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Cecumo
Cell-Culture real time Monitoring system
Analog Design Contest 2013
Team: José A. Maldonado, Juan N. Olmo, Gloria Huertas, Alberto Yúfera
“The important thing is not to stop questioning”. Albert Einstein
AGENDA
Motivation
Theoretical background
Simulations
System description
Implementation
Features
Results
Final conclusions
Questions and comments
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Analog Design Contest 2013
José A. Maldonado, Juan N. Olmo
MOTIVATION
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Analog Design Contest 2013
José A. Maldonado, Juan N. Olmo
THEORETICAL BACKGROUND
Z(w)/A
CELL
Rs
Z(w)/(A-Ac)
Rs
Z(w)/Ac Rgap
Low-Pass Behaviour
function of cell-culture
occupation area (Ac)
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Analog Design Contest 2013
José A. Maldonado, Juan N. Olmo
THEORETICAL BACKGROUND: SIMULATIONS
Zcell-electrode(s)
Vout2
Rin
Vout
HBP(s)
Oscillation-Based Test approach
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Analog Design Contest 2013
José A. Maldonado, Juan N. Olmo
SYSTEM DESCRIPTION: IMPLEMENTATION
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Analog Design Contest 2013
José A. Maldonado, Juan N. Olmo
SYSTEM DESCRIPTION: RESULTS
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Analog Design Contest 2013
José A. Maldonado, Juan N. Olmo
SYSTEM DESCRIPTION: RESULTS
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Analog Design Contest 2013
José A. Maldonado, Juan N. Olmo
SYSTEM DESCRIPTION: FEATURES
Real time monitoring
“Cell friendly” (Max. 30mV/30μA)
Immediate result
Up to 8 cultures
Wireless connectivity
Data logging
Long battery lifetime (100mA/10mA@±5V)
Compact and light-weight design (160x80x25mm)
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Analog Design Contest 2013
José A. Maldonado, Juan N. Olmo
CONCLUSIONS
Low cost & reusable “biological” oscillator for Cell
Culture growing measurements.
Amplitude and frequency to characterize occupation.
AGC for better noise inmunity
Frequency and AGC control voltage (Vg) to extract Fill
Factor (ff) parameter.
Potential fields of application: medicine and biology
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Analog Design Contest 2013
José A. Maldonado, Juan N. Olmo
QUESTIONS AND COMMENTS
Thank you for your attention!
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Analog Design Contest 2013
José A. Maldonado, Juan N. Olmo
SYSTEM DESCRIPTION: IMPLEMENTATION
Band Pass Filter
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Analog Design Contest 2013
José A. Maldonado, Juan N. Olmo
SYSTEM DESCRIPTION: IMPLEMENTATION
AGC
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Analog Design Contest 2013
José A. Maldonado, Juan N. Olmo
SYSTEM DESCRIPTION: IMPLEMENTATION
BioZ Interface
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Analog Design Contest 2013
José A. Maldonado, Juan N. Olmo
SYSTEM DESCRIPTION: IMPLEMENTATION
High Pass Filter & Comparator
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Analog Design Contest 2013
José A. Maldonado, Juan N. Olmo