Transcript The Future of the NIA-LOAD Study Continuation, Funding and Reality
The Future of the NIA-LOAD Study
Continuation, Funding and Reality
NIA-LOAD Study
• 2002 to 2003 - 10 Centers involved • 2003 to 2004 - 8 more Centers added
1000 500 0 year 01 year 02 current goal families with samples families
Centers and Families
WU Mayo IU/NCRAD CU UWStL 13 other ADCs
A remarkable achievement in two years!
BU CU DUKE IU+NCRAD MGH MAYO MtS OU UK UPENN UPITT UTSW WU UWStL NW UAB UCLA USC RUSH
NIA-LOAD: Next Step
NIA Cognitive Assessment Rush University GCC at Columbia
Columbia Indiana Mayo (R&J) Washington Univ UWStL
NIA LOAD Consortium NCRAD Other 13 ADCs & ADRC Cell Bank Advisory Committee
Specific Aims
1.
2.
3.
4.
5.
6.
Complete the current collection of 1,000+ families Identify newly affected family members and unaffected members in current families Develop and implement standardized follow-up procedures Ascertain a series of quantitative traits Complete the recruitment and begin follow-up of controls Apply to the Center for Inherited Disease Research for genotyping in the first 500 families
Aim 1
• Complete the current collection of 1,000+ families – recruitment primarily at five centers* – review of all pedigrees, standardized assessment – a regional network to travel for assessment – recruitment of ethnic minorities
Aim 2
• Identify newly affected members and evaluate appropriate unaffected in participating families – expand all pedigrees* – examine eligible family members not previously studied – re-contact family members that were unavailable or postponed
Aim 3
• Develop and implement standardized follow up – NIA-LOAD Study quarterly newsletter for families* – create and validate follow-up data forms – develop a standardized cognitive battery for both “in person” and telephone use – continue “in person” assessments using a regional travel team – develop and implement procedures for autopsy
Aim 4
• Improve statistical power for the subsequent genetic linkage analysis by implementing procedures to ascertain a series of quantitative traits: – Age-at-onset – Cognitive performance, particularly memory – Biological markers of disease risk and progression
Aim 5
• Complete the recruitment and begin follow up of controls: – use similar assessments as in families with Alzheimer’s disease – use similar follow-up methods – autopsy
Aim 6 • Apply to CIDR for genotyping of first 500 families:
– provide all raw genotyping data in a secure, web based format for perform genetic analyses – solicit proposals to complete basic preliminary linkage analyses which will be posted on web site available to all qualified investigators – provide genotype-phenotype information for qualified investigators
What We Will Have Produced
• 500 families with familial Alzheimer’s disease – Approximately four individuals per family – Well characterized – Raw genotyping data – Basic linkage results • An additional 500 families with LOAD • 1,000 controls • All data, family structure and genotypes available to qualified investigators
Continued Role of ADC/ADRC
• Leadership of this research resource – Report directly to NIA and ADC leadership – Original 18 centers will continue to be involved • Subcontracts for follow-up • Identification of new families • Subcontracts for genetic analysis in later years • Publications will be required to identify the ALL NIA-LOAD Study investigators • This is an ADC/ADRC related program