Neurobiological and functional consequences of chronic partial sleep deprivation

Roman, Viktor

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2007 Link to publication in University of Groningen/UMCG research database

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Roman, V. (2007). Neurobiological and functional consequences of chronic partial sleep deprivation: The role of the serotonergic system s.n.

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EUROBIOLOGICAL AND FUNCTIONAL CONSEQUENCES OF CHRONIC PARTIAL SLEEP DEPRIVATION

The role of the serotonergic system

Viktor Román

RIJKSUNIVERSITEIT GRONINGEN Neurobiological and functional consequences of chronic partial sleep deprivation

The role of the serotonergic system

Proefschrift

ter verkrijging van het doctoraat in de Wiskunde en Natuurwetenschappen aan de Rijksuniversiteit Groningen op gezag van de Rector Magnificus, dr. F. Zwarts, in het openbaar te verdedigen op vrijdag 16 februari 2007 om 16.15 uur door Viktor Román geboren op 15 juli 1978 te Kecskemét, Hongarije

Promotor: Copromotor: Beoordelingscommissie: ISBN printed version:

90-367-2917-3

ISBN e-version:

90-367-2916-5 Prof. dr. P.G.M. Luiten Dr. P. Meerlo Prof. dr. J. Adrien

„The best of the rest is sleep.”

William Shakespeare: Measure for Measure

The studies described in the present thesis were carried out at the Department of Molecular Neurobiology, University of Groningen, The Netherlands, and were financially supported by the School of Behavioral and Cognitive Neurosciences (BCN) and the Netherlands Organisation for Scientific Research (NWO grant 864.04.002 to Peter Meerlo). T he printing of the present thesis was financially supported by the Dutch Society for Sleep - Wake Research (Nederlandse vereneging voor Slaap - Waak Onderzoek; NSWO), the University of Groningen and the BCN.

C over:

François Boucher - The Interrupted Sleep (1750)

Design:

Viktor Román

Printed by:

PrintPartne rs Ipskamp B.V., Enschede, The Netherlands

C

ONTENTS

Chapter 1 Chapter 2 Chapter 3 Chapter 4 Chapter 5 Chapter 6 Chapter 7 Chapter 8 Chapter 9

General introduction Too little sleep gradually desensitizes the serotonin-1A receptor system Differential effects of chronic partial sleep deprivation and stress on serotonin-1A and muscarinic cholinergic receptor sensitivity Altered serotonergic and corticotropin releasing hormone regulation of the hypothalamo-pituitary- adrenal axis in chronic partial sleep deprivation Losing too much sleep alters serotonin signalling in the amygdala Chronic partial sleep deprivation diminishes fear and alters fear-related hippocampal neuronal activation patterns No evidence for cross-talk between the adenosine and the serotonin-1A receptor system after chronic adenosine receptor stimulation Sleep restriction by forced activity reduces hippocampal cell proliferation General discussion 9 21 31 45 55 65 73 83 93 References 103 samenvatting 121 127 133 135 List of publications List of abbreviations 136 137 138