Transcript 52 陳黎68 曾資斌
Emotional Memory
( The Prefrontal Cortex)
&
Phineas Gage
B9902052 陳 黎
B9902068 曾資斌
A Gruesome but True Story
Phineas P. Gage (1823 –1860)
construction foreman
left frontal lobe destroyed
effects ?
"no longer Gage".
生理機能正常
左前額葉與生
理機能無關
情緒表現異常
左前額葉與情
緒表現相關
左前額葉皮
質嚴重損壞
How?
Before & After
The Limbic System
Take a Closer Look……
Before
After
Why?? Prefrontal cortex damaged
Emotionally
detached
impatient
erratic
The Lymbic System
Prefrontal cortex(PFC)
Frontal lobe
granular
electrical stimulation
evoke movements
Motor cortex
Premotor area
Prefrontal cortex
Function
Importance?
CEO of the brain
Jiminy cricket
“It is the tiny voice help you decide what is right
and wrong.”
When PFC goes wrong…
運作過度……
活動低落……
(lack of dopamine)
What happened to Gage?
•
•
Destroyed
Not destroyed
PFC & ADHD
意力不足過動障礙症(過動症)
Attention Deficit Hyperactivity Disorder
Why?
Dopamine
dopa decarboxylase
多巴脫羧酵素
Lobotomy 前額葉切離手術
Egas Moniz, 1935
Schizophrenia, clinical depression
Connections to PFC
Reference
PHINEAS GAGE :A Gruesome but True Story About Brain Science,
by John Fleischman, 2002
Making A Good Brain Great, by Daniel G. Amen, 2007
認識你的頭腦, 洪祖培教授、邱浩彰醫師著
http://en.wikipedia.org/wiki/Prefrontal_cortex
http://en.wikipedia.org/wiki/Lobotomy
http://www.dls.ym.edu.tw/neuroscience/adhd_c.html
http://sanitaryplaza.blogspot.com/2007/07/lobotomy.html