90 dpi 110 dpi 130 dpi Terminal DLK DLK DLK DLK DLK MKK7 MKK7 MKK7 MKK7 MKK7 JNK2 JNK2 JNK2 JNK2 JNK2 MST1 MST1 MST1 MST1 MST1 FOXO3 FOXO3 FOXO3 FOXO3 FOXO3 Neuronal death Neuronal death Neuronal death Neuronal death Neuronal death DLK DLK DLK DLK DLK MKK7 MKK7 MKK7 MKK7 MKK7 JNK2 JNK2 JNK2 JNK2 JNK2 MST1 MST1 MST1 MST1 MST1 FOXO3 FOXO3 FOXO3 FOXO3 FOXO3 Neuronal death Neuronal death Neuronal death Neuronal death Neuronal death 70 dpi 90 dpi 110 dpi 130 dpi Terminal DLK DLK DLK DLK DLK MKK7 MKK7 MKK7 MKK7 MKK7 T183 Y185 T183 Y185 T183
Download ReportTranscript 90 dpi 110 dpi 130 dpi Terminal DLK DLK DLK DLK DLK MKK7 MKK7 MKK7 MKK7 MKK7 JNK2 JNK2 JNK2 JNK2 JNK2 MST1 MST1 MST1 MST1 MST1 FOXO3 FOXO3 FOXO3 FOXO3 FOXO3 Neuronal death Neuronal death Neuronal death Neuronal death Neuronal death DLK DLK DLK DLK DLK MKK7 MKK7 MKK7 MKK7 MKK7 JNK2 JNK2 JNK2 JNK2 JNK2 MST1 MST1 MST1 MST1 MST1 FOXO3 FOXO3 FOXO3 FOXO3 FOXO3 Neuronal death Neuronal death Neuronal death Neuronal death Neuronal death 70 dpi 90 dpi 110 dpi 130 dpi Terminal DLK DLK DLK DLK DLK MKK7 MKK7 MKK7 MKK7 MKK7 T183 Y185 T183 Y185 T183
90 dpi 110 dpi 130 dpi Terminal DLK DLK DLK DLK DLK MKK7 MKK7 MKK7 MKK7 MKK7 JNK2 JNK2 JNK2 JNK2 JNK2 MST1 MST1 MST1 MST1 MST1 FOXO3 FOXO3 FOXO3 FOXO3 FOXO3 Neuronal death Neuronal death Neuronal death Neuronal death Neuronal death DLK DLK DLK DLK DLK MKK7 MKK7 MKK7 MKK7 MKK7 JNK2 JNK2 JNK2 JNK2 JNK2 MST1 MST1 MST1 MST1 MST1 FOXO3 FOXO3 FOXO3 FOXO3 FOXO3 Neuronal death Neuronal death Neuronal death Neuronal death Neuronal death 70 dpi 90 dpi 110 dpi 130 dpi Terminal DLK DLK DLK DLK DLK MKK7 MKK7 MKK7 MKK7 MKK7 T183 Y185 T183 Y185 T183 Y185 T183 Y185 T183 Y185 JNK JNK JNK JNK JNK T183 S82 MST1 FOXO3 Neuronal death Cortical MST1 Caspase-3 S208 Cleaved MST1 T183 S82 MST1 S208 FOXO3 T183 S82 Caspase-3 FOXO3 Neuronal death MST1 Caspase-3 S208 Cleaved MST1 FOXO3 FOXO3 DLK DLK DLK DLK MKK7 MKK7 MKK7 MKK7 MKK7 T183 Y185 T183 Y185 T183 Y185 T183 Y185 T183 Y185 JNK JNK JNK JNK JNK T183 MST1 S82 Caspase-3 Cleaved MST1 FOXO3 MST1 S82 Caspase-3 S208 Cleaved MST1 Neuronal death Neuronal death T183 S82 Caspase-3 S208 S208 FOXO3 T183 MST1 FOXO3 T183 Caspase-3 Neuronal death FOXO3 MST1 Caspase-3 S208 S208 Cleaved MST1 T183 S82 MST1 Cleaved MST1 Neuronal death DLK S82 Caspase-3 S208 Cleaved MST1 Neuronal death Neuronal death T183 S82 MST1 S208 Cleaved MST1 T183 S82 Caspase-3 Cleaved MST1 Neuronal death FOXO3 Cleaved MST1 Neuronal death Expression/Phosphorylation Level 1.51 1.31-1.50 1.11-1.30 0.91-1.10 0.71-0.90 0.51-0.70 0.01-0.50 Not measurable ACTIVATION Cortical Subcortical B. EXPRESSION 70 dpi Subcortical A. A. 90 dpi 110 dpi 130 dpi Terminal DLK DLK DLK DLK DLK MKK7 MKK7 MKK7 MKK7 MKK7 JNK2 JNK2 JNK2 JNK2 JNK2 MST1 MST1 MST1 MST1 MST1 FOXO3 FOXO3 FOXO3 FOXO3 FOXO3 Neuronal death Neuronal death Neuronal death Cortical Neuronal death Neuronal death 70 dpi 90 dpi 110 dpi 130 dpi Terminal DLK DLK DLK DLK DLK MKK7 MKK7 MKK7 MKK7 MKK7 JNK2 JNK2 JNK2 JNK2 JNK2 MST1 MST1 MST1 MST1 MST1 FOXO3 FOXO3 FOXO3 FOXO3 FOXO3 Neuronal death Neuronal death Neuronal death Neuronal death Neuronal death EXPRESSION Subcortical 70 dpi B. Subcortical 90 dpi 130 dpi Terminal DLK DLK DLK DLK DLK MKK7 MKK7 MKK7 MKK7 MKK7 T183 Y185 T183 Y185 T183 Y185 T183 Y185 T183 Y185 JNK JNK JNK JNK JNK T183 S82 MST1 FOXO3 T183 S82 MST1 Caspase-3 S208 FOXO3 MST1 FOXO3 MST1 FOXO3 MST1 110 dpi FOXO3 130 dpi Terminal DLK DLK DLK DLK MKK7 MKK7 MKK7 MKK7 MKK7 T183 Y185 T183 Y185 T183 Y185 T183 Y185 T183 Y185 JNK JNK JNK JNK JNK T183 MST1 S82 S82 Caspase-3 S208 S208 FOXO3 T183 MST1 Caspase-3 Cleaved MST1 Neuronal death 1.31-1.50 FOXO3 S82 Caspase-3 S208 Cleaved MST1 Neuronal death 1.11-1.30 T183 MST1 0.91-1.10 FOXO3 T183 MST1 S82 Caspase-3 Neuronal death 0.71-0.90 FOXO3 T183 MST1 Caspase-3 S208 S208 Cleaved MST1 Cleaved MST1 Neuronal death DLK S82 Caspase-3 S208 Cleaved MST1 Neuronal death Cortical T183 S82 Caspase-3 S208 Cleaved MST1 Neuronal death 90 dpi T183 S82 Caspase-3 S208 Cleaved MST1 Neuronal death 70 dpi T183 S82 Caspase-3 S208 Cleaved MST1 Neuronal death 1.51 110 dpi ACTIVATION 70 dpi Cleaved MST1 Neuronal death 0.51-0.70 FOXO3 Cleaved MST1 Neuronal death 0.01-0.50 Not measurable