Transcript PKG_Signalling - Kinexus Bioinformatics Corporation

cGMP-dependent Protein
Kinase Signalling Pathways
Produced by Dr. Steven Pelech
Kinexus Bioinformatics Corporation
Copyright 2010
PKG Signalling
?
PDK1
PKCa
T516
T58
PKG
cGMP
PKG Signalling
?
PDK1
PKCa
T516
T58
cGMP
PKG
S23
S1105
T1122
S1177
S64
S106
PLCB3
eNOS
GUCY1A3
PDE5A
PKG Signalling
?
PDK1
PKCa
T516
T58
cGMP
PKG
S23
S1105
T1122
S1177
S64
S106
PLCB3
eNOS
GUCY1A3
PDE5A
NO
PKG Signalling
?
PDK1
PKCa
T516
T58
cGMP
PKG
S23
S1105
T1122
S1177
S64
S106
PLCB3
eNOS
GUCY1A3
PDE5A
DAG
NO
IP3
Ca2+
www.phosphoNET.ca
PKG Signalling
Substrate
Short Name
Substrate Full Name
ProteinType
eNOS
Endothelial nitric oxide
synthetase
Synthetase
GUCY1A3
Substrate Phospho- Effect of
Swissprot site
Phosphorylation
P29474
S1177
Soluble guanylate cyclase Cyclase
Q02108
S64
PDE5A
cGMP phosphodiesterase Phosphodiesterase
5
O76074
S106
PKG1
cGMP-dependent protein
kinase 1, alpha
PLCB3
1-phosphatidylinositol-4,5- Enzyme, phospholipid
bisphosphate
phospholipase C,
phosphodiesterase beta 3 phosphatidylinositolspecific
1-phosphatidylinositol-4,5- Enzyme, phospholipid
bisphosphate
phospholipase C,
phosphodiesterase beta 3 phosphatidylinositolspecific
1-phosphatidylinositol-4,5- Enzyme, phospholipid
bisphosphate
phospholipase C,
phosphodiesterase beta 3 phosphatidylinositolspecific
cGMP-dependent protein Protein-serine kinase,
kinase 1, alpha
AGC group, PKG family
PLCB3
PLCB3
PKG1
Kinase
All Kinases
Affecting Affecting
Phosphorylation increases PKG1
enzymatic activity of
eNOS.
Phosphorylation inhibits
PKG1
cyclase activity.
Phosphorylation increases PKG1
phosphodiesterase activity.
PKACa,
PKBa/Akt1,
PKG1
PKG1
T58
Phosphorylation increases PKG1
phosphotransferase
activity and affinity for
cGMP
PKCa, PKG1
Q01970
S1105
Phosphorylation inhibits of PKG1
G-protein-activated PLCbeta3 activity.
PKG1
Q01970
S26
Phosphorylation inhibits of PKG1
G-protein-activated PLCbeta3 activity.
PKG1
Q01970
T1122
Phosphorylation inhibits of PKG1
G-protein-activated PLCbeta3 activity.
PKG1
Q13976
T516
Phosphorylation increases ?
phosphotransferase
activity.
?
Protein-serine kinase,
Q13976
AGC group, PKG family
PKACa, PKG1
Phosphatase
Affecting
PPP1CA