Transcript Supplementary material 4: Gene Set Enrichment Analysis (GSEA) enrichment score curve for the proteasome pathway The green curve corresponds to the enrichment.

Supplementary material 4: Gene Set Enrichment Analysis (GSEA) enrichment score
curve for the proteasome pathway
The green curve corresponds to the enrichment score (ES)
curve, which is the running sum of the weighted enrichment
score obtained from GSEA software.
Individual genes are represented by vertical lines.
Genes on the far left (red) were associated with a high risk to
develop oral cancer (hazard ratio > 1), and genes on the far right
(blue) were associated with a low risk to develop oral cancer.
The proteasome pathway was enriched because most of the
genes included in this pathway (represented as vertical lines)
were associated with a high hazard ratio.
The graph on the bottom represents the ordered, non-redundant
list of the ~20,000 genes analyzed in the platform, and ranked
according to their corresponding hazard ratio.
Gene set
Proteasome pathway
Enrichment Score (ES)
0.6893
Normalized Enrichment Score
1.9870
Nominal p-value
0.0018
False discovery rate
0.0120