Transcript NIC’s Pandemic influenza response and activities in New Zealand Dr. Sue Huang Head, WHO National Influenza Centre Institute of Environmental Science and Research Wellington, New.

NIC’s Pandemic influenza response
and activities in New Zealand
Dr. Sue Huang
Head, WHO National Influenza Centre
Institute of Environmental Science and Research
Wellington, New Zealand
The 3rd WHO National Influenza Centre meeting, Beijing
18-20 August 2009
Specialist Science Solutions
Manaaki Tangata Taiao Hoki
protecting people and their environment through science
Outline
• Pandemic influenza & seasonal influenza
situation
• NIC’s response & activities during early
containment phase
• NIC’s response & activities during late
containment phase
• NIC’s response & activities during
management phase
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800
Confirmed
700
Probable
600
MANAGE IT PHASE
BEGINS 22 JUNE
500
400
300
200
Earliest date (by week ending)
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2 Aug
26 Jul
19 Jul
12 Jul
5 Jul
28 Jun
21 Jun
14 Jun
7 Jun
31 May
24 May
17 May
10 May
3 May
26 Apr
0
19 Apr
100
12 Apr
Number of cases (per week)
Epidemic curve of pandemic (H1N1) 2009
cases
As of 2 August:
•Total cases: 2934
•610 hospitalised
•109 pneumonia
•25 ARDS
•39 fatal cases
reported with10
being confirmed to
have pandemic
virus as the primary
cause
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week 44
week 42
week 40
week 38
week 36
week 34
week 32
week 30
week 28
week 26
week 24
week 22
300
275
250
225
200
175
150
125
100
75
50
25
0
week 20
week 18
week 16
week 14
Consultation rate (per 100 000)
Weekly ILI consultation rates in 2009
2009
2008
2007
Basel i ne l evel
of acti vi ty
Weekly ILI consultation rates, 1992-2009
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Influenza strain surveillance
Number of viruses
100
Seasonal A (H3N2)
Seasonal A (H1N1)
Seasonal A
Novel A (H1N1)
B (not typed)
A (not sub-typed)
50
0
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
7
8
9
10
11
12
13
14
15
16
17
18
Week
19
20
21
22
23
24
25
26
27
28
29
30
31
1000
900
800
700
600
500
400
300
200
100
0
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NIC’s response & activities during
early containment phase
(25 April-Mid May)
• NIC developed a nested PCR and
sequencing method for NA gene with
good sensitivity: confirmed 3 pandemic
(H1N1) 2009 cases
• NIC did a contingency plan and identified
5 bottle necks: test result reporting;
specimen reception; automation; testing
algorithm; technical staff
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NIC’s response & activities during late
containment phase
(Mid May-21 June 2009)
•High political commitment:
mobilize resources from MAF
IDC, AgResearch, ESR CD
group;
1000
900
800
No. Specimens
•Highest sample volume:
- For a week: ~1000
samples
- For a day: ~350 samples
700
600
500
400
300
200
100
0
18 19 20 21 22 23 24 25 26 27 28 29 30 31 32
Week
•Test for Pacific Island
countries: Cook Island,
Samoa, Togan
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NIC’s response & activities during
management phase
(22 June-present)
• Viral culture and antigenic typing
• Tamiflu resistance monitoring
• Investigation of coinfection of pandemic
A(H1N1) and seasonal A(H1N1) cases
• Full genome sequencing for fatal and ICU
cases
• Potential sero-survey
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Oseltamivir resistance monitoring
Influenza Virus
Year
Seasonal AH1N1
Novel AH1N1
2006
2007
2008
2009
2009
17
138
4
25
20
Mean IC50*
1.84
0.83
728
1399
0.372
Std. dev.
0.71
0.63
136
2690
0.145
Min IC50
0.25
0.01
547
305
0.183
Max IC50
3.099
4.226
870
7912
0.745
Number of viruses
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Thank you
© ESR 2006