Transcript New Glycosylation Protocols for the Synthesis of Complex Glycoconjugates of Biological Significance

Department of Chemistry
Seminar Announcement
Date/Time/Venue
Title/Speaker
1 Feb (Tue)
3pm – 4pm
New Glycosylation Protocols for the
Synthesis of Complex Glycoconjugates
of Biological Significance
@ S8 Level 3
Executive
Classroom
Professor Yu Biao
Shanghai Institute of Organic Chemistry
Chinese Academy of Sciences
Host : Asst Prof Wang Jian
About the Speaker
Professor Yu Biao received his B.S. in Nuclear chemistry from
Peking University in 1989, his M.S and Ph.D (with Prof. Y.Z.Hui)
from Shanghai Institute of Organic Chemistry (SIOC), Chinese
Academy of Sciences (CAS), in 1992 and 1995, respectively.
After one-year postdoctoral research in New York University,
Professor Yu returned to SIOC as an Assistant Professor, and
became an Associate Professor in 1997 and Professor in 1999.
His research interests include total synthesis, synthetic
methodology and chemical biology of biologically significant
oligosaccharides, glycoconjugates, and other natural products,
especially the glycosaminoglycans of mammal, antibiotics of microbe, glycosides
of plants and marine species and Chemistry in the Traditional Chinese Medicine.
He received the National Award for Natural Sciences (2nd Class) in 2010.
Abstract
Glycoconjugates of the secondary metabolites exist abundantly in plants,
microorganisms, and lower marine animals. Many of those compounds bear
complicated carbohydrate residues which occur as heterogeneous ‘glycoforms’,
so that isolation of a homogeneous congener, especially in an appreciable
amount, is always a formidable task. The poor accessibility remains as a hurdle
for elucidation of the structure-activity relationships and the mechanism of action
of glycoconjugates, which have shown a variety of the pharmacological activities.
This lecture focuses on our synthetic accesses to the complex glycoconjugates of
steroids and triterpenes, which are mostly from the traditional Chinese medicinal
plants. Highlighted are new glycosylation methods which have been developed to
tackle the emerged synthetic problems.
All are Welcome