Transcript Saliva [PPT]

SALIVA

Protective nature

Mechanically cleansing

Defense against microbial invasion
COSTITUENTS OF SALIVA

Inorganic Factors

Organic Factors

Agglutinins
INORGANIC FACTORS
Ions & Gases
 Bicarbonate
 Sodium,Potassium,Phosphates
 Calcium,Fluorides
 Ammonium,Carbon dioxide

ORGANIC FACTORS

Lysozyme

Lactoferrin

Myeloperoxidase

Lactoperoxidase
AGGLUTININS
Glycoproteins
 Mucins
 Beeta 2 macroglobulins
 Fibronectins
 Antibodies

FUNCTIONS OF SALIVA
Lubrication
 Physical protection
 Cleansing
 Buffering
 Tooth integrity maintenance
 Antibacterial action

ANTIBACTERIAL FACTORS
Inorganic&Organic factors
 Lysozyme
(1)Hydrolytic enzyme
(2)Both gm+&gm-ve
 Lactoperoxidase-thiocyanate –Bactericidal
 Myeloperoxidase

SALIVARY ANTIBODIES
IgG – more prevalent in GCF
 IgM
 IgA (1)preponderant,
(2)many bacteria coated with IgA
(3)inhibit attachment of Strepto. sp.
(4)impair the ability of bacteria to
attach mucosal/dental surfaces

ENZYMES
Parotid amylase- major
 Periodontal diseases- increase conc
(i)hyaluronidase&lipase
(ii)beeta glucuronidase&chondroitin
(iii)aspartate aminotransferase&ALP
(iv)amino acid decorboxylases
(v)catalase,peroxidase&collaganase

ENGYME Contd..


Antiproteases
-Inhibit cysteine proteases cathepsin
-Antileukoprotiases-elastase
-TIMP
Mucinous glycoprotein
BUFFERS&COAGULATION
FACTORS

Bicarbonate-carbonic acid

Maintenance of physiologic pH

Factors VIII,IX and X,PTA;Hageman factor

Fibrinolytic enzyme
LEUKOCYTES

PMNs
-varies from person to person
-living form in saliva Orogranulocytes
Orogranulocytic migratory rate
ROLE IN PERIODONTAL
PATHOLOGY

Removal of salivary glands
-dental caries
-periodantal diseases
-delays wound healing

Xerostomia
MCQ -1

Which of the following immunoglobulin is
most commonly found in saliva
(a)IgG
(b)IgM
(c)IgA
(d)IgE
MCQ-2

Which of the following is responsible for
the antibacterial action of saliva in oral
health?
(a)Glycoprotein
(b)Bicarbonate
(c) Minerals
(d)Lysozyme
MCQ-3

The various mechanisms that play an
important role in the defense of the
periodontal tissues against infections
EXCEPT
(a)GCF
(b)Saliva
(c)Epithelial barrier
(d)Monoglycerides
MCQ-4

Which of the following leukocytes are
most commonly found in Saliva
(a)Lymphocytes
(b)Basophils
(c)Eosinophils
(d)Neutrophils
MCQ-5

Salivary secretions are protective in nature
because they
(a)help in plaque maturation
(b)initiate calculus formation
(c)mechanically cleansing oral cavity
(d)contains proteases