Transcript NIH Nutrition Research Dr. Griffin P. Rodgers Director National Institute of Diabetes and

NIH Nutrition Research
Dr. Griffin P. Rodgers
Director
National Institute of Diabetes and
Digestive and Kidney Diseases, NIH
April 5, 2008
American Society for Nutrition, Experimental Biology 2008
Federal Expenditures in Support of Human
Nutrition Research and Training, FY 2005
NIH
$1B
(90%)
Other Non-DHHS
$11M*
(1%)
* Estimate
Source: Human Nutrition Research and Information Management
(HNRIM) System database
USDA
$97M
(8%)
Other DHHS
$13M*
(1%)
NIH Nutrition Research and Training Support
(FY 1997-2006)
Expenditures
(Dollars in millions)
1,200
Number of Projects
4,500
4,000
1,000
3,500
800
3,000
600
2,500
400
2,000
97
98
99
00
01
02
03
04
05
Fiscal Year
Source: Human Nutrition Research and Information
Management (HNRIM) System database
06
97
98
99
00
01
02
Fiscal Year
03
04
05
06
NIH Nutrition Research and Training Support
FY 2006 (NIH Total ~$1 billion)
NIMH 2%
NIEHS 3%
Other ICs
(15) 9%
NCCAM
5%
NCRR
5%
NIA
5%
NICHD
5%
NIDDK
26%
NHLBI
19%
Source: Human Nutrition Research and Information
Management (HNRIM) System database
NCI
21%
NIH Division of Nutrition Research
Coordination (DNRC)
•
Advises NIH Director and others on nutrition research issues and
works with the NIH organizational components to coordinate
nutrition research and research training initiatives.
•
Coordination of nutrition research and nutrition policy-related
activities by the DNRC occurs at 3 major organizational levels:
(1) trans-NIH activities;
(2) interagency activities at the Department of Health and Human
Services (DHHS) level
(3) interagency activities at the Federal level.
Additional Coordination of Trans-NIH
Nutrition Research Activities
NIH Nutrition Coordinating Committee (NCC)
•
Established in 1975 in the Office of the Director, NIH
•
Operates as NIH-wide forum to review, stimulate, and
encourage the support of nutrition research and training to
better define the role of nutrition in the promotion and
maintenance of health and in the prevention and treatment of
disease. Functions and responsibilities of the NCC are now
encompassed within the framework of the DNRC.
•
Currently consists of representatives from 27 institutes &
Centers and of several Offices at the NIH. Additionally, all
other agencies of the DHHS, as well as other Departments
(USDA, DOD, DOEd) have liaison representatives to the
committee.
Sources of Information on Federally
Funded Nutrition Research
• Human Nutrition Research Information Management
(HNRIM) System: Maintained by HNRIM staff, NIH DNRC
• Searchable database of nutrition research and research
training activities supported by the federal government
• Operational since 1985; Updated yearly
• For more information: http://hnrim.nih.gov/
• Other databases:
– CRISP: http://crisp.cit.nih.gov/
– CARDS:
http://ods.od.nih.gov/Research/CARDS_Database.aspx/
NIH Nutrition Research Areas—
Examples
• Cancer and Nutrition
• Obesity, Anorexia, and Appetite
• Cardiovascular Disease and Nutrition
• Genetics and Nutrition
• Prevention and Nutrition
• Clinical Trials, Nutrition
• Lipids (Fats and Oils)
• Vitamins
• Dietary Supplements (Nutrient ingredients;
Botanical and other non-nutrient ingredients)
Source: Human Nutrition Research and Information
Management (HNRIM) System database
NIDDK Nutrition Research and Training
Support (FY 1997-2006)
Expenditures
(Dollars in millions)
Number of Projects
300
1,200
250
1,000
200
150
800
100
600
50
97
97
99
00
01
02
03
04
05
Fiscal Year
Source: Human Nutrition Research and Information
Management (HNRIM) System database
06
97
98
99
00
01
02
03
Fiscal Year
04
05
06
NIDDK’s Division of Digestive Diseases and Nutrition
(DDN): Nutrition-Related Programs
INVESTIGATOR INITIATED:
• Genetics and Genomics of Nutrition and Obesity
• Clinical Obesity and Nutrition
• Nutritional Epidemiology & Data Systems
• Nutrient Metabolism
• Childhood Obesity
• Obesity Prevention & Treatment
• Obesity & Eating Disorders
INITIATIVE SUPPORT:
• Look AHEAD Clinical Trial of long-term decreased caloric intake and
exercise to achieve and maintain weight loss
• Longitudinal Assessment of Bariatric Surgery
• Nonalcoholic Steatohepatitis Network Trials of Vitamin E or insulinsensitizing drugs in adults and children
• Clinical Nutrition Research Units
• Obesity/Nutrition Research Centers
NIDDK’s Division of Diabetes, Endocrinology, and
Metabolic Diseases: Nutrition-Related Programs
INVESTIGATOR INITIATED:
• Role of nutrition in the treatment of cystic fibrosis—newborn screening for early
diagnosis and pancreatic enzyme replacement to enhance dietary absorption, and
behavioral interventions have been shown to prevent growth failure in kids.
• Nuclear receptor research—Understanding mechanism of action of vitamin D; role of
vitamin D in bone health.
INITIATIVE SUPPORT:
• Diabetes Prevention Program Outcomes Study (DPPOS) lifestyle arm
• HEALTHY Study: school-based nutrition and physical activity changes to reduce risk
factors for type 2 diabetes
• Treatment Options for type 2 Diabetes in Adolescents and Youth (TODAY) Study
lifestyle arm
• Diabetes Prevention and Control projects (R18) include providing DPP LS intervention
in YMCA setting, culturally sensitive approaches to lifestyle change, etc.
• Dietary treatment for inborn errors of metabolism—Clinical studies to test new dietary
treatments (PAR-06-387)
• Nuclear receptor research—Nuclear Receptor Signaling Atlas (e.g., role of dietary
lipids as nuclear receptor ligands)
• Special Statutory Funding Program for Type 1 Diabetes Research funds several
nutrition-related programs, including: TEDDY (The Environmental Determinants of
Diabetes in the Young study), TrialNet, and TRIGR (Type 1 Diabetes in the Genetically
at Risk study)
NIDDK’s Division of Kidney, Urologic, and
Hematologic Diseases: Nutrition-Related Programs
INVESTIGATOR INITIATED:
• Iron Metabolism
• Nutrition in Kidney Disease Patients
• Kidney Stones
• Mineral Nutrition
• Obesity and Urologic Disease
INITIATIVE SUPPORT:
• Chronic Renal Insufficiency Cohort (CRIC)
• Prospective Cohort Study of Kidney in Children (CKiD)
• Program to Reduce Incontinence by Diet and Exercise
(PRIDE) Clinical Trial
Examples of NIH Initiatives Related to
Obesity/Nutrition
Ongoing initiatives:
– PAR-07-259 and 06-103 Improving Diet and Physical
Activity Assessment (R01 and R21)
– PA-07-218 Diet Composition and Energy Balance (R01)
– PA-08-078 Research on the Economics of Diet, Activity,
and Energy Balance (R01)
– PA-07-013 Research on Improving Health Care for Obese
Patients (R01)
– PA-07-180 School-based Interventions to Prevent Obesity
(R01)
– PAR-06-532 Translational Research for the Prevention and
Control of Diabetes and Obesity (R18)
Additional opportunities listed in the NIH Guide:
http://grants2.nih.gov/grants/guide/
NIDDK Major Areas of Focus
• Maintain vigorous investigator-initiated research
portfolio
• Support pivotal clinical studies and trials
• Preserve stable pool of talented new investigators
• Foster exceptional research training and mentoring
opportunities
• Ensure knowledge dissemination through outreach
and communications
Focus Area:
Vigorous Investigator-Initiated
Research Portfolio
• Promote innovation and problem-solving by
individual investigators crucial for research progress.
• Maintain commitment to a vigorous investigatorinitiated research portfolio at the highest possible
level.
• Maximize investments through cross-cutting research
applicable to disease-specific research issues.
 66% of current NIDDK budget devoted to RPGs, with
66% of RPG budget for investigator-initiated R01s
Focus Area:
Pivotal Clinical Studies and Trials
• Support clinical studies and trials on a range of
nutrition-related diseases, including:
-HEALTHY Study of school-based nutrition and physical activity
changes to reduce risk factors for type 2 diabetes
-Nonalcoholic Steatohepatitis Network Trials of Vitamin E or
insulin-sensitizing drugs in adults and children
-Program to Reduce Incontinence by Diet and Exercise (PRIDE)
• Strive for substantial minority participation
• Maximize investment in clinical research by expanding
access to research resources through ancillary studies
and repositories
Focus Area:
New Investigators
• Sustaining support for new investigators is both an NIH and a
Congressional priority
• Bring innovative ideas and fresh perspectives that invigorate
research.
• Strive to ensure new investigators realize their potential.
• Foster mentorship activities and promote special consideration
for funding new investigators.
 118 new investigators funded last year by DK;
116 to date this year
 15% of DK competing RPG budget for new investigator R01s;
21% of DK competing R01 budget for new investigator R01s
Focus Area:
Research Training and Mentoring
• Maintain pipeline of outstanding investigators
focused on NIDDK-related issues as critically
important to research progress.
• Continue to support undergraduate/
graduate/postdoctoral training opportunities,
as well as research career development
awards.
 K awardee training; plan for helping 1st-time R01
recipients increase chance of renewal
• Analyze data to optimize deployment of
research training resources.
Focus Area:
Outreach and Communications
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NIDDK Website
Educational/ awareness campaigns
Workshops, Conferences
Yearly compendium of Institute-sponsored
research advances and opportunities
Focus Area:
Outreach and Communications
http://www.niddk.nih.gov
National Nutrition-Related Health
Information Resources
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Weight-control Information Network
http://win.niddk.nih.gov/
National Digestive Diseases
Information Clearinghouse
http://digestive.niddk.nih.gov
National Kidney and Urologic Diseases
Information Clearinghouse
http://kidney.niddk.nih.gov
National Diabetes Information
Clearinghouse
http://diabetes.niddk.nih.gov/
National Endocrine and Metabolic
Diseases Information Service
http://www.endocrine.niddk.nih.gov
Focus Area:
Outreach and Communications
http://www.celiac.nih.gov
Focus Area:
Outreach and Communications
Workshops, Meetings on Topics Relevant to Nutrition Research
Recent Meetings:
• Gastrointestinal Microbiota and Advances in Prebiotic and Probiotic
Research, December 11-12, 2007, Rockville, MD
• 2007 Intrauterine Environment Investigators’ Meeting and Workshop
Upcoming Meetings:
• Workshop on the Establishment, Maintenance, & Turnover of Fat Depots,
May 21-22, 2008, Lister Hill Auditorium, NIH, Bethesda, MD
• Diabetes and Obesity Disparities in Healthcare Systems Conference, June 30July 1, 2008, Natcher Auditorium, NIH, Bethesda
• Neuroimaging in Obesity Research, October 27-28, 2008, Natcher
Auditorium, NIH, Bethesda
• Dynamic Epigenome and Metabolic Syndrome, November 2008, Washington
DC.
Focus Area:
Outreach and Communications
•Features:
• We Can! (Ways to Enhance
Children’s Activity and Nutrition)
• New Metabolic Clinical Research
Unit
•Research Advances:
• Omega-3 fatty acids reduce T1D
risk in kids
• Newly discovered molecular
regulators of metabolism
• Gut bacterial effects on metabolic
efficiency and obesity risk
• Dietary oxalate and kidney stones
http://www.niddk.nih.gov
For More Information
http://www.niddk.nih.gov
http://dnrc.nih.gov