Transcript Phosphorus.pptx

PHOSPHORUS
Mohammed Almeziny BsPharm R,Ph. Msc PhD
Consultant clinical Pharmacist
INTRODUCTION
Phosphorus is found primarily in
 Bone (85%)
 Soft tissue (14%);
 <1% extracellular fluid

 Free
phosphorus exists as phosphates in the
plasma.
 70% exists as the organic form and 30% as the
inorganic form
HYPOPHOSPHATEMIA ETIOLOGY

Impair intestinal absorption.
malabsorptive conditions, prolonged nasogastric
suction, and protracted vomiting.
 Drug e.g. Antacids, Sucralfate, iron


Increase renal elimination,


renal tubular acidosis, hyperparathyroidism,
hypokalemia, hypomagnesemia, and extracellular
volume expansion.
Shift phosphorus from the extracellular to the
intracellular compartments.
HYPOPHOSPHATEMIA ETIOLOGY CONT’D

Shift phosphorus from the extracellular to the
intracellular compartments.
 glucose
or insulin and profound respiratory
alkalosis, especially during alcoholic withdrawal.

Other conditions Diabetic ketoacidosis, chronic
alcoholism, chronic obstructive airway disease,
and extensive thermal burns
HYPOPHOSPHATEMIA ETIOLOGY CONT’D

Mannitol may cause
pseudohypophosphatemia.
 Assay
method
SIGNS AND SYMPTOMS
Can be attributed to impaired cellular energy
stores and tissue hypoxia secondary to
depletion of ATP.
 Generalised muscle weakness, Confusion,
Paresthesias, Seizures, Coma , reduced cardiac
contractility, hypotension, respiratory failure,
and rhabdomyolysis


SIGNS AND SYMPTOMS CONT’D

Chronic phosphorus depletion has been
associated with decreased mentation; muscle
weakness; osteomalacia; rickets; anorexia;
dysphagia; cardiomyopathy; tachypnea;
reduced sensitivity to insulin; and dysfunction
of red blood cells, white blood cells, and
platelets.
TREATMENT
The specific treatment of hypophosphatemia
depends on the presence of signs and
symptoms, as well as the anticipated duration
and severity of hypophosphatemia.
 The foods are reached by Phosphorus and they
can be used to treat Hypophosphatemia

TREATMENT CONT’D
I.V
 Each 1 ml of potassium phosphate
3 mmol phosphate. – 4.4 mmol potassium.
 Each 1 ml Sodium phosphate
3 mmol phosphate. –
4 mmol sodium.

Questions?