Transcript upayapencegahankariesmelaluipenelaahanbiofilm

Mochamad Fahlevi Rizal
Infeksi akibat biofilm
Perkembangan teori biofilm
Skema biofilm
Properti biofilm
General property
Dental plaque example
Open architecture
Presence of channels and voids
Protection from host defences,
desiccation etc.
Enhanced
resistance
to
antimicrobials
Neutralization of inhibitors
Production of extracellular polymers to form a
functional matrix
Increased resistance to chlorhexidine and
antibiotics
Β-lactamase production by neighbouring cells to
protect sensitive organisms
Novel gene expression
Synthesis of novel proteins; up-regulation of gtfBC
Co-ordinated gene responses
Production of cell-cell signaling molecules (e.g.
CSP, autoinducer 2)
Spatial
and
environmental pH and O2 gradients; co-adhesion
heterogeneity
Broader habitat range
Obligate anaerobes in an overtly aerobic
environment
More efficient metabolism
Complete
catabolism
of
complex
host
macromolecules (e.g. mucins) by consortia
Host
Agent
• Saliva
• Struktur Gigi
• dll
• Bakteri
Fungsi komponen saliva
Jalur metabolik spesifik dan
mekanisme transport S. mutans
Salivary Mucin MG2
.5
.4
.3
.2
.1
0.0
Observed
-.1
Cubic
-2
deft
0
2
4
6
8
10
12
14
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