. Rossi, Verona, Italy.
Nov. 11, 2016: Chairman at the Session “Iron rare diseases” at the Workshop “Iron
metabolism disorders: an expanding landscape” – November 11, 2016 - Verona, Italy.
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24/11/2016: Lecture on “From minimal residual disease monitoring to the study of stem
cell compartment in leukemia development: research, teaching and clinical practice” at the
Department of Medicine, University of Verona, Policlinico G.B. Rossi, Verona, Italy.
CONFERENCES AND CHAIRMANSHIP AT INTERNATIONAL CONGRESSES AND
SCIENTIFIC EVENTS:
May 12-13, 2008: Co-organizer, chairman and speaker about ‘Mesenchymal stem cells and
neoplasia’ at the 2nd International Workshop on Mesenchymal Stem Cells for Regenerative
Medicine and Immune Regulation, Palais des Congrès Vinci, Tours – France.
July 2, 2008: Invited speaker at the ESH-EHA Scientific Workshop on Biology and Clinical
Applications of Mesenchymal Stem Cells, about ‘Expression of TLRs on MSCs’ – Sofitel,
Mandelieu La Napoule, France.
June 12-13, 2009: Co-organizer, chairman and speaker about ‘Engineered Mesenchymal
stem cells for the treatment of cancer’ at the 3rd International Workshop Multipotent Stromal
Cells (MSCs) for Regenerative Medicine and Immune Regulation, Frankfurt – Germany.
Nov. 18-20, 2010: Co-organizer, chairman and speaker about ‘Licencing of mesenchymal
stem cells’ at the First European Conference on MSC and Regeneration - from molecular
mechanisms to clinical trials, Toulouse – France.
June 10-12, 2011: Invited speaker about ‘Clinical use of mesenchymal stem cells (MSC):
CASCADE and REBORNE projects (European Commission 7th Framework Programme)’ Stem Cell Research Italy - International Society For Cellular Therapy - Europe - Joint
Meeting, Montesilvano (PE), Italy.
June 5-9, 2012: Chairman of the Session ‘Mesenchymal Stromal Cells (MSCs) and Clinical
Uses’ - 18th International Society for Cellular Therapy (ISCT) Annual Meeting - Seattle, USA
Dec. 10, 2012: Chairman of the Oral Session “Hematopoiesis and Stem Cells Microenvironment, Cell Adhesion and Stromal Stem Cells: The Hematopoietic
Microenvironment”, 54th American Society of Hematology (ASH) Annual Meeting and
Exposition (December 8-11, 2012), Atlanta, GA, USA.
March 25-27, 2013: Invited speaker about “Immune regulation by mesenchymal stromal
cells” - “Working Together on MSC Standards: A UK/USA/Canada Led Workshop at the
NIH” – Bethesda, MA, USA.
March 31, 2014: Chairman of the Oral Session 16 ‘Regenerative Medicine’ - European
Society for Blood and Marrow Transplantation (EBMT) 2014 Meeting, March 30 – April 2,
2014 - Milan, Italy.
April 25, 2014: Co-organizer and Chairman of the Plenary Session ‘Cellular therapies in
solid organ transplantation and tissue engineering’ - 19th International Society for Cellular
Therapy (ISCT) Annual Meeting – April 23-26, 2014 - Paris, France.
June 6, 2014: Invited speaker about “Stromal bone marrow microenvironment in cancer
development" at the XI International Conference “Haematopoiesis Immunology”, Budapest
(Hungary), June 6-7, 2014.
May 29, 2015: Co-organizer and invited speaker about “Immunological Assays as Potency
Release Criteria for mesenchymal stromal cells” at the 20th International Society for
Cellular Therapy (ISCT) Annual Meeting – May 27-30, 2015 – Las Vegas, USA.
Sept. 24-26, 2015: Co-organizer and Chairman at the International Society for Cellular
Therapy (ISCT) Europe 2015 Regional Meeting – Seville, Spain.
Oct. 16, 2015: Invited speaker about "Immunological assays as functional release criteria
for mesenchymal stromal cells (MSCs)" at the “Second Symposium on Mesenchymal
Stromal Cell (MSC) biology and clinical potential”, Stockholm (Sweden) 15-16 October
2015.
PERSONAL SKILLS AND
COMPETENCES
MOTHER TONGUE
Italian
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OTHER LANGUAGES
Reading skills
Writing skills
Verbal skills
Organization skills
Technical Skills
English
very good
very good
very good
Excellent, acquired during his work activity in Verona and abroad. He coordinates clinical
and diagnostic activity, as well as experimental and clinical research.
a. Cell cultures:
- isolation and culture of human and murine mononuclear cells
- in vitro expansion of human and murine mesenchymal stem cells
b. Co-culture of human and murine mesenchymal stem cells and lymphocytes
c. Functional assays to measure cell proliferation and cytotoxicity
d. Flow-cytometry:
- surface and intracellular staining with monoclonal antibodies
- intracellular cytokine detection after activation by specific peptides
- quantitative flow-cytometry
- cell sorting
- immunophenotypic analysis of minimal residual disease in acute and chronic leukemias
e. Management of mouse and rabbit models for in vitro and in vivo experiments
f. Management of advanced cell therapies according to GMP rules
g. Management and statistical analysis of clinical and laboratory experimental data.
Clinical skills
Since 1998 he acquired broad professional experience and competence, with continuous
clinical activity (including night and day on-call-service and consultancy in other Hospital
Units) and direct responsibility for patient management, in all the services of the Section of
Hematology, University of Verona, including Inpatient Ward, Bone Marrow Transplant Unit
(whose he was Responsible for Quality Assurance), Outpatient Service (Clinic and
Hospital Day), and Laboratory of Hematological Diagnostics. In particular, he has specific
competences for diagnosis, treatment, management of complications and follow-up of
hematological patients undergoing chemotherapy and autologous or allogeneic stem cell
transplantation. Such competences include:
- management and organization of standard and intensive care activity, diagnostic and
therapeutic management of acute and chronic leukemias, indolent and aggressive
lymphomas, myeloma, bone marrow aplasia, non-oncological blood diseases,
complications of immuno-chemotherapy
- selection and treatment of patients undergoing autologous or allogeneic hematopoietic
stem cell transplantation and management of infectious and immunological complications
(Graft-versus-Host disease, secondary immunodeficiency)
- management and organization of Hematology Outpatient Service and Hospital Day
activities
- consultancy activity in standard care and emergency
- morphological and immunophenotypic diagnostics of blood disorders.
Computer skills
Very good, with both Windows and Mac platforms (Office, Adobe and similar programs, as
well as internet browsers and videoconference programs).
Driving licence
B
12
ADDITIONAL
INFORMATION
PUBLICATIONS
1. P. Gasparini, A. Savoia, A. Ambrosetti, F. Bernardi, M. Krampera, P.F. Pignatti. Analisi
del riarrangiamento bcr-abl in alcuni pazienti affetti da leucemia mieloide cronica.
Haematologica 5(1):598-599, 1989.
2. A. Ambrosetti, M. Krampera, D. Veneri, V. Meneghini, F. Aprili, G. Martinelli, G. Pizzolo
and G. Perona - Early lymphoid blastic crisis following major karyotypic conversion in a
chronic myeloid leukemia patient treated with interferon-α. Int J Clin Lab Res 24:58-59,
1994.
3. F. Vinante, A. Vassanelli, R. Zanotti, G. Nadali, M. Krampera, C. Vincenzi, L. Morosato,
M. Chilosi, G. Pizzolo. Circulating levels of soluble CD23 reflect clinical and biological
features of leukemic B-cell chronic lymphoproliferative disorders. Int J Clin Lab Res
25:189-194, 1995.
4. M. Chilosi, C. Doglioni, A. Magalini, G. Inghirami, M. Krampera, G. Nadali, D. Rahal, S.
Pedron, A. Benedetti, M. Scardoni, E. Macrì, M. Lestani, F. Menestrina, G. Pizzolo, A.
Scarpa. p21/WAF1 cyclin-kinase inhibitor expression in non-Hodgkin's lymphomas: a
potential marker of p53 tumor-suppressor gene function. Blood 88:4012-4020, 1996.
5. G. Pizzolo, F. Vinante, G. Nadali, M. Krampera, L. Morosato, M. Chilosi, R. Raiteri, A.
Sinicco. High serum level of soluble CD30 in acute primary HIV-1 infection. Clin Exp
Immunol 108: 251-253, 1997.
6. G. Nadali, L. Tavecchia, E. Zanolin, V. Bonfante, S. Viviani, E. Camerini, P. Musto, N. Di
Renzo, M. Carotenuto, M. Chilosi, M. Krampera, G. Pizzolo. Serum level of the soluble
form of CD30 molecule identifies patients with Hodgkin's disease at high risk of
unfavourable outcome. Blood 91:3011-3016, 1998.
7. F. Vinante, A. Rigo, C. Tecchio, L. Morosato, G. Nadali, M.M. Ricetti, M. Krampera, E.
Zanolin, F. Locatelli, H. Gallati, M. Chilosi, G. Pizzolo. Serum levels of p55 and p75 soluble
TNF receptors in adult acute leukemia at diagnosis: correlation with clinical and biological
features and outcome. Br J Haematol 102: 1025-1034, 1998.
8. M. Krampera, A. Antico, F. Vinante, L. Morosato, G. Pizzolo. Lymphocyte membrane
antigen expression and intracellular cytokine patterns in an asymptomatic patient with
persistently high serum levels of IgE. Ann Allergy, Asthma, & Immunol 83:144-148, 1999.
9. M. Krampera, F. Vinante, L. Tavecchia, L. Morosato, M. Chilosi, S. Romagnani, M.E.
Zanolin, G. Pizzolo. Progressive polarization towards a T-helper/cytotoxic type-1 cytokine
pattern during age-dependent maturation of the immune response inversely correlates with
CD30 cell expression and serum concentration. Clin Exp Immunol 117: 291-297, 1999.
10. F. Vinante, M. Krampera, L. Morosato, A. Rigo, S. Romagnani, G. Pizzolo. Peripheral
T lymphocytes cytokine profile (IFN-γ, IL-2, IL-4) and CD30 expression/release during
measles infection. Haematologica 84: 683-689, 1999.
11. M. Krampera, L. Tavecchia, F. Benedetti, G. Nadali, G. Pizzolo. Intracellular cytokine
profile of cord blood T-, and NK cells, and monocytes. Haematologica 85: 675-679, 2000.
12. C. Mecucci, R. La Starza, M. Negrini, S. Sabbioni, B. Crescenzi, P. Leoni, F. Di
Raimondo, M. Krampera, G. Cimino, A. Tafuri, A. Cuneo, A. Vitale, R. Foa.
t(4;11)(q21;p15) translocation involving NUP98 and RAP1GDS1 genes: characterization of
a new subset of T acute lymphoblastic leukemia. Br J Haematol 109(4): 788-793, 2000.
13. M. Krampera, G. Fattovich, M.T. Scupoli, G. Pizzolo. Early decrease of interferon-γ+
and interleukin-2+ T cells during combination treatment with interferon-alpha and ribavirin
in patients with chronic hepatitis C. Am J Gastroenterol 95(12): 3670-3673, 2000 (letter).
13
14. M. Krampera, O. Perbellini, A. Maggioni, F. Scognamiglio, G. Todeschini, G. Pizzolo.
Flow-cytometric detection of minimal residual disease in adult acute lymphoblastic
leukemia. Haematologica 86(3): 322-323, 2001 (letter).
15. D. Veneri, M. Gottardi, E. Guizzardi, C. Zanuso, M. Krampera, M. Franchini. Idiopathic
thrombocytopenic purpura, Helicobacter pylori infection and HLA class II alleles. Blood
100(5): 1925-1926, 2002 (letter).
16. D. Veneri, M. Franchini, M. Gottardi, M. D'Adda, A. Ambrosetti, M. Krampera, F.
Zanetti, G. Pizzolo. Efficacy of Helicobacter Pilorii eradication in raising platelet count in
adult patients with idiopathic thrombocytopenic purpura. Haematologica 87: 1177-1179,
2002.
17. D. Veneri, F. Zanetti, M. Franchini, M. Krampera, G. Pizzolo. Low-dose epirubicin in
combination with cyclophosphamide, vinblastine and prednisone (mini-CEOP) for the
treatment of aggressive non-Hodgkin’s lymphoma in elderly patients. Haematologica
87(11):ELT43, 2002 (letter).
18. M. Krampera, A. Vitale, C. Vincenzi, O. Perbellini, A. Guarini, L. Annino, G.
Todeschini, A. Camera, F. Fabbiano, G. Fioritoni, F. Nobile, R. Szydlo, F. Mandellli, R.
Foà, G. Pizzolo. Outcome prediction by immunophenotypic minimal residual disease
detection in adult T-cell acute lymphoblastic leukemia. Br J Haematol 120(1): 74-79, 2003.
19. M. Krampera, S. Glennie, R. Laylor, J. Dyson, D. Scott, E. Simpson, F. Dazzi. Bone
marrow mesenchymal stem cells inhibit the response of naïve and memory antigenspecific T cells to their cognate peptide. Blood 101: 3722-3729, 2003.
20. M. Franchini, M. Krampera, D. Veneri. Helicobacter pylori eradication in adults with
idiopathic thrombocytopenic purpura. Am J Med 114:420-1, 2003 (letter).
21. L. Elia, M. Mancini, L. Moleti, G. Meloni, S. Buffolino, M. Krampera, G. De Rossi, R.
Foà, G. Cimino. A multiplex reverse transcriptase-polymerase chain reaction strategy for
the diagnostic molecular screening of chimeric genes: a clinical evaluation on 170 patients
with acute lymphoblastic leukemia. Haematologica 88: 275-279, 2003.
22. D. Veneri, M. Krampera, L. Zaffanello, G. de Matteis, P. Solero, M. Franchini.
Screening for hemochromatosis in a population with abnormal iron status. Haematologica
88: 593-594, 2003 (letter).
23. D. Veneri, M. Franchini, F. Zanetti, M. Krampera, G. de Matteis, F. Federici, P. Solero,
G. Pizzolo. Iron overload in acute myeloid leukemia patients is not related to HFE and
TFR2 gene mutations Haematologica 88:1069-1070, 2003 (letter).
24. M. Franchini, M. Krampera, D. Veneri. Deep vein thrombosis after orthopedic surgery
in a patient with type 1 von Willebrand disease and mutations in the MTHFR and betafibrinogen genes. Thrombosis and Haemostasis 90: 963-4, 2003 (letter).
25. M.T. Scupoli, F. Vinante, M. Krampera, C. Vincenzi, G. Nadali, F. Zampieri, M.A.
Ritter, E. Eeren, F. Santini, G. Pizzolo. Thymic epithelial cells promote survival of human
T-cell acute lymphoblastic leukemia blasts: the role of interleukin-7. Haematologica 88:
1229-37, 2003.
26. M. Krampera, F. Venturini, F. Benedetti, A. Oliani, S. Carolei, C. Visco, H. Aqel, G.
Pizzolo, G. Scroccaro. Computer-based drug management in a bone marrow transplant
unit: a suitable tool for multiple prescriptions even in critical conditions Br J Haematol
125(1): 50-7, 2004.
27. D. Veneri, M. Krampera, M. Franchini. Helicobacter pylori infection and idiopathic
thrombocytopenic purpura: description of 21 newly diagnosed cases. Haematologica
89(4): ECR08, 2004.
14
28. D. Veneri, H. Aqel, M. Franchini, M. Krampera, R. Zanotti, G. Pizzolo. Malignant
evolution of monoclonal gammopathy of undetermined significance: analysis of 633
consecutive cases with a long term follow-up. Haematologica 89(7): 876-878, 2004.
29. G.M. Bendle, A. Holler, L.K. Pang, S. Hsu, M. Krampera, E. Simpson, H.J. Stauss.
Induction of unresponsiveness limits tumor protection by adoptively transferred MDM2specific cytotoxic T lymphocytes. Cancer Res 64: 8052-8056, 2004.
30. D. Veneri, H. Aqel, M. Franchini, V. Meneghini, M. Krampera. Prevalence of hepatitis
C virus infection in IgM-type monoclonal gammopathy of uncertain significance and
Waldenstrom macroglobulinemia. Am J Hematol 77: 421, 2004 (letter).
31. D. Veneri, M. Krampera, M. Franchini. High prevalence of sustained remission of
idiopathic thrombocytopenic purpura after Helicobacter Pilori eradication: a long-term
follow-up study. Platelets 16:117-119, 2005.
32. D. Veneri, M. Franchini, M. Krampera, G. de Matteis, P. Solero, G. Pizzolo. Analysis
of HFE and TFR2 gene mutations in patients with acute leukaemia. Leukemia Res 29:661664, 2005.
33. M. Krampera, A. Pasini, A. Rigo, M.T. Scupoli, C. Tecchio, G. Malpeli, A. Scarpa, F.
Dazzi, G. Pizzolo, F. Vinante. HB-EGF/HER-1 signalling in bone marrow mesenchymal
stem cells: inducing cell expansion and reversibly preventing multi-lineage differentiation.
Blood 106:59-66, 2005
34. M. Krampera, L. Cosmi, R. Angeli, A. Pasini, F. Liotta, A. Andreini, V. Santarlasci, B.
Mazzinghi, G. Pizzolo, F. Vinante, P. Romagnani, E. Maggi, S. Romagnani, F. Annunziato.
Role for Interferon-γ in the immunomodulatory activity of human bone marrow
mesenchymal stem cells. Stem Cells 2006;24:386-398.
35. A. Vitale, A. Guarini, C. Ariola, M. Mancini, C. Mecucci, A. Cuneo, F. Pane, G. Saglio,
G. Cimino, A. Tafuri, G. Meloni, F. Fabbiano, A. Recchia, M.G. Kropp, M. Krampera, N.
Cascavilla, F. Ferrara, A. Romano, P. Mazza, C. Fozza, F. Paoloni, M. Vignetti, R. Foà.
Adult T-cell acute lymphoblastic leukemia: biologic profile at presentation and correlation
with response to induction treatment in patients enrolled in the GIMEMA LAL 0496
protocol. Blood 2006;107;473-479.
36. M. Krampera, A. Pasini, G. Pizzolo, L. Cosmi, S. Romagnani, F. Annunziato.
Regenerative and immunomodulatory potential of mesenchymal stem cells. Curr Opin
Pharmacol 2006;6:435-441 (review).
37. M. Krampera, G. Pizzolo, G. Aprili, M. Franchini. Mesenchymal stem cells for bone,
cartilage, tendon and skeletal muscle repair. Bone 39:678-683, 2006 (review).
38. C. Visco, F. Canal, C. Parolini, A. Andreoli, A. Ambrosetti, M. Krampera, M. Lestani,
G. Pizzolo, M. Chilosi. The impact of p53 and p21waf1 expression on the survival of
patients with the germinal center phenotype of diffuse large B-cell lymphoma.
Haematologica 2006;91;687-690.
39. M. Krampera, G. Pizzolo. Le cellule staminali mesenchimali. Seminari di Ematologia
Oncologica 3(2):131-153, 2006 (review).
40. M. Krampera, O. Perbellini, C. Vincenzi, F. Zampieri, A. Pasini, M.T. Scupoli, A.
Guarini, M.S. De Propris, E. Coustan-Smith, A. Vitale, D. Campana, R. Foà, G. Pizzolo.
Methodological approach to minimal residual disease detection by flow cytometry in adult
B-lineage acute lymphoblastic leukemia. Haematologica 2006;91;1109-1112.
41. G. Rigotti, A. Marchi, M. Galiè, G. Baroni, D. Benati, M. Krampera, A. Pasini, A.
Sbarbati. Clinical treatment of radiotherapy tissue damages by lipoaspirates transplant: a
15
healing process mediated by adipose-derived adult stem cells (ASCs). Plast Reconstr
Surg, 119:1409-1422, 2007.
42. M. Krampera, S. Marconi, A. Pasini, M. Galiè, F. Mosna, M. Tinelli, L. Lovato, E.
Anghileri, A. Andreini, G. Pizzolo, A. Sbarbati, B. Bonetti. Induction of neural-like
differentiation in human mesenchymal stem cells derived from bone marrow, fat, spleen
and thymus. Bone 40;382-390, 2007.
43. M.T. Scupoli, O. Perbellini, M. Krampera, F. Vinante, F. Cioffi, G. Pizzolo. Interleukin-7
requirement for survival of T cell acute lymphoblastic leukemia and human thymocytes on
bone marrow stroma. Haematologica 2007;92;264-266.
44. M. Krampera, S. Sartoris, L. Cosmi, A. Pasini, R. Angeli, F. Liotta, M. Tinelli, A.
Andreini, F. Mosna, E. Rebellato, M.G. Testi, V. Santarlasci, G. Pizzolo, G. Tridente, E.
Maggi, S. Romagnani, F. Annunziato. Immune regulation by mesenchymal stem cells
derived from adult spleen and thymus. Stem Cells and Development 16;797-810, 2007.
45. M. Krampera, M. Franchini, G. Pizzolo, G. Aprili. Mesenchymal stem cells: from
biology to clinical use. Blood Transfusion 5;120-129, 2007 (review).
46. M. Krampera, P. Ghia, M. Chilosi. Valutazione immunofenotipica nelle malattie oncoematologiche acute e croniche. Seminari di Ematologia Oncologica 2007;2:115-143
(review).
47. F. Bifari, V. Lisi, E. Mimiola, A. Pasini, M. Krampera. Immunological properties of
mesenchymal stem cells. Transfusion Medicine and Hemotherapy 35:194-204, 2008
(review).
48. D. Peroni, I. Scambi, A. Pasini, V. Lisi, F. Bifari, M. Krampera, G. Rigotti, A. Sbarbati,
M. Galiè. Stem molecular signature of adipose-derived stromal cells. Exp Cell Research
314:603-615, 2008.
49. E. Anghileri, S. Marconi, A. Pignatelli, P. Cifelli, M. Galié, A. Sbarbati, M. Krampera,
O. Belluzzi, B. Bonetti. Neuronal differentiation potential of human mesenchymal stem
cells. Stem Cells and Development 17:909-916, 2008.
50. M. Galiè, G. Konstantinidou, D. Peroni, I. Scambi, C. Marchini, V. Lisi, M. Krampera,
P. Magnani, F. Merigo, M. Montani, F. Boschi, P. Marzola, R. Orrù, P. Farace, A. Sbarbati,
A. Amici. Mesenchymal stem cells share molecular signature with mesenchymal tumor
cells and favor early tumor growth in syngeneic mice. Oncogene 2008;27: 2542-2551.
51. F. Liotta, R. Angeli, L. Cosmi, L. Filì, C. Manuelli, F. Frosali, B. Mazzinghi, L. Maggi, A.
Pasini, V. Lisi, V. Santarlasci, L. Consoloni, M.L. Angelotti, P. Romagnani, P. Parronchi, M.
Krampera, E. Maggi, S. Romagnani, F. Annunziato. Toll-like receptors 3 and 4 are
expressed by human bone marrow-derived mesenchymal stem cells and can inhibit their
T-cell modulatory activity by impairing Notch signalling. Stem Cells 2008;26:279-89.
52. M.T. Scupoli, M. Donadelli, F. Cioffi, M. Rossi, O. Perbellini, G. Malpeli, S. Corbioli, F.
Vinante, M. Krampera, M. Palmieri, A. Scarpa, C. Ariola, R. Foà, G. Pizzolo. Bone marrow
stromal cells and the upregulation of interleukin-8 production in human T-cell acute
lymphoblastic leukemia through the CXCL12/CXCR4 axis and the NF-kB and JNK/AP-1
pathways. Haematologica 2008;93:524-532.
53. F. Bifari, I. Decimo, C. Chiamulera, E. Bersan, G. Malpeli, J. Johanson, V. Lisi, B.
Bonetti, G. Fumagalli, G. Pizzolo, M. Krampera. Novel stem/progenitor cells with neuronal
differentiation potential reside in the leptomeningeal niche. J Cell Mol Med 13(9B):31953208, 2009.
54. D. Gemmati, M. De Mattei, L. Catozzi, M. Della Porta, M.L. Serino, C. Ambrosio, A.
Cuneo, S. Friso, M. Krampera, E. Orioli, G. Zeri, A. Ongaro. DHFR 19-bp
16
insertion/deletion polymorphism and MTHFR C677T in adult acute lymphoblastic
leukemia: is the risk reduction due to intracellular folate unbalancing? Am J Hematol
84:526-529, 2009.
55. L. Sensebé, M. Krampera, H. Schrezenmeier, P. Bourin, R. Giordano. Mesenchymal
stem cells for clinical application. Vox Sanguinis 2010;98:93-107 (review).
56. G. Constantin, S. Marconi, B. Rossi, S. Angiari, A. Pasini, M. Galiè, B. Gini, F. Bifari, A.
Sbarbati, M. Krampera, B. Bonetti. Adipose-derived mesenchymal stem cells ameliorate
chronic EAE by immunosuppression and neuroregeneration. Stem Cells 27:2624-2635,
2009.
57. C. Tecchio, C. Colato, M. Bonifacio, M. Krampera, S. Maluta, G. Pizzolo, G.
Girolomoni. Plasmacytoid dendritic cell leukemia: a rapidly evolving disease presenting
with skin lesions sensitive to radiotherapy plus hyperthermia. The Oncologist
2009;14:1205-1208.
58. F. Giannone, G. Malpeli, V. Lisi., S. Grasso, P. Shukla, D. Ramarli, V. Monsurrò, S.
Sartoris, M. Krampera, E. Amato, G. Tridente, M. Colombatti, M. Parenti, G. Innamorati.
The puzzling uniqueness of the heterotrimeric G15 protein and its potential beyond
hematopoiesis. Journal of Molecular Endocrinology 2010;44(5):259-269.
59. M. Martini, M.G. Testi, M. Pasetto, M.C. Picchio, G. Innamorati, M. Mazzocco, S. Ugel,
S. Cingarlini, V. Bronte, P. Zanovello, M. Krampera, F. Mosna, T. Cestari, A.P. Riviera, N.
Brutti, O. Barbieri, L. Matera, G. Tridente, M. Colombatti, S. Sartoris. IFN-γ- Mediated
Upmodulation of MHC Class I Expression Activates Tumor-Specific Immune Response in
a Mouse Model of Prostate Cancer. Vaccine 2010;28(20):3548-3557.
60. F. Bifari, L. Pacelli, M. Krampera. Immunological properties of embryonic and adult
stem cells. World J Stem Cells 2010 2(3):50-60 (review).
61. F. Mosna, L. Sensebé, M. Krampera. Human bone-marrow and adipose tissue
mesenchymal stem cells: a user’s guide. Stem Cells and Development 2010;19:1449-70
(review).
62. F. Mosna, F. Annunziato, G. Pizzolo, M. Krampera. Cell therapy for cardiac
regeneration after myocardial infarct: which cell is the best? Cardiovascular &
Hematological Agents in Medicinal Chemistry (former Current Medicinal Chemistry Cardiovascular & Hematological Agents) 2010;8:227-43 (review).
63. S. Sartoris, M. Mazzocco, M. Tinelli, M. Martini, F. Mosna, V. Lisi, S. Indraccolo, L.
Moserle, T. Cestari, A.P. Riviera, F. Bifari, G. Tridente, G. Pizzolo, M. Krampera. Efficacy
assessment of interferon-alpha-engineered mesenchymal stromal cells in a mouse
plasmacytoma model. Stem Cells and Development 2011;20:709-19.
64. A. Rigo, M. Gottardi, A. Zamò, P. Mauri, E. Damiani, M. Krampera, G. Pizzolo, F.
Vinante. Monocytes/Macrophages cooperate with metastatic cancer cells through a GMCSF/HB-EGF paracrine loop enhanced by CXCL12. Mol Cancer 2010;9:273.
65. F. Dazzi, M. Krampera. MSCs in autoimmune disorders. In ‘Mesenchymal Stem Cells:
basic in clinical aspects’. Best Pract Res Clin Haematol 2011;24:49-57 (review).
66. M. Krampera. Mesenchymal stromal cells: more than inhibitory cells. Leukemia
2011;25:565-566. (Editorial).
67. M.A. Cassatella, F. Mosna, A. Micheletti, V. Lisi, N. Tamassia, C. Cont, F. Calzetti, M.
Pellettier, G. Pizzolo, M. Krampera. Toll-like receptor-3-activated human mesenchymal
stromal cells significantly prolong the survival and function of neutrophils. Stem Cells
2011;29:1001–1011.
17
68. M. Krampera. Mesenchymal stromal cell ‘licensing’: a multistep process. Leukemia
2011;25:1408-1414 (review).
69. A.H. Nwabo Kamdje, F. Mosna, F. Bifari, V. Lisi, G. Bassi, G. Malpeli, M. Ricciardi, O.
Perbellini, M.T. Scupoli, G. Pizzolo, M. Krampera. Notch-3 and Notch-4 signaling rescue
from apoptosis human B-ALL cells in contact with human bone marrow-derived
mesenchymal stromal cells. Blood 2011;118:380-389.
70. F. Mosna, G. Pizzolo, M. Krampera. Stem cells and cardiac regeneration. Seminari di
Ematologia Oncologica 2, 2011;8(2):35-54 (review).
71. I. Decimo, F. Bifari, M. Krampera, G. Fumagalli. Neural stem cell niches in health and
diseases. Current Pharmaceutical Design 2012;18(13):1755-83 (review).
72. I. Decimo, F. Bifari, F.J. Rodriguez, S. Dolci, V. Lavarini, S. Pretto, S. Vasquez, G.
Malpeli, M. Sciancalepore, A. Montalbano, M. Krampera, G. Fumagalli. Nestin- and DCXpositive cells reside in adult spinal cord meninges and participate to injury-induced
parenchymal reaction. Stem Cells 2011;29:2062-2076.
73. A.H. Nwabo Kamdje, M. Krampera. Notch signaling in acute lymphoblastic leukemia:
any role for stromal microenvironment? Blood 2011;118:6506-6514 (review).
74. E.N. Oliva, A. Piccin, M.G. Mazzucconi, E. Morra, U. Recine, E.M. Pogliani, F. Pane,
M. Gobbi, L. Gugliotta, M. Krampera, N. Cascavilla, R. Cacciola, E. Cacciola, G. Fioritoni,
R. Fanin, A. Liberati, E.Angelucci, S. Tura. Quality of life in essential thrombocythaemia.
An italian multicentre study. Ann Hematol 2012;91(4):527-32.
75. L. Sensebé, K. Tarte, J. Galipeau, M. Krampera, I. Martin, D.G. Phinney, Y. Shi, on
behalf of the MSC Committee of the International Society for Cellular Therapy (ISCT).
Limited acquisition of chromosomal aberrations in human adult mesenchymal stromal
cells. Cell Stem Cell 2012;10;9-10.
76. M. Ricciardi, G. Malpeli, F. Bifari, G. Bassi, L. Pacelli, A.H. Nwabo Kamdje, M. Chilosi,
M. Krampera. Comparison of epithelial differentiation and immune regulatory properties of
mesenchymal stromal cells derived from human lung and bone marrow. PLoS One
2012;7(5):e35639.
77. I. Decimo, G. Fumagalli, V. Berton, M. Krampera, F. Bifari. Meninges: from protective
membrane to stem cell niche. Am J Stem Cell 2012; 1(2):92-105 (review).
78. A.H. Nwabo Kamdje, G. Bassi, L. Pacelli, G. Malpeli, E. Amati, I. Nichele, G. Pizzolo,
M. Krampera. Role of stromal cell-mediated Notch signaling in CLL resistance to
chemotherapy. Blood Cancer Journal 2012; 2:e73.
79. G. Bassi, L. Pacelli, R. Carusone, J. Zanoncello, M. Krampera. Adipose-derived
stromal cells (ASCs). Transfusion and Apheresis Science 2012; 47:193-198.
80. I. Nichele, A. Zamò, A. Bertolaso, F. Bifari, M. Tinelli, M. Franchini, R. Stradoni, F.
Aprili, G. Pizzolo, M. Krampera. VR09 cell line: an EBV-positive lymphoblastoid cell line
with in vivo characteristics of diffuse large B cell lymphoma of activated B-cell type. PLoS
One 2012;7(12):e52811.
81. P.F. Seke Etet, L. Vecchio, P. Bogne Kamga, E.N. Nukenine, M. Krampera, A.H.
Nwabo Kamdje. Normal hematopoiesis and hematologic malignancies: role of canonical
Wnt signaling pathway and stromal microenvironment. BBA Review on Cancer
2013;1835:1–10 (review).
82. M. Krampera, J. Galipeau, Y. Shi, K. Tarte, L. Sensebé, on behalf of the MSC
Committee of the International Society for Cellular Therapy (ISCT). Immunological
characterization of Multipotent Mesenchymal Stromal Cells. The International Society for
18
Cellular Therapy (ISCT) working proposal. Cytotherapy 2013;15:1054-61.
83. C. Cavallini, O. Lovato, A. Bertolaso, L. Pacelli, E. Zoratti, E. Zanolin, M. Krampera, A.
Zamò, C. Tecchio, M.A. Cassatella, G. Pizzolo, M.T. Scupoli. The TNF-family cytokine
TL1A inhibits the proliferation of human activated B cells. PLoS One 2013;8(4):e60136.
84. C. Menard, L. Pacelli, G. Bassi, J. Dulong, F. Bifari, I. Bezier, J. Zanoncello, M.
Ricciardi, M. Latour, P. Bourin, H. Schrezenmeier, L. Sensebé, K. Tarte, M. Krampera.
Clinical-grade mesenchymal stromal cells produced under various Good Manufacturing
Practice processes differ in their immunomodulatory properties: Standardization of
immune quality controls. Stem Cells Dev. 2013;22(12):1789-801.
85. L. Vecchio, P.F. Seke Etet, M.J. Kipanyula, M. Krampera, A.H. Nwabo Kamdje.
Importance of epigenetic changes in cancer etiology, pathogenesis, clinical profiling, and
treatment: what can be learned from hematologic malignancies? BBA Review on Cancer
2013;1836:90-104.
86. D.G. Phinney, J. Galipeau, M. Krampera, I. Martin, Y. Shi, L. Sensebe. MSCs: science
and trials. Nature Medicine 2013;19(7):812 (letter).
87. M. Di Trapani, G. Bassi, M. Ricciardi, E. Fontana, F. Bifari, L. Pacelli, L. Giacomello,
M. Pozzobon, F. Feron, P. De Coppi, P. Anversa, G. Fumagalli, I. Decimo, C. Menard, K.
Tarte, M. Krampera. Comparative study of immune regulatory properties of stem cells
derived from different tissues. Stem Cells Dev. 2013;22(22):2990-3002.
88. W. Zhao, D.G. Phinney, D. Bonnet, M. Dominici, M. Krampera. Mesenchymal stem
cell biodistibution, migration, and homing in vivo. Stem Cells Int. 2014;2014:292109.
89. A.H. Nwabo Kamdje, P.F. Seke Etet, L. Vecchio, J.M. Muller, M. Krampera, K.E.
Lukong. Signaling pathways in breast cancer: therapeutic targeting of the
microenvironment. Cell Signalling 2014;26(12):2843-2856.
90. A.H. Nwabo Kamdje, P.F. Seke Etet, L. Vecchio, R. Simo Tagne, J. Mbo Amvene, J.M.
Muller, M. Krampera, K.E. Lukong. New targeted therapies for breast cancer: a focus on
tumor microenvironmental signals and chemoresistant breast cancers. World J Clin Cases
2014;2(12):769-86.
91. M. Di Trapani, G. Bassi, E. Fontana, L. Giacomello, M. Pozzobon, P.V. Guillot, P. De
Coppi, M. Krampera. Immune regulatory properties of CD117pos amniotic fluid stem cells
vary according to gestational age. Stem Cells Dev. 2015; 24(1):132-143.
92. G. Bassi, F. Guilloton, C. Menard, M. Di Trapani, F. Deschaseaux, L. Sensebé, H.
Schrezenmeier, R. Giordano, P. Bourin, M. Dominici, K. Tarte, M. Krampera. Effects of a
ceramic biomaterial on immune modulatory properties and differentiation potential of
human mesenchymal stromal cells of different origin. Tissue Engineering: Part A
2015;21(3-4):767-81.
93. A. Mercuri, E. Cannata, O. Perbellini, C. Cugno, R. Balter, A. Zaccaron, G. Tridello,
G.Pizzolo, M. De Bortoli, M. Krampera, M. Cipolli, S. Cesaro. Immunophenotypic Analysis
of Hematopoiesis in Patients suffering from Shwachman-Bodian-Diamond Syndrome. Eur
J Haematol 2015;95(4):308-15.
94. J. Galipeau, M. Krampera. The challenge of defining MSC potency assays and their
potential use as release criterion. Cytotherapy 2015;17(2):125-7 (commentary).
95. A. Piccin, M. Steurer, M. Mitterer, E.M. Blöchl, L. Marcheselli, I. Pusceddu, A.
Marabese, I. Bertozzi, D. Corvetta, M.L. Randi, E. Elli, E.M. Pogliani, D. Veneri, O.
Perbellini, M. Krampera, E. Pacquola, M. Gottardi, M. Tiribelli, A. Guella, B. Innella, P.
Vivaldi, E. De Biasi, R. Sancetta, R. Rocconi, R. Bassan, F. Gherlinzoni, G. Pizzolo, G.
Gastl, S. Cortelazzo. Role of blood cells dynamism on hemostatic complications in low risk
19
patients with Essential
2015;10(4):451-60.
Thrombocythemia.
Internal
and
Emergency
Medicine
96. M. Ricciardi, M. Zanotto, G. Malpeli, G. Bassi, O. Perbellini, M. Chilosi, F. Bifari, M.
Krampera. Epithelial-to-Mesenchymal Transition (EMT) induced by inflammatory priming
elicits mesenchymal stromal cell-like immune modulatory properties in cancer cells. Br J
Cancer 2015;112:1067-75.
97. E. Zanchetta, E. Guidi, G. Della Giustina, M. Sorgato, M. Krampera, G. Bassi, R. Di
Liddo, G. Lucchetta, M.T. Conconi, G. Brusatin. Injection Moulded polymeric micropatterns
for bone regeneration study. ACS Appl Mater Interfaces 2015;7(13):7273-81.
98. M. Bonifacio, G. Binotto, E. Maino, E. Calistri, L. Marin, L. Scaffidi, L. Frison, F. De
Marchi, M. Krampera, G. Semenzato, R. Fanin, A. Ambrosetti, M. Tiribelli (Gruppo
Triveneto LMC). Imatinib-treated Chronic Myeloid Leukemia patients with discordant
response between cytogenetic and molecular tests at 3 and 6 month time-points have a
reduced probability of subsequent optimal response. Haematologica 2015;100(8):e299301.
99. O.E. Simonson, D. Mougiakakos, N. Heldring, G. Bassi, H.J. Johansson, M. Dalén, R.
Jitschin, S. Rodin, M. Corbascio, S. EL Andaloussi, O.P.B. Wiklander, J.Z. Nordin, J.
Skog, C. Romain, T. Koestler, L. Hellgren-Johansson, P. Schiller, P-O. Joachimsson, H.
Hägglund, M. Mattsson, J. Lehtiö, O.R. Faridani, R. Sandberg, O. Korsgren, M. Krampera,
D.J. Weiss, K-H. Grinnemo, K. Le Blanc. In vivo effects of mesenchymal stromal cells in
two patients with severe acute respiratory distress syndrome. Stem Cells Translational
Medicine 2015;4(10):1199-213.
100. F. Bifari, V. Berton, A. Pino, M. Kusalo, G. Malpeli, M. Di Chio, E. Bersan, E. Amato,
A. Scarpa, M. Krampera, G. Fumagalli, I. Decimo. Meninges harbor cells expressing
neural precursor markers during development and adulthood. Frontiers in Cellular
Neuroscience 2015;9:383.
101. J. Galipeau, M. Krampera, J. Barrett, F. Dazzi, R.J. Deans, J. DeBruijn, M. Dominici,
W.E. Fibbe, A.P. Gee, J.M. Gimble, P. Hematti, M.B.C. Koh, K. LeBlanc, I. Martin, I.K.
McNiece, M. Mendicino, S. Oh, L. Ortiz, D.G. Phinney, V. Planat, Y. Shi, D.F. Stroncek, S.
Viswanathan, D.J. Weiss, L. Sensebé. International Society for Cellular Therapy
perspective on immune functional assays for mesenchymal stromal cells as potency
release criterion for advanced phase clinical trials. Cytotherapy 2016;18(2):151-9.
102. P. Takam Kamga, G. Bassi, A. Cassaro, M. Midolo, M. Di Trapani, A. Gatti, R.
Carusone, F. Resci, O. Perbellini, M. Gottardi, M. Bonifacio, A.H. Nwabo Kamdje, A.
Ambrosetti, M. Krampera. Notch signaling drives bone marrow stromal cell-mediated
chemoresistance in acute myeloid leukemia. Oncotarget 2016;7(16):21713-27.
103. M. Di Trapani, G. Bassi, M. Midolo, A. Gatti, P. Takam Kamga, A. Cassaro, R.
Carusone, A. Adamo, M. Krampera. Differential and transferable modulatory effects of
mesenchymal stromal cell-derived extracellular vesicles on T, B and NK cell functions.
Scientific Reports 2016;6:24120.
104. G. Malpeli, S. Barbi, S. Zupo, G. Tosadori, G. Scardoni, A. Bertolaso, S. Sartoris, S.
Ugel, A. Adamo, M. Krampera, M.T. Scupoli, C.M. Croce, A. Scarpa. Identification of
microRNAs implicated in the late differentiation stages of normal B cells suggest a central
role for miRNA targets ZEB1 and TP53. Oncotarget 2016 (in press).
20
Journals
ACS Appl Mater Interfaces
Am J Stem Cells
Am J Gastroenterol
Am J Hematol
Am J Med
Ann Allergy Asthma Immunol
Ann Hematol
BBA Review on Cancer
papers
1
1
1
2
1
1
1
2
Best Practice & Research Clinical Haematology
Blood
Blood Cancer Journal
Blood Transfusion
Bone
Br J Cancer
Br J Haematol
Cancer Res
Cardiovascular & Hematological Agents in Medicinal
Chemistry (former Current Medicinal Chemistry Cardiovascular & Hematological Agents)
Cell Signalling
1
8
1
1
2
1
4
1
(1 review)
(1 letter)
1
(1 review)
1
(1 review)
Cell Stem Cell
Clin Exp Immunol
Curr Opin Pharmacol
Curr Pharmaceutical Design
Cytotherapy
Eur J Haematol
Exp Cell Research
Frontiers in Cellular Neuroscience
Haematologica
Internal and Emergency Medicine
Int J Clin Lab Res
J Cell Mol Med
J Mol Endocrinology
Leukemia
Leukemia Research
Molecular Cancer
Nature Medicine
Oncogene
The Oncologist
Oncotarget
Plastic and Reconstructive Surgery
Platelets
PlosOne
Scientific Reports
Seminari di Ematologia Oncologica
Stem Cells
Stem Cells and Development
Stem Cells International
Stem Cells Translational Medicine
Thromb Haemostasis
Tissue Engineering
Transfusion and Apheresis Science
1
(1 letter)
2
1
1
3
1
1
1
17
1
2
1
1
2
1
1
1
1
1
2
1
1
3
1
3
5
7
1
1
1
1
1
Transfusion Medicine & Hemotherapy
Vaccine
Vox Sanguinis
1
1
1
(1 review)
(1 letter)
(1 letter)
(1 letter)
(2 review)
(1 review)
(1 review)
(1 review)
(1 review)
(1 review, 1 commentary)
(5 letters)
(1 commentary, 1 review)
(1 letter)
Impact Factor (*)
7.145
Impact
7.145
10.383
5.000
5.610
3.475
3.022
7.841
2.740
11.841
4.411
1.514
3.736
5.569
5.401
8.556
10.383
10.000
5.610
3.475
3.022
15.682
2.740
94.728
4.411
1.514
7.472
5.569
21.604
8.556
4.191
22.387
4.191
22.387
3.148
4.769
3.052
3.625
2.544
3.378
4.609
6.671
2.340
6.296
4.769
3.052
10.875
2.544
3.378
4.609
113.407
2.340
4.938
2.947
12.104
2.606
5.888
30.357
7.932
4.789
5.008
3.087
3.213
3.057
5.228
4.938
2.947
24.208
2.606
5.888
30.357
7.932
4.789
10.016
3.087
3.213
9.171
5.228
5.902
3.777
3.687
4.247
5.255
3.892
0.963
2.160
29.510
26.439
3.687
4.247
5.255
3.892
0.963
2.160
3.413
2.628
3.413
2.628
(3 review)
(1 review)
(1 commentary)
(1 letter)
(1 review)
(1 review)
(1 review)
21
World J Clin Cases
World Journal of Stem Cells
1
1
(*) SJIF 2015
104
(1 review)
(1 review)
(12 letters, 21 reviews, 3
commentaries)
GLOBAL IMPACT
576.333
Global evaluation: 5,518 citations according to Scopus (4,809 according to Web of Science), with h-index = 35 according to
Scopus and h-index = 32 according to Web of Science.
BOOK CHAPTERS
1. M. Ricciardi, L. Pacelli, G. Bassi, F. Bifari, F. Mosna, M. Krampera. Mesenchymal stem
cell isolation and expansion methodology. In: Stem Cells And Cancer Stem Cells:
Therapeutic Applications in Disease and Injury. Springer Editor, Volume 3, 2012.
2. M. Ricciardi, M. Krampera, M. Chilosi. Quantitative fluorescence in situ hybridization
(Q-FISH) on paraffine embedded tissue. In: Aging and Stem Cells. Methods Mol Biol.
2013;976:167-73, Springer Editor.
3. A.H. Nwabo Kamdje, P.F. Seke Etet, P. Takam Kanga, J.M. Muller, G. Bassi, K.E.
Lukong, R. Kumar Goel, M. Krampera. Mesenchymal Stromal Cells as Tumor Stromal
Modulators: Mesenchymal stem/stromal cell trafficking and homing. Elsevier Editor, 2016.
ABSTRACTS AT NATIONAL
AND INTERNATIONAL
CONGRESSES
178
GRANTS AWARDED
(as Scientific Coordinator
or Head of Research Unit in
cooperative projects)
2000 - 2002:
2000:
2001-2003:
2002-2004:
2004-2006:
2003-2005:
2003-2005:
2005-2007:
2005-2007:
“Flow-cytometric cytokine detection in cord blood T- and NK cells and
monocytes”, financed by MURST 60% (Italian Ministry of University,
Scientific Research and Technology) (Scientific Coordinator: Dr. Mauro
Krampera)
“Use of donor lymphocyte infusion (DLI) in leukemic patients in relapse after
stem cell transplantation”, financed by AIRC (Italian Association for Cancer
Research) (Scientific Coordinator: Dr. Mauro Krampera)
“Use of bone marrow mesenchymal stem cells to hinder the hemopoietic
stem cell rejection after allogeneic transplantation”, financed by MURST
60% (Italian Ministry of University, Scientific Research and Technology)
(Scientific Coordinator: Dr. Mauro Krampera)
“Expansion of anti-cytomegalovirus CTLs following allogeneic stem cell
transplantation”, financed by MIUR 60% (Italian Ministry of University and
Scientific Research) (Scientific Coordinator: Dr. Mauro Krampera)
"Immune response modulation by mesenchymal stem and differentiated
cells from human bone marrow: analysis of the effector target cells and of
the inter- and intracellular pathways involved", financed by MIUR 60%
(Italian Ministry of University and Scientific Research) (Scientific
Coordinator: Dr. Mauro Krampera)
"In vivo infusion of mesenchymal stem cells (MSC) transfected with genes
of immunoregulatory cytokines to enhance the local, anti-tumour immune
response", financed by MIUR 60% (Italian Ministry of University and
Scientific Research) (Scientific Coordinator: Dr. Mauro Krampera)
'Microenviroment and neoplastic progression: regulating network induced by
stromal cells. Biology and therapeutical application', financed by
CARIVERONA Foundation (Scientific Coordinator: Prof. Giovanni Pizzolo;
Head of Research Unit: Dr. Mauro Krampera)
“Analysis of the biological effects of Heparin Binding-Epidermal Growth
Factor-like Growth Factor (HB-EGF) on bone marrow mesenchymal stem
cells”, financed by MIUR 60% (Italian Ministry of University and Scientific
Research) (Scientific Coordinator: Dr. Mauro Krampera)
"Analysis of the mechanisms involved in the immunoregulatory effect of
human bone marrow mesenchymal stem cells”, financed by COFIN/MIUR
22
2004-2006:
2005-2007:
2007-2010:
2007-2009:
2009-2011:
2009-2013:
2010-2012:
2010-2011:
2009-2010:
2010-2012:
2012-2017:
2012-2017:
40% (Italian Ministry of University and Scientific Research) (Scientific
Coordinator: Prof. Sergio Romagnani; Head of Research Unit: Dr. Mauro
Krampera)
“Innovative, combined strategies for prostate cancer diagnosis and therapy”,
financed by CARIVERONA Foundation (Scientific Coordinator: Prof. Marco
Colombatti; Head of Research Unit: Dr. Mauro Krampera)
“Treatment of neurological autoimmune diseases with mesenchymal stem
cells: analysis of efficacy and molecular mechanisms”, financed by
CARIVERONA Foundation (Scientific Coordinator: Prof. Bruno Bonetti;
Head of Research Unit: Dr. Mauro Krampera)
7TH Framework Programme on Research, Technological Development and
Demonstration of European Commission, CASCADE (Cultivated Adult Stem
Cells as Alternative for Damaged tissuE) project (Scientific Coordinator: Dr.
Luc Sensebé, Tours, France; Head of Research Unit: Dr. Mauro
Krampera)
"Influence of stromal microenviroment derived from mesenchymal stem
cells on neoplastic growth and anti-cancer innate and adaptive immunity",
financed by COFIN/MIUR 40% (Italian Ministry of University and Scientific
Research) (Scientific Coordinator: Prof. Sergio Romagnani; Head of
Research Unit: Dr. Mauro Krampera)
“Exploitation of the regenerative and immune regulation properties of
mesenchymal stem cells for the treatment of bone, neurological and
cardiological diseases”, financed by CARIVERONA Foundation (Scientific
Coordinator: Dr. Mauro Krampera)
7TH Framework Programme on Research, Technological Development and
Demonstration of European Commission REBORNE (Regenerating Bone
defects using New biomedical Engineering approaches) (Scientific
Coordinator: Dr. Pierre Layrolle, INSERM, France; Head of Research Unit:
Dr. Mauro Krampera)
“New gene and cell therapy-based approaches to the treatment of Cystic
Fibrosis”, financed by Italian Ministry of Health – Direzione Generale della
Ricerca Scientifica e Tecnologica (Scientific Coordinator: Dr. Anna
Tamanini; Head of Research Unit: Dr. Mauro Krampera).
“Assessment of the physiological role and regenerative properties of
Leptomeningeal Stem Cells (LeSC) in spinal cord injury” - GALM (Gruppo di
Animazione Lesionati Midollari) (Scientific Coordinator: Dr. Mauro
Krampera).
“In vivo use of mesenchymal stem cells (MSC) for bone regeneration in
maxillo-facial surgery”, financed by Italian Ministry of Health – General
Office for Scientific and Technological Research (Scientific Coordinator:
Dr. Mauro Krampera).
‘Comparison of the immune regulatory properties of mesenchymal stem
cells of different origin and other adult stem cells’ financed by COFIN/MIUR
40% (Italian Ministry of University and Scientific Research) (Scientific
Coordinator: Prof. Enrico Maggi; Head of Research Unit: Dr. Mauro
Krampera).
“Bone marrow-derived mesenchymal stem cell use (MSC) for bone and
corneal regeneration and Graft-versus-host disease (GvHD) immunotherapy
following hematopoietic stem cell transplantation”, financed by
CARIVERONA Foundation (Scientific Coordinator: Dr. Mauro
Krampera).
“Bone marrow-derived mesenchymal stem cell use (MSC) for bone and
corneal regeneration and Graft-versus-host disease (GvHD) immunotherapy
following hematopoietic stem cell transplantation”, financed by Finalized
Health Research –Veneto Region 2012 (Scientific Coordinator: Dr.
Giuseppe Aprili until 2014, Prof. Mauro Krampera since January 2015).
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GRANTS AWARDED
(as co-applicant)
1993, 1994:
"Biological and clinical utilization of soluble molecule quantification in
hematological malignancies”, financed by AIRC (Italian Association for
Cancer Research) (Scientific Coordinator: Prof. Giovanni Pizzolo)
1993,'94,'95,'96: "Monoclonal antibodies for diagnostic and biological evaluation of cell
antigens and soluble molecules in leukemias and lymphomas”, financed by
CNR (National Council for Research, Italy), Progetto Finalizzato ACRO
(Scientific Coordinator: Prof. Giovanni Pizzolo)
1995,'96,'97: "Cell receptors and soluble molecules: biology and clinical use in Oncohematology”, financed by AIRC (Italian Association for Cancer Research)
(Scientific Coordinator: Prof. Giovanni Pizzolo)
1996:
"Biological and clinical-prognostic meaning of CD30-CD30 ligand complex
in HIV infection”, financed by Italian Ministry of Health (Istituto Superiore di
Sanità, “IX programma nazionale di ricerca sull'AIDS”) (Scientific
Coordinator: Prof. Giovanni Pizzolo)
1997:
"CD30/CD30-Ligand, sCD30 and modulation of SDF-1, MIP-1α, RANTES,
CXCR4 and CCR5", financed by Italian Ministry of Health (Istituto Superiore
di Sanità, “X programma nazionale di ricerca sull'AIDS”) (Scientific
Coordinator: Prof. Giovanni Pizzolo)
1995-'97:
"Use of hemopoietic stem cells as therapy for non-Hodgkin lymphomas”,
financed by Veneto Region, Italy (Scientific Coordinator: Prof. Giovanni
Pizzolo)
1996, '97:
"Functional characterisation of hematopoietic precursors from peripheral
blood, bone marrow and cord blood”, financed by AIRC (Italian Association
for Cancer Research) (Scientific Coordinator: Prof. Giovanni Pizzolo)
1998:
"Malignant/bystander cell interactions in leukemia and lymphoma", financed
by AIRC (Italian Association for Cancer Research) (Scientific Coordinator:
Prof. Giovanni Pizzolo)
1999:
“Diagnostic and prognostic use for response-to –treatment assessment of
molecular markers and receptor complexes in lymphoproliferative
diseases”, financed by Veneto Region, Italy (Scientific Coordinator: Prof.
Marco Chilosi)
1999-2000:
"BCR/ABL rearrangement and production of angiogenetic and antiangiogenetic factors", financed by MURST 40% (Italian Ministry of
University, Scientific Research and Technology) (Scientific Coordinator:
Prof. Giovanni Pizzolo)
2000:
“Angiogenetic factors in myeloma: biological meaning and therapeuticalprognostic implications”, financed by AIL (Italian Association against
Leukemia, Trenta ore per la vita 2000) (Scientific Coordinator: Prof.
Giuseppe Perona)
2000:
“Control mechanisms in Philadelphia-chromosome positive leukemias: role
and therapeutic use. BCR-ABL rearrangements and production of
angiogenetic and anti-angiogenetic factors”, financed by MURST 40%
(Italian Ministry of University, Scientific Research and Technology)
(Scientific Coordinator: Giovanni Pizzolo)
2000:
“Angiogenic and anti-angiogenic factors in B-Cell Chronic Lymphocytic
Leukemia”, financed by MURST 40% (Italian Ministry of University,
Scientific Research and Technology) (Scientific Coordinator: Prof. Giovanni
Pizzolo – National Coordinator: Prof. Francesco Lauria)
2000-2001:
“The use of mesenchymal cells to modulate HvG and GvH in a pre-clinical
model”, financed by Imperial College School of Medicine, Hammersmith
Hospital, London, U.K. (Scientific Coordinator: Dr. Francesco Dazzi)
2000-2001:
“Host-versus-Graft reaction on MHC-matched allogeneic stem cell
transplant: a preclinical model”, financed by Imperial College School of
Medicine, Hammersmith Hospital, London, U.K. (Scientific Coordinator: Dr.
Francesco Dazzi)
2001-2003:
“The use of bone marrow mesenchymal cells to modulate host-versus-graft
in allogeneic cell transplantation,” financed by Leukaemia Research Fund,
Hammersmith Hospital, London, U.K. (Scientific Coordinator: Dr. Francesco
Dazzi)
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2002-2003:
2007:
2008-2011:
2011-2012:
2012-2015:
2015:
"Biological characterisation and new therapeutic strategies in systemic
diseases of adulthood and childhood. Clinical and prognostic significance of
the immunophenotypic analysis of minimal residual disease in adult T-cell
acute lymphoblastic leukemia", financed by MIUR/CNR (Italian Ministry of
Education, University, and Research - National Research Council)
(Scientific Coordinator: Prof. Giovanni Pizzolo)
Finalized Research Project financed by Italian Ministry of Health – FSN
2007 – Extraordinary Oncological Project RO 12/07// “Cellular drugs,
vaccines and innovative biotherapies of tumors”. Convention n. 7OAF/7 "Implementation and optimization of adaptive immunotherapy protocols and
vaccine therapy for EBV-correlated cancers" (Scientific Coordinator: Prof.
Giovanni Pizzolo).
“An integrated approach to chronic lymphoproliferative disorders: B-CLL
and virus-related neoplasia”, financed by AIRC (Italian Association for
Cancer Research) (Scientific Coordinator: Prof. Giovanni Pizzolo)
“Role of leptomeningeal stem cells in spinal cord injury”, financed by IRP/IFP
Foundation Councils (International Foundation for Research in Paraplegia)
(Scientific Coordinator: Prof. Guido Fumagalli).
“Pilot project to set up a research biobank network in Veneto Region”,
financed by Finalized Health Research –Veneto Region 2012 (Scientific
Coordinator: Prof. Aldo Scarpa).
“LeukoPredict: an in vitro system predicting and monitoring the therapeutic
response of patients in the cure of Chronic Myeloid Leukemia (CML)” Horizon 2020, Call: H2020-SMEINST-1-2015, Topic: PHC-12-2015-1, Type
of action: SME-1, Proposal number: 698801 (Scientific Coordinator: Dr.
Dino Paladin, Abnanotec, Padua, Italy).
PATENTS
Patent n. TO2010U000026, deposited on 23rd February 2010, entitled: "Device for cell
culture ", then converted into national (n. 272134) and international patent
(PCT/IB2011/000365) - International and European Patent: WO2011104612 (A2). Date:
09/01/2011 DEVICE FOR CELL CULTURE AND ANALYSIS
AWARDS
- 2000-2001: “Leonino Fontana e Maria Lionello” annual grant supporting oncological
research activity abroad, assigned by Fondazione Italiana per la Ricerca sul Cancro
(FIRC) for the research project entitled ‘Donor Lymphocyte Infusion (DLI) for leukemia
relapse after bone marrow or peripheral blood allogeneic hematopoietic stem cells: role of
T cells specific for histocompatibility minor antigens in maintaining anti-leukemia effect
(GvL, Graft versus Leukemia) in absence of Graft versus Host Disease (GvHD)’.
- 30-11-2009: Premio Apindustria Verona Giovani “Because of the important discovery of
Leptomeningeal Stem Cells and the collaborative team work in research conduction”.
Verona (Italy), December 21, 2016
Prof. Mauro Krampera
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