Transcript Northern Ireland Clinical Research Networks Judy Bradley PhD MCSP Reader in Physiotherapy Joint Clinical Lead NICRN (Respiratory Health) Objectives • Background to Clinical Research Networks (CRN) and.

Northern Ireland Clinical
Research Networks
Judy Bradley PhD MCSP
Reader in Physiotherapy
Joint Clinical Lead NICRN (Respiratory Health)
Objectives
• Background to Clinical Research
Networks (CRN) and the NICRN
• UKCRC and NICRN
• Infrastructure of NICRN
• Study Adoption
• The NICRN and the AHP Forum
Why do we need Clinical
Research Networks?
The NICRN
NICRN Co-ordinating Centre
Clinical Director
Senior Manager
Network Co-ordinators x3
NICRN interest
groups 9 in total
Clinical Lead(s)
R&D Office Funding
CRF
Nodes (Trusts)
Research Office(s)
Research co ordinators(s)
Other supporting staff
Components of the NICRN
NICRN
Steering
Committee
Overall scientific direction &
performance
C M G’s of each
Themed network
Coordinating Centre
at CRF
Site PI’s & Clinical Research Staff
Topic-specific scientific direction &
performance
Research Methods & Processes,
Databases, Communications
Recruiting & managing
patients
NICRN Themed Groups
Links with the UK
NIHRCRN CC
NICRN Coordinating Centre
NIHR CRNs
Methodological expertise
Data management
ICT coordination & support
Monitoring
Training
Admin support
UK linkage
Local Topic Specific
Network
Clinical lead
Prioritise studies
Study design
Recruit participants
Study management
UKCRN
Functions of NICRN
Maintain a portfolio of network studies
Assist with processes involved in setting up a
study, in particular ethical, regulatory and
local research governance approval for clinical
trials
Communications hub
Promote the work of the NICRN and
disseminate NICRN publications and
information material.
Functions contd.
IT & administrative support
Provision of Training & Education
Proactively manage the topic network budget
ensuring that research opportunities are
maximised within available resources
Staffing Levels
Trust
WTE
Fund
WTE
Post
Respir
Stroke
Crit
Care
Diabet
Demen
1ary
Care
Cardiov
as
Vision
Child
BHSC
T
19.3
9.8
3.0/3.
0
0.0/1.
0
1.0/1.
0
0.6/2.
0
2.0/2.
0
1.0/1.
0
0.2/2.
2
2.0/6.
1
0.0/1.
0
SEHS
CT
2.5
1.5
NA
0.5/0.
5
0.5/0.
5
0.5/0.
5
NA
NA
0.0/1.
0
NA
NA
NHSC
T
4.0
1.0
NA
0.5/1.
0
0.5/0.
5
0.0/1.
0
NA
NA
0.0/1.
0
NA
0.0/0.
5
WHSC
T
2.5
1.0
NA
0.5/0.
5
NA
0.5/0.
5
NA
NA
0.0/1.
0
NA
0.0/0.
5
SHSC
T
2.5
0.0
NA
0.0/1.
0
NA
NA
NA
NA
0.0/1.
0
NA
0.0/0.
5
Total
30.8
13.8
0
-2.5
0
-2.4
0
0
-6.0
-4.1
-2.5
NICRN Study Adoption
Process
 The adoption process is carried out by the
relevant CMG supported by NICRNCC and in
liaison with sponsor/PI/CI
Adoption forms completed by PI and submitted
to CMG for consideration
NICRN Study Adoption Process
To be adopted studies must be fully funded
• Studies that are funded by:
– A UKCRC partner
– Commercial organisations
– Non-UKCRC partners
• Provided that:
– Funding is nationally competitive
– Studies are independently peer reviewed
– Studies fit within remit of a themed group
Benefits of Adoption
 Coordinated, efficient access to a large and diverse
patient population across a range of clinical
services/trusts and demographics
 Add value for both researchers and funders, ensuring
projects are set up quickly and remove the
administrative burden for financial, ethics and
governance arrangements
 NICRN staff assist in recruitment/execution
 Adverse event reporting
 Efficient start up and roll out of studies making sure
they can be completed on time
Performance Matrix
•
•
•
•
Portfolio of studies
Accrual
Timelines (set up, completion)
Data quality
Portfolio
Group
Adopt
BHSCT
SEHSCT
NHSCT
WHSCT
SHSCT
PIPELINE
Respiratory
8
8
0
0
0
0
5
Stroke
3
1
2
2
0
0
7
Crit care
6
5
3
0
0
0
2
Diabetes
6
6
3
1
1
1
5
Dementia
2
2
0
0
0
0
5
1ary care
0
0
0
0
0
0
5
Cardiovas
1
1
1
1
1
0
24
Vision
4
4
0
0
0
0
0
Childrens
7
7
0
0
0
0
6
Total
37
34(9.8)
9(1.5)
4(1.0)
2(1.0)
1(0.0)
59
Studies
Different groups have very different studies
• Commercial Studies vs non commercial studies
• Single site vs multicentre
• Local/National/International studies
NICRN (Respiratory Health) Clinical
Management Group Members (CMG)
Co- Leads
 Dr Lorcan McGarvey (Consultant Physician RVH and QUB)
 Dr Judy Bradley (Reader in Physiotherapy BCH and UUJ)
Clinical Management Group
 Dr Liam Heany (Consultant Physician, QUB and BCH)
 Prof Stuart Elborn (Consultant Physician, QUB and BCH)
 Dr Martin Kelly ( Consultant Physician, Altnagelvin)
 Anne Marie Marley (Nurse Consultant, Matter)
 Jackie Meggary (Clinical Physiologist, BCH)
 Dr Joe Kidney ( Consultant Physician, Matter)
 Dr Brenda O’Neill (Physiotherapy Lecturer, UUJ)
Principal Investigators
The NICRN (Resp Health) Staff
• 3 Staff
– 1 research nurse
– 1 clinical physiologist
– 1 physiotherapist
• Staff currently based at Belfast Trust City
Hospital Site
• Submitting a proposal for additional staff/? Based at
other trusts
The NICRN (Resp Health)
Portfolio
• 9 studies adopted (5 in pipeline)
• 8 commericial Studies and 1 non commercial
study (Charity)
• 1 Single site and 8 multicentre
• 1 Local and 2 UK and 6 International studies
THE FUTURE……….
Increased participation in studies
Improved accrual to studies
Enhanced Communication
Better Co-ordination of resources
Consistency of practice & performance
Quality of research
More patients benefit from clinical research
Improving the health & well being of patients
The AHP Research Forum and the
NICRN
Getting research supported that is important
to you
Get to know key players in research in NI and
at your site
Job opportunities within the NICRN
Opportunity to support national & international
multi-centre trials
CONTACT DETAILS
NICRN Co-ordinating Centre
Room 2007 K.E.B.
Royal Hospital
Belfast
BT12 6BA
Tel: 028 90636367
Email:
[email protected]
[email protected]
[email protected]