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Glycogen Regulation
AMP
cAMP
Ca2+
AMPKa1
PKA
p38a MAPK
Grk3
GSK3b
PASK
PHKg1
DYRK1A
DYRK1B
DYRK2
S8
S641
S645
GYS2
S82
CK1
MAPKAPK2
S15
S15
S15
S8
S11
S641
S645
PYGB
PYGL
PYGM
GYS1
Glycogen Degradation
Glycogen Regulation
AMP
cAMP
Ca2+
AMPKa1
PKA
p38a MAPK
Grk3
GSK3b
PASK
PHKg1
DYRK1A
DYRK1B
DYRK2
S8
S641
S645
GYS2
S82
CK1
MAPKAPK2
S15
S15
S15
S8
S11
S641
S645
PYGB
PYGL
PYGM
GYS1
Glycogen Degradation
Glycogen Synthesis
Glycogen Regulation
AMP
cAMP
Ca2+
AMPKa1
PKA
p38a MAPK
Grk3
GSK3b
PASK
PHKg1
DYRK1A
DYRK1B
DYRK2
S8
S641
S645
GYS2
S82
CK1
MAPKAPK2
S15
S15
S15
S8
S11
S641
S645
PYGB
PYGL
PYGM
GYS1
Glycogen Degradation
Glycogen Synthesis
Glycogen Regulation
AMP
cAMP
Ca2+
AMPKa1
PKA
p38a MAPK
Grk3
GSK3b
PASK
PHKg1
DYRK1A
DYRK1B
DYRK2
S8
S641
S645
GYS2
S82
CK1
MAPKAPK2
S15
S15
S15
S8
S11
S641
S645
PYGB
PYGL
PYGM
GYS1
Glycogen Degradation
Glycogen Synthesis
Glycogen Regulation
AMP
cAMP
Ca2+
AMPKa1
PKA
p38a MAPK
Grk3
GSK3b
PASK
PHKg1
DYRK1A
DYRK1B
DYRK2
S8
S641
S645
GYS2
S82
CK1
MAPKAPK2
S15
S15
S15
S8
S11
S641
S645
PYGB
PYGL
PYGM
GYS1
Glycogen Degradation
Glycogen Synthesis
Glycogen Regulation
Substrate
Short Name
GYS1
GYS1
Substrate Full Name
ProteinType
Glycogen synthase, muscleGlygcogen synthesis
enzyme
Glycogen synthase, muscleGlygcogen synthesis
enzyme
Substrate Phospho- Effect of
Kinase
Swissprot site
Phosphorylation
Affecting
P13807
S11
Phosphorylation inhibits CK1
enzyme activity.
P13807
S641
Phosphorylation inhibits DYRK1A
enzyme activity.
GYS1
Glycogen synthase, muscleGlygcogen synthesis
enzyme
P13807
S641
GYS1
Glycogen synthase, muscleGlygcogen synthesis
enzyme
P13807
S641
GYS1
Glycogen synthase, muscleGlygcogen synthesis
enzyme
P13807
S641
GYS1
Glycogen synthase, muscleGlygcogen synthesis
enzyme
P13807
S641
GYS1
Glycogen synthase, muscleGlygcogen synthesis
enzyme
P13807
S641
GYS1
Glycogen synthase, muscleGlygcogen synthesis
enzyme
Glycogen synthase, muscleGlygcogen synthesis
enzyme
Glycogen synthase, muscleGlygcogen synthesis
enzyme
Glycogen synthase, muscleGlygcogen synthesis
enzyme
P13807
S645
P13807
S645
P13807
S645
P13807
S8
GYS1
Glycogen synthase, muscleGlygcogen synthesis
enzyme
P13807
S8
GYS1
Glycogen synthase, muscleGlygcogen synthesis
enzyme
P13807
S8
GYS1
Glycogen synthase, muscleGlygcogen synthesis
enzyme
P13807
S8
GYS1
GYS1
GYS1
All Kinases
Affecting
CK1
Phosphatase
Affecting
DYRK1A,
DYRK1B, DYRK2,
Grk3, GSK3b,
PASK
Phosphorylation inhibits DYRK1B
DYRK1A,
enzyme activity.
DYRK1B, DYRK2,
Grk3, GSK3b,
PASK
Phosphorylation inhibits DYRK2
DYRK1A,
enzyme activity.
DYRK1B, DYRK2,
Grk3, GSK3b,
PASK
Phosphorylation inhibits Grk3
DYRK1A,
enzyme activity.
DYRK1B, DYRK2,
Grk3, GSK3b,
PASK
Phosphorylation inhibits GSK3b
DYRK1A,
enzyme activity.
DYRK1B, DYRK2,
Grk3, GSK3b,
PASK
Phosphorylation inhibits PASK
DYRK1A,
enzyme activity.
DYRK1B, DYRK2,
Grk3, GSK3b,
PASK
Phosphorylation inhibits Grk3
Grk3, GSK3b, p38b
enzyme activity.
MAPK
Phosphorylation inhibits GSK3b
Grk3, GSK3b, p38b
enzyme activity.
MAPK
Phosphorylation inhibits p38b MAPK Grk3, GSK3b, p38b
enzyme activity.
MAPK
Phosphorylation inhibits AMPKa1
AMPKa1, CK1,
enzyme activity.
MAPKAPK2, PhKg, PKACa
Phosphorylation inhibits CK1
AMPKa1, CK1,
enzyme activity.
MAPKAPK2, PhKg, PKACa
Phosphorylation inhibits MAPKAPK2 AMPKa1, CK1,
enzyme activity.
MAPKAPK2, PhKg, PKACa
Phosphorylation inhibits PhK-g
AMPKa1, CK1,
enzyme activity.
MAPKAPK2, PhKg, PKACa
Glycogen Regulation
Substrate Substrate Full Name
Short Name
ProteinType
Substrate Phospho- Effect of
Swissprot site
Phosphorylation
GYS1
Glycogen synthase, muscleGlygcogen synthesis
enzyme
P13807
S8
GYS2
Glycogen synthase, liver
Glygcogen synthesis
enzyme
P54840
S641
GYS2
Glycogen synthase, liver
Glygcogen synthesis
enzyme
P54840
S641
GYS2
Glycogen synthase, liver
Glygcogen synthesis
enzyme
P54840
S641
GYS2
Glycogen synthase, liver
Glygcogen synthesis
enzyme
P54840
S641
GYS2
Glycogen synthase, liver
Glygcogen synthesis
enzyme
P54840
S641
GYS2
Glycogen synthase, liver
Glygcogen synthesis
enzyme
P54840
S641
GYS2
Glycogen synthase, liver
P54840
S645
GYS2
Glycogen synthase, liver
P54840
S645
GYS2
Glycogen synthase, liver
P54840
S645
GYS2
Glycogen synthase, liver
Glygcogen synthesis
enzyme
Glygcogen synthesis
enzyme
Glygcogen synthesis
enzyme
Glygcogen synthesis
enzyme
P54840
S8
GYS2
Glycogen synthase, liver
Glygcogen synthesis
enzyme
P54840
S8
GYS2
Glycogen synthase, liver
Glygcogen synthesis
enzyme
P54840
S8
GYS2
Glycogen synthase, liver
Glygcogen synthesis
enzyme
P54840
S8
Kinase All Kinases
Affecting Affecting
Phosphorylation inhibits PKACa
enzyme activity.
Phosphatase
Affecting
AMPKa1, CK1,
MAPKAPK2, PhKg, PKACa
Phosphorylation inhibits DYRK1A
DYRK1A,
enzyme activity.
DYRK1B, DYRK2,
Grk3, GSK3b,
PASK
Phosphorylation inhibits DYRK1B
DYRK1A,
enzyme activity.
DYRK1B, DYRK2,
Grk3, GSK3b,
PASK
Phosphorylation inhibits DYRK2
DYRK1A,
enzyme activity.
DYRK1B, DYRK2,
Grk3, GSK3b,
PASK
Phosphorylation inhibits Grk3
DYRK1A,
enzyme activity.
DYRK1B, DYRK2,
Grk3, GSK3b,
PASK
Phosphorylation inhibits GSK3b
DYRK1A,
enzyme activity.
DYRK1B, DYRK2,
Grk3, GSK3b,
PASK
Phosphorylation inhibits PASK
DYRK1A,
enzyme activity.
DYRK1B, DYRK2,
Grk3, GSK3b,
PASK
Phosphorylation inhibits Grk3
Grk3, GSK3b, p38b
enzyme activity.
MAPK
Phosphorylation inhibits GSK3b
Grk3, GSK3b, p38b
enzyme activity.
MAPK
Phosphorylation inhibits p38b MAPK Grk3, GSK3b, p38b
enzyme activity.
MAPK
Phosphorylation inhibits AMPKa1
AMPKa1, CK1,
enzyme activity.
MAPKAPK2, PhKg, PKACa
Phosphorylation inhibits CK1
AMPKa1, CK1,
enzyme activity.
MAPKAPK2, PhKg, PKACa
Phosphorylation inhibits MAPKAPK2 AMPKa1, CK1,
enzyme activity.
MAPKAPK2, PhKg, PKACa
Phosphorylation inhibits PhK-g
AMPKa1, CK1,
enzyme activity.
MAPKAPK2, PhKg, PKACa
Glycogen Regulation
Substrate Substrate Full Name
Short Name
ProteinType
Substrate Phospho- Effect of
Swissprot site
Phosphorylation
P54840
GYS2
Glycogen synthase, liver
Glygcogen synthesis
enzyme
PHKG1
Phosphorylase B kinase
gamma catalytic subunit 1
Glycogen phosphorylase,
brain form
Glycogen phosphorylase,
liver form
Glycogen phosphorylase,
muscle form
Glygcogen regulation Q16816
enzyme
Glygcogen degradation P11216
enzyme
Glygcogen degradation P06737
enzyme
Glygcogen degradation P11217
enzyme
PYGB
PYGL
PYGM
Kinase All Kinases
Affecting Affecting
S8
Phosphorylation inhibits PKACa
enzyme activity.
S82
Phosphorylation may
PKACa
stimulate kinase activity.
Glycogen phosphorylase,PhK-g
brain form
Glycogen phosphorylase,PhK-g
liver form
Glycogen phosphorylase,PhK-g
muscle form
S15
S15
S15
AMPKa1, CK1,
MAPKAPK2, PhKg, PKACa
PKACa
PhK-g
PhK-g
PhK-g
Phosphatase
Affecting