Transcript The IAEA Coordinated Research Project

The IAEA Coordinated Research Project
Molybdenum-99 Production Using LEU Fission or
Neutron Activation (T1.20.18)
Ira N. Goldman, Natesan Ramamoorthy, Pablo Adelfang
International Atomic Energy Agency
2006 RERTR International Meeting
29 October - 3 November 2006
Cape Town, South Africa
CRP on Mo99 Production LEU / NA
Background
• Most Mo99 is currently produced with HEU.
• Efforts to shift production of medical isotopes away
from use of HEU (thru RERTR).
• Some member states are seeking to become small
scale, indigenous producers of Mo99
• Encourage and provide access to LEU technology
or neutron activation (NA) methods as HEU no
longer available or accepted.
CRP on Mo99 Production LEU / NA
CRP
• CRPs: research institutes in developing and
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developed Member States collaborate.
Encourage dissemination of new knowledge
involving nuclear/isotopic techniques.
IAEA acts as sponsoring and coordinating body for
research carried out by selected institutions.
4000 Euro per contract per year and support for
participation in RCM.
Additional training activities as EB funds permit.
CRP on Mo99 Production LEU / NA
History
• November 2004 - Consultants Meeting
• February 2005 - CRP approved
• May 2005 - Potential Mo99 Producer’s Workshop, Buenos
Aires
• September 2005 – Contracts/Agreements approved
• December 2005 – 1st Research Coordination Meeting,
Vienna
• March 2006 – Foil Targets Workshop, Serpong, Indonesia
CRP - Mo99 Production LEU / NA
Objectives
• Assist member states with adoption of LEU Cintichem (foil
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targets) or neutron activation (gel moly) technology.
Further demonstrate efficacy of LEU production of Mo99
Advance intl non-proliferation and nuclear security
objectives, promote sustainable development.
Foster capacity building for local/regional self-sufficiency to
meet Mo99 needs
NOT aimed at existing large-scale producers (but they are
participating/contributing)
CRP - Mo99 Production LEU / NA
Purpose
• Assist recipients to research, test, and evaluate:
- LEU modified Cintichem process with LEU foil
targets
-Neutron activation of natural molybdenum oxide
targets and utilization of gel generators.
• Disseminate information on Mo99 production using
LEU foil targets or gel generators obtained from
experimental evaluation of the technologies.
CRP - Mo99 Production LEU / NA
Output
• Participants will obtain necessary know-how for
small-scale production using transferred LEU/ NA
technologies.
• Technology transfer will address all steps: target
preparation, irradiation, radiochemical processing,
safety, waste management, quality control, and
quality assurance.
CRP - Mo99 Production LEU/NA
Research Contracts
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Chile: LEU modified Cintichem w/foil targets
Kazakhstan: gel generators
Libya: LEU modified Cintichem w/foil targets
Pakistan: LEU modified Cintichem w/foil targets
Romania (IFIN-HH): gel generators
Romania (Pitesti): LEU modified Cintichem w/foil
targets
CRP - Mo99 Production LEU/NA
Research Agreements
• Argentina: LEU fission moly implementation
• Republic of Korea: development of LEU foil targets
• India: standardization of gel generators and feasibility of
fission moly.
• Indonesia: development of LEU foil targets
• U.S. (ANL): LEU-modified Cintichem foil targets technology
transfer
• U.S. (U. Missouri MURR):LEU-modified Cintichem foil
targets; requirements for FDA approval of LEU-produced
Mo-99
CRP - Mo99 Production LEU/NA
First RCM
11-14 December 2005, Vienna
• Individual country workplans reviewed and revised.
• Coordinated activities and experimental program
established.
• Necessary materials and expertise specified.
• Actions and milestones established.
• Project website initiated after first RCM
CRP - Mo99 Production LEU/NA
LEU Foil Workshop, 6-10 March 2006, Serpong,
Indonesia
• Lectures and facility visits
• Foil preparation, target fabrication, assembly and
disassembly, irradiated target processing
• ANL lecturers, BATAN personnel facility
demonstrations.
• Based upon U.S. DOE – Indonesia bilateral
cooperation program
CRP - Mo99 Production LEU/NA
CRP - Mo99 Production LEU/NA
CRP - Mo99 Production LEU/NA
CRP - Mo99 Production LEU/NA
CRP - Mo99 Production LEU/NA
CRP - Mo99 Production LEU/NA
Provision of Materials
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Aluminum tubing shipped from ANL (03/06).
KAERI agreed to supply test foils.
IAEA review of legal requirements for transfers.
Discussions with other foil supplier (CERCA).
Glassware procured by IAEA with DOE funding
(shipment 12/06).
• Receipt of DU, NU, LEU foils (Winter/07).
CRP - Mo99 Production LEU / NA
Commercial Industry Involvement
• Major Mo-99 producers observers at 1st
RCM
• Major producers agreed to support Nov.
2006 workshop (lecturers)
• CERCA, BWXT also to participate
• Possible test foils from CERCA
CRP - Mo99 Production LEU / NA
28 November – 1 December 2006, Vienna
Workshop on Operational Aspects of Mo-99 Production
• Lectures on:
- target plate manufacture, foil target production
-target irradiation
-irradiated plate processing
-logistics, storage, and transportation
-environmental and waste management
-quality management
-physical protection/security
• Lecturers from BWXT, CERCA, KAERI, MDS Nordion, NECSA, NRG
Petten. Tyco Health Care
• Supported with DOE funding
CRP - Mo99 Production LEU / NA
Second Year Activities
• Completion of calculations for target irradiation
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(12/06).
Finalize and submit safety analysis reports (12/06).
Finalize irradiation rig and target designs.
Cold assembly, testing, and disassembly of targets
(NU, DU, later LEU)
Finalize procedures and protocols, including
process facilities, quality control and assurance.
Second Research Coordination Meeting (RCM),
Bucharest (16-20 April 2007, tentative).
CRP - Mo99 Production LEU / NA
Third Year/Future Activities
• Irradiation of LEU targets (12/07) and processing
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of hot targets (02/08)
Irradiation of Mo oxide and preparation of ‘moly
Mo-99 gel’ powder for gel column generators
Compare, assess, and interpret results, provide
follow-up, and suggest adaptive changes
Review compliance with specifications and purity
requirements.
Make modifications to improve future efforts.
Publish Agency TECDOC on the final results
CRP - Mo99 Production LEU/NA
Conclusions (1)
CRP has had a good start in the first year:
1. calculational work and other prep activities for fission
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moly have progressed in each country,
gel moly experiments and gel generator trial productin
carried out; additional analysis work underway
aluminium tubing supplied, glassware by early 2007,
arrangements for foil are falling into place, 1st quarter
2007
two workshops/training held, including one in cooperation
with Mo-99 industry
CRP - Mo99 Production LEU/NA
Conclusions (2)
• Papers later in this session by Chile and Romania (Pitesti)
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will describe their specific progress in fission moly work.
India completed commissioning production facility for gel
generators, limited supply now to hospital radiopharms.
Some activities are behind schedule
Plan to hold a technical training workshop for gel moly
group
Work remains to be done to achieve irradiation and
processing at end of 2007/beginning of 2008
CRP - Mo99 Production LEU/NA
Conclusions (3)
• CRP directly supportive of RERTR objectives.
• Will help build experience, consensus on use of
(a) LEU for Mo-99 production and (b) gel generator
option using NA produced Mo-99.
• Results and experience gained will help strengthen
local capability for undertaking small scale Mo-99
production in participant countries.
• Facilitate enhanced utilization of research reactors
by local production of radioisotopes
CRP - Mo99 Production LEU/NA
THANKS FOR YOUR
ATTENTION!!!!