Transcript Rough Endoplasmic Reticulum (RER)

By Jamie Richardson
& Derek DeFazio
Function

Rough Endoplasmic Reticulum- Network of
channels that are created by membranes located in the
cytoplasm

Found in the cytoplasm of eukaryotic cells
The Rough ER synthesizes
proteins for export to the outside
of the cell and enzymes to be
incorporated into cellular
organelles

Structure
The rough ER gets its name from its surface
appearance, which
is pebbly due to the
presence of
ribosome's

The ER is
composed of a
phospholipid
bi-layer embedded
with proteins

Location
Pseudoachondroplastic Dwarfism

A rough-surfaced Endoplasmic Reticulum storage disease

Patients with pseudoachondroplastic dwarfism had indications of a
specific ultrastructural defect—a storage in the rough-surfaced
endoplasmic reticulum of inclusions with alternately electron-dense
and electron-lucent layers

This disease is a rare inherited disorder consisting of skeletal
malformations resulting in short legs and mild to moderate short
stature.
THE END
Work cited
Cooper, Reginald, and Jerry Maynard. "Pseudoachondroplastic Dwarfism."
JB&JS The Journal of Bone and Joint Surgery, 1973. Web. 25 Mar 2010.
<http://www.ejbjs.org/cgi/content/abstract/55/3/475>.
"Pseudoachondroplastic Dysplasia." CIGNA. National Organization for Rare
Disorders, Inc., 22 Apr 2008. Web. 25 Mar 2010.
<http://www.cigna.com/healthinfo/nord1120.html>.
"rough endoplasmic reticulum ." The Free Dictionary. Elsevier, Inc, 2007. Web.
25 Mar 2010. <http://medicaldictionary.thefreedictionary.com/rough+endoplasmic+reticulum
Raven, Peter. Biology. 8th ed. Boston: McGraw-Hill company, inc, 2008. 70.
Print.