Transcript New strategies to reprogram microglia

PASTEUR INSTITUTE SEMINAR SERIES
BIOLOGIA MOLECOLARE
Giovedì 24 novembre, ore 16:00
M
presso l'Aula Magna - Viale Regina Elena 295
G
DEGLI EUCARIOTI
Prof. Cristina Limatola
M
Dip. Fisiologia e Farmacologia
DI INTERESSE B
Sapienza Università
Istituto Pasteur Italia
New strategies to reprogram microglia/
macrophages in brain tumors:
the effect of the environment
BIOL
Antitumor responses of innate immune cells are deactivated in glioblastoma (GBM).
GBMs show accumulation of numerous innate immune cells: microglia, natural
killer (NK), dendritic cells (DC), Gperipheral monocytes and myeloid-derived
DEGLI EUCARIOTI
suppressor cells (MDSC). Microglia are
myeloid cells present in the nervous system
from early embryonic life and consist
M the first line of immune defense. These cells
acquire a pro-inflammatory phenotype
which carries
anti-tumor activities in benign
DI INTERESSE
B
tumors. Glioma-associated microglia and macrophages (GAMs) do not secrete many
pro-inflammatory cytokines, have impaired cytotoxicity, stimulate accumulation of
T-suppressor cells. Instead of fighting tumor, GAMs display a protumorigenic
phenotype (resembling the immunosuppressive, anti-inflammatory phenotype),
express factors that support invasion and angiogenesis, while inducing
immunosuppression. I will present our recent data on new mechanisms to reprogram
the phenotype of GAM in brain tumors.
per informazioni: [email protected]