Transcript TNFa induced signaling pathways

Some TNFa induced signaling pathways
TNF-mediated
clustering
TNFa
TNFR1
TNFa
TNFR2
TNF-Receptor 1
TNF-Receptor 2
(p75)
(p55)
DD
FADD
TRAF2
TRADD
TRAF2
Death domain
Pro-Caspase-8
NIK
P
GCK
MAPKKKs
NIK
IKKg
RIP
Caspase-8
IKAP
IKK1 IKK2
P
IkB Phosphorylation on Tyr42 (via c-Src)
MEKK1
Apoptosis
IkB
MKK6
MKK7
p38
pathway
TRAF-domain
TRAF1
IAP1/2
p38s
SAPKs
(JNKs)
Jun, Elk, Fos, ATF2
AP-1
JNK
NFkB
IkB phosphorylation (S32,36)
p50
p65
ubiquitinylation
p65 phosphorylation on S276
p65 phosphorylation on Ser529
CBP..
p38 pathway
co-activators
transcription
mRNA for inflammatory genes,
IkB, IAPs, A20, TRAFs,...
DNA
nucleus
PKA pathway
pathway
P
Johannes Schmid 12/98
degradation
in proteasomes
LPS