Functional Hierarchical Structures from Peptide Building Blocks
Transcript Functional Hierarchical Structures from Peptide Building Blocks
Department of Chemistry
28 Feb (Mon)
3pm – 4pm
Functional Hierarchical Structures from
Peptide Building Blocks
@ S8 Level 3
Professor Sandeep Verma
Indian Institute of Technology - Kanpur
Host : Assoc Prof Suresh Valiyaveettil
About the Speaker
Professor Sandeep Verma was born in Kanpur, grew up and
completed his schooling in the holy city of Varanasi. He studied
Organic Chemistry in Banaras Hindu University, where he secured
First Rank in M.Sc. examination (1989) and was awarded the Vice
Chancellor’s Gold Medal and P.N. Bhargava Silver Medal for
excelling in Organic Chemistry. He moved to University of Illinois
Medical Center, Chicago, USA, for his Ph.D. (1994) in the area of
anti-HIV drug design. After two successive postdoctoral stays at Johns Hopkins
University, USA, and Max-Planck-Institute for Experimental Medicine, Germany, he
joined IIT-Kanpur in 1997, where he is currently a Professor in the Department of
Chemistry. Prof Verma was awarded the Shanti Swarup Bhatnagar Prize in
Chemical Sciences in 2010. His research interests lie in the areas of nucleobase
and peptide scaffolds as artificial enzymes and disease models, chemical origins
of life and biopolymer-mineral composites as bone formation mimics.
Biological superstructures are conventionally generated via recruitment of
nanoscopic components in a “bottom-up” approach. In this context, amino acids,
peptides and proteins, have received considerable attention for the construction of
self-assembled entitites owing to their side-chain diversity, potential to form
hydrogen bonds and other non-covalent interactions. We have contributed to
ordered aggregation of peptide conjugates.1 These soft structures exhibit stability
and high structural integrity and amenable to microfabrication using ion beams.1c
This talk will present our recent observations and efforts to employ peptide-based
soft structures as stimuli-responsive materials and as substrates for ion-beam
mediated fabrication methods.
1. (a) J. Pep. Sci. 2011, 17, 148‐153; (b) J. Org. Chem. 2010, 75, 4280‐4283; (c) Angew.
Chem., Int. Ed. 2008, 47, 2860‐2863; (d) Angew. Chem., Int. Ed. 2008, 47, 2217‐2221; (e)
Chem. Eur. J. 2008, 14, 1415‐1419; (f) Angew. Chem., Int. Ed. 2007, 46, 2002‐2004; (e) J.
Phys. Chem. B 2007, 111, 3750‐3757; (f) Chem. Commun. 2007, 2296‐2298.
All are Welcome