Transcript moly CRP - International Atomic Energy Agency

Fostering New Sources of Mo-99
for International Nuclear Medicine Needs
IAEA CRP on Mo-99 Production Using LEU
or Neutron Activation
Ira N. Goldman, Natesan Ramamoorthy, Pablo Adelfang
International Atomic Energy Agency
2008 RERTR International Meeting
October 5 - 9, 2008
Washington, DC
RERTR 2008
IAEA Mo-99 CRP
Outline
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Background and History
Participants
Recent Activities and Progress
Training/Technical Support and Procurements
Near-Term Plans
Conclusion
RERTR 2008
IAEA Mo-99 CRP
Background
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99mTc
reigns as the most used diagnostic tracer; 7580% of all imaging  >25 million studies/year
Weekly 99Mo requirements: ~450000 GBq (12000Ci, ‘6day curies’) at reference time (~50% for USA). Well over
95% of 99Mo is produced using HEU targets (~50 kg)
Efforts to shift production of medical isotopes away
from use of HEU (through RERTR, DOE/USA)
Some Member States (MS) of IAEA are seeking to
become small scale, indigenous producers of 99Mo
Need to encourage and provide access to LEU
technology or neutron activation (NA) methods as HEU
is phased out from commercial use
RERTR 2008
IAEA Mo-99 CRP
Objectives
• Assist member states with adoption of LEU Cintichem
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(foil targets) or neutron activation (gel moly)
technology.
Further demonstrate efficacy of LEU production of 99Mo
Advance intnl coopn for non-proliferation and nuclear
security objectives, promote sustainable development.
Foster capacity building for local/regional selfsufficiency to meet 99Mo needs
Not Aimed: Engaging the large-scale industrial
producers (but some are participating/contributing)
www.iaea.org/OurWork/ST/NE/NEFW/nfcms_researchreactors_Mo99.html
RERTR 2008
IAEA Mo-99 CRP
History
• November 2004 - Project Design Consultancy, Vienna
• February 2005 - CRP approved
• May 2005 - Potential Mo-99 Producer’s Workshop, Buenos
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Aires, Argentina
December 2005 – 1st RCM, Vienna, Austria
March 2006 – Foil Targets Workshop, Serpong, Indonesia
November 2006 - Workshop on Operational Aspects of Mo99 Production, Vienna, Austria
April 2007 – 2nd RCM, Bucharest and Pitesti, Romania
2007-2008 – Various training activities in Argentina, Chile,
India, and Indonesia; equipment procurement, process
installation, testing
Oct 13-16, 2008: 3rd RCM, MURR, Columbia, Mo, USA
RERTR 2008
Mo-99 CRP
Participants
• Contract Holders:
-Chile/CCHEN - LEU foil targets fission moly
-Egypt/EAEA – fission moly and gel generators
-Kazakhstan/INP - gel moly portable generators
-Libya/DRETC - LEU foil targets fission moly
-Pakistan/PINSTECH - LEU foil plate targets fission
moly
-Romania/IFIN-HH Magurele - gel moly
-Romania/INR Pitesti - LEU foil targets fission moly
RERTR 2008
Mo-99 CRP
Participants
• Agreement Holders:
-Argentina/CNEA
-India/BARC-BRIT
-Indonesia/BATAN
-Korea/KAERI
-Poland/POLATOM
-US/ANL
-US/MURR
RERTR 2008
IAEA Mo-99 CRP
Recent Progress/Activities
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KAERI LEU foils sent to Poland, U.S. (ANL and MURR), October 2007
Further calculation and analytical work (Chile, Egypt, Libya, Pakistan)
Annular foil target assembly and testing (Chile, Romania2)
R&D LEU foil plate target and LEU electro-deposition (Pakistan)
Hot cell modifications and preparations (Chile – new manipulators;
Libya, Romania2, MURR)
Development of processing procedures, cold run (Chile, MURR,
Romania2)
Development of QA procedures (Chile, MURR, Romania2)
Substantial intra-participant training and HR development (next slide)
Gel moly development and implementation (Kazakhstan, Romania1)
RERTR 2008
IAEA Mo-99 CRP
Fostering Provision of Materials, Information Exchange
• Aluminium tubing shipped from ANL (03/06)
• KAERI supply of test foils with IAEA facilitation for transfers.
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LEU foils delivered to 4-5 participants (2007)
Glassware procured by IAEA with DOE funding; received
by late 2006/early 2007
ANSTO safety documentation distributed (early 2007)
MURR assistance in performing and evaluating thermal
hydraulics calculations
BRIT/BARC assistance with gel generator know-how
CRP website increasingly important tool with several
technical reports posted
RERTR 2008
IAEA Mo-99 CRP
Training/Technical Assistance and Procurements
• BRIT (India), February 2008, 1 Kazakhstan SV re: portable
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gel moly generator technology
BATAN, March 2008 - 1 Chilean, 2 Libyan Fellows LEU
ingot rolling process, foil target fabrication, waste treatment
CNEA, June 2008 - 1 Libyan SV, QC for Mo-99 production
CCHEN, August 2008 - 1 Poland SV, LEU annular target
fabrication equipment design, assembly, welding (2 Libyans
unable to reach Chile)
Additional aluminum tubes procured by ANL for Chile and
Poland
Bids for Cintichem laboratory equipment and supplies for
Libya; evaluation underway
RERTR 2008: IAEA Mo-99 CRP
Progress Status and Perspectives
• Several groups in the CRP will advance to
demonstrating 99Mo production using LEU
• Objective findings on all related aspects: feasibility
to adaptability – scope, requirements
• Possible role of a few groups significant: (i)
MURR, USA to establish compliance of LEU moly
for generator use; (ii) 4 groups already handling
generator production, thus well placed to use local
LEU moly
• 2 other groups will show the scale of applicability
of gel moly system
RERTR 2008
IAEA Mo-99 CRP
Future Activities
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3rd RCM, 13-16 October, MURR
Provision of fabricated annular targets to Libya
1 Poland Fellowship to MURR (1 month, Oct-Nov. 2008)
Extension of CRP for an additional two years
Irradiation of LEU targets and processing of hot targets
Irradiation of Mo oxide and preparation of ‘moly Mo-99 gel
powder for gel column generators
• Compare, assess, and interpret results, provide follow-up,
and suggest adaptive changes
• Review compliance with specifications and purity
requirements
• Document/publish results
RERTR 2008
IAEA Mo-99 CRP
Other Activities
• Participated in Global Initiative (GI) for Preventing
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Proliferation Workshop on Mo-99 Production, Sydney,
December 2007
Maintain contact/input to NAS Mo-99 Study
Participated in DOE Isotopes Workshop, August 2008
Respond to many inquiries regarding research reactors and
Mo-99 production.
Encouraging RR networking, collaboration for isotope
production (and other activities) under IAEA Research
Reactor Coalitions Initiative.
Sydney Workshop on the
Production of 99Mo using LEU
• GICNT: NNSA, DOE/USA and ANSTO; Sydney
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Dec 2-5, 2007; 50 participants from 14 countries
IAEA invited to, (I) join Executive Committee; (ii)
present a talk; (iii) chair a Session
Practically all stakeholders sat together!
Workshop report: key issues, challenges
(technical; economic; political) and path forward
Formal report to GI plenary in summer 2008
RERTR 2008
IAEA Mo-99 CRP
Other influencing events
• Vulnerability of Mo-99 supplies: Fall 2007 Canadian event;
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Summer 2008 European scenario
May 2008: Closure of MAPLE reactor project announced
NAS Mo-99 Study complete; Report awaited
Follow-up on DOE Isotopes Workshop held in August 2008
Enquiries regarding the IAEA help: research reactor
availability and Mo-99 production
Progress in additional production plans and identifying
potential possibilities
RERTR 2008
IAEA Mo-99 CRP
Conclusion
• Many CRP participants continue to make excellent progress.
• Increasing technology transfer between the contract holders.
• Participants are developing physical and human resource infrastructure
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to carry out successful trial irradiation and processing.
Recent events have demonstrated the fragility of the global Mo-99
supply infrastructure.
Medium term outlook for global Mo-99 supply highly uncertain due to
aging isotope production reactors, lack of planned replacements.
Several participants have significant facilities that could be utilized in
addressing global Mo-99 requirements.
Partnerships, joint ventures, or other commercial arrangements needed
to further develop such potential alternative producers.
IAEA prepared to provide a forum to bring together all
stakeholders for an objective analysis of requirements and to
consider options for path forward.
Acknowledgements
• DOE/NNSA – primary
project funding
• NTI: project
management finances
• Government of Norway
– financial support
• ANSTO, KAERI,
CERCA: in-kind
support
Thank you all for your attention
[email protected]