Transcript Bioactives, Iridoids and More Words You Need to Know

The Science Behind
TAHITIAN NONI®
Bioactive Beverages
It’s all about adaptogens and bioactive iridoids
Clinically Proven Health
Benefits
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Antioxidant
Healthy joints
Boosts immune system
Healthy cardiovascular system
Increases physical endurance
DNA protection
Healthy quality of life
Healthy cardiovascular system
These statements have not been evaluated by the Food and Drug Administration. This product is
not intended to diagnose, treat, cure, or prevent any disease.
Why So Many Health Benefits?
• Tahitian Noni® Original Bioactive Beverage is
an adaptogen
• Simply put, an adaptogen helps the body
adapt to the stresses imposed by its
environment.
Three Properties of an Adaptogen
1. Safe
2. Imparts non-specific resistance to biological,
chemical, or physical stresses. This means it
has a wide range of health benefits
3. Has a normalizing effect on the body
Safe Approvals include:
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Australia
Japan
European Union
Malaysia
People’s Republic of China
Russian Federation
Taiwan
Ukraine
USA
many others
Non-specific Help and Resistance
Tahitian Noni® Original Bioactive Beverage has a
wide range of health benefits
What is in
Tahitian Noni®
Bioactive Beverages?
• Bioactives: susbtances in medicinal plants that
cause positive biological effects.
– These are good for your health!
Food Plants provide basic nutrients
to sustain life
Apple
Cherry
Banana
Acai
Pear
Mangosteen
Strawberry
Medicinal Plants such as noni provide
bioactive compounds to improve health
A Tell All Comparison
# clinical studies
# with
significant
results
Source of
flavonoids
Significant
source of
iridoids
TAHITIAN NONI
14
14


MonaVie
1
0

Xango
1
0

Xyngular
0
0

Zrii
0
0

Zija
0
0

Koopuwa
0
0

Product
What are Iridoids?
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Bioactives that are not common in fruits
Also found in some Chinese medicinal plants
Have a wide range of bioactivity
Not polyphenols (i.e. flavonoids) or
carotenoids (beta-carotene), but belong to a
different class of phytonutrients
• Heat stable and stable during storage
Iridoid & Noni Bioactivity
Published bioactivities of
iridoids
Antioxidant
Healthy joints
Boosts immune system
Healthy cardiovascular
system
DNA protection
Increases energy
Etc.
TAHITIAN NONI Health
Benefits
Antioxidant
Healthy joints
Boosts immune system
Healthy cardiovascular
system
DNA protection
Increases energy
Etc.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose,
treat, cure, or prevent any disease.
Which Iridoids are in Noni?
Two predominant iridoids are:
– Deacetylasperulosidic acid, or DAA for
short, is the major bioactive component.
– Asperulosidic acid, or AA for short, is the
second major iridoid.
Chemical Structure of the iridoid DAA
Deacetylasperulosidic acid, or DAA
is a cyclopenta[c]pyran monoterpenoid
An Example of DAA & AA Bioactivity
• Tahitian Noni® Original Bioactive Beverage
protects DNA in human subjects
• DAA & AA reduce DNA damage in vitro
100 %
Noni contains More Iridoids Than
Some Well Known Chinese Herbs
Iridoid Content
mg/g
2
1
0
Noni
Ginseng
(人参)
Goji Dong quai Ginger
(枸杞)
(生姜)
(当归)
Licorice
(甘草)
mg/mL
2
Which Fruit is Really Super?
Iridoid Content
1
not a noni iridoid
0
Noni
Goji
Açai
Mangosteen Cupuaçu
Blueberry
concentrate
Rapid flavonoid degradation
explains why there is no significant
research to substantiate the claims
of products such as MonaVie, Xango
Zrii and others
Comparison of Bioactive Stability
Level of major actives (µg/mL)
400
350
300
250
200
150
100
50
0
TNJ- 7 years past expiration date
MovaVie Active- 1 month before
expiration date
Note: DAA is major bioactive in noni fruit; cyanidin 3-glucoside is a major
bioactive in fresh açai fruit
Stability of Cyanidin-3-Glucoside in Açai Pulp
Total cyanidin-3-glucoside
mg/mL
0.08
0.04
0
0
4
8
months storage at 20°C
Source: Food Research International 40 (2007) 620–628
12
Fruits from Food Plants
are most bioactive
when
eaten fresh
Every new super juice
touting ORAC scores, flavonoids
and/or carotenoids is significantly
less effective than Tahitian Noni®
Original Bioactive Beverage due to
flavonoid degradation and a lack
of true bioactives.
Stability of Iridoids
in Tahitian Noni® Original Bioactive Beverage
Total iridoids
mg/serving
40
20
0
0
4
8
months storage at 23°C
12
Stability of Major Noni Iridoid
Total Deacetylaspersulosidic acid (DAA)
mg/serving
30
20
10
0
0
2
4
years storage
6
8
Iridoids in noni retain potency
after processing, pasteurization
and storage
Many Scientific Studies Prove…
• Tahitian Noni® Original Bioactive Beverage has
adaptogenic properties
• Tahitian Noni® Original Bioactive Beverage is a
rich source of adaptogenic iridoids
• These iridoids are stable, thus ensuring long
term product quality and efficacy