Slide 1

Dysport ® is a prescription
injection for temporary
improvement in the look of
moderate to severe frown
lines between the eyebrows
(glabellar lines) in adults less
than 65 years of age.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.
The Dysport trademark is used under license. All other trademarks are the property of their respective owners. DSP 11-060 10/31/12

I do special things for myself,
and I’ll bet you do, too.
I work out, eat right, and take care of my
skin. Of course, cosmetic creams and lotions
will always have their place in my regimen—
but for my moderate to severe frown lines,
I was ready for a prescription treatment.
Maybe you are, too.

IMPORTANT SAFETY INFORMATION
What is the most important information you should know about Dysport?
Spread of Toxin Effects: In some cases, the effects of Dysport and all botulinum toxin products
may affect areas of the body away from the injection site. These effects can cause symptoms of
a serious condition called botulism. Symptoms of botulism can happen hours to weeks after
injection and may include swallowing and breathing problems, loss of strength and muscle
weakness all over the body, double vision, blurred vision and drooping eyelids, hoarseness or
change or loss of voice, trouble saying words clearly, or loss of bladder control.
PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

2

What is Dysport?
Prescription Dysport is an injection used to temporarily improve
the look of your moderate to severe frown lines without changing
the look of your whole face. The untreated facial muscles still
work normally, allowing you to freely show facial expressions,
such as smiling, in untreated areas.
Dysport is a formulation that has been shown to deliver temporary
improvement in moderate to severe frown lines, even with repeat
treatments. So, the effect of repeat treatment with Dysport may
be comparable to your first use.

IMPORTANT SAFETY INFORMATION
Swallowing and breathing problems can be life threatening and there have
been reports of death.
The risk of symptoms is probably greatest in children and adults treated for
muscle spasms, particularly in those patients who have underlying medical
conditions that could make these symptoms more likely.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

3

How does Dysport Work?
With just 1 injection into each of 5 points between and over
the eyebrows, Dysport blocks the signal from the nerve to the
muscles, ultimately resulting in a reduction of muscle activity
and temporarily preventing contraction of the muscles that
cause frown lines. You should not be treated with Dysport more
frequently than every 90 days.
Ask your doctor about your prescription treatment options for
temporarily improving the look of moderate to severe frown lines.
IMPORTANT SAFETY INFORMATION
The toxic effects have been reported at doses similar to those used to treat
muscle spasms in the neck. Lower doses, in both approved and unapproved
uses, have also caused toxic effects. This includes treatment of children and
adults for muscle spasms.

These effects could make it unsafe for you to drive a car, operate machinery,
or do other dangerous activities.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

4

What causes frown lines?
Over time, repeated movement of the facial skin by the
forehead muscles forms lines between the eyebrows.
Frown lines are “dynamic”—they happen because of
the way a person’s face moves.

IMPORTANT SAFETY INFORMATION
Do not have Dysport treatment if you: are allergic to Dysport or any of its ingredients
(see the end of the Medication Guide for a list of ingredients), are allergic to cow’s milk protein,
had an allergic reaction to any other botulinum toxin product (such as Myobloc® or Botox®),
or have a skin infection at the planned injection site.
The dose of Dysport is not the same as the dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to the dose of any other botulinum toxin
product you may have used.
Dysport may not be right for you if: you have surgical changes to your face, very weak
muscles in the treatment area, your face looks very different from side to side, the injection site
is inflamed, you have droopy eyelids or sagging eyelid folds, deep facial scars, thick oily skin, or
if your wrinkles can’t be smoothed by spreading them apart.
5

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Are frown lines always related to age?
No. Because frown lines are created by facial movements,
such as frowning or squinting, they may develop even in
younger adults.

IMPORTANT SAFETY INFORMATION
Tell your doctor about all your medical conditions, including if you have: a disease
that affects your muscles and nerves (such as amyotrophic lateral sclerosis [ALS or Lou
Gehrig’s disease], myasthenia gravis, or Lambert-Eaton syndrome), allergies to any
botulinum toxin product or had any side effect from any botulinum toxin product in the past,
a breathing problem (such as asthma or emphysema), swallowing problems, bleeding
problems, diabetes, a slow heart beat or other problem with your heart rate or rhythm, plans
to have surgery, had surgery on your face, weakness of your forehead muscles (such as
trouble raising your eyebrows), drooping eyelids, or any other change in the way your face
normally looks. Patients with a disease that affects muscles and nerves who are treated with
typical doses of Dysport may have a higher risk of serious side effects, including severe
swallowing and breathing problems.
6

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What can you do about frown lines?
Treatment with prescription Dysport can temporarily
improve the look of your moderate to severe frown lines.
Treatment generally takes just 10 to 20 minutes.
The most common side effects are nose and throat
irritation, headache, injection site pain, injection site skin
reaction, upper respiratory tract infection, eyelid swelling,
eyelid drooping, sinus inflammation, and nausea.

IMPORTANT SAFETY INFORMATION
Human Albumin
This product contains albumin taken from human plasma. Steps taken during donor
screening and product manufacturing processes make the risk of spreading viral diseases
extremely rare. In theory, there is also an extremely rare risk of contracting CreutzfeldtJakob disease (CJD). No cases of spread of viral diseases or CJD have ever been
reported for albumin.
7

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

How do you know if Dysport works?
Clinically proven results with 1 treatment
In 3 clinical studies of people whose frown lines were rated “moderate” or
“severe” by a doctor before their treatment with Dysport:a
• Doctor rating: 30 days after treatment, the majority (88%, 85%, and 86% in each of the 3 studies)
had their frown lines rated by a doctor as “mild” or “moderate” at maximum frown. For example, a
patient could improve from “severe” to “moderate” or from “moderate” to “mild.”
• Patient rating: 30 days after treatment, the majority (74%, 79%, and 82% in each of the 3 studies)
rated their own frown lines as “mild” or “moderate” at maximum frown. For example, a patient could
improve from “severe” to “moderate” or from “moderate” to “mild.”

a

Three double-blind, randomized, placebo-controlled, clinical studies evaluated the efficacy of Dysport for use in the temporary improvement of the appearance of moderate to severe
glabellar lines. These 3 studies enrolled healthy adults (ages 19-75) with glabellar lines of at least moderate severity at maximum frown. Subjects were excluded if they had marked
ptosis, deep dermal scarring, or a substantial inability to lessen glabellar lines, even by physically spreading them apart. The subjects in these studies received either Dysport or a
placebo. The total dose was delivered in equally divided aliquots to specified injection sites.

IMPORTANT SAFETY INFORMATION
Allergic Reaction to Injecting in the Skin
It is not known if an allergic reaction can be caused by injecting Dysport into the skin. The safety of
treating excessive sweating with Dysport is not known.
8

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Common Side Effects
The most common side effects are nose and throat irritation, headache, injection site pain, injection site skin
reaction, upper respiratory tract infection, eyelid swelling, eyelid drooping, sinus inflammation, and nausea.
9

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Tell your doctor about all the medicines you take, including prescription and nonprescription medicines,
vitamins and herbal and other natural products. Using Dysport with certain other medicines may cause
serious side effects.
Do not start any new medicines while taking Dysport without talking to your doctor first.
10

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Especially tell your doctor if you: have received any other botulinum toxin product in the last four
months, have received injections of botulinum toxin, such as Myobloc® (rimabotulinumtoxinB) or Botox®
(onabotulinumtoxinA) in the past (be sure your doctor knows exactly which product you received), have
recently received an antibiotic by injection, take muscle relaxants, take an allergy or cold medicine, or take
a sleep medicine.
11

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Use In Specific Populations
Dysport should not be used in children or in women who are pregnant or breastfeeding.
Ask your doctor if Dysport is right for you.
12

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What to expect with Dysport
A step-by-step guide to your treatment†

1

The Dysport treatment consultation
Discuss your expectations with your doctor and
whether you have any health conditions or
allergies that could interfere with your treatment.
† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

IMPORTANT SAFETY INFORMATION
What is the most important information you should know about Dysport?
Spread of Toxin Effects: In some cases, the effects of Dysport and all botulinum toxin products may affect
areas of the body away from the injection site. These effects can cause symptoms of a serious condition
called botulism. Symptoms of botulism can happen hours to weeks after injection and may include
swallowing and breathing problems, loss of strength and muscle weakness all over the body, double
vision, blurred vision and drooping eyelids, hoarseness or change or loss of voice, trouble saying words
clearly, or loss of bladder control. Swallowing and breathing problems can be life threatening and there
have been reports of death.
The risk of symptoms is probably greatest in children and adults treated for muscle spasms, particularly
in those patients who have underlying medical conditions that could make these symptoms more likely.
13

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What to expect with Dysport
A step-by-step guide to your treatment†

2

The Dysport treatment
Effective treatment requires 1 injection into each
of 5 points between and over the eyebrows.
Although office visit times may vary, the procedure
generally takes 10 to 20 minutes. Your healthcare
professional will determine the exact placement of
each injection to get results that are right for you.

IMPORTANT SAFETY INFORMATION
The toxic effects have been reported at doses similar to those used to treat muscle spasms in
the neck. Lower doses, in both approved and unapproved uses, have also caused toxic effects.
This includes treatment of children and adults for muscle spasms.
These effects could make it unsafe for you to drive a car, operate machinery, or do other
dangerous activities.
Do not have Dysport treatment if you: are allergic to Dysport or any of its ingredients (see the end
of the Medication Guide for a list of ingredients), are allergic to cow’s milk protein, had an allergic
reaction to any other botulinum toxin product, such as Myobloc® or Botox,® or have a skin infection at
the planned injection site.
14

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

What to expect with Dysport
A step-by-step guide to your treatment†

3

After your Dysport treatment
Ask your doctor about any precautions you
should take after your treatment. Call your doctor
or get medical help right away if you have any
problems swallowing, speaking, or breathing.
If this happens, do not drive a car, operate
machinery, or do other dangerous activities.

IMPORTANT SAFETY INFORMATION
The dose of Dysport is not the same as the dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to the dose of any other botulinum toxin
product you may have used.
Dysport may not be right for you if: you have surgical changes to your face, very weak
muscles in the treatment area, your face looks very different from side to side, the injection
site is inflamed, you have droopy eyelids or sagging eyelid folds, deep facial scars, thick oily
skin, or if your wrinkles can’t be smoothed by spreading them apart.
15

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

What to expect with Dysport
A step-by-step guide to your treatment†

4

Follow up
To maintain your improvements, you should
discuss a treatment schedule with your doctor.
As with any botulinum toxin product, you should
wait at least 90 days between treatments.

IMPORTANT SAFETY INFORMATION
Tell your doctor about all your medical conditions, including if you have: a disease that
affects your muscles and nerves (suchas amyotrophic lateral sclerosis [ALS or Lou Gehrig’s
disease], myasthenia gravis, or Lambert-Eaton syndrome), allergies to any botulinum toxin
product or had any side effect from any botulinum toxin product in the past, a breathing problem
(such as asthma or emphysema), swallowing problems, bleeding problems, diabetes, a slow
heart beat or other problem with your heart rate or rhythm, plans to have surgery, had surgery on
your face, weakness of your forehead muscles (such as trouble raising your eyebrows), drooping
eyelids, or any other change in the way your face normally looks. Patients with a disease that
affects muscles and nerves who are treated with typical doses of Dysport may have a higher risk
of serious side effects, including severe swallowing and breathing problems.
16

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

Why not start the Dysport
discussion with your doctor today?
Questions to ask your doctor:
• How soon will I see treatment results?
• How long does one treatment last?
• How often can I receive a Dysport treatment?
• Is there any way to save money on
my treatment?
• Can I have a treatment today?
• What are the risks associated with treatment?
IMPORTANT SAFETY INFORMATION
Human Albumin
This product contains albumin taken from human plasma. Steps taken during donor screening and product
manufacturing processes make the risk of spreading viral diseases extremely rare. In theory, there is also an
extremely rare risk of contracting Creutzfeldt-Jakob disease (CJD). No cases of spread of viral diseases or CJD
have ever been reported for albumin.
17

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Important Safety Information

What is the most important information you
should know about Dysport
(abobotulinumtoxinA) 300 Units for Injection?
Spread of Toxin Effects: In some cases, the
effects of Dysport and all botulinum toxin
products may affect areas of the body away
from the injection site. These effects can
cause symptoms of a serious condition called
botulism. Symptoms of botulism can happen
hours to weeks after injection and may
include swallowing and breathing problems,
loss of strength and muscle weakness all over
the body, double vision, blurred vision and
drooping eyelids, hoarseness or change or
loss of voice, trouble saying words clearly, or
loss of bladder control. Swallowing and
breathing problems can be life threatening
and there have been reports of death.

18

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

The risk of symptoms is probably greatest in
children and adults treated for muscle spasms,
particularly in those patients who have
underlying medical conditions that could make
these symptoms more likely.
The toxic effects have been reported at doses
similar to those used to treat muscle spasms in
the neck. Lower doses, in both approved and
unapproved uses, have also caused toxic
effects. This includes treatment of children and
adults for muscle spasms.
These effects could make it unsafe for you to
drive a car, operate machinery, or do other
dangerous activities.
Do not have Dysport treatment if you: are allergic
to Dysport or any of its ingredients (see the end of
the Medication Guide for a list of ingredients), are
allergic to cow’s milk protein, had an allergic
reaction to any other botulinum toxin product, such
as Myobloc® or Botox,® or have a skin infection at
the planned injection site.

Important Safety Information (cont.)

The dose of Dysport is not the same as the
dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to
the dose of any other botulinum toxin product
you may have used.
Dysport may not be right for you if: you have
surgical changes to your face, very weak muscles
in the treatment area, your face looks very
different from side to side, the injection site is
inflamed, you have droopy eyelids or sagging
eyelid folds, deep facial scars, thick oily skin, or if
your wrinkles can’t be smoothed by spreading
them apart.
Tell your doctor about all your medical
conditions, including if you have: a disease
that affects your muscles and nerves (such as
amyotrophic lateral sclerosis [ALS or Lou
Gehrig’s disease], myasthenia gravis, or LambertEaton syndrome), allergies to any botulinum toxin
product or had any side effect from any

19

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

botulinum toxin product in the past, a breathing
problem (such as asthma or emphysema),
swallowing problems, bleeding problems, diabetes,
a slow heart beat or other problem with your heart
rate or rhythm, plans to have surgery, had surgery
on your face, weakness of your forehead muscles
(such as trouble raising your eyebrows), drooping
eyelids, or any other change in the way your face
normally looks. Patients with a disease that affects
muscles and nerves who are treated with typical
doses of Dysport may have a higher risk of serious
side effects, including severe swallowing and
breathing problems.
Human Albumin
This product contains albumin taken from human
plasma. Steps taken during donor screening and
product manufacturing processes make the risk of
spreading viral diseases extremely rare. In theory,
there is also an extremely rare risk of contracting
Creutzfeldt-Jakob disease (CJD). No cases of
spread of viral diseases or CJD have ever been
reported for albumin.

Important Safety Information (cont.)

Allergic Reaction to Injecting in the Skin
It is not known if an allergic reaction can be
caused by injecting Dysport into the skin. The
safety of treating excessive sweating with Dysport
is not known.
Common Side Effects
The most common side effects are nose and
throat irritation, headache, injection site pain,
injection site skin reaction, upper respiratory tract
infection, eyelid swelling, eyelid drooping, sinus
inflammation, and nausea.
Tell your doctor about all the medicines you
take, including prescription and nonprescription
medicines, vitamins and herbal and other natural
products. Using Dysport with certain other
medicines may cause serious side effects.

20

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

Do not start any new medicines while taking
Dysport without talking to your doctor first.

Especially tell your doctor if you: have received
any other botulinum toxin product in the last four
months, have received injections of botulinum toxin,
such as Myobloc® (rimabotulinumtoxinB) or Botox®
(onabotulinumtoxinA) in the past (be sure your
doctor knows exactly which product you received),
have recently received an antibiotic by injection,
take muscle relaxants, take an allergy or cold
medicine, or take a sleep medicine.
Use In Specific Populations
Dysport should not be used in children or in women
who are pregnant or breastfeeding.
Ask your doctor if Dysport is right for you.

Medication Guide

21

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

22

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

23

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

24

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

25

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

26

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

27

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

28

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

29

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

30

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

31

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

32

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medicis Family
of Aesthetic Products

Products are not FDA approved for combination use.

www.DysportUSA.com

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.
33

The Dysport trademark is used under license. Restylane is a registered trademark of HA North American Sales AB. All other trademarks
are the property of their respective owners. DSP 11-060 10/31/12


Slide 2

Dysport ® is a prescription
injection for temporary
improvement in the look of
moderate to severe frown
lines between the eyebrows
(glabellar lines) in adults less
than 65 years of age.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.
The Dysport trademark is used under license. All other trademarks are the property of their respective owners. DSP 11-060 10/31/12

I do special things for myself,
and I’ll bet you do, too.
I work out, eat right, and take care of my
skin. Of course, cosmetic creams and lotions
will always have their place in my regimen—
but for my moderate to severe frown lines,
I was ready for a prescription treatment.
Maybe you are, too.

IMPORTANT SAFETY INFORMATION
What is the most important information you should know about Dysport?
Spread of Toxin Effects: In some cases, the effects of Dysport and all botulinum toxin products
may affect areas of the body away from the injection site. These effects can cause symptoms of
a serious condition called botulism. Symptoms of botulism can happen hours to weeks after
injection and may include swallowing and breathing problems, loss of strength and muscle
weakness all over the body, double vision, blurred vision and drooping eyelids, hoarseness or
change or loss of voice, trouble saying words clearly, or loss of bladder control.
PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

2

What is Dysport?
Prescription Dysport is an injection used to temporarily improve
the look of your moderate to severe frown lines without changing
the look of your whole face. The untreated facial muscles still
work normally, allowing you to freely show facial expressions,
such as smiling, in untreated areas.
Dysport is a formulation that has been shown to deliver temporary
improvement in moderate to severe frown lines, even with repeat
treatments. So, the effect of repeat treatment with Dysport may
be comparable to your first use.

IMPORTANT SAFETY INFORMATION
Swallowing and breathing problems can be life threatening and there have
been reports of death.
The risk of symptoms is probably greatest in children and adults treated for
muscle spasms, particularly in those patients who have underlying medical
conditions that could make these symptoms more likely.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

3

How does Dysport Work?
With just 1 injection into each of 5 points between and over
the eyebrows, Dysport blocks the signal from the nerve to the
muscles, ultimately resulting in a reduction of muscle activity
and temporarily preventing contraction of the muscles that
cause frown lines. You should not be treated with Dysport more
frequently than every 90 days.
Ask your doctor about your prescription treatment options for
temporarily improving the look of moderate to severe frown lines.
IMPORTANT SAFETY INFORMATION
The toxic effects have been reported at doses similar to those used to treat
muscle spasms in the neck. Lower doses, in both approved and unapproved
uses, have also caused toxic effects. This includes treatment of children and
adults for muscle spasms.

These effects could make it unsafe for you to drive a car, operate machinery,
or do other dangerous activities.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

4

What causes frown lines?
Over time, repeated movement of the facial skin by the
forehead muscles forms lines between the eyebrows.
Frown lines are “dynamic”—they happen because of
the way a person’s face moves.

IMPORTANT SAFETY INFORMATION
Do not have Dysport treatment if you: are allergic to Dysport or any of its ingredients
(see the end of the Medication Guide for a list of ingredients), are allergic to cow’s milk protein,
had an allergic reaction to any other botulinum toxin product (such as Myobloc® or Botox®),
or have a skin infection at the planned injection site.
The dose of Dysport is not the same as the dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to the dose of any other botulinum toxin
product you may have used.
Dysport may not be right for you if: you have surgical changes to your face, very weak
muscles in the treatment area, your face looks very different from side to side, the injection site
is inflamed, you have droopy eyelids or sagging eyelid folds, deep facial scars, thick oily skin, or
if your wrinkles can’t be smoothed by spreading them apart.
5

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Are frown lines always related to age?
No. Because frown lines are created by facial movements,
such as frowning or squinting, they may develop even in
younger adults.

IMPORTANT SAFETY INFORMATION
Tell your doctor about all your medical conditions, including if you have: a disease
that affects your muscles and nerves (such as amyotrophic lateral sclerosis [ALS or Lou
Gehrig’s disease], myasthenia gravis, or Lambert-Eaton syndrome), allergies to any
botulinum toxin product or had any side effect from any botulinum toxin product in the past,
a breathing problem (such as asthma or emphysema), swallowing problems, bleeding
problems, diabetes, a slow heart beat or other problem with your heart rate or rhythm, plans
to have surgery, had surgery on your face, weakness of your forehead muscles (such as
trouble raising your eyebrows), drooping eyelids, or any other change in the way your face
normally looks. Patients with a disease that affects muscles and nerves who are treated with
typical doses of Dysport may have a higher risk of serious side effects, including severe
swallowing and breathing problems.
6

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What can you do about frown lines?
Treatment with prescription Dysport can temporarily
improve the look of your moderate to severe frown lines.
Treatment generally takes just 10 to 20 minutes.
The most common side effects are nose and throat
irritation, headache, injection site pain, injection site skin
reaction, upper respiratory tract infection, eyelid swelling,
eyelid drooping, sinus inflammation, and nausea.

IMPORTANT SAFETY INFORMATION
Human Albumin
This product contains albumin taken from human plasma. Steps taken during donor
screening and product manufacturing processes make the risk of spreading viral diseases
extremely rare. In theory, there is also an extremely rare risk of contracting CreutzfeldtJakob disease (CJD). No cases of spread of viral diseases or CJD have ever been
reported for albumin.
7

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

How do you know if Dysport works?
Clinically proven results with 1 treatment
In 3 clinical studies of people whose frown lines were rated “moderate” or
“severe” by a doctor before their treatment with Dysport:a
• Doctor rating: 30 days after treatment, the majority (88%, 85%, and 86% in each of the 3 studies)
had their frown lines rated by a doctor as “mild” or “moderate” at maximum frown. For example, a
patient could improve from “severe” to “moderate” or from “moderate” to “mild.”
• Patient rating: 30 days after treatment, the majority (74%, 79%, and 82% in each of the 3 studies)
rated their own frown lines as “mild” or “moderate” at maximum frown. For example, a patient could
improve from “severe” to “moderate” or from “moderate” to “mild.”

a

Three double-blind, randomized, placebo-controlled, clinical studies evaluated the efficacy of Dysport for use in the temporary improvement of the appearance of moderate to severe
glabellar lines. These 3 studies enrolled healthy adults (ages 19-75) with glabellar lines of at least moderate severity at maximum frown. Subjects were excluded if they had marked
ptosis, deep dermal scarring, or a substantial inability to lessen glabellar lines, even by physically spreading them apart. The subjects in these studies received either Dysport or a
placebo. The total dose was delivered in equally divided aliquots to specified injection sites.

IMPORTANT SAFETY INFORMATION
Allergic Reaction to Injecting in the Skin
It is not known if an allergic reaction can be caused by injecting Dysport into the skin. The safety of
treating excessive sweating with Dysport is not known.
8

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Common Side Effects
The most common side effects are nose and throat irritation, headache, injection site pain, injection site skin
reaction, upper respiratory tract infection, eyelid swelling, eyelid drooping, sinus inflammation, and nausea.
9

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Tell your doctor about all the medicines you take, including prescription and nonprescription medicines,
vitamins and herbal and other natural products. Using Dysport with certain other medicines may cause
serious side effects.
Do not start any new medicines while taking Dysport without talking to your doctor first.
10

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Especially tell your doctor if you: have received any other botulinum toxin product in the last four
months, have received injections of botulinum toxin, such as Myobloc® (rimabotulinumtoxinB) or Botox®
(onabotulinumtoxinA) in the past (be sure your doctor knows exactly which product you received), have
recently received an antibiotic by injection, take muscle relaxants, take an allergy or cold medicine, or take
a sleep medicine.
11

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Use In Specific Populations
Dysport should not be used in children or in women who are pregnant or breastfeeding.
Ask your doctor if Dysport is right for you.
12

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What to expect with Dysport
A step-by-step guide to your treatment†

1

The Dysport treatment consultation
Discuss your expectations with your doctor and
whether you have any health conditions or
allergies that could interfere with your treatment.
† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

IMPORTANT SAFETY INFORMATION
What is the most important information you should know about Dysport?
Spread of Toxin Effects: In some cases, the effects of Dysport and all botulinum toxin products may affect
areas of the body away from the injection site. These effects can cause symptoms of a serious condition
called botulism. Symptoms of botulism can happen hours to weeks after injection and may include
swallowing and breathing problems, loss of strength and muscle weakness all over the body, double
vision, blurred vision and drooping eyelids, hoarseness or change or loss of voice, trouble saying words
clearly, or loss of bladder control. Swallowing and breathing problems can be life threatening and there
have been reports of death.
The risk of symptoms is probably greatest in children and adults treated for muscle spasms, particularly
in those patients who have underlying medical conditions that could make these symptoms more likely.
13

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What to expect with Dysport
A step-by-step guide to your treatment†

2

The Dysport treatment
Effective treatment requires 1 injection into each
of 5 points between and over the eyebrows.
Although office visit times may vary, the procedure
generally takes 10 to 20 minutes. Your healthcare
professional will determine the exact placement of
each injection to get results that are right for you.

IMPORTANT SAFETY INFORMATION
The toxic effects have been reported at doses similar to those used to treat muscle spasms in
the neck. Lower doses, in both approved and unapproved uses, have also caused toxic effects.
This includes treatment of children and adults for muscle spasms.
These effects could make it unsafe for you to drive a car, operate machinery, or do other
dangerous activities.
Do not have Dysport treatment if you: are allergic to Dysport or any of its ingredients (see the end
of the Medication Guide for a list of ingredients), are allergic to cow’s milk protein, had an allergic
reaction to any other botulinum toxin product, such as Myobloc® or Botox,® or have a skin infection at
the planned injection site.
14

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

What to expect with Dysport
A step-by-step guide to your treatment†

3

After your Dysport treatment
Ask your doctor about any precautions you
should take after your treatment. Call your doctor
or get medical help right away if you have any
problems swallowing, speaking, or breathing.
If this happens, do not drive a car, operate
machinery, or do other dangerous activities.

IMPORTANT SAFETY INFORMATION
The dose of Dysport is not the same as the dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to the dose of any other botulinum toxin
product you may have used.
Dysport may not be right for you if: you have surgical changes to your face, very weak
muscles in the treatment area, your face looks very different from side to side, the injection
site is inflamed, you have droopy eyelids or sagging eyelid folds, deep facial scars, thick oily
skin, or if your wrinkles can’t be smoothed by spreading them apart.
15

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

What to expect with Dysport
A step-by-step guide to your treatment†

4

Follow up
To maintain your improvements, you should
discuss a treatment schedule with your doctor.
As with any botulinum toxin product, you should
wait at least 90 days between treatments.

IMPORTANT SAFETY INFORMATION
Tell your doctor about all your medical conditions, including if you have: a disease that
affects your muscles and nerves (suchas amyotrophic lateral sclerosis [ALS or Lou Gehrig’s
disease], myasthenia gravis, or Lambert-Eaton syndrome), allergies to any botulinum toxin
product or had any side effect from any botulinum toxin product in the past, a breathing problem
(such as asthma or emphysema), swallowing problems, bleeding problems, diabetes, a slow
heart beat or other problem with your heart rate or rhythm, plans to have surgery, had surgery on
your face, weakness of your forehead muscles (such as trouble raising your eyebrows), drooping
eyelids, or any other change in the way your face normally looks. Patients with a disease that
affects muscles and nerves who are treated with typical doses of Dysport may have a higher risk
of serious side effects, including severe swallowing and breathing problems.
16

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

Why not start the Dysport
discussion with your doctor today?
Questions to ask your doctor:
• How soon will I see treatment results?
• How long does one treatment last?
• How often can I receive a Dysport treatment?
• Is there any way to save money on
my treatment?
• Can I have a treatment today?
• What are the risks associated with treatment?
IMPORTANT SAFETY INFORMATION
Human Albumin
This product contains albumin taken from human plasma. Steps taken during donor screening and product
manufacturing processes make the risk of spreading viral diseases extremely rare. In theory, there is also an
extremely rare risk of contracting Creutzfeldt-Jakob disease (CJD). No cases of spread of viral diseases or CJD
have ever been reported for albumin.
17

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Important Safety Information

What is the most important information you
should know about Dysport
(abobotulinumtoxinA) 300 Units for Injection?
Spread of Toxin Effects: In some cases, the
effects of Dysport and all botulinum toxin
products may affect areas of the body away
from the injection site. These effects can
cause symptoms of a serious condition called
botulism. Symptoms of botulism can happen
hours to weeks after injection and may
include swallowing and breathing problems,
loss of strength and muscle weakness all over
the body, double vision, blurred vision and
drooping eyelids, hoarseness or change or
loss of voice, trouble saying words clearly, or
loss of bladder control. Swallowing and
breathing problems can be life threatening
and there have been reports of death.

18

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

The risk of symptoms is probably greatest in
children and adults treated for muscle spasms,
particularly in those patients who have
underlying medical conditions that could make
these symptoms more likely.
The toxic effects have been reported at doses
similar to those used to treat muscle spasms in
the neck. Lower doses, in both approved and
unapproved uses, have also caused toxic
effects. This includes treatment of children and
adults for muscle spasms.
These effects could make it unsafe for you to
drive a car, operate machinery, or do other
dangerous activities.
Do not have Dysport treatment if you: are allergic
to Dysport or any of its ingredients (see the end of
the Medication Guide for a list of ingredients), are
allergic to cow’s milk protein, had an allergic
reaction to any other botulinum toxin product, such
as Myobloc® or Botox,® or have a skin infection at
the planned injection site.

Important Safety Information (cont.)

The dose of Dysport is not the same as the
dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to
the dose of any other botulinum toxin product
you may have used.
Dysport may not be right for you if: you have
surgical changes to your face, very weak muscles
in the treatment area, your face looks very
different from side to side, the injection site is
inflamed, you have droopy eyelids or sagging
eyelid folds, deep facial scars, thick oily skin, or if
your wrinkles can’t be smoothed by spreading
them apart.
Tell your doctor about all your medical
conditions, including if you have: a disease
that affects your muscles and nerves (such as
amyotrophic lateral sclerosis [ALS or Lou
Gehrig’s disease], myasthenia gravis, or LambertEaton syndrome), allergies to any botulinum toxin
product or had any side effect from any

19

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

botulinum toxin product in the past, a breathing
problem (such as asthma or emphysema),
swallowing problems, bleeding problems, diabetes,
a slow heart beat or other problem with your heart
rate or rhythm, plans to have surgery, had surgery
on your face, weakness of your forehead muscles
(such as trouble raising your eyebrows), drooping
eyelids, or any other change in the way your face
normally looks. Patients with a disease that affects
muscles and nerves who are treated with typical
doses of Dysport may have a higher risk of serious
side effects, including severe swallowing and
breathing problems.
Human Albumin
This product contains albumin taken from human
plasma. Steps taken during donor screening and
product manufacturing processes make the risk of
spreading viral diseases extremely rare. In theory,
there is also an extremely rare risk of contracting
Creutzfeldt-Jakob disease (CJD). No cases of
spread of viral diseases or CJD have ever been
reported for albumin.

Important Safety Information (cont.)

Allergic Reaction to Injecting in the Skin
It is not known if an allergic reaction can be
caused by injecting Dysport into the skin. The
safety of treating excessive sweating with Dysport
is not known.
Common Side Effects
The most common side effects are nose and
throat irritation, headache, injection site pain,
injection site skin reaction, upper respiratory tract
infection, eyelid swelling, eyelid drooping, sinus
inflammation, and nausea.
Tell your doctor about all the medicines you
take, including prescription and nonprescription
medicines, vitamins and herbal and other natural
products. Using Dysport with certain other
medicines may cause serious side effects.

20

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

Do not start any new medicines while taking
Dysport without talking to your doctor first.

Especially tell your doctor if you: have received
any other botulinum toxin product in the last four
months, have received injections of botulinum toxin,
such as Myobloc® (rimabotulinumtoxinB) or Botox®
(onabotulinumtoxinA) in the past (be sure your
doctor knows exactly which product you received),
have recently received an antibiotic by injection,
take muscle relaxants, take an allergy or cold
medicine, or take a sleep medicine.
Use In Specific Populations
Dysport should not be used in children or in women
who are pregnant or breastfeeding.
Ask your doctor if Dysport is right for you.

Medication Guide

21

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

22

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

23

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

24

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

25

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

26

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

27

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

28

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

29

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

30

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

31

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

32

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medicis Family
of Aesthetic Products

Products are not FDA approved for combination use.

www.DysportUSA.com

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.
33

The Dysport trademark is used under license. Restylane is a registered trademark of HA North American Sales AB. All other trademarks
are the property of their respective owners. DSP 11-060 10/31/12


Slide 3

Dysport ® is a prescription
injection for temporary
improvement in the look of
moderate to severe frown
lines between the eyebrows
(glabellar lines) in adults less
than 65 years of age.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.
The Dysport trademark is used under license. All other trademarks are the property of their respective owners. DSP 11-060 10/31/12

I do special things for myself,
and I’ll bet you do, too.
I work out, eat right, and take care of my
skin. Of course, cosmetic creams and lotions
will always have their place in my regimen—
but for my moderate to severe frown lines,
I was ready for a prescription treatment.
Maybe you are, too.

IMPORTANT SAFETY INFORMATION
What is the most important information you should know about Dysport?
Spread of Toxin Effects: In some cases, the effects of Dysport and all botulinum toxin products
may affect areas of the body away from the injection site. These effects can cause symptoms of
a serious condition called botulism. Symptoms of botulism can happen hours to weeks after
injection and may include swallowing and breathing problems, loss of strength and muscle
weakness all over the body, double vision, blurred vision and drooping eyelids, hoarseness or
change or loss of voice, trouble saying words clearly, or loss of bladder control.
PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

2

What is Dysport?
Prescription Dysport is an injection used to temporarily improve
the look of your moderate to severe frown lines without changing
the look of your whole face. The untreated facial muscles still
work normally, allowing you to freely show facial expressions,
such as smiling, in untreated areas.
Dysport is a formulation that has been shown to deliver temporary
improvement in moderate to severe frown lines, even with repeat
treatments. So, the effect of repeat treatment with Dysport may
be comparable to your first use.

IMPORTANT SAFETY INFORMATION
Swallowing and breathing problems can be life threatening and there have
been reports of death.
The risk of symptoms is probably greatest in children and adults treated for
muscle spasms, particularly in those patients who have underlying medical
conditions that could make these symptoms more likely.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

3

How does Dysport Work?
With just 1 injection into each of 5 points between and over
the eyebrows, Dysport blocks the signal from the nerve to the
muscles, ultimately resulting in a reduction of muscle activity
and temporarily preventing contraction of the muscles that
cause frown lines. You should not be treated with Dysport more
frequently than every 90 days.
Ask your doctor about your prescription treatment options for
temporarily improving the look of moderate to severe frown lines.
IMPORTANT SAFETY INFORMATION
The toxic effects have been reported at doses similar to those used to treat
muscle spasms in the neck. Lower doses, in both approved and unapproved
uses, have also caused toxic effects. This includes treatment of children and
adults for muscle spasms.

These effects could make it unsafe for you to drive a car, operate machinery,
or do other dangerous activities.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

4

What causes frown lines?
Over time, repeated movement of the facial skin by the
forehead muscles forms lines between the eyebrows.
Frown lines are “dynamic”—they happen because of
the way a person’s face moves.

IMPORTANT SAFETY INFORMATION
Do not have Dysport treatment if you: are allergic to Dysport or any of its ingredients
(see the end of the Medication Guide for a list of ingredients), are allergic to cow’s milk protein,
had an allergic reaction to any other botulinum toxin product (such as Myobloc® or Botox®),
or have a skin infection at the planned injection site.
The dose of Dysport is not the same as the dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to the dose of any other botulinum toxin
product you may have used.
Dysport may not be right for you if: you have surgical changes to your face, very weak
muscles in the treatment area, your face looks very different from side to side, the injection site
is inflamed, you have droopy eyelids or sagging eyelid folds, deep facial scars, thick oily skin, or
if your wrinkles can’t be smoothed by spreading them apart.
5

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Are frown lines always related to age?
No. Because frown lines are created by facial movements,
such as frowning or squinting, they may develop even in
younger adults.

IMPORTANT SAFETY INFORMATION
Tell your doctor about all your medical conditions, including if you have: a disease
that affects your muscles and nerves (such as amyotrophic lateral sclerosis [ALS or Lou
Gehrig’s disease], myasthenia gravis, or Lambert-Eaton syndrome), allergies to any
botulinum toxin product or had any side effect from any botulinum toxin product in the past,
a breathing problem (such as asthma or emphysema), swallowing problems, bleeding
problems, diabetes, a slow heart beat or other problem with your heart rate or rhythm, plans
to have surgery, had surgery on your face, weakness of your forehead muscles (such as
trouble raising your eyebrows), drooping eyelids, or any other change in the way your face
normally looks. Patients with a disease that affects muscles and nerves who are treated with
typical doses of Dysport may have a higher risk of serious side effects, including severe
swallowing and breathing problems.
6

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What can you do about frown lines?
Treatment with prescription Dysport can temporarily
improve the look of your moderate to severe frown lines.
Treatment generally takes just 10 to 20 minutes.
The most common side effects are nose and throat
irritation, headache, injection site pain, injection site skin
reaction, upper respiratory tract infection, eyelid swelling,
eyelid drooping, sinus inflammation, and nausea.

IMPORTANT SAFETY INFORMATION
Human Albumin
This product contains albumin taken from human plasma. Steps taken during donor
screening and product manufacturing processes make the risk of spreading viral diseases
extremely rare. In theory, there is also an extremely rare risk of contracting CreutzfeldtJakob disease (CJD). No cases of spread of viral diseases or CJD have ever been
reported for albumin.
7

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

How do you know if Dysport works?
Clinically proven results with 1 treatment
In 3 clinical studies of people whose frown lines were rated “moderate” or
“severe” by a doctor before their treatment with Dysport:a
• Doctor rating: 30 days after treatment, the majority (88%, 85%, and 86% in each of the 3 studies)
had their frown lines rated by a doctor as “mild” or “moderate” at maximum frown. For example, a
patient could improve from “severe” to “moderate” or from “moderate” to “mild.”
• Patient rating: 30 days after treatment, the majority (74%, 79%, and 82% in each of the 3 studies)
rated their own frown lines as “mild” or “moderate” at maximum frown. For example, a patient could
improve from “severe” to “moderate” or from “moderate” to “mild.”

a

Three double-blind, randomized, placebo-controlled, clinical studies evaluated the efficacy of Dysport for use in the temporary improvement of the appearance of moderate to severe
glabellar lines. These 3 studies enrolled healthy adults (ages 19-75) with glabellar lines of at least moderate severity at maximum frown. Subjects were excluded if they had marked
ptosis, deep dermal scarring, or a substantial inability to lessen glabellar lines, even by physically spreading them apart. The subjects in these studies received either Dysport or a
placebo. The total dose was delivered in equally divided aliquots to specified injection sites.

IMPORTANT SAFETY INFORMATION
Allergic Reaction to Injecting in the Skin
It is not known if an allergic reaction can be caused by injecting Dysport into the skin. The safety of
treating excessive sweating with Dysport is not known.
8

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Common Side Effects
The most common side effects are nose and throat irritation, headache, injection site pain, injection site skin
reaction, upper respiratory tract infection, eyelid swelling, eyelid drooping, sinus inflammation, and nausea.
9

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Tell your doctor about all the medicines you take, including prescription and nonprescription medicines,
vitamins and herbal and other natural products. Using Dysport with certain other medicines may cause
serious side effects.
Do not start any new medicines while taking Dysport without talking to your doctor first.
10

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Especially tell your doctor if you: have received any other botulinum toxin product in the last four
months, have received injections of botulinum toxin, such as Myobloc® (rimabotulinumtoxinB) or Botox®
(onabotulinumtoxinA) in the past (be sure your doctor knows exactly which product you received), have
recently received an antibiotic by injection, take muscle relaxants, take an allergy or cold medicine, or take
a sleep medicine.
11

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Use In Specific Populations
Dysport should not be used in children or in women who are pregnant or breastfeeding.
Ask your doctor if Dysport is right for you.
12

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What to expect with Dysport
A step-by-step guide to your treatment†

1

The Dysport treatment consultation
Discuss your expectations with your doctor and
whether you have any health conditions or
allergies that could interfere with your treatment.
† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

IMPORTANT SAFETY INFORMATION
What is the most important information you should know about Dysport?
Spread of Toxin Effects: In some cases, the effects of Dysport and all botulinum toxin products may affect
areas of the body away from the injection site. These effects can cause symptoms of a serious condition
called botulism. Symptoms of botulism can happen hours to weeks after injection and may include
swallowing and breathing problems, loss of strength and muscle weakness all over the body, double
vision, blurred vision and drooping eyelids, hoarseness or change or loss of voice, trouble saying words
clearly, or loss of bladder control. Swallowing and breathing problems can be life threatening and there
have been reports of death.
The risk of symptoms is probably greatest in children and adults treated for muscle spasms, particularly
in those patients who have underlying medical conditions that could make these symptoms more likely.
13

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What to expect with Dysport
A step-by-step guide to your treatment†

2

The Dysport treatment
Effective treatment requires 1 injection into each
of 5 points between and over the eyebrows.
Although office visit times may vary, the procedure
generally takes 10 to 20 minutes. Your healthcare
professional will determine the exact placement of
each injection to get results that are right for you.

IMPORTANT SAFETY INFORMATION
The toxic effects have been reported at doses similar to those used to treat muscle spasms in
the neck. Lower doses, in both approved and unapproved uses, have also caused toxic effects.
This includes treatment of children and adults for muscle spasms.
These effects could make it unsafe for you to drive a car, operate machinery, or do other
dangerous activities.
Do not have Dysport treatment if you: are allergic to Dysport or any of its ingredients (see the end
of the Medication Guide for a list of ingredients), are allergic to cow’s milk protein, had an allergic
reaction to any other botulinum toxin product, such as Myobloc® or Botox,® or have a skin infection at
the planned injection site.
14

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

What to expect with Dysport
A step-by-step guide to your treatment†

3

After your Dysport treatment
Ask your doctor about any precautions you
should take after your treatment. Call your doctor
or get medical help right away if you have any
problems swallowing, speaking, or breathing.
If this happens, do not drive a car, operate
machinery, or do other dangerous activities.

IMPORTANT SAFETY INFORMATION
The dose of Dysport is not the same as the dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to the dose of any other botulinum toxin
product you may have used.
Dysport may not be right for you if: you have surgical changes to your face, very weak
muscles in the treatment area, your face looks very different from side to side, the injection
site is inflamed, you have droopy eyelids or sagging eyelid folds, deep facial scars, thick oily
skin, or if your wrinkles can’t be smoothed by spreading them apart.
15

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

What to expect with Dysport
A step-by-step guide to your treatment†

4

Follow up
To maintain your improvements, you should
discuss a treatment schedule with your doctor.
As with any botulinum toxin product, you should
wait at least 90 days between treatments.

IMPORTANT SAFETY INFORMATION
Tell your doctor about all your medical conditions, including if you have: a disease that
affects your muscles and nerves (suchas amyotrophic lateral sclerosis [ALS or Lou Gehrig’s
disease], myasthenia gravis, or Lambert-Eaton syndrome), allergies to any botulinum toxin
product or had any side effect from any botulinum toxin product in the past, a breathing problem
(such as asthma or emphysema), swallowing problems, bleeding problems, diabetes, a slow
heart beat or other problem with your heart rate or rhythm, plans to have surgery, had surgery on
your face, weakness of your forehead muscles (such as trouble raising your eyebrows), drooping
eyelids, or any other change in the way your face normally looks. Patients with a disease that
affects muscles and nerves who are treated with typical doses of Dysport may have a higher risk
of serious side effects, including severe swallowing and breathing problems.
16

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

Why not start the Dysport
discussion with your doctor today?
Questions to ask your doctor:
• How soon will I see treatment results?
• How long does one treatment last?
• How often can I receive a Dysport treatment?
• Is there any way to save money on
my treatment?
• Can I have a treatment today?
• What are the risks associated with treatment?
IMPORTANT SAFETY INFORMATION
Human Albumin
This product contains albumin taken from human plasma. Steps taken during donor screening and product
manufacturing processes make the risk of spreading viral diseases extremely rare. In theory, there is also an
extremely rare risk of contracting Creutzfeldt-Jakob disease (CJD). No cases of spread of viral diseases or CJD
have ever been reported for albumin.
17

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Important Safety Information

What is the most important information you
should know about Dysport
(abobotulinumtoxinA) 300 Units for Injection?
Spread of Toxin Effects: In some cases, the
effects of Dysport and all botulinum toxin
products may affect areas of the body away
from the injection site. These effects can
cause symptoms of a serious condition called
botulism. Symptoms of botulism can happen
hours to weeks after injection and may
include swallowing and breathing problems,
loss of strength and muscle weakness all over
the body, double vision, blurred vision and
drooping eyelids, hoarseness or change or
loss of voice, trouble saying words clearly, or
loss of bladder control. Swallowing and
breathing problems can be life threatening
and there have been reports of death.

18

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

The risk of symptoms is probably greatest in
children and adults treated for muscle spasms,
particularly in those patients who have
underlying medical conditions that could make
these symptoms more likely.
The toxic effects have been reported at doses
similar to those used to treat muscle spasms in
the neck. Lower doses, in both approved and
unapproved uses, have also caused toxic
effects. This includes treatment of children and
adults for muscle spasms.
These effects could make it unsafe for you to
drive a car, operate machinery, or do other
dangerous activities.
Do not have Dysport treatment if you: are allergic
to Dysport or any of its ingredients (see the end of
the Medication Guide for a list of ingredients), are
allergic to cow’s milk protein, had an allergic
reaction to any other botulinum toxin product, such
as Myobloc® or Botox,® or have a skin infection at
the planned injection site.

Important Safety Information (cont.)

The dose of Dysport is not the same as the
dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to
the dose of any other botulinum toxin product
you may have used.
Dysport may not be right for you if: you have
surgical changes to your face, very weak muscles
in the treatment area, your face looks very
different from side to side, the injection site is
inflamed, you have droopy eyelids or sagging
eyelid folds, deep facial scars, thick oily skin, or if
your wrinkles can’t be smoothed by spreading
them apart.
Tell your doctor about all your medical
conditions, including if you have: a disease
that affects your muscles and nerves (such as
amyotrophic lateral sclerosis [ALS or Lou
Gehrig’s disease], myasthenia gravis, or LambertEaton syndrome), allergies to any botulinum toxin
product or had any side effect from any

19

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

botulinum toxin product in the past, a breathing
problem (such as asthma or emphysema),
swallowing problems, bleeding problems, diabetes,
a slow heart beat or other problem with your heart
rate or rhythm, plans to have surgery, had surgery
on your face, weakness of your forehead muscles
(such as trouble raising your eyebrows), drooping
eyelids, or any other change in the way your face
normally looks. Patients with a disease that affects
muscles and nerves who are treated with typical
doses of Dysport may have a higher risk of serious
side effects, including severe swallowing and
breathing problems.
Human Albumin
This product contains albumin taken from human
plasma. Steps taken during donor screening and
product manufacturing processes make the risk of
spreading viral diseases extremely rare. In theory,
there is also an extremely rare risk of contracting
Creutzfeldt-Jakob disease (CJD). No cases of
spread of viral diseases or CJD have ever been
reported for albumin.

Important Safety Information (cont.)

Allergic Reaction to Injecting in the Skin
It is not known if an allergic reaction can be
caused by injecting Dysport into the skin. The
safety of treating excessive sweating with Dysport
is not known.
Common Side Effects
The most common side effects are nose and
throat irritation, headache, injection site pain,
injection site skin reaction, upper respiratory tract
infection, eyelid swelling, eyelid drooping, sinus
inflammation, and nausea.
Tell your doctor about all the medicines you
take, including prescription and nonprescription
medicines, vitamins and herbal and other natural
products. Using Dysport with certain other
medicines may cause serious side effects.

20

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

Do not start any new medicines while taking
Dysport without talking to your doctor first.

Especially tell your doctor if you: have received
any other botulinum toxin product in the last four
months, have received injections of botulinum toxin,
such as Myobloc® (rimabotulinumtoxinB) or Botox®
(onabotulinumtoxinA) in the past (be sure your
doctor knows exactly which product you received),
have recently received an antibiotic by injection,
take muscle relaxants, take an allergy or cold
medicine, or take a sleep medicine.
Use In Specific Populations
Dysport should not be used in children or in women
who are pregnant or breastfeeding.
Ask your doctor if Dysport is right for you.

Medication Guide

21

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

22

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

23

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

24

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

25

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

26

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

27

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

28

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

29

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

30

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

31

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

32

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medicis Family
of Aesthetic Products

Products are not FDA approved for combination use.

www.DysportUSA.com

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.
33

The Dysport trademark is used under license. Restylane is a registered trademark of HA North American Sales AB. All other trademarks
are the property of their respective owners. DSP 11-060 10/31/12


Slide 4

Dysport ® is a prescription
injection for temporary
improvement in the look of
moderate to severe frown
lines between the eyebrows
(glabellar lines) in adults less
than 65 years of age.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.
The Dysport trademark is used under license. All other trademarks are the property of their respective owners. DSP 11-060 10/31/12

I do special things for myself,
and I’ll bet you do, too.
I work out, eat right, and take care of my
skin. Of course, cosmetic creams and lotions
will always have their place in my regimen—
but for my moderate to severe frown lines,
I was ready for a prescription treatment.
Maybe you are, too.

IMPORTANT SAFETY INFORMATION
What is the most important information you should know about Dysport?
Spread of Toxin Effects: In some cases, the effects of Dysport and all botulinum toxin products
may affect areas of the body away from the injection site. These effects can cause symptoms of
a serious condition called botulism. Symptoms of botulism can happen hours to weeks after
injection and may include swallowing and breathing problems, loss of strength and muscle
weakness all over the body, double vision, blurred vision and drooping eyelids, hoarseness or
change or loss of voice, trouble saying words clearly, or loss of bladder control.
PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

2

What is Dysport?
Prescription Dysport is an injection used to temporarily improve
the look of your moderate to severe frown lines without changing
the look of your whole face. The untreated facial muscles still
work normally, allowing you to freely show facial expressions,
such as smiling, in untreated areas.
Dysport is a formulation that has been shown to deliver temporary
improvement in moderate to severe frown lines, even with repeat
treatments. So, the effect of repeat treatment with Dysport may
be comparable to your first use.

IMPORTANT SAFETY INFORMATION
Swallowing and breathing problems can be life threatening and there have
been reports of death.
The risk of symptoms is probably greatest in children and adults treated for
muscle spasms, particularly in those patients who have underlying medical
conditions that could make these symptoms more likely.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

3

How does Dysport Work?
With just 1 injection into each of 5 points between and over
the eyebrows, Dysport blocks the signal from the nerve to the
muscles, ultimately resulting in a reduction of muscle activity
and temporarily preventing contraction of the muscles that
cause frown lines. You should not be treated with Dysport more
frequently than every 90 days.
Ask your doctor about your prescription treatment options for
temporarily improving the look of moderate to severe frown lines.
IMPORTANT SAFETY INFORMATION
The toxic effects have been reported at doses similar to those used to treat
muscle spasms in the neck. Lower doses, in both approved and unapproved
uses, have also caused toxic effects. This includes treatment of children and
adults for muscle spasms.

These effects could make it unsafe for you to drive a car, operate machinery,
or do other dangerous activities.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

4

What causes frown lines?
Over time, repeated movement of the facial skin by the
forehead muscles forms lines between the eyebrows.
Frown lines are “dynamic”—they happen because of
the way a person’s face moves.

IMPORTANT SAFETY INFORMATION
Do not have Dysport treatment if you: are allergic to Dysport or any of its ingredients
(see the end of the Medication Guide for a list of ingredients), are allergic to cow’s milk protein,
had an allergic reaction to any other botulinum toxin product (such as Myobloc® or Botox®),
or have a skin infection at the planned injection site.
The dose of Dysport is not the same as the dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to the dose of any other botulinum toxin
product you may have used.
Dysport may not be right for you if: you have surgical changes to your face, very weak
muscles in the treatment area, your face looks very different from side to side, the injection site
is inflamed, you have droopy eyelids or sagging eyelid folds, deep facial scars, thick oily skin, or
if your wrinkles can’t be smoothed by spreading them apart.
5

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Are frown lines always related to age?
No. Because frown lines are created by facial movements,
such as frowning or squinting, they may develop even in
younger adults.

IMPORTANT SAFETY INFORMATION
Tell your doctor about all your medical conditions, including if you have: a disease
that affects your muscles and nerves (such as amyotrophic lateral sclerosis [ALS or Lou
Gehrig’s disease], myasthenia gravis, or Lambert-Eaton syndrome), allergies to any
botulinum toxin product or had any side effect from any botulinum toxin product in the past,
a breathing problem (such as asthma or emphysema), swallowing problems, bleeding
problems, diabetes, a slow heart beat or other problem with your heart rate or rhythm, plans
to have surgery, had surgery on your face, weakness of your forehead muscles (such as
trouble raising your eyebrows), drooping eyelids, or any other change in the way your face
normally looks. Patients with a disease that affects muscles and nerves who are treated with
typical doses of Dysport may have a higher risk of serious side effects, including severe
swallowing and breathing problems.
6

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What can you do about frown lines?
Treatment with prescription Dysport can temporarily
improve the look of your moderate to severe frown lines.
Treatment generally takes just 10 to 20 minutes.
The most common side effects are nose and throat
irritation, headache, injection site pain, injection site skin
reaction, upper respiratory tract infection, eyelid swelling,
eyelid drooping, sinus inflammation, and nausea.

IMPORTANT SAFETY INFORMATION
Human Albumin
This product contains albumin taken from human plasma. Steps taken during donor
screening and product manufacturing processes make the risk of spreading viral diseases
extremely rare. In theory, there is also an extremely rare risk of contracting CreutzfeldtJakob disease (CJD). No cases of spread of viral diseases or CJD have ever been
reported for albumin.
7

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

How do you know if Dysport works?
Clinically proven results with 1 treatment
In 3 clinical studies of people whose frown lines were rated “moderate” or
“severe” by a doctor before their treatment with Dysport:a
• Doctor rating: 30 days after treatment, the majority (88%, 85%, and 86% in each of the 3 studies)
had their frown lines rated by a doctor as “mild” or “moderate” at maximum frown. For example, a
patient could improve from “severe” to “moderate” or from “moderate” to “mild.”
• Patient rating: 30 days after treatment, the majority (74%, 79%, and 82% in each of the 3 studies)
rated their own frown lines as “mild” or “moderate” at maximum frown. For example, a patient could
improve from “severe” to “moderate” or from “moderate” to “mild.”

a

Three double-blind, randomized, placebo-controlled, clinical studies evaluated the efficacy of Dysport for use in the temporary improvement of the appearance of moderate to severe
glabellar lines. These 3 studies enrolled healthy adults (ages 19-75) with glabellar lines of at least moderate severity at maximum frown. Subjects were excluded if they had marked
ptosis, deep dermal scarring, or a substantial inability to lessen glabellar lines, even by physically spreading them apart. The subjects in these studies received either Dysport or a
placebo. The total dose was delivered in equally divided aliquots to specified injection sites.

IMPORTANT SAFETY INFORMATION
Allergic Reaction to Injecting in the Skin
It is not known if an allergic reaction can be caused by injecting Dysport into the skin. The safety of
treating excessive sweating with Dysport is not known.
8

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Common Side Effects
The most common side effects are nose and throat irritation, headache, injection site pain, injection site skin
reaction, upper respiratory tract infection, eyelid swelling, eyelid drooping, sinus inflammation, and nausea.
9

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Tell your doctor about all the medicines you take, including prescription and nonprescription medicines,
vitamins and herbal and other natural products. Using Dysport with certain other medicines may cause
serious side effects.
Do not start any new medicines while taking Dysport without talking to your doctor first.
10

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Especially tell your doctor if you: have received any other botulinum toxin product in the last four
months, have received injections of botulinum toxin, such as Myobloc® (rimabotulinumtoxinB) or Botox®
(onabotulinumtoxinA) in the past (be sure your doctor knows exactly which product you received), have
recently received an antibiotic by injection, take muscle relaxants, take an allergy or cold medicine, or take
a sleep medicine.
11

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Use In Specific Populations
Dysport should not be used in children or in women who are pregnant or breastfeeding.
Ask your doctor if Dysport is right for you.
12

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What to expect with Dysport
A step-by-step guide to your treatment†

1

The Dysport treatment consultation
Discuss your expectations with your doctor and
whether you have any health conditions or
allergies that could interfere with your treatment.
† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

IMPORTANT SAFETY INFORMATION
What is the most important information you should know about Dysport?
Spread of Toxin Effects: In some cases, the effects of Dysport and all botulinum toxin products may affect
areas of the body away from the injection site. These effects can cause symptoms of a serious condition
called botulism. Symptoms of botulism can happen hours to weeks after injection and may include
swallowing and breathing problems, loss of strength and muscle weakness all over the body, double
vision, blurred vision and drooping eyelids, hoarseness or change or loss of voice, trouble saying words
clearly, or loss of bladder control. Swallowing and breathing problems can be life threatening and there
have been reports of death.
The risk of symptoms is probably greatest in children and adults treated for muscle spasms, particularly
in those patients who have underlying medical conditions that could make these symptoms more likely.
13

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What to expect with Dysport
A step-by-step guide to your treatment†

2

The Dysport treatment
Effective treatment requires 1 injection into each
of 5 points between and over the eyebrows.
Although office visit times may vary, the procedure
generally takes 10 to 20 minutes. Your healthcare
professional will determine the exact placement of
each injection to get results that are right for you.

IMPORTANT SAFETY INFORMATION
The toxic effects have been reported at doses similar to those used to treat muscle spasms in
the neck. Lower doses, in both approved and unapproved uses, have also caused toxic effects.
This includes treatment of children and adults for muscle spasms.
These effects could make it unsafe for you to drive a car, operate machinery, or do other
dangerous activities.
Do not have Dysport treatment if you: are allergic to Dysport or any of its ingredients (see the end
of the Medication Guide for a list of ingredients), are allergic to cow’s milk protein, had an allergic
reaction to any other botulinum toxin product, such as Myobloc® or Botox,® or have a skin infection at
the planned injection site.
14

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

What to expect with Dysport
A step-by-step guide to your treatment†

3

After your Dysport treatment
Ask your doctor about any precautions you
should take after your treatment. Call your doctor
or get medical help right away if you have any
problems swallowing, speaking, or breathing.
If this happens, do not drive a car, operate
machinery, or do other dangerous activities.

IMPORTANT SAFETY INFORMATION
The dose of Dysport is not the same as the dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to the dose of any other botulinum toxin
product you may have used.
Dysport may not be right for you if: you have surgical changes to your face, very weak
muscles in the treatment area, your face looks very different from side to side, the injection
site is inflamed, you have droopy eyelids or sagging eyelid folds, deep facial scars, thick oily
skin, or if your wrinkles can’t be smoothed by spreading them apart.
15

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

What to expect with Dysport
A step-by-step guide to your treatment†

4

Follow up
To maintain your improvements, you should
discuss a treatment schedule with your doctor.
As with any botulinum toxin product, you should
wait at least 90 days between treatments.

IMPORTANT SAFETY INFORMATION
Tell your doctor about all your medical conditions, including if you have: a disease that
affects your muscles and nerves (suchas amyotrophic lateral sclerosis [ALS or Lou Gehrig’s
disease], myasthenia gravis, or Lambert-Eaton syndrome), allergies to any botulinum toxin
product or had any side effect from any botulinum toxin product in the past, a breathing problem
(such as asthma or emphysema), swallowing problems, bleeding problems, diabetes, a slow
heart beat or other problem with your heart rate or rhythm, plans to have surgery, had surgery on
your face, weakness of your forehead muscles (such as trouble raising your eyebrows), drooping
eyelids, or any other change in the way your face normally looks. Patients with a disease that
affects muscles and nerves who are treated with typical doses of Dysport may have a higher risk
of serious side effects, including severe swallowing and breathing problems.
16

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

Why not start the Dysport
discussion with your doctor today?
Questions to ask your doctor:
• How soon will I see treatment results?
• How long does one treatment last?
• How often can I receive a Dysport treatment?
• Is there any way to save money on
my treatment?
• Can I have a treatment today?
• What are the risks associated with treatment?
IMPORTANT SAFETY INFORMATION
Human Albumin
This product contains albumin taken from human plasma. Steps taken during donor screening and product
manufacturing processes make the risk of spreading viral diseases extremely rare. In theory, there is also an
extremely rare risk of contracting Creutzfeldt-Jakob disease (CJD). No cases of spread of viral diseases or CJD
have ever been reported for albumin.
17

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Important Safety Information

What is the most important information you
should know about Dysport
(abobotulinumtoxinA) 300 Units for Injection?
Spread of Toxin Effects: In some cases, the
effects of Dysport and all botulinum toxin
products may affect areas of the body away
from the injection site. These effects can
cause symptoms of a serious condition called
botulism. Symptoms of botulism can happen
hours to weeks after injection and may
include swallowing and breathing problems,
loss of strength and muscle weakness all over
the body, double vision, blurred vision and
drooping eyelids, hoarseness or change or
loss of voice, trouble saying words clearly, or
loss of bladder control. Swallowing and
breathing problems can be life threatening
and there have been reports of death.

18

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

The risk of symptoms is probably greatest in
children and adults treated for muscle spasms,
particularly in those patients who have
underlying medical conditions that could make
these symptoms more likely.
The toxic effects have been reported at doses
similar to those used to treat muscle spasms in
the neck. Lower doses, in both approved and
unapproved uses, have also caused toxic
effects. This includes treatment of children and
adults for muscle spasms.
These effects could make it unsafe for you to
drive a car, operate machinery, or do other
dangerous activities.
Do not have Dysport treatment if you: are allergic
to Dysport or any of its ingredients (see the end of
the Medication Guide for a list of ingredients), are
allergic to cow’s milk protein, had an allergic
reaction to any other botulinum toxin product, such
as Myobloc® or Botox,® or have a skin infection at
the planned injection site.

Important Safety Information (cont.)

The dose of Dysport is not the same as the
dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to
the dose of any other botulinum toxin product
you may have used.
Dysport may not be right for you if: you have
surgical changes to your face, very weak muscles
in the treatment area, your face looks very
different from side to side, the injection site is
inflamed, you have droopy eyelids or sagging
eyelid folds, deep facial scars, thick oily skin, or if
your wrinkles can’t be smoothed by spreading
them apart.
Tell your doctor about all your medical
conditions, including if you have: a disease
that affects your muscles and nerves (such as
amyotrophic lateral sclerosis [ALS or Lou
Gehrig’s disease], myasthenia gravis, or LambertEaton syndrome), allergies to any botulinum toxin
product or had any side effect from any

19

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

botulinum toxin product in the past, a breathing
problem (such as asthma or emphysema),
swallowing problems, bleeding problems, diabetes,
a slow heart beat or other problem with your heart
rate or rhythm, plans to have surgery, had surgery
on your face, weakness of your forehead muscles
(such as trouble raising your eyebrows), drooping
eyelids, or any other change in the way your face
normally looks. Patients with a disease that affects
muscles and nerves who are treated with typical
doses of Dysport may have a higher risk of serious
side effects, including severe swallowing and
breathing problems.
Human Albumin
This product contains albumin taken from human
plasma. Steps taken during donor screening and
product manufacturing processes make the risk of
spreading viral diseases extremely rare. In theory,
there is also an extremely rare risk of contracting
Creutzfeldt-Jakob disease (CJD). No cases of
spread of viral diseases or CJD have ever been
reported for albumin.

Important Safety Information (cont.)

Allergic Reaction to Injecting in the Skin
It is not known if an allergic reaction can be
caused by injecting Dysport into the skin. The
safety of treating excessive sweating with Dysport
is not known.
Common Side Effects
The most common side effects are nose and
throat irritation, headache, injection site pain,
injection site skin reaction, upper respiratory tract
infection, eyelid swelling, eyelid drooping, sinus
inflammation, and nausea.
Tell your doctor about all the medicines you
take, including prescription and nonprescription
medicines, vitamins and herbal and other natural
products. Using Dysport with certain other
medicines may cause serious side effects.

20

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

Do not start any new medicines while taking
Dysport without talking to your doctor first.

Especially tell your doctor if you: have received
any other botulinum toxin product in the last four
months, have received injections of botulinum toxin,
such as Myobloc® (rimabotulinumtoxinB) or Botox®
(onabotulinumtoxinA) in the past (be sure your
doctor knows exactly which product you received),
have recently received an antibiotic by injection,
take muscle relaxants, take an allergy or cold
medicine, or take a sleep medicine.
Use In Specific Populations
Dysport should not be used in children or in women
who are pregnant or breastfeeding.
Ask your doctor if Dysport is right for you.

Medication Guide

21

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

22

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

23

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

24

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

25

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

26

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

27

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

28

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

29

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

30

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

31

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

32

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medicis Family
of Aesthetic Products

Products are not FDA approved for combination use.

www.DysportUSA.com

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.
33

The Dysport trademark is used under license. Restylane is a registered trademark of HA North American Sales AB. All other trademarks
are the property of their respective owners. DSP 11-060 10/31/12


Slide 5

Dysport ® is a prescription
injection for temporary
improvement in the look of
moderate to severe frown
lines between the eyebrows
(glabellar lines) in adults less
than 65 years of age.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.
The Dysport trademark is used under license. All other trademarks are the property of their respective owners. DSP 11-060 10/31/12

I do special things for myself,
and I’ll bet you do, too.
I work out, eat right, and take care of my
skin. Of course, cosmetic creams and lotions
will always have their place in my regimen—
but for my moderate to severe frown lines,
I was ready for a prescription treatment.
Maybe you are, too.

IMPORTANT SAFETY INFORMATION
What is the most important information you should know about Dysport?
Spread of Toxin Effects: In some cases, the effects of Dysport and all botulinum toxin products
may affect areas of the body away from the injection site. These effects can cause symptoms of
a serious condition called botulism. Symptoms of botulism can happen hours to weeks after
injection and may include swallowing and breathing problems, loss of strength and muscle
weakness all over the body, double vision, blurred vision and drooping eyelids, hoarseness or
change or loss of voice, trouble saying words clearly, or loss of bladder control.
PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

2

What is Dysport?
Prescription Dysport is an injection used to temporarily improve
the look of your moderate to severe frown lines without changing
the look of your whole face. The untreated facial muscles still
work normally, allowing you to freely show facial expressions,
such as smiling, in untreated areas.
Dysport is a formulation that has been shown to deliver temporary
improvement in moderate to severe frown lines, even with repeat
treatments. So, the effect of repeat treatment with Dysport may
be comparable to your first use.

IMPORTANT SAFETY INFORMATION
Swallowing and breathing problems can be life threatening and there have
been reports of death.
The risk of symptoms is probably greatest in children and adults treated for
muscle spasms, particularly in those patients who have underlying medical
conditions that could make these symptoms more likely.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

3

How does Dysport Work?
With just 1 injection into each of 5 points between and over
the eyebrows, Dysport blocks the signal from the nerve to the
muscles, ultimately resulting in a reduction of muscle activity
and temporarily preventing contraction of the muscles that
cause frown lines. You should not be treated with Dysport more
frequently than every 90 days.
Ask your doctor about your prescription treatment options for
temporarily improving the look of moderate to severe frown lines.
IMPORTANT SAFETY INFORMATION
The toxic effects have been reported at doses similar to those used to treat
muscle spasms in the neck. Lower doses, in both approved and unapproved
uses, have also caused toxic effects. This includes treatment of children and
adults for muscle spasms.

These effects could make it unsafe for you to drive a car, operate machinery,
or do other dangerous activities.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

4

What causes frown lines?
Over time, repeated movement of the facial skin by the
forehead muscles forms lines between the eyebrows.
Frown lines are “dynamic”—they happen because of
the way a person’s face moves.

IMPORTANT SAFETY INFORMATION
Do not have Dysport treatment if you: are allergic to Dysport or any of its ingredients
(see the end of the Medication Guide for a list of ingredients), are allergic to cow’s milk protein,
had an allergic reaction to any other botulinum toxin product (such as Myobloc® or Botox®),
or have a skin infection at the planned injection site.
The dose of Dysport is not the same as the dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to the dose of any other botulinum toxin
product you may have used.
Dysport may not be right for you if: you have surgical changes to your face, very weak
muscles in the treatment area, your face looks very different from side to side, the injection site
is inflamed, you have droopy eyelids or sagging eyelid folds, deep facial scars, thick oily skin, or
if your wrinkles can’t be smoothed by spreading them apart.
5

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Are frown lines always related to age?
No. Because frown lines are created by facial movements,
such as frowning or squinting, they may develop even in
younger adults.

IMPORTANT SAFETY INFORMATION
Tell your doctor about all your medical conditions, including if you have: a disease
that affects your muscles and nerves (such as amyotrophic lateral sclerosis [ALS or Lou
Gehrig’s disease], myasthenia gravis, or Lambert-Eaton syndrome), allergies to any
botulinum toxin product or had any side effect from any botulinum toxin product in the past,
a breathing problem (such as asthma or emphysema), swallowing problems, bleeding
problems, diabetes, a slow heart beat or other problem with your heart rate or rhythm, plans
to have surgery, had surgery on your face, weakness of your forehead muscles (such as
trouble raising your eyebrows), drooping eyelids, or any other change in the way your face
normally looks. Patients with a disease that affects muscles and nerves who are treated with
typical doses of Dysport may have a higher risk of serious side effects, including severe
swallowing and breathing problems.
6

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What can you do about frown lines?
Treatment with prescription Dysport can temporarily
improve the look of your moderate to severe frown lines.
Treatment generally takes just 10 to 20 minutes.
The most common side effects are nose and throat
irritation, headache, injection site pain, injection site skin
reaction, upper respiratory tract infection, eyelid swelling,
eyelid drooping, sinus inflammation, and nausea.

IMPORTANT SAFETY INFORMATION
Human Albumin
This product contains albumin taken from human plasma. Steps taken during donor
screening and product manufacturing processes make the risk of spreading viral diseases
extremely rare. In theory, there is also an extremely rare risk of contracting CreutzfeldtJakob disease (CJD). No cases of spread of viral diseases or CJD have ever been
reported for albumin.
7

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

How do you know if Dysport works?
Clinically proven results with 1 treatment
In 3 clinical studies of people whose frown lines were rated “moderate” or
“severe” by a doctor before their treatment with Dysport:a
• Doctor rating: 30 days after treatment, the majority (88%, 85%, and 86% in each of the 3 studies)
had their frown lines rated by a doctor as “mild” or “moderate” at maximum frown. For example, a
patient could improve from “severe” to “moderate” or from “moderate” to “mild.”
• Patient rating: 30 days after treatment, the majority (74%, 79%, and 82% in each of the 3 studies)
rated their own frown lines as “mild” or “moderate” at maximum frown. For example, a patient could
improve from “severe” to “moderate” or from “moderate” to “mild.”

a

Three double-blind, randomized, placebo-controlled, clinical studies evaluated the efficacy of Dysport for use in the temporary improvement of the appearance of moderate to severe
glabellar lines. These 3 studies enrolled healthy adults (ages 19-75) with glabellar lines of at least moderate severity at maximum frown. Subjects were excluded if they had marked
ptosis, deep dermal scarring, or a substantial inability to lessen glabellar lines, even by physically spreading them apart. The subjects in these studies received either Dysport or a
placebo. The total dose was delivered in equally divided aliquots to specified injection sites.

IMPORTANT SAFETY INFORMATION
Allergic Reaction to Injecting in the Skin
It is not known if an allergic reaction can be caused by injecting Dysport into the skin. The safety of
treating excessive sweating with Dysport is not known.
8

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Common Side Effects
The most common side effects are nose and throat irritation, headache, injection site pain, injection site skin
reaction, upper respiratory tract infection, eyelid swelling, eyelid drooping, sinus inflammation, and nausea.
9

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Tell your doctor about all the medicines you take, including prescription and nonprescription medicines,
vitamins and herbal and other natural products. Using Dysport with certain other medicines may cause
serious side effects.
Do not start any new medicines while taking Dysport without talking to your doctor first.
10

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Especially tell your doctor if you: have received any other botulinum toxin product in the last four
months, have received injections of botulinum toxin, such as Myobloc® (rimabotulinumtoxinB) or Botox®
(onabotulinumtoxinA) in the past (be sure your doctor knows exactly which product you received), have
recently received an antibiotic by injection, take muscle relaxants, take an allergy or cold medicine, or take
a sleep medicine.
11

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Use In Specific Populations
Dysport should not be used in children or in women who are pregnant or breastfeeding.
Ask your doctor if Dysport is right for you.
12

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What to expect with Dysport
A step-by-step guide to your treatment†

1

The Dysport treatment consultation
Discuss your expectations with your doctor and
whether you have any health conditions or
allergies that could interfere with your treatment.
† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

IMPORTANT SAFETY INFORMATION
What is the most important information you should know about Dysport?
Spread of Toxin Effects: In some cases, the effects of Dysport and all botulinum toxin products may affect
areas of the body away from the injection site. These effects can cause symptoms of a serious condition
called botulism. Symptoms of botulism can happen hours to weeks after injection and may include
swallowing and breathing problems, loss of strength and muscle weakness all over the body, double
vision, blurred vision and drooping eyelids, hoarseness or change or loss of voice, trouble saying words
clearly, or loss of bladder control. Swallowing and breathing problems can be life threatening and there
have been reports of death.
The risk of symptoms is probably greatest in children and adults treated for muscle spasms, particularly
in those patients who have underlying medical conditions that could make these symptoms more likely.
13

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What to expect with Dysport
A step-by-step guide to your treatment†

2

The Dysport treatment
Effective treatment requires 1 injection into each
of 5 points between and over the eyebrows.
Although office visit times may vary, the procedure
generally takes 10 to 20 minutes. Your healthcare
professional will determine the exact placement of
each injection to get results that are right for you.

IMPORTANT SAFETY INFORMATION
The toxic effects have been reported at doses similar to those used to treat muscle spasms in
the neck. Lower doses, in both approved and unapproved uses, have also caused toxic effects.
This includes treatment of children and adults for muscle spasms.
These effects could make it unsafe for you to drive a car, operate machinery, or do other
dangerous activities.
Do not have Dysport treatment if you: are allergic to Dysport or any of its ingredients (see the end
of the Medication Guide for a list of ingredients), are allergic to cow’s milk protein, had an allergic
reaction to any other botulinum toxin product, such as Myobloc® or Botox,® or have a skin infection at
the planned injection site.
14

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

What to expect with Dysport
A step-by-step guide to your treatment†

3

After your Dysport treatment
Ask your doctor about any precautions you
should take after your treatment. Call your doctor
or get medical help right away if you have any
problems swallowing, speaking, or breathing.
If this happens, do not drive a car, operate
machinery, or do other dangerous activities.

IMPORTANT SAFETY INFORMATION
The dose of Dysport is not the same as the dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to the dose of any other botulinum toxin
product you may have used.
Dysport may not be right for you if: you have surgical changes to your face, very weak
muscles in the treatment area, your face looks very different from side to side, the injection
site is inflamed, you have droopy eyelids or sagging eyelid folds, deep facial scars, thick oily
skin, or if your wrinkles can’t be smoothed by spreading them apart.
15

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

What to expect with Dysport
A step-by-step guide to your treatment†

4

Follow up
To maintain your improvements, you should
discuss a treatment schedule with your doctor.
As with any botulinum toxin product, you should
wait at least 90 days between treatments.

IMPORTANT SAFETY INFORMATION
Tell your doctor about all your medical conditions, including if you have: a disease that
affects your muscles and nerves (suchas amyotrophic lateral sclerosis [ALS or Lou Gehrig’s
disease], myasthenia gravis, or Lambert-Eaton syndrome), allergies to any botulinum toxin
product or had any side effect from any botulinum toxin product in the past, a breathing problem
(such as asthma or emphysema), swallowing problems, bleeding problems, diabetes, a slow
heart beat or other problem with your heart rate or rhythm, plans to have surgery, had surgery on
your face, weakness of your forehead muscles (such as trouble raising your eyebrows), drooping
eyelids, or any other change in the way your face normally looks. Patients with a disease that
affects muscles and nerves who are treated with typical doses of Dysport may have a higher risk
of serious side effects, including severe swallowing and breathing problems.
16

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

Why not start the Dysport
discussion with your doctor today?
Questions to ask your doctor:
• How soon will I see treatment results?
• How long does one treatment last?
• How often can I receive a Dysport treatment?
• Is there any way to save money on
my treatment?
• Can I have a treatment today?
• What are the risks associated with treatment?
IMPORTANT SAFETY INFORMATION
Human Albumin
This product contains albumin taken from human plasma. Steps taken during donor screening and product
manufacturing processes make the risk of spreading viral diseases extremely rare. In theory, there is also an
extremely rare risk of contracting Creutzfeldt-Jakob disease (CJD). No cases of spread of viral diseases or CJD
have ever been reported for albumin.
17

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Important Safety Information

What is the most important information you
should know about Dysport
(abobotulinumtoxinA) 300 Units for Injection?
Spread of Toxin Effects: In some cases, the
effects of Dysport and all botulinum toxin
products may affect areas of the body away
from the injection site. These effects can
cause symptoms of a serious condition called
botulism. Symptoms of botulism can happen
hours to weeks after injection and may
include swallowing and breathing problems,
loss of strength and muscle weakness all over
the body, double vision, blurred vision and
drooping eyelids, hoarseness or change or
loss of voice, trouble saying words clearly, or
loss of bladder control. Swallowing and
breathing problems can be life threatening
and there have been reports of death.

18

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

The risk of symptoms is probably greatest in
children and adults treated for muscle spasms,
particularly in those patients who have
underlying medical conditions that could make
these symptoms more likely.
The toxic effects have been reported at doses
similar to those used to treat muscle spasms in
the neck. Lower doses, in both approved and
unapproved uses, have also caused toxic
effects. This includes treatment of children and
adults for muscle spasms.
These effects could make it unsafe for you to
drive a car, operate machinery, or do other
dangerous activities.
Do not have Dysport treatment if you: are allergic
to Dysport or any of its ingredients (see the end of
the Medication Guide for a list of ingredients), are
allergic to cow’s milk protein, had an allergic
reaction to any other botulinum toxin product, such
as Myobloc® or Botox,® or have a skin infection at
the planned injection site.

Important Safety Information (cont.)

The dose of Dysport is not the same as the
dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to
the dose of any other botulinum toxin product
you may have used.
Dysport may not be right for you if: you have
surgical changes to your face, very weak muscles
in the treatment area, your face looks very
different from side to side, the injection site is
inflamed, you have droopy eyelids or sagging
eyelid folds, deep facial scars, thick oily skin, or if
your wrinkles can’t be smoothed by spreading
them apart.
Tell your doctor about all your medical
conditions, including if you have: a disease
that affects your muscles and nerves (such as
amyotrophic lateral sclerosis [ALS or Lou
Gehrig’s disease], myasthenia gravis, or LambertEaton syndrome), allergies to any botulinum toxin
product or had any side effect from any

19

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

botulinum toxin product in the past, a breathing
problem (such as asthma or emphysema),
swallowing problems, bleeding problems, diabetes,
a slow heart beat or other problem with your heart
rate or rhythm, plans to have surgery, had surgery
on your face, weakness of your forehead muscles
(such as trouble raising your eyebrows), drooping
eyelids, or any other change in the way your face
normally looks. Patients with a disease that affects
muscles and nerves who are treated with typical
doses of Dysport may have a higher risk of serious
side effects, including severe swallowing and
breathing problems.
Human Albumin
This product contains albumin taken from human
plasma. Steps taken during donor screening and
product manufacturing processes make the risk of
spreading viral diseases extremely rare. In theory,
there is also an extremely rare risk of contracting
Creutzfeldt-Jakob disease (CJD). No cases of
spread of viral diseases or CJD have ever been
reported for albumin.

Important Safety Information (cont.)

Allergic Reaction to Injecting in the Skin
It is not known if an allergic reaction can be
caused by injecting Dysport into the skin. The
safety of treating excessive sweating with Dysport
is not known.
Common Side Effects
The most common side effects are nose and
throat irritation, headache, injection site pain,
injection site skin reaction, upper respiratory tract
infection, eyelid swelling, eyelid drooping, sinus
inflammation, and nausea.
Tell your doctor about all the medicines you
take, including prescription and nonprescription
medicines, vitamins and herbal and other natural
products. Using Dysport with certain other
medicines may cause serious side effects.

20

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

Do not start any new medicines while taking
Dysport without talking to your doctor first.

Especially tell your doctor if you: have received
any other botulinum toxin product in the last four
months, have received injections of botulinum toxin,
such as Myobloc® (rimabotulinumtoxinB) or Botox®
(onabotulinumtoxinA) in the past (be sure your
doctor knows exactly which product you received),
have recently received an antibiotic by injection,
take muscle relaxants, take an allergy or cold
medicine, or take a sleep medicine.
Use In Specific Populations
Dysport should not be used in children or in women
who are pregnant or breastfeeding.
Ask your doctor if Dysport is right for you.

Medication Guide

21

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

22

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

23

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

24

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

25

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

26

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

27

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

28

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

29

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

30

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

31

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

32

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medicis Family
of Aesthetic Products

Products are not FDA approved for combination use.

www.DysportUSA.com

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.
33

The Dysport trademark is used under license. Restylane is a registered trademark of HA North American Sales AB. All other trademarks
are the property of their respective owners. DSP 11-060 10/31/12


Slide 6

Dysport ® is a prescription
injection for temporary
improvement in the look of
moderate to severe frown
lines between the eyebrows
(glabellar lines) in adults less
than 65 years of age.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.
The Dysport trademark is used under license. All other trademarks are the property of their respective owners. DSP 11-060 10/31/12

I do special things for myself,
and I’ll bet you do, too.
I work out, eat right, and take care of my
skin. Of course, cosmetic creams and lotions
will always have their place in my regimen—
but for my moderate to severe frown lines,
I was ready for a prescription treatment.
Maybe you are, too.

IMPORTANT SAFETY INFORMATION
What is the most important information you should know about Dysport?
Spread of Toxin Effects: In some cases, the effects of Dysport and all botulinum toxin products
may affect areas of the body away from the injection site. These effects can cause symptoms of
a serious condition called botulism. Symptoms of botulism can happen hours to weeks after
injection and may include swallowing and breathing problems, loss of strength and muscle
weakness all over the body, double vision, blurred vision and drooping eyelids, hoarseness or
change or loss of voice, trouble saying words clearly, or loss of bladder control.
PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

2

What is Dysport?
Prescription Dysport is an injection used to temporarily improve
the look of your moderate to severe frown lines without changing
the look of your whole face. The untreated facial muscles still
work normally, allowing you to freely show facial expressions,
such as smiling, in untreated areas.
Dysport is a formulation that has been shown to deliver temporary
improvement in moderate to severe frown lines, even with repeat
treatments. So, the effect of repeat treatment with Dysport may
be comparable to your first use.

IMPORTANT SAFETY INFORMATION
Swallowing and breathing problems can be life threatening and there have
been reports of death.
The risk of symptoms is probably greatest in children and adults treated for
muscle spasms, particularly in those patients who have underlying medical
conditions that could make these symptoms more likely.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

3

How does Dysport Work?
With just 1 injection into each of 5 points between and over
the eyebrows, Dysport blocks the signal from the nerve to the
muscles, ultimately resulting in a reduction of muscle activity
and temporarily preventing contraction of the muscles that
cause frown lines. You should not be treated with Dysport more
frequently than every 90 days.
Ask your doctor about your prescription treatment options for
temporarily improving the look of moderate to severe frown lines.
IMPORTANT SAFETY INFORMATION
The toxic effects have been reported at doses similar to those used to treat
muscle spasms in the neck. Lower doses, in both approved and unapproved
uses, have also caused toxic effects. This includes treatment of children and
adults for muscle spasms.

These effects could make it unsafe for you to drive a car, operate machinery,
or do other dangerous activities.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

4

What causes frown lines?
Over time, repeated movement of the facial skin by the
forehead muscles forms lines between the eyebrows.
Frown lines are “dynamic”—they happen because of
the way a person’s face moves.

IMPORTANT SAFETY INFORMATION
Do not have Dysport treatment if you: are allergic to Dysport or any of its ingredients
(see the end of the Medication Guide for a list of ingredients), are allergic to cow’s milk protein,
had an allergic reaction to any other botulinum toxin product (such as Myobloc® or Botox®),
or have a skin infection at the planned injection site.
The dose of Dysport is not the same as the dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to the dose of any other botulinum toxin
product you may have used.
Dysport may not be right for you if: you have surgical changes to your face, very weak
muscles in the treatment area, your face looks very different from side to side, the injection site
is inflamed, you have droopy eyelids or sagging eyelid folds, deep facial scars, thick oily skin, or
if your wrinkles can’t be smoothed by spreading them apart.
5

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Are frown lines always related to age?
No. Because frown lines are created by facial movements,
such as frowning or squinting, they may develop even in
younger adults.

IMPORTANT SAFETY INFORMATION
Tell your doctor about all your medical conditions, including if you have: a disease
that affects your muscles and nerves (such as amyotrophic lateral sclerosis [ALS or Lou
Gehrig’s disease], myasthenia gravis, or Lambert-Eaton syndrome), allergies to any
botulinum toxin product or had any side effect from any botulinum toxin product in the past,
a breathing problem (such as asthma or emphysema), swallowing problems, bleeding
problems, diabetes, a slow heart beat or other problem with your heart rate or rhythm, plans
to have surgery, had surgery on your face, weakness of your forehead muscles (such as
trouble raising your eyebrows), drooping eyelids, or any other change in the way your face
normally looks. Patients with a disease that affects muscles and nerves who are treated with
typical doses of Dysport may have a higher risk of serious side effects, including severe
swallowing and breathing problems.
6

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What can you do about frown lines?
Treatment with prescription Dysport can temporarily
improve the look of your moderate to severe frown lines.
Treatment generally takes just 10 to 20 minutes.
The most common side effects are nose and throat
irritation, headache, injection site pain, injection site skin
reaction, upper respiratory tract infection, eyelid swelling,
eyelid drooping, sinus inflammation, and nausea.

IMPORTANT SAFETY INFORMATION
Human Albumin
This product contains albumin taken from human plasma. Steps taken during donor
screening and product manufacturing processes make the risk of spreading viral diseases
extremely rare. In theory, there is also an extremely rare risk of contracting CreutzfeldtJakob disease (CJD). No cases of spread of viral diseases or CJD have ever been
reported for albumin.
7

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

How do you know if Dysport works?
Clinically proven results with 1 treatment
In 3 clinical studies of people whose frown lines were rated “moderate” or
“severe” by a doctor before their treatment with Dysport:a
• Doctor rating: 30 days after treatment, the majority (88%, 85%, and 86% in each of the 3 studies)
had their frown lines rated by a doctor as “mild” or “moderate” at maximum frown. For example, a
patient could improve from “severe” to “moderate” or from “moderate” to “mild.”
• Patient rating: 30 days after treatment, the majority (74%, 79%, and 82% in each of the 3 studies)
rated their own frown lines as “mild” or “moderate” at maximum frown. For example, a patient could
improve from “severe” to “moderate” or from “moderate” to “mild.”

a

Three double-blind, randomized, placebo-controlled, clinical studies evaluated the efficacy of Dysport for use in the temporary improvement of the appearance of moderate to severe
glabellar lines. These 3 studies enrolled healthy adults (ages 19-75) with glabellar lines of at least moderate severity at maximum frown. Subjects were excluded if they had marked
ptosis, deep dermal scarring, or a substantial inability to lessen glabellar lines, even by physically spreading them apart. The subjects in these studies received either Dysport or a
placebo. The total dose was delivered in equally divided aliquots to specified injection sites.

IMPORTANT SAFETY INFORMATION
Allergic Reaction to Injecting in the Skin
It is not known if an allergic reaction can be caused by injecting Dysport into the skin. The safety of
treating excessive sweating with Dysport is not known.
8

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Common Side Effects
The most common side effects are nose and throat irritation, headache, injection site pain, injection site skin
reaction, upper respiratory tract infection, eyelid swelling, eyelid drooping, sinus inflammation, and nausea.
9

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Tell your doctor about all the medicines you take, including prescription and nonprescription medicines,
vitamins and herbal and other natural products. Using Dysport with certain other medicines may cause
serious side effects.
Do not start any new medicines while taking Dysport without talking to your doctor first.
10

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Especially tell your doctor if you: have received any other botulinum toxin product in the last four
months, have received injections of botulinum toxin, such as Myobloc® (rimabotulinumtoxinB) or Botox®
(onabotulinumtoxinA) in the past (be sure your doctor knows exactly which product you received), have
recently received an antibiotic by injection, take muscle relaxants, take an allergy or cold medicine, or take
a sleep medicine.
11

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Use In Specific Populations
Dysport should not be used in children or in women who are pregnant or breastfeeding.
Ask your doctor if Dysport is right for you.
12

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What to expect with Dysport
A step-by-step guide to your treatment†

1

The Dysport treatment consultation
Discuss your expectations with your doctor and
whether you have any health conditions or
allergies that could interfere with your treatment.
† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

IMPORTANT SAFETY INFORMATION
What is the most important information you should know about Dysport?
Spread of Toxin Effects: In some cases, the effects of Dysport and all botulinum toxin products may affect
areas of the body away from the injection site. These effects can cause symptoms of a serious condition
called botulism. Symptoms of botulism can happen hours to weeks after injection and may include
swallowing and breathing problems, loss of strength and muscle weakness all over the body, double
vision, blurred vision and drooping eyelids, hoarseness or change or loss of voice, trouble saying words
clearly, or loss of bladder control. Swallowing and breathing problems can be life threatening and there
have been reports of death.
The risk of symptoms is probably greatest in children and adults treated for muscle spasms, particularly
in those patients who have underlying medical conditions that could make these symptoms more likely.
13

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What to expect with Dysport
A step-by-step guide to your treatment†

2

The Dysport treatment
Effective treatment requires 1 injection into each
of 5 points between and over the eyebrows.
Although office visit times may vary, the procedure
generally takes 10 to 20 minutes. Your healthcare
professional will determine the exact placement of
each injection to get results that are right for you.

IMPORTANT SAFETY INFORMATION
The toxic effects have been reported at doses similar to those used to treat muscle spasms in
the neck. Lower doses, in both approved and unapproved uses, have also caused toxic effects.
This includes treatment of children and adults for muscle spasms.
These effects could make it unsafe for you to drive a car, operate machinery, or do other
dangerous activities.
Do not have Dysport treatment if you: are allergic to Dysport or any of its ingredients (see the end
of the Medication Guide for a list of ingredients), are allergic to cow’s milk protein, had an allergic
reaction to any other botulinum toxin product, such as Myobloc® or Botox,® or have a skin infection at
the planned injection site.
14

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

What to expect with Dysport
A step-by-step guide to your treatment†

3

After your Dysport treatment
Ask your doctor about any precautions you
should take after your treatment. Call your doctor
or get medical help right away if you have any
problems swallowing, speaking, or breathing.
If this happens, do not drive a car, operate
machinery, or do other dangerous activities.

IMPORTANT SAFETY INFORMATION
The dose of Dysport is not the same as the dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to the dose of any other botulinum toxin
product you may have used.
Dysport may not be right for you if: you have surgical changes to your face, very weak
muscles in the treatment area, your face looks very different from side to side, the injection
site is inflamed, you have droopy eyelids or sagging eyelid folds, deep facial scars, thick oily
skin, or if your wrinkles can’t be smoothed by spreading them apart.
15

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

What to expect with Dysport
A step-by-step guide to your treatment†

4

Follow up
To maintain your improvements, you should
discuss a treatment schedule with your doctor.
As with any botulinum toxin product, you should
wait at least 90 days between treatments.

IMPORTANT SAFETY INFORMATION
Tell your doctor about all your medical conditions, including if you have: a disease that
affects your muscles and nerves (suchas amyotrophic lateral sclerosis [ALS or Lou Gehrig’s
disease], myasthenia gravis, or Lambert-Eaton syndrome), allergies to any botulinum toxin
product or had any side effect from any botulinum toxin product in the past, a breathing problem
(such as asthma or emphysema), swallowing problems, bleeding problems, diabetes, a slow
heart beat or other problem with your heart rate or rhythm, plans to have surgery, had surgery on
your face, weakness of your forehead muscles (such as trouble raising your eyebrows), drooping
eyelids, or any other change in the way your face normally looks. Patients with a disease that
affects muscles and nerves who are treated with typical doses of Dysport may have a higher risk
of serious side effects, including severe swallowing and breathing problems.
16

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

Why not start the Dysport
discussion with your doctor today?
Questions to ask your doctor:
• How soon will I see treatment results?
• How long does one treatment last?
• How often can I receive a Dysport treatment?
• Is there any way to save money on
my treatment?
• Can I have a treatment today?
• What are the risks associated with treatment?
IMPORTANT SAFETY INFORMATION
Human Albumin
This product contains albumin taken from human plasma. Steps taken during donor screening and product
manufacturing processes make the risk of spreading viral diseases extremely rare. In theory, there is also an
extremely rare risk of contracting Creutzfeldt-Jakob disease (CJD). No cases of spread of viral diseases or CJD
have ever been reported for albumin.
17

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Important Safety Information

What is the most important information you
should know about Dysport
(abobotulinumtoxinA) 300 Units for Injection?
Spread of Toxin Effects: In some cases, the
effects of Dysport and all botulinum toxin
products may affect areas of the body away
from the injection site. These effects can
cause symptoms of a serious condition called
botulism. Symptoms of botulism can happen
hours to weeks after injection and may
include swallowing and breathing problems,
loss of strength and muscle weakness all over
the body, double vision, blurred vision and
drooping eyelids, hoarseness or change or
loss of voice, trouble saying words clearly, or
loss of bladder control. Swallowing and
breathing problems can be life threatening
and there have been reports of death.

18

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

The risk of symptoms is probably greatest in
children and adults treated for muscle spasms,
particularly in those patients who have
underlying medical conditions that could make
these symptoms more likely.
The toxic effects have been reported at doses
similar to those used to treat muscle spasms in
the neck. Lower doses, in both approved and
unapproved uses, have also caused toxic
effects. This includes treatment of children and
adults for muscle spasms.
These effects could make it unsafe for you to
drive a car, operate machinery, or do other
dangerous activities.
Do not have Dysport treatment if you: are allergic
to Dysport or any of its ingredients (see the end of
the Medication Guide for a list of ingredients), are
allergic to cow’s milk protein, had an allergic
reaction to any other botulinum toxin product, such
as Myobloc® or Botox,® or have a skin infection at
the planned injection site.

Important Safety Information (cont.)

The dose of Dysport is not the same as the
dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to
the dose of any other botulinum toxin product
you may have used.
Dysport may not be right for you if: you have
surgical changes to your face, very weak muscles
in the treatment area, your face looks very
different from side to side, the injection site is
inflamed, you have droopy eyelids or sagging
eyelid folds, deep facial scars, thick oily skin, or if
your wrinkles can’t be smoothed by spreading
them apart.
Tell your doctor about all your medical
conditions, including if you have: a disease
that affects your muscles and nerves (such as
amyotrophic lateral sclerosis [ALS or Lou
Gehrig’s disease], myasthenia gravis, or LambertEaton syndrome), allergies to any botulinum toxin
product or had any side effect from any

19

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

botulinum toxin product in the past, a breathing
problem (such as asthma or emphysema),
swallowing problems, bleeding problems, diabetes,
a slow heart beat or other problem with your heart
rate or rhythm, plans to have surgery, had surgery
on your face, weakness of your forehead muscles
(such as trouble raising your eyebrows), drooping
eyelids, or any other change in the way your face
normally looks. Patients with a disease that affects
muscles and nerves who are treated with typical
doses of Dysport may have a higher risk of serious
side effects, including severe swallowing and
breathing problems.
Human Albumin
This product contains albumin taken from human
plasma. Steps taken during donor screening and
product manufacturing processes make the risk of
spreading viral diseases extremely rare. In theory,
there is also an extremely rare risk of contracting
Creutzfeldt-Jakob disease (CJD). No cases of
spread of viral diseases or CJD have ever been
reported for albumin.

Important Safety Information (cont.)

Allergic Reaction to Injecting in the Skin
It is not known if an allergic reaction can be
caused by injecting Dysport into the skin. The
safety of treating excessive sweating with Dysport
is not known.
Common Side Effects
The most common side effects are nose and
throat irritation, headache, injection site pain,
injection site skin reaction, upper respiratory tract
infection, eyelid swelling, eyelid drooping, sinus
inflammation, and nausea.
Tell your doctor about all the medicines you
take, including prescription and nonprescription
medicines, vitamins and herbal and other natural
products. Using Dysport with certain other
medicines may cause serious side effects.

20

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

Do not start any new medicines while taking
Dysport without talking to your doctor first.

Especially tell your doctor if you: have received
any other botulinum toxin product in the last four
months, have received injections of botulinum toxin,
such as Myobloc® (rimabotulinumtoxinB) or Botox®
(onabotulinumtoxinA) in the past (be sure your
doctor knows exactly which product you received),
have recently received an antibiotic by injection,
take muscle relaxants, take an allergy or cold
medicine, or take a sleep medicine.
Use In Specific Populations
Dysport should not be used in children or in women
who are pregnant or breastfeeding.
Ask your doctor if Dysport is right for you.

Medication Guide

21

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

22

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

23

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

24

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

25

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

26

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

27

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

28

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

29

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

30

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

31

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

32

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medicis Family
of Aesthetic Products

Products are not FDA approved for combination use.

www.DysportUSA.com

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.
33

The Dysport trademark is used under license. Restylane is a registered trademark of HA North American Sales AB. All other trademarks
are the property of their respective owners. DSP 11-060 10/31/12


Slide 7

Dysport ® is a prescription
injection for temporary
improvement in the look of
moderate to severe frown
lines between the eyebrows
(glabellar lines) in adults less
than 65 years of age.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.
The Dysport trademark is used under license. All other trademarks are the property of their respective owners. DSP 11-060 10/31/12

I do special things for myself,
and I’ll bet you do, too.
I work out, eat right, and take care of my
skin. Of course, cosmetic creams and lotions
will always have their place in my regimen—
but for my moderate to severe frown lines,
I was ready for a prescription treatment.
Maybe you are, too.

IMPORTANT SAFETY INFORMATION
What is the most important information you should know about Dysport?
Spread of Toxin Effects: In some cases, the effects of Dysport and all botulinum toxin products
may affect areas of the body away from the injection site. These effects can cause symptoms of
a serious condition called botulism. Symptoms of botulism can happen hours to weeks after
injection and may include swallowing and breathing problems, loss of strength and muscle
weakness all over the body, double vision, blurred vision and drooping eyelids, hoarseness or
change or loss of voice, trouble saying words clearly, or loss of bladder control.
PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

2

What is Dysport?
Prescription Dysport is an injection used to temporarily improve
the look of your moderate to severe frown lines without changing
the look of your whole face. The untreated facial muscles still
work normally, allowing you to freely show facial expressions,
such as smiling, in untreated areas.
Dysport is a formulation that has been shown to deliver temporary
improvement in moderate to severe frown lines, even with repeat
treatments. So, the effect of repeat treatment with Dysport may
be comparable to your first use.

IMPORTANT SAFETY INFORMATION
Swallowing and breathing problems can be life threatening and there have
been reports of death.
The risk of symptoms is probably greatest in children and adults treated for
muscle spasms, particularly in those patients who have underlying medical
conditions that could make these symptoms more likely.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

3

How does Dysport Work?
With just 1 injection into each of 5 points between and over
the eyebrows, Dysport blocks the signal from the nerve to the
muscles, ultimately resulting in a reduction of muscle activity
and temporarily preventing contraction of the muscles that
cause frown lines. You should not be treated with Dysport more
frequently than every 90 days.
Ask your doctor about your prescription treatment options for
temporarily improving the look of moderate to severe frown lines.
IMPORTANT SAFETY INFORMATION
The toxic effects have been reported at doses similar to those used to treat
muscle spasms in the neck. Lower doses, in both approved and unapproved
uses, have also caused toxic effects. This includes treatment of children and
adults for muscle spasms.

These effects could make it unsafe for you to drive a car, operate machinery,
or do other dangerous activities.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

4

What causes frown lines?
Over time, repeated movement of the facial skin by the
forehead muscles forms lines between the eyebrows.
Frown lines are “dynamic”—they happen because of
the way a person’s face moves.

IMPORTANT SAFETY INFORMATION
Do not have Dysport treatment if you: are allergic to Dysport or any of its ingredients
(see the end of the Medication Guide for a list of ingredients), are allergic to cow’s milk protein,
had an allergic reaction to any other botulinum toxin product (such as Myobloc® or Botox®),
or have a skin infection at the planned injection site.
The dose of Dysport is not the same as the dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to the dose of any other botulinum toxin
product you may have used.
Dysport may not be right for you if: you have surgical changes to your face, very weak
muscles in the treatment area, your face looks very different from side to side, the injection site
is inflamed, you have droopy eyelids or sagging eyelid folds, deep facial scars, thick oily skin, or
if your wrinkles can’t be smoothed by spreading them apart.
5

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Are frown lines always related to age?
No. Because frown lines are created by facial movements,
such as frowning or squinting, they may develop even in
younger adults.

IMPORTANT SAFETY INFORMATION
Tell your doctor about all your medical conditions, including if you have: a disease
that affects your muscles and nerves (such as amyotrophic lateral sclerosis [ALS or Lou
Gehrig’s disease], myasthenia gravis, or Lambert-Eaton syndrome), allergies to any
botulinum toxin product or had any side effect from any botulinum toxin product in the past,
a breathing problem (such as asthma or emphysema), swallowing problems, bleeding
problems, diabetes, a slow heart beat or other problem with your heart rate or rhythm, plans
to have surgery, had surgery on your face, weakness of your forehead muscles (such as
trouble raising your eyebrows), drooping eyelids, or any other change in the way your face
normally looks. Patients with a disease that affects muscles and nerves who are treated with
typical doses of Dysport may have a higher risk of serious side effects, including severe
swallowing and breathing problems.
6

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What can you do about frown lines?
Treatment with prescription Dysport can temporarily
improve the look of your moderate to severe frown lines.
Treatment generally takes just 10 to 20 minutes.
The most common side effects are nose and throat
irritation, headache, injection site pain, injection site skin
reaction, upper respiratory tract infection, eyelid swelling,
eyelid drooping, sinus inflammation, and nausea.

IMPORTANT SAFETY INFORMATION
Human Albumin
This product contains albumin taken from human plasma. Steps taken during donor
screening and product manufacturing processes make the risk of spreading viral diseases
extremely rare. In theory, there is also an extremely rare risk of contracting CreutzfeldtJakob disease (CJD). No cases of spread of viral diseases or CJD have ever been
reported for albumin.
7

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

How do you know if Dysport works?
Clinically proven results with 1 treatment
In 3 clinical studies of people whose frown lines were rated “moderate” or
“severe” by a doctor before their treatment with Dysport:a
• Doctor rating: 30 days after treatment, the majority (88%, 85%, and 86% in each of the 3 studies)
had their frown lines rated by a doctor as “mild” or “moderate” at maximum frown. For example, a
patient could improve from “severe” to “moderate” or from “moderate” to “mild.”
• Patient rating: 30 days after treatment, the majority (74%, 79%, and 82% in each of the 3 studies)
rated their own frown lines as “mild” or “moderate” at maximum frown. For example, a patient could
improve from “severe” to “moderate” or from “moderate” to “mild.”

a

Three double-blind, randomized, placebo-controlled, clinical studies evaluated the efficacy of Dysport for use in the temporary improvement of the appearance of moderate to severe
glabellar lines. These 3 studies enrolled healthy adults (ages 19-75) with glabellar lines of at least moderate severity at maximum frown. Subjects were excluded if they had marked
ptosis, deep dermal scarring, or a substantial inability to lessen glabellar lines, even by physically spreading them apart. The subjects in these studies received either Dysport or a
placebo. The total dose was delivered in equally divided aliquots to specified injection sites.

IMPORTANT SAFETY INFORMATION
Allergic Reaction to Injecting in the Skin
It is not known if an allergic reaction can be caused by injecting Dysport into the skin. The safety of
treating excessive sweating with Dysport is not known.
8

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Common Side Effects
The most common side effects are nose and throat irritation, headache, injection site pain, injection site skin
reaction, upper respiratory tract infection, eyelid swelling, eyelid drooping, sinus inflammation, and nausea.
9

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Tell your doctor about all the medicines you take, including prescription and nonprescription medicines,
vitamins and herbal and other natural products. Using Dysport with certain other medicines may cause
serious side effects.
Do not start any new medicines while taking Dysport without talking to your doctor first.
10

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Especially tell your doctor if you: have received any other botulinum toxin product in the last four
months, have received injections of botulinum toxin, such as Myobloc® (rimabotulinumtoxinB) or Botox®
(onabotulinumtoxinA) in the past (be sure your doctor knows exactly which product you received), have
recently received an antibiotic by injection, take muscle relaxants, take an allergy or cold medicine, or take
a sleep medicine.
11

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Use In Specific Populations
Dysport should not be used in children or in women who are pregnant or breastfeeding.
Ask your doctor if Dysport is right for you.
12

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What to expect with Dysport
A step-by-step guide to your treatment†

1

The Dysport treatment consultation
Discuss your expectations with your doctor and
whether you have any health conditions or
allergies that could interfere with your treatment.
† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

IMPORTANT SAFETY INFORMATION
What is the most important information you should know about Dysport?
Spread of Toxin Effects: In some cases, the effects of Dysport and all botulinum toxin products may affect
areas of the body away from the injection site. These effects can cause symptoms of a serious condition
called botulism. Symptoms of botulism can happen hours to weeks after injection and may include
swallowing and breathing problems, loss of strength and muscle weakness all over the body, double
vision, blurred vision and drooping eyelids, hoarseness or change or loss of voice, trouble saying words
clearly, or loss of bladder control. Swallowing and breathing problems can be life threatening and there
have been reports of death.
The risk of symptoms is probably greatest in children and adults treated for muscle spasms, particularly
in those patients who have underlying medical conditions that could make these symptoms more likely.
13

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What to expect with Dysport
A step-by-step guide to your treatment†

2

The Dysport treatment
Effective treatment requires 1 injection into each
of 5 points between and over the eyebrows.
Although office visit times may vary, the procedure
generally takes 10 to 20 minutes. Your healthcare
professional will determine the exact placement of
each injection to get results that are right for you.

IMPORTANT SAFETY INFORMATION
The toxic effects have been reported at doses similar to those used to treat muscle spasms in
the neck. Lower doses, in both approved and unapproved uses, have also caused toxic effects.
This includes treatment of children and adults for muscle spasms.
These effects could make it unsafe for you to drive a car, operate machinery, or do other
dangerous activities.
Do not have Dysport treatment if you: are allergic to Dysport or any of its ingredients (see the end
of the Medication Guide for a list of ingredients), are allergic to cow’s milk protein, had an allergic
reaction to any other botulinum toxin product, such as Myobloc® or Botox,® or have a skin infection at
the planned injection site.
14

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

What to expect with Dysport
A step-by-step guide to your treatment†

3

After your Dysport treatment
Ask your doctor about any precautions you
should take after your treatment. Call your doctor
or get medical help right away if you have any
problems swallowing, speaking, or breathing.
If this happens, do not drive a car, operate
machinery, or do other dangerous activities.

IMPORTANT SAFETY INFORMATION
The dose of Dysport is not the same as the dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to the dose of any other botulinum toxin
product you may have used.
Dysport may not be right for you if: you have surgical changes to your face, very weak
muscles in the treatment area, your face looks very different from side to side, the injection
site is inflamed, you have droopy eyelids or sagging eyelid folds, deep facial scars, thick oily
skin, or if your wrinkles can’t be smoothed by spreading them apart.
15

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

What to expect with Dysport
A step-by-step guide to your treatment†

4

Follow up
To maintain your improvements, you should
discuss a treatment schedule with your doctor.
As with any botulinum toxin product, you should
wait at least 90 days between treatments.

IMPORTANT SAFETY INFORMATION
Tell your doctor about all your medical conditions, including if you have: a disease that
affects your muscles and nerves (suchas amyotrophic lateral sclerosis [ALS or Lou Gehrig’s
disease], myasthenia gravis, or Lambert-Eaton syndrome), allergies to any botulinum toxin
product or had any side effect from any botulinum toxin product in the past, a breathing problem
(such as asthma or emphysema), swallowing problems, bleeding problems, diabetes, a slow
heart beat or other problem with your heart rate or rhythm, plans to have surgery, had surgery on
your face, weakness of your forehead muscles (such as trouble raising your eyebrows), drooping
eyelids, or any other change in the way your face normally looks. Patients with a disease that
affects muscles and nerves who are treated with typical doses of Dysport may have a higher risk
of serious side effects, including severe swallowing and breathing problems.
16

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

Why not start the Dysport
discussion with your doctor today?
Questions to ask your doctor:
• How soon will I see treatment results?
• How long does one treatment last?
• How often can I receive a Dysport treatment?
• Is there any way to save money on
my treatment?
• Can I have a treatment today?
• What are the risks associated with treatment?
IMPORTANT SAFETY INFORMATION
Human Albumin
This product contains albumin taken from human plasma. Steps taken during donor screening and product
manufacturing processes make the risk of spreading viral diseases extremely rare. In theory, there is also an
extremely rare risk of contracting Creutzfeldt-Jakob disease (CJD). No cases of spread of viral diseases or CJD
have ever been reported for albumin.
17

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Important Safety Information

What is the most important information you
should know about Dysport
(abobotulinumtoxinA) 300 Units for Injection?
Spread of Toxin Effects: In some cases, the
effects of Dysport and all botulinum toxin
products may affect areas of the body away
from the injection site. These effects can
cause symptoms of a serious condition called
botulism. Symptoms of botulism can happen
hours to weeks after injection and may
include swallowing and breathing problems,
loss of strength and muscle weakness all over
the body, double vision, blurred vision and
drooping eyelids, hoarseness or change or
loss of voice, trouble saying words clearly, or
loss of bladder control. Swallowing and
breathing problems can be life threatening
and there have been reports of death.

18

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

The risk of symptoms is probably greatest in
children and adults treated for muscle spasms,
particularly in those patients who have
underlying medical conditions that could make
these symptoms more likely.
The toxic effects have been reported at doses
similar to those used to treat muscle spasms in
the neck. Lower doses, in both approved and
unapproved uses, have also caused toxic
effects. This includes treatment of children and
adults for muscle spasms.
These effects could make it unsafe for you to
drive a car, operate machinery, or do other
dangerous activities.
Do not have Dysport treatment if you: are allergic
to Dysport or any of its ingredients (see the end of
the Medication Guide for a list of ingredients), are
allergic to cow’s milk protein, had an allergic
reaction to any other botulinum toxin product, such
as Myobloc® or Botox,® or have a skin infection at
the planned injection site.

Important Safety Information (cont.)

The dose of Dysport is not the same as the
dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to
the dose of any other botulinum toxin product
you may have used.
Dysport may not be right for you if: you have
surgical changes to your face, very weak muscles
in the treatment area, your face looks very
different from side to side, the injection site is
inflamed, you have droopy eyelids or sagging
eyelid folds, deep facial scars, thick oily skin, or if
your wrinkles can’t be smoothed by spreading
them apart.
Tell your doctor about all your medical
conditions, including if you have: a disease
that affects your muscles and nerves (such as
amyotrophic lateral sclerosis [ALS or Lou
Gehrig’s disease], myasthenia gravis, or LambertEaton syndrome), allergies to any botulinum toxin
product or had any side effect from any

19

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

botulinum toxin product in the past, a breathing
problem (such as asthma or emphysema),
swallowing problems, bleeding problems, diabetes,
a slow heart beat or other problem with your heart
rate or rhythm, plans to have surgery, had surgery
on your face, weakness of your forehead muscles
(such as trouble raising your eyebrows), drooping
eyelids, or any other change in the way your face
normally looks. Patients with a disease that affects
muscles and nerves who are treated with typical
doses of Dysport may have a higher risk of serious
side effects, including severe swallowing and
breathing problems.
Human Albumin
This product contains albumin taken from human
plasma. Steps taken during donor screening and
product manufacturing processes make the risk of
spreading viral diseases extremely rare. In theory,
there is also an extremely rare risk of contracting
Creutzfeldt-Jakob disease (CJD). No cases of
spread of viral diseases or CJD have ever been
reported for albumin.

Important Safety Information (cont.)

Allergic Reaction to Injecting in the Skin
It is not known if an allergic reaction can be
caused by injecting Dysport into the skin. The
safety of treating excessive sweating with Dysport
is not known.
Common Side Effects
The most common side effects are nose and
throat irritation, headache, injection site pain,
injection site skin reaction, upper respiratory tract
infection, eyelid swelling, eyelid drooping, sinus
inflammation, and nausea.
Tell your doctor about all the medicines you
take, including prescription and nonprescription
medicines, vitamins and herbal and other natural
products. Using Dysport with certain other
medicines may cause serious side effects.

20

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

Do not start any new medicines while taking
Dysport without talking to your doctor first.

Especially tell your doctor if you: have received
any other botulinum toxin product in the last four
months, have received injections of botulinum toxin,
such as Myobloc® (rimabotulinumtoxinB) or Botox®
(onabotulinumtoxinA) in the past (be sure your
doctor knows exactly which product you received),
have recently received an antibiotic by injection,
take muscle relaxants, take an allergy or cold
medicine, or take a sleep medicine.
Use In Specific Populations
Dysport should not be used in children or in women
who are pregnant or breastfeeding.
Ask your doctor if Dysport is right for you.

Medication Guide

21

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

22

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

23

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

24

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

25

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

26

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

27

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

28

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

29

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

30

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

31

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

32

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medicis Family
of Aesthetic Products

Products are not FDA approved for combination use.

www.DysportUSA.com

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.
33

The Dysport trademark is used under license. Restylane is a registered trademark of HA North American Sales AB. All other trademarks
are the property of their respective owners. DSP 11-060 10/31/12


Slide 8

Dysport ® is a prescription
injection for temporary
improvement in the look of
moderate to severe frown
lines between the eyebrows
(glabellar lines) in adults less
than 65 years of age.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.
The Dysport trademark is used under license. All other trademarks are the property of their respective owners. DSP 11-060 10/31/12

I do special things for myself,
and I’ll bet you do, too.
I work out, eat right, and take care of my
skin. Of course, cosmetic creams and lotions
will always have their place in my regimen—
but for my moderate to severe frown lines,
I was ready for a prescription treatment.
Maybe you are, too.

IMPORTANT SAFETY INFORMATION
What is the most important information you should know about Dysport?
Spread of Toxin Effects: In some cases, the effects of Dysport and all botulinum toxin products
may affect areas of the body away from the injection site. These effects can cause symptoms of
a serious condition called botulism. Symptoms of botulism can happen hours to weeks after
injection and may include swallowing and breathing problems, loss of strength and muscle
weakness all over the body, double vision, blurred vision and drooping eyelids, hoarseness or
change or loss of voice, trouble saying words clearly, or loss of bladder control.
PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

2

What is Dysport?
Prescription Dysport is an injection used to temporarily improve
the look of your moderate to severe frown lines without changing
the look of your whole face. The untreated facial muscles still
work normally, allowing you to freely show facial expressions,
such as smiling, in untreated areas.
Dysport is a formulation that has been shown to deliver temporary
improvement in moderate to severe frown lines, even with repeat
treatments. So, the effect of repeat treatment with Dysport may
be comparable to your first use.

IMPORTANT SAFETY INFORMATION
Swallowing and breathing problems can be life threatening and there have
been reports of death.
The risk of symptoms is probably greatest in children and adults treated for
muscle spasms, particularly in those patients who have underlying medical
conditions that could make these symptoms more likely.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

3

How does Dysport Work?
With just 1 injection into each of 5 points between and over
the eyebrows, Dysport blocks the signal from the nerve to the
muscles, ultimately resulting in a reduction of muscle activity
and temporarily preventing contraction of the muscles that
cause frown lines. You should not be treated with Dysport more
frequently than every 90 days.
Ask your doctor about your prescription treatment options for
temporarily improving the look of moderate to severe frown lines.
IMPORTANT SAFETY INFORMATION
The toxic effects have been reported at doses similar to those used to treat
muscle spasms in the neck. Lower doses, in both approved and unapproved
uses, have also caused toxic effects. This includes treatment of children and
adults for muscle spasms.

These effects could make it unsafe for you to drive a car, operate machinery,
or do other dangerous activities.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

4

What causes frown lines?
Over time, repeated movement of the facial skin by the
forehead muscles forms lines between the eyebrows.
Frown lines are “dynamic”—they happen because of
the way a person’s face moves.

IMPORTANT SAFETY INFORMATION
Do not have Dysport treatment if you: are allergic to Dysport or any of its ingredients
(see the end of the Medication Guide for a list of ingredients), are allergic to cow’s milk protein,
had an allergic reaction to any other botulinum toxin product (such as Myobloc® or Botox®),
or have a skin infection at the planned injection site.
The dose of Dysport is not the same as the dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to the dose of any other botulinum toxin
product you may have used.
Dysport may not be right for you if: you have surgical changes to your face, very weak
muscles in the treatment area, your face looks very different from side to side, the injection site
is inflamed, you have droopy eyelids or sagging eyelid folds, deep facial scars, thick oily skin, or
if your wrinkles can’t be smoothed by spreading them apart.
5

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Are frown lines always related to age?
No. Because frown lines are created by facial movements,
such as frowning or squinting, they may develop even in
younger adults.

IMPORTANT SAFETY INFORMATION
Tell your doctor about all your medical conditions, including if you have: a disease
that affects your muscles and nerves (such as amyotrophic lateral sclerosis [ALS or Lou
Gehrig’s disease], myasthenia gravis, or Lambert-Eaton syndrome), allergies to any
botulinum toxin product or had any side effect from any botulinum toxin product in the past,
a breathing problem (such as asthma or emphysema), swallowing problems, bleeding
problems, diabetes, a slow heart beat or other problem with your heart rate or rhythm, plans
to have surgery, had surgery on your face, weakness of your forehead muscles (such as
trouble raising your eyebrows), drooping eyelids, or any other change in the way your face
normally looks. Patients with a disease that affects muscles and nerves who are treated with
typical doses of Dysport may have a higher risk of serious side effects, including severe
swallowing and breathing problems.
6

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What can you do about frown lines?
Treatment with prescription Dysport can temporarily
improve the look of your moderate to severe frown lines.
Treatment generally takes just 10 to 20 minutes.
The most common side effects are nose and throat
irritation, headache, injection site pain, injection site skin
reaction, upper respiratory tract infection, eyelid swelling,
eyelid drooping, sinus inflammation, and nausea.

IMPORTANT SAFETY INFORMATION
Human Albumin
This product contains albumin taken from human plasma. Steps taken during donor
screening and product manufacturing processes make the risk of spreading viral diseases
extremely rare. In theory, there is also an extremely rare risk of contracting CreutzfeldtJakob disease (CJD). No cases of spread of viral diseases or CJD have ever been
reported for albumin.
7

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

How do you know if Dysport works?
Clinically proven results with 1 treatment
In 3 clinical studies of people whose frown lines were rated “moderate” or
“severe” by a doctor before their treatment with Dysport:a
• Doctor rating: 30 days after treatment, the majority (88%, 85%, and 86% in each of the 3 studies)
had their frown lines rated by a doctor as “mild” or “moderate” at maximum frown. For example, a
patient could improve from “severe” to “moderate” or from “moderate” to “mild.”
• Patient rating: 30 days after treatment, the majority (74%, 79%, and 82% in each of the 3 studies)
rated their own frown lines as “mild” or “moderate” at maximum frown. For example, a patient could
improve from “severe” to “moderate” or from “moderate” to “mild.”

a

Three double-blind, randomized, placebo-controlled, clinical studies evaluated the efficacy of Dysport for use in the temporary improvement of the appearance of moderate to severe
glabellar lines. These 3 studies enrolled healthy adults (ages 19-75) with glabellar lines of at least moderate severity at maximum frown. Subjects were excluded if they had marked
ptosis, deep dermal scarring, or a substantial inability to lessen glabellar lines, even by physically spreading them apart. The subjects in these studies received either Dysport or a
placebo. The total dose was delivered in equally divided aliquots to specified injection sites.

IMPORTANT SAFETY INFORMATION
Allergic Reaction to Injecting in the Skin
It is not known if an allergic reaction can be caused by injecting Dysport into the skin. The safety of
treating excessive sweating with Dysport is not known.
8

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Common Side Effects
The most common side effects are nose and throat irritation, headache, injection site pain, injection site skin
reaction, upper respiratory tract infection, eyelid swelling, eyelid drooping, sinus inflammation, and nausea.
9

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Tell your doctor about all the medicines you take, including prescription and nonprescription medicines,
vitamins and herbal and other natural products. Using Dysport with certain other medicines may cause
serious side effects.
Do not start any new medicines while taking Dysport without talking to your doctor first.
10

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Especially tell your doctor if you: have received any other botulinum toxin product in the last four
months, have received injections of botulinum toxin, such as Myobloc® (rimabotulinumtoxinB) or Botox®
(onabotulinumtoxinA) in the past (be sure your doctor knows exactly which product you received), have
recently received an antibiotic by injection, take muscle relaxants, take an allergy or cold medicine, or take
a sleep medicine.
11

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Use In Specific Populations
Dysport should not be used in children or in women who are pregnant or breastfeeding.
Ask your doctor if Dysport is right for you.
12

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What to expect with Dysport
A step-by-step guide to your treatment†

1

The Dysport treatment consultation
Discuss your expectations with your doctor and
whether you have any health conditions or
allergies that could interfere with your treatment.
† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

IMPORTANT SAFETY INFORMATION
What is the most important information you should know about Dysport?
Spread of Toxin Effects: In some cases, the effects of Dysport and all botulinum toxin products may affect
areas of the body away from the injection site. These effects can cause symptoms of a serious condition
called botulism. Symptoms of botulism can happen hours to weeks after injection and may include
swallowing and breathing problems, loss of strength and muscle weakness all over the body, double
vision, blurred vision and drooping eyelids, hoarseness or change or loss of voice, trouble saying words
clearly, or loss of bladder control. Swallowing and breathing problems can be life threatening and there
have been reports of death.
The risk of symptoms is probably greatest in children and adults treated for muscle spasms, particularly
in those patients who have underlying medical conditions that could make these symptoms more likely.
13

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What to expect with Dysport
A step-by-step guide to your treatment†

2

The Dysport treatment
Effective treatment requires 1 injection into each
of 5 points between and over the eyebrows.
Although office visit times may vary, the procedure
generally takes 10 to 20 minutes. Your healthcare
professional will determine the exact placement of
each injection to get results that are right for you.

IMPORTANT SAFETY INFORMATION
The toxic effects have been reported at doses similar to those used to treat muscle spasms in
the neck. Lower doses, in both approved and unapproved uses, have also caused toxic effects.
This includes treatment of children and adults for muscle spasms.
These effects could make it unsafe for you to drive a car, operate machinery, or do other
dangerous activities.
Do not have Dysport treatment if you: are allergic to Dysport or any of its ingredients (see the end
of the Medication Guide for a list of ingredients), are allergic to cow’s milk protein, had an allergic
reaction to any other botulinum toxin product, such as Myobloc® or Botox,® or have a skin infection at
the planned injection site.
14

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

What to expect with Dysport
A step-by-step guide to your treatment†

3

After your Dysport treatment
Ask your doctor about any precautions you
should take after your treatment. Call your doctor
or get medical help right away if you have any
problems swallowing, speaking, or breathing.
If this happens, do not drive a car, operate
machinery, or do other dangerous activities.

IMPORTANT SAFETY INFORMATION
The dose of Dysport is not the same as the dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to the dose of any other botulinum toxin
product you may have used.
Dysport may not be right for you if: you have surgical changes to your face, very weak
muscles in the treatment area, your face looks very different from side to side, the injection
site is inflamed, you have droopy eyelids or sagging eyelid folds, deep facial scars, thick oily
skin, or if your wrinkles can’t be smoothed by spreading them apart.
15

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

What to expect with Dysport
A step-by-step guide to your treatment†

4

Follow up
To maintain your improvements, you should
discuss a treatment schedule with your doctor.
As with any botulinum toxin product, you should
wait at least 90 days between treatments.

IMPORTANT SAFETY INFORMATION
Tell your doctor about all your medical conditions, including if you have: a disease that
affects your muscles and nerves (suchas amyotrophic lateral sclerosis [ALS or Lou Gehrig’s
disease], myasthenia gravis, or Lambert-Eaton syndrome), allergies to any botulinum toxin
product or had any side effect from any botulinum toxin product in the past, a breathing problem
(such as asthma or emphysema), swallowing problems, bleeding problems, diabetes, a slow
heart beat or other problem with your heart rate or rhythm, plans to have surgery, had surgery on
your face, weakness of your forehead muscles (such as trouble raising your eyebrows), drooping
eyelids, or any other change in the way your face normally looks. Patients with a disease that
affects muscles and nerves who are treated with typical doses of Dysport may have a higher risk
of serious side effects, including severe swallowing and breathing problems.
16

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

Why not start the Dysport
discussion with your doctor today?
Questions to ask your doctor:
• How soon will I see treatment results?
• How long does one treatment last?
• How often can I receive a Dysport treatment?
• Is there any way to save money on
my treatment?
• Can I have a treatment today?
• What are the risks associated with treatment?
IMPORTANT SAFETY INFORMATION
Human Albumin
This product contains albumin taken from human plasma. Steps taken during donor screening and product
manufacturing processes make the risk of spreading viral diseases extremely rare. In theory, there is also an
extremely rare risk of contracting Creutzfeldt-Jakob disease (CJD). No cases of spread of viral diseases or CJD
have ever been reported for albumin.
17

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Important Safety Information

What is the most important information you
should know about Dysport
(abobotulinumtoxinA) 300 Units for Injection?
Spread of Toxin Effects: In some cases, the
effects of Dysport and all botulinum toxin
products may affect areas of the body away
from the injection site. These effects can
cause symptoms of a serious condition called
botulism. Symptoms of botulism can happen
hours to weeks after injection and may
include swallowing and breathing problems,
loss of strength and muscle weakness all over
the body, double vision, blurred vision and
drooping eyelids, hoarseness or change or
loss of voice, trouble saying words clearly, or
loss of bladder control. Swallowing and
breathing problems can be life threatening
and there have been reports of death.

18

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

The risk of symptoms is probably greatest in
children and adults treated for muscle spasms,
particularly in those patients who have
underlying medical conditions that could make
these symptoms more likely.
The toxic effects have been reported at doses
similar to those used to treat muscle spasms in
the neck. Lower doses, in both approved and
unapproved uses, have also caused toxic
effects. This includes treatment of children and
adults for muscle spasms.
These effects could make it unsafe for you to
drive a car, operate machinery, or do other
dangerous activities.
Do not have Dysport treatment if you: are allergic
to Dysport or any of its ingredients (see the end of
the Medication Guide for a list of ingredients), are
allergic to cow’s milk protein, had an allergic
reaction to any other botulinum toxin product, such
as Myobloc® or Botox,® or have a skin infection at
the planned injection site.

Important Safety Information (cont.)

The dose of Dysport is not the same as the
dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to
the dose of any other botulinum toxin product
you may have used.
Dysport may not be right for you if: you have
surgical changes to your face, very weak muscles
in the treatment area, your face looks very
different from side to side, the injection site is
inflamed, you have droopy eyelids or sagging
eyelid folds, deep facial scars, thick oily skin, or if
your wrinkles can’t be smoothed by spreading
them apart.
Tell your doctor about all your medical
conditions, including if you have: a disease
that affects your muscles and nerves (such as
amyotrophic lateral sclerosis [ALS or Lou
Gehrig’s disease], myasthenia gravis, or LambertEaton syndrome), allergies to any botulinum toxin
product or had any side effect from any

19

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

botulinum toxin product in the past, a breathing
problem (such as asthma or emphysema),
swallowing problems, bleeding problems, diabetes,
a slow heart beat or other problem with your heart
rate or rhythm, plans to have surgery, had surgery
on your face, weakness of your forehead muscles
(such as trouble raising your eyebrows), drooping
eyelids, or any other change in the way your face
normally looks. Patients with a disease that affects
muscles and nerves who are treated with typical
doses of Dysport may have a higher risk of serious
side effects, including severe swallowing and
breathing problems.
Human Albumin
This product contains albumin taken from human
plasma. Steps taken during donor screening and
product manufacturing processes make the risk of
spreading viral diseases extremely rare. In theory,
there is also an extremely rare risk of contracting
Creutzfeldt-Jakob disease (CJD). No cases of
spread of viral diseases or CJD have ever been
reported for albumin.

Important Safety Information (cont.)

Allergic Reaction to Injecting in the Skin
It is not known if an allergic reaction can be
caused by injecting Dysport into the skin. The
safety of treating excessive sweating with Dysport
is not known.
Common Side Effects
The most common side effects are nose and
throat irritation, headache, injection site pain,
injection site skin reaction, upper respiratory tract
infection, eyelid swelling, eyelid drooping, sinus
inflammation, and nausea.
Tell your doctor about all the medicines you
take, including prescription and nonprescription
medicines, vitamins and herbal and other natural
products. Using Dysport with certain other
medicines may cause serious side effects.

20

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

Do not start any new medicines while taking
Dysport without talking to your doctor first.

Especially tell your doctor if you: have received
any other botulinum toxin product in the last four
months, have received injections of botulinum toxin,
such as Myobloc® (rimabotulinumtoxinB) or Botox®
(onabotulinumtoxinA) in the past (be sure your
doctor knows exactly which product you received),
have recently received an antibiotic by injection,
take muscle relaxants, take an allergy or cold
medicine, or take a sleep medicine.
Use In Specific Populations
Dysport should not be used in children or in women
who are pregnant or breastfeeding.
Ask your doctor if Dysport is right for you.

Medication Guide

21

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

22

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

23

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

24

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

25

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

26

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

27

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

28

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

29

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

30

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

31

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

32

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medicis Family
of Aesthetic Products

Products are not FDA approved for combination use.

www.DysportUSA.com

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.
33

The Dysport trademark is used under license. Restylane is a registered trademark of HA North American Sales AB. All other trademarks
are the property of their respective owners. DSP 11-060 10/31/12


Slide 9

Dysport ® is a prescription
injection for temporary
improvement in the look of
moderate to severe frown
lines between the eyebrows
(glabellar lines) in adults less
than 65 years of age.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.
The Dysport trademark is used under license. All other trademarks are the property of their respective owners. DSP 11-060 10/31/12

I do special things for myself,
and I’ll bet you do, too.
I work out, eat right, and take care of my
skin. Of course, cosmetic creams and lotions
will always have their place in my regimen—
but for my moderate to severe frown lines,
I was ready for a prescription treatment.
Maybe you are, too.

IMPORTANT SAFETY INFORMATION
What is the most important information you should know about Dysport?
Spread of Toxin Effects: In some cases, the effects of Dysport and all botulinum toxin products
may affect areas of the body away from the injection site. These effects can cause symptoms of
a serious condition called botulism. Symptoms of botulism can happen hours to weeks after
injection and may include swallowing and breathing problems, loss of strength and muscle
weakness all over the body, double vision, blurred vision and drooping eyelids, hoarseness or
change or loss of voice, trouble saying words clearly, or loss of bladder control.
PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

2

What is Dysport?
Prescription Dysport is an injection used to temporarily improve
the look of your moderate to severe frown lines without changing
the look of your whole face. The untreated facial muscles still
work normally, allowing you to freely show facial expressions,
such as smiling, in untreated areas.
Dysport is a formulation that has been shown to deliver temporary
improvement in moderate to severe frown lines, even with repeat
treatments. So, the effect of repeat treatment with Dysport may
be comparable to your first use.

IMPORTANT SAFETY INFORMATION
Swallowing and breathing problems can be life threatening and there have
been reports of death.
The risk of symptoms is probably greatest in children and adults treated for
muscle spasms, particularly in those patients who have underlying medical
conditions that could make these symptoms more likely.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

3

How does Dysport Work?
With just 1 injection into each of 5 points between and over
the eyebrows, Dysport blocks the signal from the nerve to the
muscles, ultimately resulting in a reduction of muscle activity
and temporarily preventing contraction of the muscles that
cause frown lines. You should not be treated with Dysport more
frequently than every 90 days.
Ask your doctor about your prescription treatment options for
temporarily improving the look of moderate to severe frown lines.
IMPORTANT SAFETY INFORMATION
The toxic effects have been reported at doses similar to those used to treat
muscle spasms in the neck. Lower doses, in both approved and unapproved
uses, have also caused toxic effects. This includes treatment of children and
adults for muscle spasms.

These effects could make it unsafe for you to drive a car, operate machinery,
or do other dangerous activities.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

4

What causes frown lines?
Over time, repeated movement of the facial skin by the
forehead muscles forms lines between the eyebrows.
Frown lines are “dynamic”—they happen because of
the way a person’s face moves.

IMPORTANT SAFETY INFORMATION
Do not have Dysport treatment if you: are allergic to Dysport or any of its ingredients
(see the end of the Medication Guide for a list of ingredients), are allergic to cow’s milk protein,
had an allergic reaction to any other botulinum toxin product (such as Myobloc® or Botox®),
or have a skin infection at the planned injection site.
The dose of Dysport is not the same as the dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to the dose of any other botulinum toxin
product you may have used.
Dysport may not be right for you if: you have surgical changes to your face, very weak
muscles in the treatment area, your face looks very different from side to side, the injection site
is inflamed, you have droopy eyelids or sagging eyelid folds, deep facial scars, thick oily skin, or
if your wrinkles can’t be smoothed by spreading them apart.
5

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Are frown lines always related to age?
No. Because frown lines are created by facial movements,
such as frowning or squinting, they may develop even in
younger adults.

IMPORTANT SAFETY INFORMATION
Tell your doctor about all your medical conditions, including if you have: a disease
that affects your muscles and nerves (such as amyotrophic lateral sclerosis [ALS or Lou
Gehrig’s disease], myasthenia gravis, or Lambert-Eaton syndrome), allergies to any
botulinum toxin product or had any side effect from any botulinum toxin product in the past,
a breathing problem (such as asthma or emphysema), swallowing problems, bleeding
problems, diabetes, a slow heart beat or other problem with your heart rate or rhythm, plans
to have surgery, had surgery on your face, weakness of your forehead muscles (such as
trouble raising your eyebrows), drooping eyelids, or any other change in the way your face
normally looks. Patients with a disease that affects muscles and nerves who are treated with
typical doses of Dysport may have a higher risk of serious side effects, including severe
swallowing and breathing problems.
6

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What can you do about frown lines?
Treatment with prescription Dysport can temporarily
improve the look of your moderate to severe frown lines.
Treatment generally takes just 10 to 20 minutes.
The most common side effects are nose and throat
irritation, headache, injection site pain, injection site skin
reaction, upper respiratory tract infection, eyelid swelling,
eyelid drooping, sinus inflammation, and nausea.

IMPORTANT SAFETY INFORMATION
Human Albumin
This product contains albumin taken from human plasma. Steps taken during donor
screening and product manufacturing processes make the risk of spreading viral diseases
extremely rare. In theory, there is also an extremely rare risk of contracting CreutzfeldtJakob disease (CJD). No cases of spread of viral diseases or CJD have ever been
reported for albumin.
7

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

How do you know if Dysport works?
Clinically proven results with 1 treatment
In 3 clinical studies of people whose frown lines were rated “moderate” or
“severe” by a doctor before their treatment with Dysport:a
• Doctor rating: 30 days after treatment, the majority (88%, 85%, and 86% in each of the 3 studies)
had their frown lines rated by a doctor as “mild” or “moderate” at maximum frown. For example, a
patient could improve from “severe” to “moderate” or from “moderate” to “mild.”
• Patient rating: 30 days after treatment, the majority (74%, 79%, and 82% in each of the 3 studies)
rated their own frown lines as “mild” or “moderate” at maximum frown. For example, a patient could
improve from “severe” to “moderate” or from “moderate” to “mild.”

a

Three double-blind, randomized, placebo-controlled, clinical studies evaluated the efficacy of Dysport for use in the temporary improvement of the appearance of moderate to severe
glabellar lines. These 3 studies enrolled healthy adults (ages 19-75) with glabellar lines of at least moderate severity at maximum frown. Subjects were excluded if they had marked
ptosis, deep dermal scarring, or a substantial inability to lessen glabellar lines, even by physically spreading them apart. The subjects in these studies received either Dysport or a
placebo. The total dose was delivered in equally divided aliquots to specified injection sites.

IMPORTANT SAFETY INFORMATION
Allergic Reaction to Injecting in the Skin
It is not known if an allergic reaction can be caused by injecting Dysport into the skin. The safety of
treating excessive sweating with Dysport is not known.
8

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Common Side Effects
The most common side effects are nose and throat irritation, headache, injection site pain, injection site skin
reaction, upper respiratory tract infection, eyelid swelling, eyelid drooping, sinus inflammation, and nausea.
9

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Tell your doctor about all the medicines you take, including prescription and nonprescription medicines,
vitamins and herbal and other natural products. Using Dysport with certain other medicines may cause
serious side effects.
Do not start any new medicines while taking Dysport without talking to your doctor first.
10

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Especially tell your doctor if you: have received any other botulinum toxin product in the last four
months, have received injections of botulinum toxin, such as Myobloc® (rimabotulinumtoxinB) or Botox®
(onabotulinumtoxinA) in the past (be sure your doctor knows exactly which product you received), have
recently received an antibiotic by injection, take muscle relaxants, take an allergy or cold medicine, or take
a sleep medicine.
11

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Use In Specific Populations
Dysport should not be used in children or in women who are pregnant or breastfeeding.
Ask your doctor if Dysport is right for you.
12

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What to expect with Dysport
A step-by-step guide to your treatment†

1

The Dysport treatment consultation
Discuss your expectations with your doctor and
whether you have any health conditions or
allergies that could interfere with your treatment.
† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

IMPORTANT SAFETY INFORMATION
What is the most important information you should know about Dysport?
Spread of Toxin Effects: In some cases, the effects of Dysport and all botulinum toxin products may affect
areas of the body away from the injection site. These effects can cause symptoms of a serious condition
called botulism. Symptoms of botulism can happen hours to weeks after injection and may include
swallowing and breathing problems, loss of strength and muscle weakness all over the body, double
vision, blurred vision and drooping eyelids, hoarseness or change or loss of voice, trouble saying words
clearly, or loss of bladder control. Swallowing and breathing problems can be life threatening and there
have been reports of death.
The risk of symptoms is probably greatest in children and adults treated for muscle spasms, particularly
in those patients who have underlying medical conditions that could make these symptoms more likely.
13

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What to expect with Dysport
A step-by-step guide to your treatment†

2

The Dysport treatment
Effective treatment requires 1 injection into each
of 5 points between and over the eyebrows.
Although office visit times may vary, the procedure
generally takes 10 to 20 minutes. Your healthcare
professional will determine the exact placement of
each injection to get results that are right for you.

IMPORTANT SAFETY INFORMATION
The toxic effects have been reported at doses similar to those used to treat muscle spasms in
the neck. Lower doses, in both approved and unapproved uses, have also caused toxic effects.
This includes treatment of children and adults for muscle spasms.
These effects could make it unsafe for you to drive a car, operate machinery, or do other
dangerous activities.
Do not have Dysport treatment if you: are allergic to Dysport or any of its ingredients (see the end
of the Medication Guide for a list of ingredients), are allergic to cow’s milk protein, had an allergic
reaction to any other botulinum toxin product, such as Myobloc® or Botox,® or have a skin infection at
the planned injection site.
14

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

What to expect with Dysport
A step-by-step guide to your treatment†

3

After your Dysport treatment
Ask your doctor about any precautions you
should take after your treatment. Call your doctor
or get medical help right away if you have any
problems swallowing, speaking, or breathing.
If this happens, do not drive a car, operate
machinery, or do other dangerous activities.

IMPORTANT SAFETY INFORMATION
The dose of Dysport is not the same as the dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to the dose of any other botulinum toxin
product you may have used.
Dysport may not be right for you if: you have surgical changes to your face, very weak
muscles in the treatment area, your face looks very different from side to side, the injection
site is inflamed, you have droopy eyelids or sagging eyelid folds, deep facial scars, thick oily
skin, or if your wrinkles can’t be smoothed by spreading them apart.
15

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

What to expect with Dysport
A step-by-step guide to your treatment†

4

Follow up
To maintain your improvements, you should
discuss a treatment schedule with your doctor.
As with any botulinum toxin product, you should
wait at least 90 days between treatments.

IMPORTANT SAFETY INFORMATION
Tell your doctor about all your medical conditions, including if you have: a disease that
affects your muscles and nerves (suchas amyotrophic lateral sclerosis [ALS or Lou Gehrig’s
disease], myasthenia gravis, or Lambert-Eaton syndrome), allergies to any botulinum toxin
product or had any side effect from any botulinum toxin product in the past, a breathing problem
(such as asthma or emphysema), swallowing problems, bleeding problems, diabetes, a slow
heart beat or other problem with your heart rate or rhythm, plans to have surgery, had surgery on
your face, weakness of your forehead muscles (such as trouble raising your eyebrows), drooping
eyelids, or any other change in the way your face normally looks. Patients with a disease that
affects muscles and nerves who are treated with typical doses of Dysport may have a higher risk
of serious side effects, including severe swallowing and breathing problems.
16

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

Why not start the Dysport
discussion with your doctor today?
Questions to ask your doctor:
• How soon will I see treatment results?
• How long does one treatment last?
• How often can I receive a Dysport treatment?
• Is there any way to save money on
my treatment?
• Can I have a treatment today?
• What are the risks associated with treatment?
IMPORTANT SAFETY INFORMATION
Human Albumin
This product contains albumin taken from human plasma. Steps taken during donor screening and product
manufacturing processes make the risk of spreading viral diseases extremely rare. In theory, there is also an
extremely rare risk of contracting Creutzfeldt-Jakob disease (CJD). No cases of spread of viral diseases or CJD
have ever been reported for albumin.
17

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Important Safety Information

What is the most important information you
should know about Dysport
(abobotulinumtoxinA) 300 Units for Injection?
Spread of Toxin Effects: In some cases, the
effects of Dysport and all botulinum toxin
products may affect areas of the body away
from the injection site. These effects can
cause symptoms of a serious condition called
botulism. Symptoms of botulism can happen
hours to weeks after injection and may
include swallowing and breathing problems,
loss of strength and muscle weakness all over
the body, double vision, blurred vision and
drooping eyelids, hoarseness or change or
loss of voice, trouble saying words clearly, or
loss of bladder control. Swallowing and
breathing problems can be life threatening
and there have been reports of death.

18

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

The risk of symptoms is probably greatest in
children and adults treated for muscle spasms,
particularly in those patients who have
underlying medical conditions that could make
these symptoms more likely.
The toxic effects have been reported at doses
similar to those used to treat muscle spasms in
the neck. Lower doses, in both approved and
unapproved uses, have also caused toxic
effects. This includes treatment of children and
adults for muscle spasms.
These effects could make it unsafe for you to
drive a car, operate machinery, or do other
dangerous activities.
Do not have Dysport treatment if you: are allergic
to Dysport or any of its ingredients (see the end of
the Medication Guide for a list of ingredients), are
allergic to cow’s milk protein, had an allergic
reaction to any other botulinum toxin product, such
as Myobloc® or Botox,® or have a skin infection at
the planned injection site.

Important Safety Information (cont.)

The dose of Dysport is not the same as the
dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to
the dose of any other botulinum toxin product
you may have used.
Dysport may not be right for you if: you have
surgical changes to your face, very weak muscles
in the treatment area, your face looks very
different from side to side, the injection site is
inflamed, you have droopy eyelids or sagging
eyelid folds, deep facial scars, thick oily skin, or if
your wrinkles can’t be smoothed by spreading
them apart.
Tell your doctor about all your medical
conditions, including if you have: a disease
that affects your muscles and nerves (such as
amyotrophic lateral sclerosis [ALS or Lou
Gehrig’s disease], myasthenia gravis, or LambertEaton syndrome), allergies to any botulinum toxin
product or had any side effect from any

19

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

botulinum toxin product in the past, a breathing
problem (such as asthma or emphysema),
swallowing problems, bleeding problems, diabetes,
a slow heart beat or other problem with your heart
rate or rhythm, plans to have surgery, had surgery
on your face, weakness of your forehead muscles
(such as trouble raising your eyebrows), drooping
eyelids, or any other change in the way your face
normally looks. Patients with a disease that affects
muscles and nerves who are treated with typical
doses of Dysport may have a higher risk of serious
side effects, including severe swallowing and
breathing problems.
Human Albumin
This product contains albumin taken from human
plasma. Steps taken during donor screening and
product manufacturing processes make the risk of
spreading viral diseases extremely rare. In theory,
there is also an extremely rare risk of contracting
Creutzfeldt-Jakob disease (CJD). No cases of
spread of viral diseases or CJD have ever been
reported for albumin.

Important Safety Information (cont.)

Allergic Reaction to Injecting in the Skin
It is not known if an allergic reaction can be
caused by injecting Dysport into the skin. The
safety of treating excessive sweating with Dysport
is not known.
Common Side Effects
The most common side effects are nose and
throat irritation, headache, injection site pain,
injection site skin reaction, upper respiratory tract
infection, eyelid swelling, eyelid drooping, sinus
inflammation, and nausea.
Tell your doctor about all the medicines you
take, including prescription and nonprescription
medicines, vitamins and herbal and other natural
products. Using Dysport with certain other
medicines may cause serious side effects.

20

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

Do not start any new medicines while taking
Dysport without talking to your doctor first.

Especially tell your doctor if you: have received
any other botulinum toxin product in the last four
months, have received injections of botulinum toxin,
such as Myobloc® (rimabotulinumtoxinB) or Botox®
(onabotulinumtoxinA) in the past (be sure your
doctor knows exactly which product you received),
have recently received an antibiotic by injection,
take muscle relaxants, take an allergy or cold
medicine, or take a sleep medicine.
Use In Specific Populations
Dysport should not be used in children or in women
who are pregnant or breastfeeding.
Ask your doctor if Dysport is right for you.

Medication Guide

21

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

22

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

23

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

24

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

25

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

26

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

27

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

28

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

29

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

30

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

31

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

32

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medicis Family
of Aesthetic Products

Products are not FDA approved for combination use.

www.DysportUSA.com

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.
33

The Dysport trademark is used under license. Restylane is a registered trademark of HA North American Sales AB. All other trademarks
are the property of their respective owners. DSP 11-060 10/31/12


Slide 10

Dysport ® is a prescription
injection for temporary
improvement in the look of
moderate to severe frown
lines between the eyebrows
(glabellar lines) in adults less
than 65 years of age.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.
The Dysport trademark is used under license. All other trademarks are the property of their respective owners. DSP 11-060 10/31/12

I do special things for myself,
and I’ll bet you do, too.
I work out, eat right, and take care of my
skin. Of course, cosmetic creams and lotions
will always have their place in my regimen—
but for my moderate to severe frown lines,
I was ready for a prescription treatment.
Maybe you are, too.

IMPORTANT SAFETY INFORMATION
What is the most important information you should know about Dysport?
Spread of Toxin Effects: In some cases, the effects of Dysport and all botulinum toxin products
may affect areas of the body away from the injection site. These effects can cause symptoms of
a serious condition called botulism. Symptoms of botulism can happen hours to weeks after
injection and may include swallowing and breathing problems, loss of strength and muscle
weakness all over the body, double vision, blurred vision and drooping eyelids, hoarseness or
change or loss of voice, trouble saying words clearly, or loss of bladder control.
PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

2

What is Dysport?
Prescription Dysport is an injection used to temporarily improve
the look of your moderate to severe frown lines without changing
the look of your whole face. The untreated facial muscles still
work normally, allowing you to freely show facial expressions,
such as smiling, in untreated areas.
Dysport is a formulation that has been shown to deliver temporary
improvement in moderate to severe frown lines, even with repeat
treatments. So, the effect of repeat treatment with Dysport may
be comparable to your first use.

IMPORTANT SAFETY INFORMATION
Swallowing and breathing problems can be life threatening and there have
been reports of death.
The risk of symptoms is probably greatest in children and adults treated for
muscle spasms, particularly in those patients who have underlying medical
conditions that could make these symptoms more likely.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

3

How does Dysport Work?
With just 1 injection into each of 5 points between and over
the eyebrows, Dysport blocks the signal from the nerve to the
muscles, ultimately resulting in a reduction of muscle activity
and temporarily preventing contraction of the muscles that
cause frown lines. You should not be treated with Dysport more
frequently than every 90 days.
Ask your doctor about your prescription treatment options for
temporarily improving the look of moderate to severe frown lines.
IMPORTANT SAFETY INFORMATION
The toxic effects have been reported at doses similar to those used to treat
muscle spasms in the neck. Lower doses, in both approved and unapproved
uses, have also caused toxic effects. This includes treatment of children and
adults for muscle spasms.

These effects could make it unsafe for you to drive a car, operate machinery,
or do other dangerous activities.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

4

What causes frown lines?
Over time, repeated movement of the facial skin by the
forehead muscles forms lines between the eyebrows.
Frown lines are “dynamic”—they happen because of
the way a person’s face moves.

IMPORTANT SAFETY INFORMATION
Do not have Dysport treatment if you: are allergic to Dysport or any of its ingredients
(see the end of the Medication Guide for a list of ingredients), are allergic to cow’s milk protein,
had an allergic reaction to any other botulinum toxin product (such as Myobloc® or Botox®),
or have a skin infection at the planned injection site.
The dose of Dysport is not the same as the dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to the dose of any other botulinum toxin
product you may have used.
Dysport may not be right for you if: you have surgical changes to your face, very weak
muscles in the treatment area, your face looks very different from side to side, the injection site
is inflamed, you have droopy eyelids or sagging eyelid folds, deep facial scars, thick oily skin, or
if your wrinkles can’t be smoothed by spreading them apart.
5

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Are frown lines always related to age?
No. Because frown lines are created by facial movements,
such as frowning or squinting, they may develop even in
younger adults.

IMPORTANT SAFETY INFORMATION
Tell your doctor about all your medical conditions, including if you have: a disease
that affects your muscles and nerves (such as amyotrophic lateral sclerosis [ALS or Lou
Gehrig’s disease], myasthenia gravis, or Lambert-Eaton syndrome), allergies to any
botulinum toxin product or had any side effect from any botulinum toxin product in the past,
a breathing problem (such as asthma or emphysema), swallowing problems, bleeding
problems, diabetes, a slow heart beat or other problem with your heart rate or rhythm, plans
to have surgery, had surgery on your face, weakness of your forehead muscles (such as
trouble raising your eyebrows), drooping eyelids, or any other change in the way your face
normally looks. Patients with a disease that affects muscles and nerves who are treated with
typical doses of Dysport may have a higher risk of serious side effects, including severe
swallowing and breathing problems.
6

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What can you do about frown lines?
Treatment with prescription Dysport can temporarily
improve the look of your moderate to severe frown lines.
Treatment generally takes just 10 to 20 minutes.
The most common side effects are nose and throat
irritation, headache, injection site pain, injection site skin
reaction, upper respiratory tract infection, eyelid swelling,
eyelid drooping, sinus inflammation, and nausea.

IMPORTANT SAFETY INFORMATION
Human Albumin
This product contains albumin taken from human plasma. Steps taken during donor
screening and product manufacturing processes make the risk of spreading viral diseases
extremely rare. In theory, there is also an extremely rare risk of contracting CreutzfeldtJakob disease (CJD). No cases of spread of viral diseases or CJD have ever been
reported for albumin.
7

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

How do you know if Dysport works?
Clinically proven results with 1 treatment
In 3 clinical studies of people whose frown lines were rated “moderate” or
“severe” by a doctor before their treatment with Dysport:a
• Doctor rating: 30 days after treatment, the majority (88%, 85%, and 86% in each of the 3 studies)
had their frown lines rated by a doctor as “mild” or “moderate” at maximum frown. For example, a
patient could improve from “severe” to “moderate” or from “moderate” to “mild.”
• Patient rating: 30 days after treatment, the majority (74%, 79%, and 82% in each of the 3 studies)
rated their own frown lines as “mild” or “moderate” at maximum frown. For example, a patient could
improve from “severe” to “moderate” or from “moderate” to “mild.”

a

Three double-blind, randomized, placebo-controlled, clinical studies evaluated the efficacy of Dysport for use in the temporary improvement of the appearance of moderate to severe
glabellar lines. These 3 studies enrolled healthy adults (ages 19-75) with glabellar lines of at least moderate severity at maximum frown. Subjects were excluded if they had marked
ptosis, deep dermal scarring, or a substantial inability to lessen glabellar lines, even by physically spreading them apart. The subjects in these studies received either Dysport or a
placebo. The total dose was delivered in equally divided aliquots to specified injection sites.

IMPORTANT SAFETY INFORMATION
Allergic Reaction to Injecting in the Skin
It is not known if an allergic reaction can be caused by injecting Dysport into the skin. The safety of
treating excessive sweating with Dysport is not known.
8

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Common Side Effects
The most common side effects are nose and throat irritation, headache, injection site pain, injection site skin
reaction, upper respiratory tract infection, eyelid swelling, eyelid drooping, sinus inflammation, and nausea.
9

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Tell your doctor about all the medicines you take, including prescription and nonprescription medicines,
vitamins and herbal and other natural products. Using Dysport with certain other medicines may cause
serious side effects.
Do not start any new medicines while taking Dysport without talking to your doctor first.
10

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Especially tell your doctor if you: have received any other botulinum toxin product in the last four
months, have received injections of botulinum toxin, such as Myobloc® (rimabotulinumtoxinB) or Botox®
(onabotulinumtoxinA) in the past (be sure your doctor knows exactly which product you received), have
recently received an antibiotic by injection, take muscle relaxants, take an allergy or cold medicine, or take
a sleep medicine.
11

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Use In Specific Populations
Dysport should not be used in children or in women who are pregnant or breastfeeding.
Ask your doctor if Dysport is right for you.
12

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What to expect with Dysport
A step-by-step guide to your treatment†

1

The Dysport treatment consultation
Discuss your expectations with your doctor and
whether you have any health conditions or
allergies that could interfere with your treatment.
† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

IMPORTANT SAFETY INFORMATION
What is the most important information you should know about Dysport?
Spread of Toxin Effects: In some cases, the effects of Dysport and all botulinum toxin products may affect
areas of the body away from the injection site. These effects can cause symptoms of a serious condition
called botulism. Symptoms of botulism can happen hours to weeks after injection and may include
swallowing and breathing problems, loss of strength and muscle weakness all over the body, double
vision, blurred vision and drooping eyelids, hoarseness or change or loss of voice, trouble saying words
clearly, or loss of bladder control. Swallowing and breathing problems can be life threatening and there
have been reports of death.
The risk of symptoms is probably greatest in children and adults treated for muscle spasms, particularly
in those patients who have underlying medical conditions that could make these symptoms more likely.
13

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What to expect with Dysport
A step-by-step guide to your treatment†

2

The Dysport treatment
Effective treatment requires 1 injection into each
of 5 points between and over the eyebrows.
Although office visit times may vary, the procedure
generally takes 10 to 20 minutes. Your healthcare
professional will determine the exact placement of
each injection to get results that are right for you.

IMPORTANT SAFETY INFORMATION
The toxic effects have been reported at doses similar to those used to treat muscle spasms in
the neck. Lower doses, in both approved and unapproved uses, have also caused toxic effects.
This includes treatment of children and adults for muscle spasms.
These effects could make it unsafe for you to drive a car, operate machinery, or do other
dangerous activities.
Do not have Dysport treatment if you: are allergic to Dysport or any of its ingredients (see the end
of the Medication Guide for a list of ingredients), are allergic to cow’s milk protein, had an allergic
reaction to any other botulinum toxin product, such as Myobloc® or Botox,® or have a skin infection at
the planned injection site.
14

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

What to expect with Dysport
A step-by-step guide to your treatment†

3

After your Dysport treatment
Ask your doctor about any precautions you
should take after your treatment. Call your doctor
or get medical help right away if you have any
problems swallowing, speaking, or breathing.
If this happens, do not drive a car, operate
machinery, or do other dangerous activities.

IMPORTANT SAFETY INFORMATION
The dose of Dysport is not the same as the dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to the dose of any other botulinum toxin
product you may have used.
Dysport may not be right for you if: you have surgical changes to your face, very weak
muscles in the treatment area, your face looks very different from side to side, the injection
site is inflamed, you have droopy eyelids or sagging eyelid folds, deep facial scars, thick oily
skin, or if your wrinkles can’t be smoothed by spreading them apart.
15

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

What to expect with Dysport
A step-by-step guide to your treatment†

4

Follow up
To maintain your improvements, you should
discuss a treatment schedule with your doctor.
As with any botulinum toxin product, you should
wait at least 90 days between treatments.

IMPORTANT SAFETY INFORMATION
Tell your doctor about all your medical conditions, including if you have: a disease that
affects your muscles and nerves (suchas amyotrophic lateral sclerosis [ALS or Lou Gehrig’s
disease], myasthenia gravis, or Lambert-Eaton syndrome), allergies to any botulinum toxin
product or had any side effect from any botulinum toxin product in the past, a breathing problem
(such as asthma or emphysema), swallowing problems, bleeding problems, diabetes, a slow
heart beat or other problem with your heart rate or rhythm, plans to have surgery, had surgery on
your face, weakness of your forehead muscles (such as trouble raising your eyebrows), drooping
eyelids, or any other change in the way your face normally looks. Patients with a disease that
affects muscles and nerves who are treated with typical doses of Dysport may have a higher risk
of serious side effects, including severe swallowing and breathing problems.
16

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

Why not start the Dysport
discussion with your doctor today?
Questions to ask your doctor:
• How soon will I see treatment results?
• How long does one treatment last?
• How often can I receive a Dysport treatment?
• Is there any way to save money on
my treatment?
• Can I have a treatment today?
• What are the risks associated with treatment?
IMPORTANT SAFETY INFORMATION
Human Albumin
This product contains albumin taken from human plasma. Steps taken during donor screening and product
manufacturing processes make the risk of spreading viral diseases extremely rare. In theory, there is also an
extremely rare risk of contracting Creutzfeldt-Jakob disease (CJD). No cases of spread of viral diseases or CJD
have ever been reported for albumin.
17

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Important Safety Information

What is the most important information you
should know about Dysport
(abobotulinumtoxinA) 300 Units for Injection?
Spread of Toxin Effects: In some cases, the
effects of Dysport and all botulinum toxin
products may affect areas of the body away
from the injection site. These effects can
cause symptoms of a serious condition called
botulism. Symptoms of botulism can happen
hours to weeks after injection and may
include swallowing and breathing problems,
loss of strength and muscle weakness all over
the body, double vision, blurred vision and
drooping eyelids, hoarseness or change or
loss of voice, trouble saying words clearly, or
loss of bladder control. Swallowing and
breathing problems can be life threatening
and there have been reports of death.

18

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

The risk of symptoms is probably greatest in
children and adults treated for muscle spasms,
particularly in those patients who have
underlying medical conditions that could make
these symptoms more likely.
The toxic effects have been reported at doses
similar to those used to treat muscle spasms in
the neck. Lower doses, in both approved and
unapproved uses, have also caused toxic
effects. This includes treatment of children and
adults for muscle spasms.
These effects could make it unsafe for you to
drive a car, operate machinery, or do other
dangerous activities.
Do not have Dysport treatment if you: are allergic
to Dysport or any of its ingredients (see the end of
the Medication Guide for a list of ingredients), are
allergic to cow’s milk protein, had an allergic
reaction to any other botulinum toxin product, such
as Myobloc® or Botox,® or have a skin infection at
the planned injection site.

Important Safety Information (cont.)

The dose of Dysport is not the same as the
dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to
the dose of any other botulinum toxin product
you may have used.
Dysport may not be right for you if: you have
surgical changes to your face, very weak muscles
in the treatment area, your face looks very
different from side to side, the injection site is
inflamed, you have droopy eyelids or sagging
eyelid folds, deep facial scars, thick oily skin, or if
your wrinkles can’t be smoothed by spreading
them apart.
Tell your doctor about all your medical
conditions, including if you have: a disease
that affects your muscles and nerves (such as
amyotrophic lateral sclerosis [ALS or Lou
Gehrig’s disease], myasthenia gravis, or LambertEaton syndrome), allergies to any botulinum toxin
product or had any side effect from any

19

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

botulinum toxin product in the past, a breathing
problem (such as asthma or emphysema),
swallowing problems, bleeding problems, diabetes,
a slow heart beat or other problem with your heart
rate or rhythm, plans to have surgery, had surgery
on your face, weakness of your forehead muscles
(such as trouble raising your eyebrows), drooping
eyelids, or any other change in the way your face
normally looks. Patients with a disease that affects
muscles and nerves who are treated with typical
doses of Dysport may have a higher risk of serious
side effects, including severe swallowing and
breathing problems.
Human Albumin
This product contains albumin taken from human
plasma. Steps taken during donor screening and
product manufacturing processes make the risk of
spreading viral diseases extremely rare. In theory,
there is also an extremely rare risk of contracting
Creutzfeldt-Jakob disease (CJD). No cases of
spread of viral diseases or CJD have ever been
reported for albumin.

Important Safety Information (cont.)

Allergic Reaction to Injecting in the Skin
It is not known if an allergic reaction can be
caused by injecting Dysport into the skin. The
safety of treating excessive sweating with Dysport
is not known.
Common Side Effects
The most common side effects are nose and
throat irritation, headache, injection site pain,
injection site skin reaction, upper respiratory tract
infection, eyelid swelling, eyelid drooping, sinus
inflammation, and nausea.
Tell your doctor about all the medicines you
take, including prescription and nonprescription
medicines, vitamins and herbal and other natural
products. Using Dysport with certain other
medicines may cause serious side effects.

20

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

Do not start any new medicines while taking
Dysport without talking to your doctor first.

Especially tell your doctor if you: have received
any other botulinum toxin product in the last four
months, have received injections of botulinum toxin,
such as Myobloc® (rimabotulinumtoxinB) or Botox®
(onabotulinumtoxinA) in the past (be sure your
doctor knows exactly which product you received),
have recently received an antibiotic by injection,
take muscle relaxants, take an allergy or cold
medicine, or take a sleep medicine.
Use In Specific Populations
Dysport should not be used in children or in women
who are pregnant or breastfeeding.
Ask your doctor if Dysport is right for you.

Medication Guide

21

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

22

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

23

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

24

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

25

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

26

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

27

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

28

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

29

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

30

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

31

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

32

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medicis Family
of Aesthetic Products

Products are not FDA approved for combination use.

www.DysportUSA.com

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.
33

The Dysport trademark is used under license. Restylane is a registered trademark of HA North American Sales AB. All other trademarks
are the property of their respective owners. DSP 11-060 10/31/12


Slide 11

Dysport ® is a prescription
injection for temporary
improvement in the look of
moderate to severe frown
lines between the eyebrows
(glabellar lines) in adults less
than 65 years of age.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.
The Dysport trademark is used under license. All other trademarks are the property of their respective owners. DSP 11-060 10/31/12

I do special things for myself,
and I’ll bet you do, too.
I work out, eat right, and take care of my
skin. Of course, cosmetic creams and lotions
will always have their place in my regimen—
but for my moderate to severe frown lines,
I was ready for a prescription treatment.
Maybe you are, too.

IMPORTANT SAFETY INFORMATION
What is the most important information you should know about Dysport?
Spread of Toxin Effects: In some cases, the effects of Dysport and all botulinum toxin products
may affect areas of the body away from the injection site. These effects can cause symptoms of
a serious condition called botulism. Symptoms of botulism can happen hours to weeks after
injection and may include swallowing and breathing problems, loss of strength and muscle
weakness all over the body, double vision, blurred vision and drooping eyelids, hoarseness or
change or loss of voice, trouble saying words clearly, or loss of bladder control.
PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

2

What is Dysport?
Prescription Dysport is an injection used to temporarily improve
the look of your moderate to severe frown lines without changing
the look of your whole face. The untreated facial muscles still
work normally, allowing you to freely show facial expressions,
such as smiling, in untreated areas.
Dysport is a formulation that has been shown to deliver temporary
improvement in moderate to severe frown lines, even with repeat
treatments. So, the effect of repeat treatment with Dysport may
be comparable to your first use.

IMPORTANT SAFETY INFORMATION
Swallowing and breathing problems can be life threatening and there have
been reports of death.
The risk of symptoms is probably greatest in children and adults treated for
muscle spasms, particularly in those patients who have underlying medical
conditions that could make these symptoms more likely.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

3

How does Dysport Work?
With just 1 injection into each of 5 points between and over
the eyebrows, Dysport blocks the signal from the nerve to the
muscles, ultimately resulting in a reduction of muscle activity
and temporarily preventing contraction of the muscles that
cause frown lines. You should not be treated with Dysport more
frequently than every 90 days.
Ask your doctor about your prescription treatment options for
temporarily improving the look of moderate to severe frown lines.
IMPORTANT SAFETY INFORMATION
The toxic effects have been reported at doses similar to those used to treat
muscle spasms in the neck. Lower doses, in both approved and unapproved
uses, have also caused toxic effects. This includes treatment of children and
adults for muscle spasms.

These effects could make it unsafe for you to drive a car, operate machinery,
or do other dangerous activities.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

4

What causes frown lines?
Over time, repeated movement of the facial skin by the
forehead muscles forms lines between the eyebrows.
Frown lines are “dynamic”—they happen because of
the way a person’s face moves.

IMPORTANT SAFETY INFORMATION
Do not have Dysport treatment if you: are allergic to Dysport or any of its ingredients
(see the end of the Medication Guide for a list of ingredients), are allergic to cow’s milk protein,
had an allergic reaction to any other botulinum toxin product (such as Myobloc® or Botox®),
or have a skin infection at the planned injection site.
The dose of Dysport is not the same as the dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to the dose of any other botulinum toxin
product you may have used.
Dysport may not be right for you if: you have surgical changes to your face, very weak
muscles in the treatment area, your face looks very different from side to side, the injection site
is inflamed, you have droopy eyelids or sagging eyelid folds, deep facial scars, thick oily skin, or
if your wrinkles can’t be smoothed by spreading them apart.
5

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Are frown lines always related to age?
No. Because frown lines are created by facial movements,
such as frowning or squinting, they may develop even in
younger adults.

IMPORTANT SAFETY INFORMATION
Tell your doctor about all your medical conditions, including if you have: a disease
that affects your muscles and nerves (such as amyotrophic lateral sclerosis [ALS or Lou
Gehrig’s disease], myasthenia gravis, or Lambert-Eaton syndrome), allergies to any
botulinum toxin product or had any side effect from any botulinum toxin product in the past,
a breathing problem (such as asthma or emphysema), swallowing problems, bleeding
problems, diabetes, a slow heart beat or other problem with your heart rate or rhythm, plans
to have surgery, had surgery on your face, weakness of your forehead muscles (such as
trouble raising your eyebrows), drooping eyelids, or any other change in the way your face
normally looks. Patients with a disease that affects muscles and nerves who are treated with
typical doses of Dysport may have a higher risk of serious side effects, including severe
swallowing and breathing problems.
6

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What can you do about frown lines?
Treatment with prescription Dysport can temporarily
improve the look of your moderate to severe frown lines.
Treatment generally takes just 10 to 20 minutes.
The most common side effects are nose and throat
irritation, headache, injection site pain, injection site skin
reaction, upper respiratory tract infection, eyelid swelling,
eyelid drooping, sinus inflammation, and nausea.

IMPORTANT SAFETY INFORMATION
Human Albumin
This product contains albumin taken from human plasma. Steps taken during donor
screening and product manufacturing processes make the risk of spreading viral diseases
extremely rare. In theory, there is also an extremely rare risk of contracting CreutzfeldtJakob disease (CJD). No cases of spread of viral diseases or CJD have ever been
reported for albumin.
7

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

How do you know if Dysport works?
Clinically proven results with 1 treatment
In 3 clinical studies of people whose frown lines were rated “moderate” or
“severe” by a doctor before their treatment with Dysport:a
• Doctor rating: 30 days after treatment, the majority (88%, 85%, and 86% in each of the 3 studies)
had their frown lines rated by a doctor as “mild” or “moderate” at maximum frown. For example, a
patient could improve from “severe” to “moderate” or from “moderate” to “mild.”
• Patient rating: 30 days after treatment, the majority (74%, 79%, and 82% in each of the 3 studies)
rated their own frown lines as “mild” or “moderate” at maximum frown. For example, a patient could
improve from “severe” to “moderate” or from “moderate” to “mild.”

a

Three double-blind, randomized, placebo-controlled, clinical studies evaluated the efficacy of Dysport for use in the temporary improvement of the appearance of moderate to severe
glabellar lines. These 3 studies enrolled healthy adults (ages 19-75) with glabellar lines of at least moderate severity at maximum frown. Subjects were excluded if they had marked
ptosis, deep dermal scarring, or a substantial inability to lessen glabellar lines, even by physically spreading them apart. The subjects in these studies received either Dysport or a
placebo. The total dose was delivered in equally divided aliquots to specified injection sites.

IMPORTANT SAFETY INFORMATION
Allergic Reaction to Injecting in the Skin
It is not known if an allergic reaction can be caused by injecting Dysport into the skin. The safety of
treating excessive sweating with Dysport is not known.
8

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Common Side Effects
The most common side effects are nose and throat irritation, headache, injection site pain, injection site skin
reaction, upper respiratory tract infection, eyelid swelling, eyelid drooping, sinus inflammation, and nausea.
9

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Tell your doctor about all the medicines you take, including prescription and nonprescription medicines,
vitamins and herbal and other natural products. Using Dysport with certain other medicines may cause
serious side effects.
Do not start any new medicines while taking Dysport without talking to your doctor first.
10

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Especially tell your doctor if you: have received any other botulinum toxin product in the last four
months, have received injections of botulinum toxin, such as Myobloc® (rimabotulinumtoxinB) or Botox®
(onabotulinumtoxinA) in the past (be sure your doctor knows exactly which product you received), have
recently received an antibiotic by injection, take muscle relaxants, take an allergy or cold medicine, or take
a sleep medicine.
11

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Use In Specific Populations
Dysport should not be used in children or in women who are pregnant or breastfeeding.
Ask your doctor if Dysport is right for you.
12

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What to expect with Dysport
A step-by-step guide to your treatment†

1

The Dysport treatment consultation
Discuss your expectations with your doctor and
whether you have any health conditions or
allergies that could interfere with your treatment.
† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

IMPORTANT SAFETY INFORMATION
What is the most important information you should know about Dysport?
Spread of Toxin Effects: In some cases, the effects of Dysport and all botulinum toxin products may affect
areas of the body away from the injection site. These effects can cause symptoms of a serious condition
called botulism. Symptoms of botulism can happen hours to weeks after injection and may include
swallowing and breathing problems, loss of strength and muscle weakness all over the body, double
vision, blurred vision and drooping eyelids, hoarseness or change or loss of voice, trouble saying words
clearly, or loss of bladder control. Swallowing and breathing problems can be life threatening and there
have been reports of death.
The risk of symptoms is probably greatest in children and adults treated for muscle spasms, particularly
in those patients who have underlying medical conditions that could make these symptoms more likely.
13

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What to expect with Dysport
A step-by-step guide to your treatment†

2

The Dysport treatment
Effective treatment requires 1 injection into each
of 5 points between and over the eyebrows.
Although office visit times may vary, the procedure
generally takes 10 to 20 minutes. Your healthcare
professional will determine the exact placement of
each injection to get results that are right for you.

IMPORTANT SAFETY INFORMATION
The toxic effects have been reported at doses similar to those used to treat muscle spasms in
the neck. Lower doses, in both approved and unapproved uses, have also caused toxic effects.
This includes treatment of children and adults for muscle spasms.
These effects could make it unsafe for you to drive a car, operate machinery, or do other
dangerous activities.
Do not have Dysport treatment if you: are allergic to Dysport or any of its ingredients (see the end
of the Medication Guide for a list of ingredients), are allergic to cow’s milk protein, had an allergic
reaction to any other botulinum toxin product, such as Myobloc® or Botox,® or have a skin infection at
the planned injection site.
14

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

What to expect with Dysport
A step-by-step guide to your treatment†

3

After your Dysport treatment
Ask your doctor about any precautions you
should take after your treatment. Call your doctor
or get medical help right away if you have any
problems swallowing, speaking, or breathing.
If this happens, do not drive a car, operate
machinery, or do other dangerous activities.

IMPORTANT SAFETY INFORMATION
The dose of Dysport is not the same as the dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to the dose of any other botulinum toxin
product you may have used.
Dysport may not be right for you if: you have surgical changes to your face, very weak
muscles in the treatment area, your face looks very different from side to side, the injection
site is inflamed, you have droopy eyelids or sagging eyelid folds, deep facial scars, thick oily
skin, or if your wrinkles can’t be smoothed by spreading them apart.
15

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

What to expect with Dysport
A step-by-step guide to your treatment†

4

Follow up
To maintain your improvements, you should
discuss a treatment schedule with your doctor.
As with any botulinum toxin product, you should
wait at least 90 days between treatments.

IMPORTANT SAFETY INFORMATION
Tell your doctor about all your medical conditions, including if you have: a disease that
affects your muscles and nerves (suchas amyotrophic lateral sclerosis [ALS or Lou Gehrig’s
disease], myasthenia gravis, or Lambert-Eaton syndrome), allergies to any botulinum toxin
product or had any side effect from any botulinum toxin product in the past, a breathing problem
(such as asthma or emphysema), swallowing problems, bleeding problems, diabetes, a slow
heart beat or other problem with your heart rate or rhythm, plans to have surgery, had surgery on
your face, weakness of your forehead muscles (such as trouble raising your eyebrows), drooping
eyelids, or any other change in the way your face normally looks. Patients with a disease that
affects muscles and nerves who are treated with typical doses of Dysport may have a higher risk
of serious side effects, including severe swallowing and breathing problems.
16

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

Why not start the Dysport
discussion with your doctor today?
Questions to ask your doctor:
• How soon will I see treatment results?
• How long does one treatment last?
• How often can I receive a Dysport treatment?
• Is there any way to save money on
my treatment?
• Can I have a treatment today?
• What are the risks associated with treatment?
IMPORTANT SAFETY INFORMATION
Human Albumin
This product contains albumin taken from human plasma. Steps taken during donor screening and product
manufacturing processes make the risk of spreading viral diseases extremely rare. In theory, there is also an
extremely rare risk of contracting Creutzfeldt-Jakob disease (CJD). No cases of spread of viral diseases or CJD
have ever been reported for albumin.
17

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Important Safety Information

What is the most important information you
should know about Dysport
(abobotulinumtoxinA) 300 Units for Injection?
Spread of Toxin Effects: In some cases, the
effects of Dysport and all botulinum toxin
products may affect areas of the body away
from the injection site. These effects can
cause symptoms of a serious condition called
botulism. Symptoms of botulism can happen
hours to weeks after injection and may
include swallowing and breathing problems,
loss of strength and muscle weakness all over
the body, double vision, blurred vision and
drooping eyelids, hoarseness or change or
loss of voice, trouble saying words clearly, or
loss of bladder control. Swallowing and
breathing problems can be life threatening
and there have been reports of death.

18

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

The risk of symptoms is probably greatest in
children and adults treated for muscle spasms,
particularly in those patients who have
underlying medical conditions that could make
these symptoms more likely.
The toxic effects have been reported at doses
similar to those used to treat muscle spasms in
the neck. Lower doses, in both approved and
unapproved uses, have also caused toxic
effects. This includes treatment of children and
adults for muscle spasms.
These effects could make it unsafe for you to
drive a car, operate machinery, or do other
dangerous activities.
Do not have Dysport treatment if you: are allergic
to Dysport or any of its ingredients (see the end of
the Medication Guide for a list of ingredients), are
allergic to cow’s milk protein, had an allergic
reaction to any other botulinum toxin product, such
as Myobloc® or Botox,® or have a skin infection at
the planned injection site.

Important Safety Information (cont.)

The dose of Dysport is not the same as the
dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to
the dose of any other botulinum toxin product
you may have used.
Dysport may not be right for you if: you have
surgical changes to your face, very weak muscles
in the treatment area, your face looks very
different from side to side, the injection site is
inflamed, you have droopy eyelids or sagging
eyelid folds, deep facial scars, thick oily skin, or if
your wrinkles can’t be smoothed by spreading
them apart.
Tell your doctor about all your medical
conditions, including if you have: a disease
that affects your muscles and nerves (such as
amyotrophic lateral sclerosis [ALS or Lou
Gehrig’s disease], myasthenia gravis, or LambertEaton syndrome), allergies to any botulinum toxin
product or had any side effect from any

19

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

botulinum toxin product in the past, a breathing
problem (such as asthma or emphysema),
swallowing problems, bleeding problems, diabetes,
a slow heart beat or other problem with your heart
rate or rhythm, plans to have surgery, had surgery
on your face, weakness of your forehead muscles
(such as trouble raising your eyebrows), drooping
eyelids, or any other change in the way your face
normally looks. Patients with a disease that affects
muscles and nerves who are treated with typical
doses of Dysport may have a higher risk of serious
side effects, including severe swallowing and
breathing problems.
Human Albumin
This product contains albumin taken from human
plasma. Steps taken during donor screening and
product manufacturing processes make the risk of
spreading viral diseases extremely rare. In theory,
there is also an extremely rare risk of contracting
Creutzfeldt-Jakob disease (CJD). No cases of
spread of viral diseases or CJD have ever been
reported for albumin.

Important Safety Information (cont.)

Allergic Reaction to Injecting in the Skin
It is not known if an allergic reaction can be
caused by injecting Dysport into the skin. The
safety of treating excessive sweating with Dysport
is not known.
Common Side Effects
The most common side effects are nose and
throat irritation, headache, injection site pain,
injection site skin reaction, upper respiratory tract
infection, eyelid swelling, eyelid drooping, sinus
inflammation, and nausea.
Tell your doctor about all the medicines you
take, including prescription and nonprescription
medicines, vitamins and herbal and other natural
products. Using Dysport with certain other
medicines may cause serious side effects.

20

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

Do not start any new medicines while taking
Dysport without talking to your doctor first.

Especially tell your doctor if you: have received
any other botulinum toxin product in the last four
months, have received injections of botulinum toxin,
such as Myobloc® (rimabotulinumtoxinB) or Botox®
(onabotulinumtoxinA) in the past (be sure your
doctor knows exactly which product you received),
have recently received an antibiotic by injection,
take muscle relaxants, take an allergy or cold
medicine, or take a sleep medicine.
Use In Specific Populations
Dysport should not be used in children or in women
who are pregnant or breastfeeding.
Ask your doctor if Dysport is right for you.

Medication Guide

21

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

22

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

23

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

24

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

25

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

26

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

27

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

28

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

29

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

30

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

31

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

32

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medicis Family
of Aesthetic Products

Products are not FDA approved for combination use.

www.DysportUSA.com

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.
33

The Dysport trademark is used under license. Restylane is a registered trademark of HA North American Sales AB. All other trademarks
are the property of their respective owners. DSP 11-060 10/31/12


Slide 12

Dysport ® is a prescription
injection for temporary
improvement in the look of
moderate to severe frown
lines between the eyebrows
(glabellar lines) in adults less
than 65 years of age.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.
The Dysport trademark is used under license. All other trademarks are the property of their respective owners. DSP 11-060 10/31/12

I do special things for myself,
and I’ll bet you do, too.
I work out, eat right, and take care of my
skin. Of course, cosmetic creams and lotions
will always have their place in my regimen—
but for my moderate to severe frown lines,
I was ready for a prescription treatment.
Maybe you are, too.

IMPORTANT SAFETY INFORMATION
What is the most important information you should know about Dysport?
Spread of Toxin Effects: In some cases, the effects of Dysport and all botulinum toxin products
may affect areas of the body away from the injection site. These effects can cause symptoms of
a serious condition called botulism. Symptoms of botulism can happen hours to weeks after
injection and may include swallowing and breathing problems, loss of strength and muscle
weakness all over the body, double vision, blurred vision and drooping eyelids, hoarseness or
change or loss of voice, trouble saying words clearly, or loss of bladder control.
PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

2

What is Dysport?
Prescription Dysport is an injection used to temporarily improve
the look of your moderate to severe frown lines without changing
the look of your whole face. The untreated facial muscles still
work normally, allowing you to freely show facial expressions,
such as smiling, in untreated areas.
Dysport is a formulation that has been shown to deliver temporary
improvement in moderate to severe frown lines, even with repeat
treatments. So, the effect of repeat treatment with Dysport may
be comparable to your first use.

IMPORTANT SAFETY INFORMATION
Swallowing and breathing problems can be life threatening and there have
been reports of death.
The risk of symptoms is probably greatest in children and adults treated for
muscle spasms, particularly in those patients who have underlying medical
conditions that could make these symptoms more likely.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

3

How does Dysport Work?
With just 1 injection into each of 5 points between and over
the eyebrows, Dysport blocks the signal from the nerve to the
muscles, ultimately resulting in a reduction of muscle activity
and temporarily preventing contraction of the muscles that
cause frown lines. You should not be treated with Dysport more
frequently than every 90 days.
Ask your doctor about your prescription treatment options for
temporarily improving the look of moderate to severe frown lines.
IMPORTANT SAFETY INFORMATION
The toxic effects have been reported at doses similar to those used to treat
muscle spasms in the neck. Lower doses, in both approved and unapproved
uses, have also caused toxic effects. This includes treatment of children and
adults for muscle spasms.

These effects could make it unsafe for you to drive a car, operate machinery,
or do other dangerous activities.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

4

What causes frown lines?
Over time, repeated movement of the facial skin by the
forehead muscles forms lines between the eyebrows.
Frown lines are “dynamic”—they happen because of
the way a person’s face moves.

IMPORTANT SAFETY INFORMATION
Do not have Dysport treatment if you: are allergic to Dysport or any of its ingredients
(see the end of the Medication Guide for a list of ingredients), are allergic to cow’s milk protein,
had an allergic reaction to any other botulinum toxin product (such as Myobloc® or Botox®),
or have a skin infection at the planned injection site.
The dose of Dysport is not the same as the dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to the dose of any other botulinum toxin
product you may have used.
Dysport may not be right for you if: you have surgical changes to your face, very weak
muscles in the treatment area, your face looks very different from side to side, the injection site
is inflamed, you have droopy eyelids or sagging eyelid folds, deep facial scars, thick oily skin, or
if your wrinkles can’t be smoothed by spreading them apart.
5

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Are frown lines always related to age?
No. Because frown lines are created by facial movements,
such as frowning or squinting, they may develop even in
younger adults.

IMPORTANT SAFETY INFORMATION
Tell your doctor about all your medical conditions, including if you have: a disease
that affects your muscles and nerves (such as amyotrophic lateral sclerosis [ALS or Lou
Gehrig’s disease], myasthenia gravis, or Lambert-Eaton syndrome), allergies to any
botulinum toxin product or had any side effect from any botulinum toxin product in the past,
a breathing problem (such as asthma or emphysema), swallowing problems, bleeding
problems, diabetes, a slow heart beat or other problem with your heart rate or rhythm, plans
to have surgery, had surgery on your face, weakness of your forehead muscles (such as
trouble raising your eyebrows), drooping eyelids, or any other change in the way your face
normally looks. Patients with a disease that affects muscles and nerves who are treated with
typical doses of Dysport may have a higher risk of serious side effects, including severe
swallowing and breathing problems.
6

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What can you do about frown lines?
Treatment with prescription Dysport can temporarily
improve the look of your moderate to severe frown lines.
Treatment generally takes just 10 to 20 minutes.
The most common side effects are nose and throat
irritation, headache, injection site pain, injection site skin
reaction, upper respiratory tract infection, eyelid swelling,
eyelid drooping, sinus inflammation, and nausea.

IMPORTANT SAFETY INFORMATION
Human Albumin
This product contains albumin taken from human plasma. Steps taken during donor
screening and product manufacturing processes make the risk of spreading viral diseases
extremely rare. In theory, there is also an extremely rare risk of contracting CreutzfeldtJakob disease (CJD). No cases of spread of viral diseases or CJD have ever been
reported for albumin.
7

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

How do you know if Dysport works?
Clinically proven results with 1 treatment
In 3 clinical studies of people whose frown lines were rated “moderate” or
“severe” by a doctor before their treatment with Dysport:a
• Doctor rating: 30 days after treatment, the majority (88%, 85%, and 86% in each of the 3 studies)
had their frown lines rated by a doctor as “mild” or “moderate” at maximum frown. For example, a
patient could improve from “severe” to “moderate” or from “moderate” to “mild.”
• Patient rating: 30 days after treatment, the majority (74%, 79%, and 82% in each of the 3 studies)
rated their own frown lines as “mild” or “moderate” at maximum frown. For example, a patient could
improve from “severe” to “moderate” or from “moderate” to “mild.”

a

Three double-blind, randomized, placebo-controlled, clinical studies evaluated the efficacy of Dysport for use in the temporary improvement of the appearance of moderate to severe
glabellar lines. These 3 studies enrolled healthy adults (ages 19-75) with glabellar lines of at least moderate severity at maximum frown. Subjects were excluded if they had marked
ptosis, deep dermal scarring, or a substantial inability to lessen glabellar lines, even by physically spreading them apart. The subjects in these studies received either Dysport or a
placebo. The total dose was delivered in equally divided aliquots to specified injection sites.

IMPORTANT SAFETY INFORMATION
Allergic Reaction to Injecting in the Skin
It is not known if an allergic reaction can be caused by injecting Dysport into the skin. The safety of
treating excessive sweating with Dysport is not known.
8

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Common Side Effects
The most common side effects are nose and throat irritation, headache, injection site pain, injection site skin
reaction, upper respiratory tract infection, eyelid swelling, eyelid drooping, sinus inflammation, and nausea.
9

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Tell your doctor about all the medicines you take, including prescription and nonprescription medicines,
vitamins and herbal and other natural products. Using Dysport with certain other medicines may cause
serious side effects.
Do not start any new medicines while taking Dysport without talking to your doctor first.
10

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Especially tell your doctor if you: have received any other botulinum toxin product in the last four
months, have received injections of botulinum toxin, such as Myobloc® (rimabotulinumtoxinB) or Botox®
(onabotulinumtoxinA) in the past (be sure your doctor knows exactly which product you received), have
recently received an antibiotic by injection, take muscle relaxants, take an allergy or cold medicine, or take
a sleep medicine.
11

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Use In Specific Populations
Dysport should not be used in children or in women who are pregnant or breastfeeding.
Ask your doctor if Dysport is right for you.
12

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What to expect with Dysport
A step-by-step guide to your treatment†

1

The Dysport treatment consultation
Discuss your expectations with your doctor and
whether you have any health conditions or
allergies that could interfere with your treatment.
† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

IMPORTANT SAFETY INFORMATION
What is the most important information you should know about Dysport?
Spread of Toxin Effects: In some cases, the effects of Dysport and all botulinum toxin products may affect
areas of the body away from the injection site. These effects can cause symptoms of a serious condition
called botulism. Symptoms of botulism can happen hours to weeks after injection and may include
swallowing and breathing problems, loss of strength and muscle weakness all over the body, double
vision, blurred vision and drooping eyelids, hoarseness or change or loss of voice, trouble saying words
clearly, or loss of bladder control. Swallowing and breathing problems can be life threatening and there
have been reports of death.
The risk of symptoms is probably greatest in children and adults treated for muscle spasms, particularly
in those patients who have underlying medical conditions that could make these symptoms more likely.
13

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What to expect with Dysport
A step-by-step guide to your treatment†

2

The Dysport treatment
Effective treatment requires 1 injection into each
of 5 points between and over the eyebrows.
Although office visit times may vary, the procedure
generally takes 10 to 20 minutes. Your healthcare
professional will determine the exact placement of
each injection to get results that are right for you.

IMPORTANT SAFETY INFORMATION
The toxic effects have been reported at doses similar to those used to treat muscle spasms in
the neck. Lower doses, in both approved and unapproved uses, have also caused toxic effects.
This includes treatment of children and adults for muscle spasms.
These effects could make it unsafe for you to drive a car, operate machinery, or do other
dangerous activities.
Do not have Dysport treatment if you: are allergic to Dysport or any of its ingredients (see the end
of the Medication Guide for a list of ingredients), are allergic to cow’s milk protein, had an allergic
reaction to any other botulinum toxin product, such as Myobloc® or Botox,® or have a skin infection at
the planned injection site.
14

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

What to expect with Dysport
A step-by-step guide to your treatment†

3

After your Dysport treatment
Ask your doctor about any precautions you
should take after your treatment. Call your doctor
or get medical help right away if you have any
problems swallowing, speaking, or breathing.
If this happens, do not drive a car, operate
machinery, or do other dangerous activities.

IMPORTANT SAFETY INFORMATION
The dose of Dysport is not the same as the dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to the dose of any other botulinum toxin
product you may have used.
Dysport may not be right for you if: you have surgical changes to your face, very weak
muscles in the treatment area, your face looks very different from side to side, the injection
site is inflamed, you have droopy eyelids or sagging eyelid folds, deep facial scars, thick oily
skin, or if your wrinkles can’t be smoothed by spreading them apart.
15

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

What to expect with Dysport
A step-by-step guide to your treatment†

4

Follow up
To maintain your improvements, you should
discuss a treatment schedule with your doctor.
As with any botulinum toxin product, you should
wait at least 90 days between treatments.

IMPORTANT SAFETY INFORMATION
Tell your doctor about all your medical conditions, including if you have: a disease that
affects your muscles and nerves (suchas amyotrophic lateral sclerosis [ALS or Lou Gehrig’s
disease], myasthenia gravis, or Lambert-Eaton syndrome), allergies to any botulinum toxin
product or had any side effect from any botulinum toxin product in the past, a breathing problem
(such as asthma or emphysema), swallowing problems, bleeding problems, diabetes, a slow
heart beat or other problem with your heart rate or rhythm, plans to have surgery, had surgery on
your face, weakness of your forehead muscles (such as trouble raising your eyebrows), drooping
eyelids, or any other change in the way your face normally looks. Patients with a disease that
affects muscles and nerves who are treated with typical doses of Dysport may have a higher risk
of serious side effects, including severe swallowing and breathing problems.
16

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

Why not start the Dysport
discussion with your doctor today?
Questions to ask your doctor:
• How soon will I see treatment results?
• How long does one treatment last?
• How often can I receive a Dysport treatment?
• Is there any way to save money on
my treatment?
• Can I have a treatment today?
• What are the risks associated with treatment?
IMPORTANT SAFETY INFORMATION
Human Albumin
This product contains albumin taken from human plasma. Steps taken during donor screening and product
manufacturing processes make the risk of spreading viral diseases extremely rare. In theory, there is also an
extremely rare risk of contracting Creutzfeldt-Jakob disease (CJD). No cases of spread of viral diseases or CJD
have ever been reported for albumin.
17

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Important Safety Information

What is the most important information you
should know about Dysport
(abobotulinumtoxinA) 300 Units for Injection?
Spread of Toxin Effects: In some cases, the
effects of Dysport and all botulinum toxin
products may affect areas of the body away
from the injection site. These effects can
cause symptoms of a serious condition called
botulism. Symptoms of botulism can happen
hours to weeks after injection and may
include swallowing and breathing problems,
loss of strength and muscle weakness all over
the body, double vision, blurred vision and
drooping eyelids, hoarseness or change or
loss of voice, trouble saying words clearly, or
loss of bladder control. Swallowing and
breathing problems can be life threatening
and there have been reports of death.

18

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

The risk of symptoms is probably greatest in
children and adults treated for muscle spasms,
particularly in those patients who have
underlying medical conditions that could make
these symptoms more likely.
The toxic effects have been reported at doses
similar to those used to treat muscle spasms in
the neck. Lower doses, in both approved and
unapproved uses, have also caused toxic
effects. This includes treatment of children and
adults for muscle spasms.
These effects could make it unsafe for you to
drive a car, operate machinery, or do other
dangerous activities.
Do not have Dysport treatment if you: are allergic
to Dysport or any of its ingredients (see the end of
the Medication Guide for a list of ingredients), are
allergic to cow’s milk protein, had an allergic
reaction to any other botulinum toxin product, such
as Myobloc® or Botox,® or have a skin infection at
the planned injection site.

Important Safety Information (cont.)

The dose of Dysport is not the same as the
dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to
the dose of any other botulinum toxin product
you may have used.
Dysport may not be right for you if: you have
surgical changes to your face, very weak muscles
in the treatment area, your face looks very
different from side to side, the injection site is
inflamed, you have droopy eyelids or sagging
eyelid folds, deep facial scars, thick oily skin, or if
your wrinkles can’t be smoothed by spreading
them apart.
Tell your doctor about all your medical
conditions, including if you have: a disease
that affects your muscles and nerves (such as
amyotrophic lateral sclerosis [ALS or Lou
Gehrig’s disease], myasthenia gravis, or LambertEaton syndrome), allergies to any botulinum toxin
product or had any side effect from any

19

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

botulinum toxin product in the past, a breathing
problem (such as asthma or emphysema),
swallowing problems, bleeding problems, diabetes,
a slow heart beat or other problem with your heart
rate or rhythm, plans to have surgery, had surgery
on your face, weakness of your forehead muscles
(such as trouble raising your eyebrows), drooping
eyelids, or any other change in the way your face
normally looks. Patients with a disease that affects
muscles and nerves who are treated with typical
doses of Dysport may have a higher risk of serious
side effects, including severe swallowing and
breathing problems.
Human Albumin
This product contains albumin taken from human
plasma. Steps taken during donor screening and
product manufacturing processes make the risk of
spreading viral diseases extremely rare. In theory,
there is also an extremely rare risk of contracting
Creutzfeldt-Jakob disease (CJD). No cases of
spread of viral diseases or CJD have ever been
reported for albumin.

Important Safety Information (cont.)

Allergic Reaction to Injecting in the Skin
It is not known if an allergic reaction can be
caused by injecting Dysport into the skin. The
safety of treating excessive sweating with Dysport
is not known.
Common Side Effects
The most common side effects are nose and
throat irritation, headache, injection site pain,
injection site skin reaction, upper respiratory tract
infection, eyelid swelling, eyelid drooping, sinus
inflammation, and nausea.
Tell your doctor about all the medicines you
take, including prescription and nonprescription
medicines, vitamins and herbal and other natural
products. Using Dysport with certain other
medicines may cause serious side effects.

20

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

Do not start any new medicines while taking
Dysport without talking to your doctor first.

Especially tell your doctor if you: have received
any other botulinum toxin product in the last four
months, have received injections of botulinum toxin,
such as Myobloc® (rimabotulinumtoxinB) or Botox®
(onabotulinumtoxinA) in the past (be sure your
doctor knows exactly which product you received),
have recently received an antibiotic by injection,
take muscle relaxants, take an allergy or cold
medicine, or take a sleep medicine.
Use In Specific Populations
Dysport should not be used in children or in women
who are pregnant or breastfeeding.
Ask your doctor if Dysport is right for you.

Medication Guide

21

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

22

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

23

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

24

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

25

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

26

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

27

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

28

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

29

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

30

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

31

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

32

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medicis Family
of Aesthetic Products

Products are not FDA approved for combination use.

www.DysportUSA.com

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.
33

The Dysport trademark is used under license. Restylane is a registered trademark of HA North American Sales AB. All other trademarks
are the property of their respective owners. DSP 11-060 10/31/12


Slide 13

Dysport ® is a prescription
injection for temporary
improvement in the look of
moderate to severe frown
lines between the eyebrows
(glabellar lines) in adults less
than 65 years of age.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.
The Dysport trademark is used under license. All other trademarks are the property of their respective owners. DSP 11-060 10/31/12

I do special things for myself,
and I’ll bet you do, too.
I work out, eat right, and take care of my
skin. Of course, cosmetic creams and lotions
will always have their place in my regimen—
but for my moderate to severe frown lines,
I was ready for a prescription treatment.
Maybe you are, too.

IMPORTANT SAFETY INFORMATION
What is the most important information you should know about Dysport?
Spread of Toxin Effects: In some cases, the effects of Dysport and all botulinum toxin products
may affect areas of the body away from the injection site. These effects can cause symptoms of
a serious condition called botulism. Symptoms of botulism can happen hours to weeks after
injection and may include swallowing and breathing problems, loss of strength and muscle
weakness all over the body, double vision, blurred vision and drooping eyelids, hoarseness or
change or loss of voice, trouble saying words clearly, or loss of bladder control.
PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

2

What is Dysport?
Prescription Dysport is an injection used to temporarily improve
the look of your moderate to severe frown lines without changing
the look of your whole face. The untreated facial muscles still
work normally, allowing you to freely show facial expressions,
such as smiling, in untreated areas.
Dysport is a formulation that has been shown to deliver temporary
improvement in moderate to severe frown lines, even with repeat
treatments. So, the effect of repeat treatment with Dysport may
be comparable to your first use.

IMPORTANT SAFETY INFORMATION
Swallowing and breathing problems can be life threatening and there have
been reports of death.
The risk of symptoms is probably greatest in children and adults treated for
muscle spasms, particularly in those patients who have underlying medical
conditions that could make these symptoms more likely.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

3

How does Dysport Work?
With just 1 injection into each of 5 points between and over
the eyebrows, Dysport blocks the signal from the nerve to the
muscles, ultimately resulting in a reduction of muscle activity
and temporarily preventing contraction of the muscles that
cause frown lines. You should not be treated with Dysport more
frequently than every 90 days.
Ask your doctor about your prescription treatment options for
temporarily improving the look of moderate to severe frown lines.
IMPORTANT SAFETY INFORMATION
The toxic effects have been reported at doses similar to those used to treat
muscle spasms in the neck. Lower doses, in both approved and unapproved
uses, have also caused toxic effects. This includes treatment of children and
adults for muscle spasms.

These effects could make it unsafe for you to drive a car, operate machinery,
or do other dangerous activities.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

4

What causes frown lines?
Over time, repeated movement of the facial skin by the
forehead muscles forms lines between the eyebrows.
Frown lines are “dynamic”—they happen because of
the way a person’s face moves.

IMPORTANT SAFETY INFORMATION
Do not have Dysport treatment if you: are allergic to Dysport or any of its ingredients
(see the end of the Medication Guide for a list of ingredients), are allergic to cow’s milk protein,
had an allergic reaction to any other botulinum toxin product (such as Myobloc® or Botox®),
or have a skin infection at the planned injection site.
The dose of Dysport is not the same as the dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to the dose of any other botulinum toxin
product you may have used.
Dysport may not be right for you if: you have surgical changes to your face, very weak
muscles in the treatment area, your face looks very different from side to side, the injection site
is inflamed, you have droopy eyelids or sagging eyelid folds, deep facial scars, thick oily skin, or
if your wrinkles can’t be smoothed by spreading them apart.
5

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Are frown lines always related to age?
No. Because frown lines are created by facial movements,
such as frowning or squinting, they may develop even in
younger adults.

IMPORTANT SAFETY INFORMATION
Tell your doctor about all your medical conditions, including if you have: a disease
that affects your muscles and nerves (such as amyotrophic lateral sclerosis [ALS or Lou
Gehrig’s disease], myasthenia gravis, or Lambert-Eaton syndrome), allergies to any
botulinum toxin product or had any side effect from any botulinum toxin product in the past,
a breathing problem (such as asthma or emphysema), swallowing problems, bleeding
problems, diabetes, a slow heart beat or other problem with your heart rate or rhythm, plans
to have surgery, had surgery on your face, weakness of your forehead muscles (such as
trouble raising your eyebrows), drooping eyelids, or any other change in the way your face
normally looks. Patients with a disease that affects muscles and nerves who are treated with
typical doses of Dysport may have a higher risk of serious side effects, including severe
swallowing and breathing problems.
6

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What can you do about frown lines?
Treatment with prescription Dysport can temporarily
improve the look of your moderate to severe frown lines.
Treatment generally takes just 10 to 20 minutes.
The most common side effects are nose and throat
irritation, headache, injection site pain, injection site skin
reaction, upper respiratory tract infection, eyelid swelling,
eyelid drooping, sinus inflammation, and nausea.

IMPORTANT SAFETY INFORMATION
Human Albumin
This product contains albumin taken from human plasma. Steps taken during donor
screening and product manufacturing processes make the risk of spreading viral diseases
extremely rare. In theory, there is also an extremely rare risk of contracting CreutzfeldtJakob disease (CJD). No cases of spread of viral diseases or CJD have ever been
reported for albumin.
7

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

How do you know if Dysport works?
Clinically proven results with 1 treatment
In 3 clinical studies of people whose frown lines were rated “moderate” or
“severe” by a doctor before their treatment with Dysport:a
• Doctor rating: 30 days after treatment, the majority (88%, 85%, and 86% in each of the 3 studies)
had their frown lines rated by a doctor as “mild” or “moderate” at maximum frown. For example, a
patient could improve from “severe” to “moderate” or from “moderate” to “mild.”
• Patient rating: 30 days after treatment, the majority (74%, 79%, and 82% in each of the 3 studies)
rated their own frown lines as “mild” or “moderate” at maximum frown. For example, a patient could
improve from “severe” to “moderate” or from “moderate” to “mild.”

a

Three double-blind, randomized, placebo-controlled, clinical studies evaluated the efficacy of Dysport for use in the temporary improvement of the appearance of moderate to severe
glabellar lines. These 3 studies enrolled healthy adults (ages 19-75) with glabellar lines of at least moderate severity at maximum frown. Subjects were excluded if they had marked
ptosis, deep dermal scarring, or a substantial inability to lessen glabellar lines, even by physically spreading them apart. The subjects in these studies received either Dysport or a
placebo. The total dose was delivered in equally divided aliquots to specified injection sites.

IMPORTANT SAFETY INFORMATION
Allergic Reaction to Injecting in the Skin
It is not known if an allergic reaction can be caused by injecting Dysport into the skin. The safety of
treating excessive sweating with Dysport is not known.
8

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Common Side Effects
The most common side effects are nose and throat irritation, headache, injection site pain, injection site skin
reaction, upper respiratory tract infection, eyelid swelling, eyelid drooping, sinus inflammation, and nausea.
9

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Tell your doctor about all the medicines you take, including prescription and nonprescription medicines,
vitamins and herbal and other natural products. Using Dysport with certain other medicines may cause
serious side effects.
Do not start any new medicines while taking Dysport without talking to your doctor first.
10

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Especially tell your doctor if you: have received any other botulinum toxin product in the last four
months, have received injections of botulinum toxin, such as Myobloc® (rimabotulinumtoxinB) or Botox®
(onabotulinumtoxinA) in the past (be sure your doctor knows exactly which product you received), have
recently received an antibiotic by injection, take muscle relaxants, take an allergy or cold medicine, or take
a sleep medicine.
11

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Use In Specific Populations
Dysport should not be used in children or in women who are pregnant or breastfeeding.
Ask your doctor if Dysport is right for you.
12

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What to expect with Dysport
A step-by-step guide to your treatment†

1

The Dysport treatment consultation
Discuss your expectations with your doctor and
whether you have any health conditions or
allergies that could interfere with your treatment.
† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

IMPORTANT SAFETY INFORMATION
What is the most important information you should know about Dysport?
Spread of Toxin Effects: In some cases, the effects of Dysport and all botulinum toxin products may affect
areas of the body away from the injection site. These effects can cause symptoms of a serious condition
called botulism. Symptoms of botulism can happen hours to weeks after injection and may include
swallowing and breathing problems, loss of strength and muscle weakness all over the body, double
vision, blurred vision and drooping eyelids, hoarseness or change or loss of voice, trouble saying words
clearly, or loss of bladder control. Swallowing and breathing problems can be life threatening and there
have been reports of death.
The risk of symptoms is probably greatest in children and adults treated for muscle spasms, particularly
in those patients who have underlying medical conditions that could make these symptoms more likely.
13

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What to expect with Dysport
A step-by-step guide to your treatment†

2

The Dysport treatment
Effective treatment requires 1 injection into each
of 5 points between and over the eyebrows.
Although office visit times may vary, the procedure
generally takes 10 to 20 minutes. Your healthcare
professional will determine the exact placement of
each injection to get results that are right for you.

IMPORTANT SAFETY INFORMATION
The toxic effects have been reported at doses similar to those used to treat muscle spasms in
the neck. Lower doses, in both approved and unapproved uses, have also caused toxic effects.
This includes treatment of children and adults for muscle spasms.
These effects could make it unsafe for you to drive a car, operate machinery, or do other
dangerous activities.
Do not have Dysport treatment if you: are allergic to Dysport or any of its ingredients (see the end
of the Medication Guide for a list of ingredients), are allergic to cow’s milk protein, had an allergic
reaction to any other botulinum toxin product, such as Myobloc® or Botox,® or have a skin infection at
the planned injection site.
14

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

What to expect with Dysport
A step-by-step guide to your treatment†

3

After your Dysport treatment
Ask your doctor about any precautions you
should take after your treatment. Call your doctor
or get medical help right away if you have any
problems swallowing, speaking, or breathing.
If this happens, do not drive a car, operate
machinery, or do other dangerous activities.

IMPORTANT SAFETY INFORMATION
The dose of Dysport is not the same as the dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to the dose of any other botulinum toxin
product you may have used.
Dysport may not be right for you if: you have surgical changes to your face, very weak
muscles in the treatment area, your face looks very different from side to side, the injection
site is inflamed, you have droopy eyelids or sagging eyelid folds, deep facial scars, thick oily
skin, or if your wrinkles can’t be smoothed by spreading them apart.
15

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

What to expect with Dysport
A step-by-step guide to your treatment†

4

Follow up
To maintain your improvements, you should
discuss a treatment schedule with your doctor.
As with any botulinum toxin product, you should
wait at least 90 days between treatments.

IMPORTANT SAFETY INFORMATION
Tell your doctor about all your medical conditions, including if you have: a disease that
affects your muscles and nerves (suchas amyotrophic lateral sclerosis [ALS or Lou Gehrig’s
disease], myasthenia gravis, or Lambert-Eaton syndrome), allergies to any botulinum toxin
product or had any side effect from any botulinum toxin product in the past, a breathing problem
(such as asthma or emphysema), swallowing problems, bleeding problems, diabetes, a slow
heart beat or other problem with your heart rate or rhythm, plans to have surgery, had surgery on
your face, weakness of your forehead muscles (such as trouble raising your eyebrows), drooping
eyelids, or any other change in the way your face normally looks. Patients with a disease that
affects muscles and nerves who are treated with typical doses of Dysport may have a higher risk
of serious side effects, including severe swallowing and breathing problems.
16

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

Why not start the Dysport
discussion with your doctor today?
Questions to ask your doctor:
• How soon will I see treatment results?
• How long does one treatment last?
• How often can I receive a Dysport treatment?
• Is there any way to save money on
my treatment?
• Can I have a treatment today?
• What are the risks associated with treatment?
IMPORTANT SAFETY INFORMATION
Human Albumin
This product contains albumin taken from human plasma. Steps taken during donor screening and product
manufacturing processes make the risk of spreading viral diseases extremely rare. In theory, there is also an
extremely rare risk of contracting Creutzfeldt-Jakob disease (CJD). No cases of spread of viral diseases or CJD
have ever been reported for albumin.
17

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Important Safety Information

What is the most important information you
should know about Dysport
(abobotulinumtoxinA) 300 Units for Injection?
Spread of Toxin Effects: In some cases, the
effects of Dysport and all botulinum toxin
products may affect areas of the body away
from the injection site. These effects can
cause symptoms of a serious condition called
botulism. Symptoms of botulism can happen
hours to weeks after injection and may
include swallowing and breathing problems,
loss of strength and muscle weakness all over
the body, double vision, blurred vision and
drooping eyelids, hoarseness or change or
loss of voice, trouble saying words clearly, or
loss of bladder control. Swallowing and
breathing problems can be life threatening
and there have been reports of death.

18

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

The risk of symptoms is probably greatest in
children and adults treated for muscle spasms,
particularly in those patients who have
underlying medical conditions that could make
these symptoms more likely.
The toxic effects have been reported at doses
similar to those used to treat muscle spasms in
the neck. Lower doses, in both approved and
unapproved uses, have also caused toxic
effects. This includes treatment of children and
adults for muscle spasms.
These effects could make it unsafe for you to
drive a car, operate machinery, or do other
dangerous activities.
Do not have Dysport treatment if you: are allergic
to Dysport or any of its ingredients (see the end of
the Medication Guide for a list of ingredients), are
allergic to cow’s milk protein, had an allergic
reaction to any other botulinum toxin product, such
as Myobloc® or Botox,® or have a skin infection at
the planned injection site.

Important Safety Information (cont.)

The dose of Dysport is not the same as the
dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to
the dose of any other botulinum toxin product
you may have used.
Dysport may not be right for you if: you have
surgical changes to your face, very weak muscles
in the treatment area, your face looks very
different from side to side, the injection site is
inflamed, you have droopy eyelids or sagging
eyelid folds, deep facial scars, thick oily skin, or if
your wrinkles can’t be smoothed by spreading
them apart.
Tell your doctor about all your medical
conditions, including if you have: a disease
that affects your muscles and nerves (such as
amyotrophic lateral sclerosis [ALS or Lou
Gehrig’s disease], myasthenia gravis, or LambertEaton syndrome), allergies to any botulinum toxin
product or had any side effect from any

19

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

botulinum toxin product in the past, a breathing
problem (such as asthma or emphysema),
swallowing problems, bleeding problems, diabetes,
a slow heart beat or other problem with your heart
rate or rhythm, plans to have surgery, had surgery
on your face, weakness of your forehead muscles
(such as trouble raising your eyebrows), drooping
eyelids, or any other change in the way your face
normally looks. Patients with a disease that affects
muscles and nerves who are treated with typical
doses of Dysport may have a higher risk of serious
side effects, including severe swallowing and
breathing problems.
Human Albumin
This product contains albumin taken from human
plasma. Steps taken during donor screening and
product manufacturing processes make the risk of
spreading viral diseases extremely rare. In theory,
there is also an extremely rare risk of contracting
Creutzfeldt-Jakob disease (CJD). No cases of
spread of viral diseases or CJD have ever been
reported for albumin.

Important Safety Information (cont.)

Allergic Reaction to Injecting in the Skin
It is not known if an allergic reaction can be
caused by injecting Dysport into the skin. The
safety of treating excessive sweating with Dysport
is not known.
Common Side Effects
The most common side effects are nose and
throat irritation, headache, injection site pain,
injection site skin reaction, upper respiratory tract
infection, eyelid swelling, eyelid drooping, sinus
inflammation, and nausea.
Tell your doctor about all the medicines you
take, including prescription and nonprescription
medicines, vitamins and herbal and other natural
products. Using Dysport with certain other
medicines may cause serious side effects.

20

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

Do not start any new medicines while taking
Dysport without talking to your doctor first.

Especially tell your doctor if you: have received
any other botulinum toxin product in the last four
months, have received injections of botulinum toxin,
such as Myobloc® (rimabotulinumtoxinB) or Botox®
(onabotulinumtoxinA) in the past (be sure your
doctor knows exactly which product you received),
have recently received an antibiotic by injection,
take muscle relaxants, take an allergy or cold
medicine, or take a sleep medicine.
Use In Specific Populations
Dysport should not be used in children or in women
who are pregnant or breastfeeding.
Ask your doctor if Dysport is right for you.

Medication Guide

21

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

22

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

23

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

24

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

25

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

26

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

27

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

28

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

29

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

30

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

31

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

32

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medicis Family
of Aesthetic Products

Products are not FDA approved for combination use.

www.DysportUSA.com

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.
33

The Dysport trademark is used under license. Restylane is a registered trademark of HA North American Sales AB. All other trademarks
are the property of their respective owners. DSP 11-060 10/31/12


Slide 14

Dysport ® is a prescription
injection for temporary
improvement in the look of
moderate to severe frown
lines between the eyebrows
(glabellar lines) in adults less
than 65 years of age.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.
The Dysport trademark is used under license. All other trademarks are the property of their respective owners. DSP 11-060 10/31/12

I do special things for myself,
and I’ll bet you do, too.
I work out, eat right, and take care of my
skin. Of course, cosmetic creams and lotions
will always have their place in my regimen—
but for my moderate to severe frown lines,
I was ready for a prescription treatment.
Maybe you are, too.

IMPORTANT SAFETY INFORMATION
What is the most important information you should know about Dysport?
Spread of Toxin Effects: In some cases, the effects of Dysport and all botulinum toxin products
may affect areas of the body away from the injection site. These effects can cause symptoms of
a serious condition called botulism. Symptoms of botulism can happen hours to weeks after
injection and may include swallowing and breathing problems, loss of strength and muscle
weakness all over the body, double vision, blurred vision and drooping eyelids, hoarseness or
change or loss of voice, trouble saying words clearly, or loss of bladder control.
PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

2

What is Dysport?
Prescription Dysport is an injection used to temporarily improve
the look of your moderate to severe frown lines without changing
the look of your whole face. The untreated facial muscles still
work normally, allowing you to freely show facial expressions,
such as smiling, in untreated areas.
Dysport is a formulation that has been shown to deliver temporary
improvement in moderate to severe frown lines, even with repeat
treatments. So, the effect of repeat treatment with Dysport may
be comparable to your first use.

IMPORTANT SAFETY INFORMATION
Swallowing and breathing problems can be life threatening and there have
been reports of death.
The risk of symptoms is probably greatest in children and adults treated for
muscle spasms, particularly in those patients who have underlying medical
conditions that could make these symptoms more likely.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

3

How does Dysport Work?
With just 1 injection into each of 5 points between and over
the eyebrows, Dysport blocks the signal from the nerve to the
muscles, ultimately resulting in a reduction of muscle activity
and temporarily preventing contraction of the muscles that
cause frown lines. You should not be treated with Dysport more
frequently than every 90 days.
Ask your doctor about your prescription treatment options for
temporarily improving the look of moderate to severe frown lines.
IMPORTANT SAFETY INFORMATION
The toxic effects have been reported at doses similar to those used to treat
muscle spasms in the neck. Lower doses, in both approved and unapproved
uses, have also caused toxic effects. This includes treatment of children and
adults for muscle spasms.

These effects could make it unsafe for you to drive a car, operate machinery,
or do other dangerous activities.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

4

What causes frown lines?
Over time, repeated movement of the facial skin by the
forehead muscles forms lines between the eyebrows.
Frown lines are “dynamic”—they happen because of
the way a person’s face moves.

IMPORTANT SAFETY INFORMATION
Do not have Dysport treatment if you: are allergic to Dysport or any of its ingredients
(see the end of the Medication Guide for a list of ingredients), are allergic to cow’s milk protein,
had an allergic reaction to any other botulinum toxin product (such as Myobloc® or Botox®),
or have a skin infection at the planned injection site.
The dose of Dysport is not the same as the dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to the dose of any other botulinum toxin
product you may have used.
Dysport may not be right for you if: you have surgical changes to your face, very weak
muscles in the treatment area, your face looks very different from side to side, the injection site
is inflamed, you have droopy eyelids or sagging eyelid folds, deep facial scars, thick oily skin, or
if your wrinkles can’t be smoothed by spreading them apart.
5

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Are frown lines always related to age?
No. Because frown lines are created by facial movements,
such as frowning or squinting, they may develop even in
younger adults.

IMPORTANT SAFETY INFORMATION
Tell your doctor about all your medical conditions, including if you have: a disease
that affects your muscles and nerves (such as amyotrophic lateral sclerosis [ALS or Lou
Gehrig’s disease], myasthenia gravis, or Lambert-Eaton syndrome), allergies to any
botulinum toxin product or had any side effect from any botulinum toxin product in the past,
a breathing problem (such as asthma or emphysema), swallowing problems, bleeding
problems, diabetes, a slow heart beat or other problem with your heart rate or rhythm, plans
to have surgery, had surgery on your face, weakness of your forehead muscles (such as
trouble raising your eyebrows), drooping eyelids, or any other change in the way your face
normally looks. Patients with a disease that affects muscles and nerves who are treated with
typical doses of Dysport may have a higher risk of serious side effects, including severe
swallowing and breathing problems.
6

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What can you do about frown lines?
Treatment with prescription Dysport can temporarily
improve the look of your moderate to severe frown lines.
Treatment generally takes just 10 to 20 minutes.
The most common side effects are nose and throat
irritation, headache, injection site pain, injection site skin
reaction, upper respiratory tract infection, eyelid swelling,
eyelid drooping, sinus inflammation, and nausea.

IMPORTANT SAFETY INFORMATION
Human Albumin
This product contains albumin taken from human plasma. Steps taken during donor
screening and product manufacturing processes make the risk of spreading viral diseases
extremely rare. In theory, there is also an extremely rare risk of contracting CreutzfeldtJakob disease (CJD). No cases of spread of viral diseases or CJD have ever been
reported for albumin.
7

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

How do you know if Dysport works?
Clinically proven results with 1 treatment
In 3 clinical studies of people whose frown lines were rated “moderate” or
“severe” by a doctor before their treatment with Dysport:a
• Doctor rating: 30 days after treatment, the majority (88%, 85%, and 86% in each of the 3 studies)
had their frown lines rated by a doctor as “mild” or “moderate” at maximum frown. For example, a
patient could improve from “severe” to “moderate” or from “moderate” to “mild.”
• Patient rating: 30 days after treatment, the majority (74%, 79%, and 82% in each of the 3 studies)
rated their own frown lines as “mild” or “moderate” at maximum frown. For example, a patient could
improve from “severe” to “moderate” or from “moderate” to “mild.”

a

Three double-blind, randomized, placebo-controlled, clinical studies evaluated the efficacy of Dysport for use in the temporary improvement of the appearance of moderate to severe
glabellar lines. These 3 studies enrolled healthy adults (ages 19-75) with glabellar lines of at least moderate severity at maximum frown. Subjects were excluded if they had marked
ptosis, deep dermal scarring, or a substantial inability to lessen glabellar lines, even by physically spreading them apart. The subjects in these studies received either Dysport or a
placebo. The total dose was delivered in equally divided aliquots to specified injection sites.

IMPORTANT SAFETY INFORMATION
Allergic Reaction to Injecting in the Skin
It is not known if an allergic reaction can be caused by injecting Dysport into the skin. The safety of
treating excessive sweating with Dysport is not known.
8

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Common Side Effects
The most common side effects are nose and throat irritation, headache, injection site pain, injection site skin
reaction, upper respiratory tract infection, eyelid swelling, eyelid drooping, sinus inflammation, and nausea.
9

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Tell your doctor about all the medicines you take, including prescription and nonprescription medicines,
vitamins and herbal and other natural products. Using Dysport with certain other medicines may cause
serious side effects.
Do not start any new medicines while taking Dysport without talking to your doctor first.
10

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Especially tell your doctor if you: have received any other botulinum toxin product in the last four
months, have received injections of botulinum toxin, such as Myobloc® (rimabotulinumtoxinB) or Botox®
(onabotulinumtoxinA) in the past (be sure your doctor knows exactly which product you received), have
recently received an antibiotic by injection, take muscle relaxants, take an allergy or cold medicine, or take
a sleep medicine.
11

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Use In Specific Populations
Dysport should not be used in children or in women who are pregnant or breastfeeding.
Ask your doctor if Dysport is right for you.
12

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What to expect with Dysport
A step-by-step guide to your treatment†

1

The Dysport treatment consultation
Discuss your expectations with your doctor and
whether you have any health conditions or
allergies that could interfere with your treatment.
† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

IMPORTANT SAFETY INFORMATION
What is the most important information you should know about Dysport?
Spread of Toxin Effects: In some cases, the effects of Dysport and all botulinum toxin products may affect
areas of the body away from the injection site. These effects can cause symptoms of a serious condition
called botulism. Symptoms of botulism can happen hours to weeks after injection and may include
swallowing and breathing problems, loss of strength and muscle weakness all over the body, double
vision, blurred vision and drooping eyelids, hoarseness or change or loss of voice, trouble saying words
clearly, or loss of bladder control. Swallowing and breathing problems can be life threatening and there
have been reports of death.
The risk of symptoms is probably greatest in children and adults treated for muscle spasms, particularly
in those patients who have underlying medical conditions that could make these symptoms more likely.
13

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What to expect with Dysport
A step-by-step guide to your treatment†

2

The Dysport treatment
Effective treatment requires 1 injection into each
of 5 points between and over the eyebrows.
Although office visit times may vary, the procedure
generally takes 10 to 20 minutes. Your healthcare
professional will determine the exact placement of
each injection to get results that are right for you.

IMPORTANT SAFETY INFORMATION
The toxic effects have been reported at doses similar to those used to treat muscle spasms in
the neck. Lower doses, in both approved and unapproved uses, have also caused toxic effects.
This includes treatment of children and adults for muscle spasms.
These effects could make it unsafe for you to drive a car, operate machinery, or do other
dangerous activities.
Do not have Dysport treatment if you: are allergic to Dysport or any of its ingredients (see the end
of the Medication Guide for a list of ingredients), are allergic to cow’s milk protein, had an allergic
reaction to any other botulinum toxin product, such as Myobloc® or Botox,® or have a skin infection at
the planned injection site.
14

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

What to expect with Dysport
A step-by-step guide to your treatment†

3

After your Dysport treatment
Ask your doctor about any precautions you
should take after your treatment. Call your doctor
or get medical help right away if you have any
problems swallowing, speaking, or breathing.
If this happens, do not drive a car, operate
machinery, or do other dangerous activities.

IMPORTANT SAFETY INFORMATION
The dose of Dysport is not the same as the dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to the dose of any other botulinum toxin
product you may have used.
Dysport may not be right for you if: you have surgical changes to your face, very weak
muscles in the treatment area, your face looks very different from side to side, the injection
site is inflamed, you have droopy eyelids or sagging eyelid folds, deep facial scars, thick oily
skin, or if your wrinkles can’t be smoothed by spreading them apart.
15

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

What to expect with Dysport
A step-by-step guide to your treatment†

4

Follow up
To maintain your improvements, you should
discuss a treatment schedule with your doctor.
As with any botulinum toxin product, you should
wait at least 90 days between treatments.

IMPORTANT SAFETY INFORMATION
Tell your doctor about all your medical conditions, including if you have: a disease that
affects your muscles and nerves (suchas amyotrophic lateral sclerosis [ALS or Lou Gehrig’s
disease], myasthenia gravis, or Lambert-Eaton syndrome), allergies to any botulinum toxin
product or had any side effect from any botulinum toxin product in the past, a breathing problem
(such as asthma or emphysema), swallowing problems, bleeding problems, diabetes, a slow
heart beat or other problem with your heart rate or rhythm, plans to have surgery, had surgery on
your face, weakness of your forehead muscles (such as trouble raising your eyebrows), drooping
eyelids, or any other change in the way your face normally looks. Patients with a disease that
affects muscles and nerves who are treated with typical doses of Dysport may have a higher risk
of serious side effects, including severe swallowing and breathing problems.
16

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

Why not start the Dysport
discussion with your doctor today?
Questions to ask your doctor:
• How soon will I see treatment results?
• How long does one treatment last?
• How often can I receive a Dysport treatment?
• Is there any way to save money on
my treatment?
• Can I have a treatment today?
• What are the risks associated with treatment?
IMPORTANT SAFETY INFORMATION
Human Albumin
This product contains albumin taken from human plasma. Steps taken during donor screening and product
manufacturing processes make the risk of spreading viral diseases extremely rare. In theory, there is also an
extremely rare risk of contracting Creutzfeldt-Jakob disease (CJD). No cases of spread of viral diseases or CJD
have ever been reported for albumin.
17

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Important Safety Information

What is the most important information you
should know about Dysport
(abobotulinumtoxinA) 300 Units for Injection?
Spread of Toxin Effects: In some cases, the
effects of Dysport and all botulinum toxin
products may affect areas of the body away
from the injection site. These effects can
cause symptoms of a serious condition called
botulism. Symptoms of botulism can happen
hours to weeks after injection and may
include swallowing and breathing problems,
loss of strength and muscle weakness all over
the body, double vision, blurred vision and
drooping eyelids, hoarseness or change or
loss of voice, trouble saying words clearly, or
loss of bladder control. Swallowing and
breathing problems can be life threatening
and there have been reports of death.

18

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

The risk of symptoms is probably greatest in
children and adults treated for muscle spasms,
particularly in those patients who have
underlying medical conditions that could make
these symptoms more likely.
The toxic effects have been reported at doses
similar to those used to treat muscle spasms in
the neck. Lower doses, in both approved and
unapproved uses, have also caused toxic
effects. This includes treatment of children and
adults for muscle spasms.
These effects could make it unsafe for you to
drive a car, operate machinery, or do other
dangerous activities.
Do not have Dysport treatment if you: are allergic
to Dysport or any of its ingredients (see the end of
the Medication Guide for a list of ingredients), are
allergic to cow’s milk protein, had an allergic
reaction to any other botulinum toxin product, such
as Myobloc® or Botox,® or have a skin infection at
the planned injection site.

Important Safety Information (cont.)

The dose of Dysport is not the same as the
dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to
the dose of any other botulinum toxin product
you may have used.
Dysport may not be right for you if: you have
surgical changes to your face, very weak muscles
in the treatment area, your face looks very
different from side to side, the injection site is
inflamed, you have droopy eyelids or sagging
eyelid folds, deep facial scars, thick oily skin, or if
your wrinkles can’t be smoothed by spreading
them apart.
Tell your doctor about all your medical
conditions, including if you have: a disease
that affects your muscles and nerves (such as
amyotrophic lateral sclerosis [ALS or Lou
Gehrig’s disease], myasthenia gravis, or LambertEaton syndrome), allergies to any botulinum toxin
product or had any side effect from any

19

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

botulinum toxin product in the past, a breathing
problem (such as asthma or emphysema),
swallowing problems, bleeding problems, diabetes,
a slow heart beat or other problem with your heart
rate or rhythm, plans to have surgery, had surgery
on your face, weakness of your forehead muscles
(such as trouble raising your eyebrows), drooping
eyelids, or any other change in the way your face
normally looks. Patients with a disease that affects
muscles and nerves who are treated with typical
doses of Dysport may have a higher risk of serious
side effects, including severe swallowing and
breathing problems.
Human Albumin
This product contains albumin taken from human
plasma. Steps taken during donor screening and
product manufacturing processes make the risk of
spreading viral diseases extremely rare. In theory,
there is also an extremely rare risk of contracting
Creutzfeldt-Jakob disease (CJD). No cases of
spread of viral diseases or CJD have ever been
reported for albumin.

Important Safety Information (cont.)

Allergic Reaction to Injecting in the Skin
It is not known if an allergic reaction can be
caused by injecting Dysport into the skin. The
safety of treating excessive sweating with Dysport
is not known.
Common Side Effects
The most common side effects are nose and
throat irritation, headache, injection site pain,
injection site skin reaction, upper respiratory tract
infection, eyelid swelling, eyelid drooping, sinus
inflammation, and nausea.
Tell your doctor about all the medicines you
take, including prescription and nonprescription
medicines, vitamins and herbal and other natural
products. Using Dysport with certain other
medicines may cause serious side effects.

20

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

Do not start any new medicines while taking
Dysport without talking to your doctor first.

Especially tell your doctor if you: have received
any other botulinum toxin product in the last four
months, have received injections of botulinum toxin,
such as Myobloc® (rimabotulinumtoxinB) or Botox®
(onabotulinumtoxinA) in the past (be sure your
doctor knows exactly which product you received),
have recently received an antibiotic by injection,
take muscle relaxants, take an allergy or cold
medicine, or take a sleep medicine.
Use In Specific Populations
Dysport should not be used in children or in women
who are pregnant or breastfeeding.
Ask your doctor if Dysport is right for you.

Medication Guide

21

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

22

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

23

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

24

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

25

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

26

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

27

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

28

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

29

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

30

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

31

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

32

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medicis Family
of Aesthetic Products

Products are not FDA approved for combination use.

www.DysportUSA.com

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.
33

The Dysport trademark is used under license. Restylane is a registered trademark of HA North American Sales AB. All other trademarks
are the property of their respective owners. DSP 11-060 10/31/12


Slide 15

Dysport ® is a prescription
injection for temporary
improvement in the look of
moderate to severe frown
lines between the eyebrows
(glabellar lines) in adults less
than 65 years of age.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.
The Dysport trademark is used under license. All other trademarks are the property of their respective owners. DSP 11-060 10/31/12

I do special things for myself,
and I’ll bet you do, too.
I work out, eat right, and take care of my
skin. Of course, cosmetic creams and lotions
will always have their place in my regimen—
but for my moderate to severe frown lines,
I was ready for a prescription treatment.
Maybe you are, too.

IMPORTANT SAFETY INFORMATION
What is the most important information you should know about Dysport?
Spread of Toxin Effects: In some cases, the effects of Dysport and all botulinum toxin products
may affect areas of the body away from the injection site. These effects can cause symptoms of
a serious condition called botulism. Symptoms of botulism can happen hours to weeks after
injection and may include swallowing and breathing problems, loss of strength and muscle
weakness all over the body, double vision, blurred vision and drooping eyelids, hoarseness or
change or loss of voice, trouble saying words clearly, or loss of bladder control.
PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

2

What is Dysport?
Prescription Dysport is an injection used to temporarily improve
the look of your moderate to severe frown lines without changing
the look of your whole face. The untreated facial muscles still
work normally, allowing you to freely show facial expressions,
such as smiling, in untreated areas.
Dysport is a formulation that has been shown to deliver temporary
improvement in moderate to severe frown lines, even with repeat
treatments. So, the effect of repeat treatment with Dysport may
be comparable to your first use.

IMPORTANT SAFETY INFORMATION
Swallowing and breathing problems can be life threatening and there have
been reports of death.
The risk of symptoms is probably greatest in children and adults treated for
muscle spasms, particularly in those patients who have underlying medical
conditions that could make these symptoms more likely.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

3

How does Dysport Work?
With just 1 injection into each of 5 points between and over
the eyebrows, Dysport blocks the signal from the nerve to the
muscles, ultimately resulting in a reduction of muscle activity
and temporarily preventing contraction of the muscles that
cause frown lines. You should not be treated with Dysport more
frequently than every 90 days.
Ask your doctor about your prescription treatment options for
temporarily improving the look of moderate to severe frown lines.
IMPORTANT SAFETY INFORMATION
The toxic effects have been reported at doses similar to those used to treat
muscle spasms in the neck. Lower doses, in both approved and unapproved
uses, have also caused toxic effects. This includes treatment of children and
adults for muscle spasms.

These effects could make it unsafe for you to drive a car, operate machinery,
or do other dangerous activities.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

4

What causes frown lines?
Over time, repeated movement of the facial skin by the
forehead muscles forms lines between the eyebrows.
Frown lines are “dynamic”—they happen because of
the way a person’s face moves.

IMPORTANT SAFETY INFORMATION
Do not have Dysport treatment if you: are allergic to Dysport or any of its ingredients
(see the end of the Medication Guide for a list of ingredients), are allergic to cow’s milk protein,
had an allergic reaction to any other botulinum toxin product (such as Myobloc® or Botox®),
or have a skin infection at the planned injection site.
The dose of Dysport is not the same as the dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to the dose of any other botulinum toxin
product you may have used.
Dysport may not be right for you if: you have surgical changes to your face, very weak
muscles in the treatment area, your face looks very different from side to side, the injection site
is inflamed, you have droopy eyelids or sagging eyelid folds, deep facial scars, thick oily skin, or
if your wrinkles can’t be smoothed by spreading them apart.
5

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Are frown lines always related to age?
No. Because frown lines are created by facial movements,
such as frowning or squinting, they may develop even in
younger adults.

IMPORTANT SAFETY INFORMATION
Tell your doctor about all your medical conditions, including if you have: a disease
that affects your muscles and nerves (such as amyotrophic lateral sclerosis [ALS or Lou
Gehrig’s disease], myasthenia gravis, or Lambert-Eaton syndrome), allergies to any
botulinum toxin product or had any side effect from any botulinum toxin product in the past,
a breathing problem (such as asthma or emphysema), swallowing problems, bleeding
problems, diabetes, a slow heart beat or other problem with your heart rate or rhythm, plans
to have surgery, had surgery on your face, weakness of your forehead muscles (such as
trouble raising your eyebrows), drooping eyelids, or any other change in the way your face
normally looks. Patients with a disease that affects muscles and nerves who are treated with
typical doses of Dysport may have a higher risk of serious side effects, including severe
swallowing and breathing problems.
6

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What can you do about frown lines?
Treatment with prescription Dysport can temporarily
improve the look of your moderate to severe frown lines.
Treatment generally takes just 10 to 20 minutes.
The most common side effects are nose and throat
irritation, headache, injection site pain, injection site skin
reaction, upper respiratory tract infection, eyelid swelling,
eyelid drooping, sinus inflammation, and nausea.

IMPORTANT SAFETY INFORMATION
Human Albumin
This product contains albumin taken from human plasma. Steps taken during donor
screening and product manufacturing processes make the risk of spreading viral diseases
extremely rare. In theory, there is also an extremely rare risk of contracting CreutzfeldtJakob disease (CJD). No cases of spread of viral diseases or CJD have ever been
reported for albumin.
7

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

How do you know if Dysport works?
Clinically proven results with 1 treatment
In 3 clinical studies of people whose frown lines were rated “moderate” or
“severe” by a doctor before their treatment with Dysport:a
• Doctor rating: 30 days after treatment, the majority (88%, 85%, and 86% in each of the 3 studies)
had their frown lines rated by a doctor as “mild” or “moderate” at maximum frown. For example, a
patient could improve from “severe” to “moderate” or from “moderate” to “mild.”
• Patient rating: 30 days after treatment, the majority (74%, 79%, and 82% in each of the 3 studies)
rated their own frown lines as “mild” or “moderate” at maximum frown. For example, a patient could
improve from “severe” to “moderate” or from “moderate” to “mild.”

a

Three double-blind, randomized, placebo-controlled, clinical studies evaluated the efficacy of Dysport for use in the temporary improvement of the appearance of moderate to severe
glabellar lines. These 3 studies enrolled healthy adults (ages 19-75) with glabellar lines of at least moderate severity at maximum frown. Subjects were excluded if they had marked
ptosis, deep dermal scarring, or a substantial inability to lessen glabellar lines, even by physically spreading them apart. The subjects in these studies received either Dysport or a
placebo. The total dose was delivered in equally divided aliquots to specified injection sites.

IMPORTANT SAFETY INFORMATION
Allergic Reaction to Injecting in the Skin
It is not known if an allergic reaction can be caused by injecting Dysport into the skin. The safety of
treating excessive sweating with Dysport is not known.
8

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Common Side Effects
The most common side effects are nose and throat irritation, headache, injection site pain, injection site skin
reaction, upper respiratory tract infection, eyelid swelling, eyelid drooping, sinus inflammation, and nausea.
9

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Tell your doctor about all the medicines you take, including prescription and nonprescription medicines,
vitamins and herbal and other natural products. Using Dysport with certain other medicines may cause
serious side effects.
Do not start any new medicines while taking Dysport without talking to your doctor first.
10

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Especially tell your doctor if you: have received any other botulinum toxin product in the last four
months, have received injections of botulinum toxin, such as Myobloc® (rimabotulinumtoxinB) or Botox®
(onabotulinumtoxinA) in the past (be sure your doctor knows exactly which product you received), have
recently received an antibiotic by injection, take muscle relaxants, take an allergy or cold medicine, or take
a sleep medicine.
11

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Use In Specific Populations
Dysport should not be used in children or in women who are pregnant or breastfeeding.
Ask your doctor if Dysport is right for you.
12

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What to expect with Dysport
A step-by-step guide to your treatment†

1

The Dysport treatment consultation
Discuss your expectations with your doctor and
whether you have any health conditions or
allergies that could interfere with your treatment.
† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

IMPORTANT SAFETY INFORMATION
What is the most important information you should know about Dysport?
Spread of Toxin Effects: In some cases, the effects of Dysport and all botulinum toxin products may affect
areas of the body away from the injection site. These effects can cause symptoms of a serious condition
called botulism. Symptoms of botulism can happen hours to weeks after injection and may include
swallowing and breathing problems, loss of strength and muscle weakness all over the body, double
vision, blurred vision and drooping eyelids, hoarseness or change or loss of voice, trouble saying words
clearly, or loss of bladder control. Swallowing and breathing problems can be life threatening and there
have been reports of death.
The risk of symptoms is probably greatest in children and adults treated for muscle spasms, particularly
in those patients who have underlying medical conditions that could make these symptoms more likely.
13

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What to expect with Dysport
A step-by-step guide to your treatment†

2

The Dysport treatment
Effective treatment requires 1 injection into each
of 5 points between and over the eyebrows.
Although office visit times may vary, the procedure
generally takes 10 to 20 minutes. Your healthcare
professional will determine the exact placement of
each injection to get results that are right for you.

IMPORTANT SAFETY INFORMATION
The toxic effects have been reported at doses similar to those used to treat muscle spasms in
the neck. Lower doses, in both approved and unapproved uses, have also caused toxic effects.
This includes treatment of children and adults for muscle spasms.
These effects could make it unsafe for you to drive a car, operate machinery, or do other
dangerous activities.
Do not have Dysport treatment if you: are allergic to Dysport or any of its ingredients (see the end
of the Medication Guide for a list of ingredients), are allergic to cow’s milk protein, had an allergic
reaction to any other botulinum toxin product, such as Myobloc® or Botox,® or have a skin infection at
the planned injection site.
14

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

What to expect with Dysport
A step-by-step guide to your treatment†

3

After your Dysport treatment
Ask your doctor about any precautions you
should take after your treatment. Call your doctor
or get medical help right away if you have any
problems swallowing, speaking, or breathing.
If this happens, do not drive a car, operate
machinery, or do other dangerous activities.

IMPORTANT SAFETY INFORMATION
The dose of Dysport is not the same as the dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to the dose of any other botulinum toxin
product you may have used.
Dysport may not be right for you if: you have surgical changes to your face, very weak
muscles in the treatment area, your face looks very different from side to side, the injection
site is inflamed, you have droopy eyelids or sagging eyelid folds, deep facial scars, thick oily
skin, or if your wrinkles can’t be smoothed by spreading them apart.
15

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

What to expect with Dysport
A step-by-step guide to your treatment†

4

Follow up
To maintain your improvements, you should
discuss a treatment schedule with your doctor.
As with any botulinum toxin product, you should
wait at least 90 days between treatments.

IMPORTANT SAFETY INFORMATION
Tell your doctor about all your medical conditions, including if you have: a disease that
affects your muscles and nerves (suchas amyotrophic lateral sclerosis [ALS or Lou Gehrig’s
disease], myasthenia gravis, or Lambert-Eaton syndrome), allergies to any botulinum toxin
product or had any side effect from any botulinum toxin product in the past, a breathing problem
(such as asthma or emphysema), swallowing problems, bleeding problems, diabetes, a slow
heart beat or other problem with your heart rate or rhythm, plans to have surgery, had surgery on
your face, weakness of your forehead muscles (such as trouble raising your eyebrows), drooping
eyelids, or any other change in the way your face normally looks. Patients with a disease that
affects muscles and nerves who are treated with typical doses of Dysport may have a higher risk
of serious side effects, including severe swallowing and breathing problems.
16

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

Why not start the Dysport
discussion with your doctor today?
Questions to ask your doctor:
• How soon will I see treatment results?
• How long does one treatment last?
• How often can I receive a Dysport treatment?
• Is there any way to save money on
my treatment?
• Can I have a treatment today?
• What are the risks associated with treatment?
IMPORTANT SAFETY INFORMATION
Human Albumin
This product contains albumin taken from human plasma. Steps taken during donor screening and product
manufacturing processes make the risk of spreading viral diseases extremely rare. In theory, there is also an
extremely rare risk of contracting Creutzfeldt-Jakob disease (CJD). No cases of spread of viral diseases or CJD
have ever been reported for albumin.
17

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Important Safety Information

What is the most important information you
should know about Dysport
(abobotulinumtoxinA) 300 Units for Injection?
Spread of Toxin Effects: In some cases, the
effects of Dysport and all botulinum toxin
products may affect areas of the body away
from the injection site. These effects can
cause symptoms of a serious condition called
botulism. Symptoms of botulism can happen
hours to weeks after injection and may
include swallowing and breathing problems,
loss of strength and muscle weakness all over
the body, double vision, blurred vision and
drooping eyelids, hoarseness or change or
loss of voice, trouble saying words clearly, or
loss of bladder control. Swallowing and
breathing problems can be life threatening
and there have been reports of death.

18

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

The risk of symptoms is probably greatest in
children and adults treated for muscle spasms,
particularly in those patients who have
underlying medical conditions that could make
these symptoms more likely.
The toxic effects have been reported at doses
similar to those used to treat muscle spasms in
the neck. Lower doses, in both approved and
unapproved uses, have also caused toxic
effects. This includes treatment of children and
adults for muscle spasms.
These effects could make it unsafe for you to
drive a car, operate machinery, or do other
dangerous activities.
Do not have Dysport treatment if you: are allergic
to Dysport or any of its ingredients (see the end of
the Medication Guide for a list of ingredients), are
allergic to cow’s milk protein, had an allergic
reaction to any other botulinum toxin product, such
as Myobloc® or Botox,® or have a skin infection at
the planned injection site.

Important Safety Information (cont.)

The dose of Dysport is not the same as the
dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to
the dose of any other botulinum toxin product
you may have used.
Dysport may not be right for you if: you have
surgical changes to your face, very weak muscles
in the treatment area, your face looks very
different from side to side, the injection site is
inflamed, you have droopy eyelids or sagging
eyelid folds, deep facial scars, thick oily skin, or if
your wrinkles can’t be smoothed by spreading
them apart.
Tell your doctor about all your medical
conditions, including if you have: a disease
that affects your muscles and nerves (such as
amyotrophic lateral sclerosis [ALS or Lou
Gehrig’s disease], myasthenia gravis, or LambertEaton syndrome), allergies to any botulinum toxin
product or had any side effect from any

19

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

botulinum toxin product in the past, a breathing
problem (such as asthma or emphysema),
swallowing problems, bleeding problems, diabetes,
a slow heart beat or other problem with your heart
rate or rhythm, plans to have surgery, had surgery
on your face, weakness of your forehead muscles
(such as trouble raising your eyebrows), drooping
eyelids, or any other change in the way your face
normally looks. Patients with a disease that affects
muscles and nerves who are treated with typical
doses of Dysport may have a higher risk of serious
side effects, including severe swallowing and
breathing problems.
Human Albumin
This product contains albumin taken from human
plasma. Steps taken during donor screening and
product manufacturing processes make the risk of
spreading viral diseases extremely rare. In theory,
there is also an extremely rare risk of contracting
Creutzfeldt-Jakob disease (CJD). No cases of
spread of viral diseases or CJD have ever been
reported for albumin.

Important Safety Information (cont.)

Allergic Reaction to Injecting in the Skin
It is not known if an allergic reaction can be
caused by injecting Dysport into the skin. The
safety of treating excessive sweating with Dysport
is not known.
Common Side Effects
The most common side effects are nose and
throat irritation, headache, injection site pain,
injection site skin reaction, upper respiratory tract
infection, eyelid swelling, eyelid drooping, sinus
inflammation, and nausea.
Tell your doctor about all the medicines you
take, including prescription and nonprescription
medicines, vitamins and herbal and other natural
products. Using Dysport with certain other
medicines may cause serious side effects.

20

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

Do not start any new medicines while taking
Dysport without talking to your doctor first.

Especially tell your doctor if you: have received
any other botulinum toxin product in the last four
months, have received injections of botulinum toxin,
such as Myobloc® (rimabotulinumtoxinB) or Botox®
(onabotulinumtoxinA) in the past (be sure your
doctor knows exactly which product you received),
have recently received an antibiotic by injection,
take muscle relaxants, take an allergy or cold
medicine, or take a sleep medicine.
Use In Specific Populations
Dysport should not be used in children or in women
who are pregnant or breastfeeding.
Ask your doctor if Dysport is right for you.

Medication Guide

21

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

22

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

23

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

24

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

25

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

26

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

27

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

28

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

29

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

30

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

31

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

32

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medicis Family
of Aesthetic Products

Products are not FDA approved for combination use.

www.DysportUSA.com

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.
33

The Dysport trademark is used under license. Restylane is a registered trademark of HA North American Sales AB. All other trademarks
are the property of their respective owners. DSP 11-060 10/31/12


Slide 16

Dysport ® is a prescription
injection for temporary
improvement in the look of
moderate to severe frown
lines between the eyebrows
(glabellar lines) in adults less
than 65 years of age.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.
The Dysport trademark is used under license. All other trademarks are the property of their respective owners. DSP 11-060 10/31/12

I do special things for myself,
and I’ll bet you do, too.
I work out, eat right, and take care of my
skin. Of course, cosmetic creams and lotions
will always have their place in my regimen—
but for my moderate to severe frown lines,
I was ready for a prescription treatment.
Maybe you are, too.

IMPORTANT SAFETY INFORMATION
What is the most important information you should know about Dysport?
Spread of Toxin Effects: In some cases, the effects of Dysport and all botulinum toxin products
may affect areas of the body away from the injection site. These effects can cause symptoms of
a serious condition called botulism. Symptoms of botulism can happen hours to weeks after
injection and may include swallowing and breathing problems, loss of strength and muscle
weakness all over the body, double vision, blurred vision and drooping eyelids, hoarseness or
change or loss of voice, trouble saying words clearly, or loss of bladder control.
PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

2

What is Dysport?
Prescription Dysport is an injection used to temporarily improve
the look of your moderate to severe frown lines without changing
the look of your whole face. The untreated facial muscles still
work normally, allowing you to freely show facial expressions,
such as smiling, in untreated areas.
Dysport is a formulation that has been shown to deliver temporary
improvement in moderate to severe frown lines, even with repeat
treatments. So, the effect of repeat treatment with Dysport may
be comparable to your first use.

IMPORTANT SAFETY INFORMATION
Swallowing and breathing problems can be life threatening and there have
been reports of death.
The risk of symptoms is probably greatest in children and adults treated for
muscle spasms, particularly in those patients who have underlying medical
conditions that could make these symptoms more likely.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

3

How does Dysport Work?
With just 1 injection into each of 5 points between and over
the eyebrows, Dysport blocks the signal from the nerve to the
muscles, ultimately resulting in a reduction of muscle activity
and temporarily preventing contraction of the muscles that
cause frown lines. You should not be treated with Dysport more
frequently than every 90 days.
Ask your doctor about your prescription treatment options for
temporarily improving the look of moderate to severe frown lines.
IMPORTANT SAFETY INFORMATION
The toxic effects have been reported at doses similar to those used to treat
muscle spasms in the neck. Lower doses, in both approved and unapproved
uses, have also caused toxic effects. This includes treatment of children and
adults for muscle spasms.

These effects could make it unsafe for you to drive a car, operate machinery,
or do other dangerous activities.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

4

What causes frown lines?
Over time, repeated movement of the facial skin by the
forehead muscles forms lines between the eyebrows.
Frown lines are “dynamic”—they happen because of
the way a person’s face moves.

IMPORTANT SAFETY INFORMATION
Do not have Dysport treatment if you: are allergic to Dysport or any of its ingredients
(see the end of the Medication Guide for a list of ingredients), are allergic to cow’s milk protein,
had an allergic reaction to any other botulinum toxin product (such as Myobloc® or Botox®),
or have a skin infection at the planned injection site.
The dose of Dysport is not the same as the dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to the dose of any other botulinum toxin
product you may have used.
Dysport may not be right for you if: you have surgical changes to your face, very weak
muscles in the treatment area, your face looks very different from side to side, the injection site
is inflamed, you have droopy eyelids or sagging eyelid folds, deep facial scars, thick oily skin, or
if your wrinkles can’t be smoothed by spreading them apart.
5

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Are frown lines always related to age?
No. Because frown lines are created by facial movements,
such as frowning or squinting, they may develop even in
younger adults.

IMPORTANT SAFETY INFORMATION
Tell your doctor about all your medical conditions, including if you have: a disease
that affects your muscles and nerves (such as amyotrophic lateral sclerosis [ALS or Lou
Gehrig’s disease], myasthenia gravis, or Lambert-Eaton syndrome), allergies to any
botulinum toxin product or had any side effect from any botulinum toxin product in the past,
a breathing problem (such as asthma or emphysema), swallowing problems, bleeding
problems, diabetes, a slow heart beat or other problem with your heart rate or rhythm, plans
to have surgery, had surgery on your face, weakness of your forehead muscles (such as
trouble raising your eyebrows), drooping eyelids, or any other change in the way your face
normally looks. Patients with a disease that affects muscles and nerves who are treated with
typical doses of Dysport may have a higher risk of serious side effects, including severe
swallowing and breathing problems.
6

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What can you do about frown lines?
Treatment with prescription Dysport can temporarily
improve the look of your moderate to severe frown lines.
Treatment generally takes just 10 to 20 minutes.
The most common side effects are nose and throat
irritation, headache, injection site pain, injection site skin
reaction, upper respiratory tract infection, eyelid swelling,
eyelid drooping, sinus inflammation, and nausea.

IMPORTANT SAFETY INFORMATION
Human Albumin
This product contains albumin taken from human plasma. Steps taken during donor
screening and product manufacturing processes make the risk of spreading viral diseases
extremely rare. In theory, there is also an extremely rare risk of contracting CreutzfeldtJakob disease (CJD). No cases of spread of viral diseases or CJD have ever been
reported for albumin.
7

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

How do you know if Dysport works?
Clinically proven results with 1 treatment
In 3 clinical studies of people whose frown lines were rated “moderate” or
“severe” by a doctor before their treatment with Dysport:a
• Doctor rating: 30 days after treatment, the majority (88%, 85%, and 86% in each of the 3 studies)
had their frown lines rated by a doctor as “mild” or “moderate” at maximum frown. For example, a
patient could improve from “severe” to “moderate” or from “moderate” to “mild.”
• Patient rating: 30 days after treatment, the majority (74%, 79%, and 82% in each of the 3 studies)
rated their own frown lines as “mild” or “moderate” at maximum frown. For example, a patient could
improve from “severe” to “moderate” or from “moderate” to “mild.”

a

Three double-blind, randomized, placebo-controlled, clinical studies evaluated the efficacy of Dysport for use in the temporary improvement of the appearance of moderate to severe
glabellar lines. These 3 studies enrolled healthy adults (ages 19-75) with glabellar lines of at least moderate severity at maximum frown. Subjects were excluded if they had marked
ptosis, deep dermal scarring, or a substantial inability to lessen glabellar lines, even by physically spreading them apart. The subjects in these studies received either Dysport or a
placebo. The total dose was delivered in equally divided aliquots to specified injection sites.

IMPORTANT SAFETY INFORMATION
Allergic Reaction to Injecting in the Skin
It is not known if an allergic reaction can be caused by injecting Dysport into the skin. The safety of
treating excessive sweating with Dysport is not known.
8

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Common Side Effects
The most common side effects are nose and throat irritation, headache, injection site pain, injection site skin
reaction, upper respiratory tract infection, eyelid swelling, eyelid drooping, sinus inflammation, and nausea.
9

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Tell your doctor about all the medicines you take, including prescription and nonprescription medicines,
vitamins and herbal and other natural products. Using Dysport with certain other medicines may cause
serious side effects.
Do not start any new medicines while taking Dysport without talking to your doctor first.
10

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Especially tell your doctor if you: have received any other botulinum toxin product in the last four
months, have received injections of botulinum toxin, such as Myobloc® (rimabotulinumtoxinB) or Botox®
(onabotulinumtoxinA) in the past (be sure your doctor knows exactly which product you received), have
recently received an antibiotic by injection, take muscle relaxants, take an allergy or cold medicine, or take
a sleep medicine.
11

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Use In Specific Populations
Dysport should not be used in children or in women who are pregnant or breastfeeding.
Ask your doctor if Dysport is right for you.
12

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What to expect with Dysport
A step-by-step guide to your treatment†

1

The Dysport treatment consultation
Discuss your expectations with your doctor and
whether you have any health conditions or
allergies that could interfere with your treatment.
† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

IMPORTANT SAFETY INFORMATION
What is the most important information you should know about Dysport?
Spread of Toxin Effects: In some cases, the effects of Dysport and all botulinum toxin products may affect
areas of the body away from the injection site. These effects can cause symptoms of a serious condition
called botulism. Symptoms of botulism can happen hours to weeks after injection and may include
swallowing and breathing problems, loss of strength and muscle weakness all over the body, double
vision, blurred vision and drooping eyelids, hoarseness or change or loss of voice, trouble saying words
clearly, or loss of bladder control. Swallowing and breathing problems can be life threatening and there
have been reports of death.
The risk of symptoms is probably greatest in children and adults treated for muscle spasms, particularly
in those patients who have underlying medical conditions that could make these symptoms more likely.
13

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What to expect with Dysport
A step-by-step guide to your treatment†

2

The Dysport treatment
Effective treatment requires 1 injection into each
of 5 points between and over the eyebrows.
Although office visit times may vary, the procedure
generally takes 10 to 20 minutes. Your healthcare
professional will determine the exact placement of
each injection to get results that are right for you.

IMPORTANT SAFETY INFORMATION
The toxic effects have been reported at doses similar to those used to treat muscle spasms in
the neck. Lower doses, in both approved and unapproved uses, have also caused toxic effects.
This includes treatment of children and adults for muscle spasms.
These effects could make it unsafe for you to drive a car, operate machinery, or do other
dangerous activities.
Do not have Dysport treatment if you: are allergic to Dysport or any of its ingredients (see the end
of the Medication Guide for a list of ingredients), are allergic to cow’s milk protein, had an allergic
reaction to any other botulinum toxin product, such as Myobloc® or Botox,® or have a skin infection at
the planned injection site.
14

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

What to expect with Dysport
A step-by-step guide to your treatment†

3

After your Dysport treatment
Ask your doctor about any precautions you
should take after your treatment. Call your doctor
or get medical help right away if you have any
problems swallowing, speaking, or breathing.
If this happens, do not drive a car, operate
machinery, or do other dangerous activities.

IMPORTANT SAFETY INFORMATION
The dose of Dysport is not the same as the dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to the dose of any other botulinum toxin
product you may have used.
Dysport may not be right for you if: you have surgical changes to your face, very weak
muscles in the treatment area, your face looks very different from side to side, the injection
site is inflamed, you have droopy eyelids or sagging eyelid folds, deep facial scars, thick oily
skin, or if your wrinkles can’t be smoothed by spreading them apart.
15

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

What to expect with Dysport
A step-by-step guide to your treatment†

4

Follow up
To maintain your improvements, you should
discuss a treatment schedule with your doctor.
As with any botulinum toxin product, you should
wait at least 90 days between treatments.

IMPORTANT SAFETY INFORMATION
Tell your doctor about all your medical conditions, including if you have: a disease that
affects your muscles and nerves (suchas amyotrophic lateral sclerosis [ALS or Lou Gehrig’s
disease], myasthenia gravis, or Lambert-Eaton syndrome), allergies to any botulinum toxin
product or had any side effect from any botulinum toxin product in the past, a breathing problem
(such as asthma or emphysema), swallowing problems, bleeding problems, diabetes, a slow
heart beat or other problem with your heart rate or rhythm, plans to have surgery, had surgery on
your face, weakness of your forehead muscles (such as trouble raising your eyebrows), drooping
eyelids, or any other change in the way your face normally looks. Patients with a disease that
affects muscles and nerves who are treated with typical doses of Dysport may have a higher risk
of serious side effects, including severe swallowing and breathing problems.
16

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

Why not start the Dysport
discussion with your doctor today?
Questions to ask your doctor:
• How soon will I see treatment results?
• How long does one treatment last?
• How often can I receive a Dysport treatment?
• Is there any way to save money on
my treatment?
• Can I have a treatment today?
• What are the risks associated with treatment?
IMPORTANT SAFETY INFORMATION
Human Albumin
This product contains albumin taken from human plasma. Steps taken during donor screening and product
manufacturing processes make the risk of spreading viral diseases extremely rare. In theory, there is also an
extremely rare risk of contracting Creutzfeldt-Jakob disease (CJD). No cases of spread of viral diseases or CJD
have ever been reported for albumin.
17

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Important Safety Information

What is the most important information you
should know about Dysport
(abobotulinumtoxinA) 300 Units for Injection?
Spread of Toxin Effects: In some cases, the
effects of Dysport and all botulinum toxin
products may affect areas of the body away
from the injection site. These effects can
cause symptoms of a serious condition called
botulism. Symptoms of botulism can happen
hours to weeks after injection and may
include swallowing and breathing problems,
loss of strength and muscle weakness all over
the body, double vision, blurred vision and
drooping eyelids, hoarseness or change or
loss of voice, trouble saying words clearly, or
loss of bladder control. Swallowing and
breathing problems can be life threatening
and there have been reports of death.

18

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

The risk of symptoms is probably greatest in
children and adults treated for muscle spasms,
particularly in those patients who have
underlying medical conditions that could make
these symptoms more likely.
The toxic effects have been reported at doses
similar to those used to treat muscle spasms in
the neck. Lower doses, in both approved and
unapproved uses, have also caused toxic
effects. This includes treatment of children and
adults for muscle spasms.
These effects could make it unsafe for you to
drive a car, operate machinery, or do other
dangerous activities.
Do not have Dysport treatment if you: are allergic
to Dysport or any of its ingredients (see the end of
the Medication Guide for a list of ingredients), are
allergic to cow’s milk protein, had an allergic
reaction to any other botulinum toxin product, such
as Myobloc® or Botox,® or have a skin infection at
the planned injection site.

Important Safety Information (cont.)

The dose of Dysport is not the same as the
dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to
the dose of any other botulinum toxin product
you may have used.
Dysport may not be right for you if: you have
surgical changes to your face, very weak muscles
in the treatment area, your face looks very
different from side to side, the injection site is
inflamed, you have droopy eyelids or sagging
eyelid folds, deep facial scars, thick oily skin, or if
your wrinkles can’t be smoothed by spreading
them apart.
Tell your doctor about all your medical
conditions, including if you have: a disease
that affects your muscles and nerves (such as
amyotrophic lateral sclerosis [ALS or Lou
Gehrig’s disease], myasthenia gravis, or LambertEaton syndrome), allergies to any botulinum toxin
product or had any side effect from any

19

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

botulinum toxin product in the past, a breathing
problem (such as asthma or emphysema),
swallowing problems, bleeding problems, diabetes,
a slow heart beat or other problem with your heart
rate or rhythm, plans to have surgery, had surgery
on your face, weakness of your forehead muscles
(such as trouble raising your eyebrows), drooping
eyelids, or any other change in the way your face
normally looks. Patients with a disease that affects
muscles and nerves who are treated with typical
doses of Dysport may have a higher risk of serious
side effects, including severe swallowing and
breathing problems.
Human Albumin
This product contains albumin taken from human
plasma. Steps taken during donor screening and
product manufacturing processes make the risk of
spreading viral diseases extremely rare. In theory,
there is also an extremely rare risk of contracting
Creutzfeldt-Jakob disease (CJD). No cases of
spread of viral diseases or CJD have ever been
reported for albumin.

Important Safety Information (cont.)

Allergic Reaction to Injecting in the Skin
It is not known if an allergic reaction can be
caused by injecting Dysport into the skin. The
safety of treating excessive sweating with Dysport
is not known.
Common Side Effects
The most common side effects are nose and
throat irritation, headache, injection site pain,
injection site skin reaction, upper respiratory tract
infection, eyelid swelling, eyelid drooping, sinus
inflammation, and nausea.
Tell your doctor about all the medicines you
take, including prescription and nonprescription
medicines, vitamins and herbal and other natural
products. Using Dysport with certain other
medicines may cause serious side effects.

20

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

Do not start any new medicines while taking
Dysport without talking to your doctor first.

Especially tell your doctor if you: have received
any other botulinum toxin product in the last four
months, have received injections of botulinum toxin,
such as Myobloc® (rimabotulinumtoxinB) or Botox®
(onabotulinumtoxinA) in the past (be sure your
doctor knows exactly which product you received),
have recently received an antibiotic by injection,
take muscle relaxants, take an allergy or cold
medicine, or take a sleep medicine.
Use In Specific Populations
Dysport should not be used in children or in women
who are pregnant or breastfeeding.
Ask your doctor if Dysport is right for you.

Medication Guide

21

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

22

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

23

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

24

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

25

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

26

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

27

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

28

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

29

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

30

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

31

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

32

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medicis Family
of Aesthetic Products

Products are not FDA approved for combination use.

www.DysportUSA.com

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.
33

The Dysport trademark is used under license. Restylane is a registered trademark of HA North American Sales AB. All other trademarks
are the property of their respective owners. DSP 11-060 10/31/12


Slide 17

Dysport ® is a prescription
injection for temporary
improvement in the look of
moderate to severe frown
lines between the eyebrows
(glabellar lines) in adults less
than 65 years of age.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.
The Dysport trademark is used under license. All other trademarks are the property of their respective owners. DSP 11-060 10/31/12

I do special things for myself,
and I’ll bet you do, too.
I work out, eat right, and take care of my
skin. Of course, cosmetic creams and lotions
will always have their place in my regimen—
but for my moderate to severe frown lines,
I was ready for a prescription treatment.
Maybe you are, too.

IMPORTANT SAFETY INFORMATION
What is the most important information you should know about Dysport?
Spread of Toxin Effects: In some cases, the effects of Dysport and all botulinum toxin products
may affect areas of the body away from the injection site. These effects can cause symptoms of
a serious condition called botulism. Symptoms of botulism can happen hours to weeks after
injection and may include swallowing and breathing problems, loss of strength and muscle
weakness all over the body, double vision, blurred vision and drooping eyelids, hoarseness or
change or loss of voice, trouble saying words clearly, or loss of bladder control.
PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

2

What is Dysport?
Prescription Dysport is an injection used to temporarily improve
the look of your moderate to severe frown lines without changing
the look of your whole face. The untreated facial muscles still
work normally, allowing you to freely show facial expressions,
such as smiling, in untreated areas.
Dysport is a formulation that has been shown to deliver temporary
improvement in moderate to severe frown lines, even with repeat
treatments. So, the effect of repeat treatment with Dysport may
be comparable to your first use.

IMPORTANT SAFETY INFORMATION
Swallowing and breathing problems can be life threatening and there have
been reports of death.
The risk of symptoms is probably greatest in children and adults treated for
muscle spasms, particularly in those patients who have underlying medical
conditions that could make these symptoms more likely.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

3

How does Dysport Work?
With just 1 injection into each of 5 points between and over
the eyebrows, Dysport blocks the signal from the nerve to the
muscles, ultimately resulting in a reduction of muscle activity
and temporarily preventing contraction of the muscles that
cause frown lines. You should not be treated with Dysport more
frequently than every 90 days.
Ask your doctor about your prescription treatment options for
temporarily improving the look of moderate to severe frown lines.
IMPORTANT SAFETY INFORMATION
The toxic effects have been reported at doses similar to those used to treat
muscle spasms in the neck. Lower doses, in both approved and unapproved
uses, have also caused toxic effects. This includes treatment of children and
adults for muscle spasms.

These effects could make it unsafe for you to drive a car, operate machinery,
or do other dangerous activities.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

4

What causes frown lines?
Over time, repeated movement of the facial skin by the
forehead muscles forms lines between the eyebrows.
Frown lines are “dynamic”—they happen because of
the way a person’s face moves.

IMPORTANT SAFETY INFORMATION
Do not have Dysport treatment if you: are allergic to Dysport or any of its ingredients
(see the end of the Medication Guide for a list of ingredients), are allergic to cow’s milk protein,
had an allergic reaction to any other botulinum toxin product (such as Myobloc® or Botox®),
or have a skin infection at the planned injection site.
The dose of Dysport is not the same as the dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to the dose of any other botulinum toxin
product you may have used.
Dysport may not be right for you if: you have surgical changes to your face, very weak
muscles in the treatment area, your face looks very different from side to side, the injection site
is inflamed, you have droopy eyelids or sagging eyelid folds, deep facial scars, thick oily skin, or
if your wrinkles can’t be smoothed by spreading them apart.
5

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Are frown lines always related to age?
No. Because frown lines are created by facial movements,
such as frowning or squinting, they may develop even in
younger adults.

IMPORTANT SAFETY INFORMATION
Tell your doctor about all your medical conditions, including if you have: a disease
that affects your muscles and nerves (such as amyotrophic lateral sclerosis [ALS or Lou
Gehrig’s disease], myasthenia gravis, or Lambert-Eaton syndrome), allergies to any
botulinum toxin product or had any side effect from any botulinum toxin product in the past,
a breathing problem (such as asthma or emphysema), swallowing problems, bleeding
problems, diabetes, a slow heart beat or other problem with your heart rate or rhythm, plans
to have surgery, had surgery on your face, weakness of your forehead muscles (such as
trouble raising your eyebrows), drooping eyelids, or any other change in the way your face
normally looks. Patients with a disease that affects muscles and nerves who are treated with
typical doses of Dysport may have a higher risk of serious side effects, including severe
swallowing and breathing problems.
6

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What can you do about frown lines?
Treatment with prescription Dysport can temporarily
improve the look of your moderate to severe frown lines.
Treatment generally takes just 10 to 20 minutes.
The most common side effects are nose and throat
irritation, headache, injection site pain, injection site skin
reaction, upper respiratory tract infection, eyelid swelling,
eyelid drooping, sinus inflammation, and nausea.

IMPORTANT SAFETY INFORMATION
Human Albumin
This product contains albumin taken from human plasma. Steps taken during donor
screening and product manufacturing processes make the risk of spreading viral diseases
extremely rare. In theory, there is also an extremely rare risk of contracting CreutzfeldtJakob disease (CJD). No cases of spread of viral diseases or CJD have ever been
reported for albumin.
7

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

How do you know if Dysport works?
Clinically proven results with 1 treatment
In 3 clinical studies of people whose frown lines were rated “moderate” or
“severe” by a doctor before their treatment with Dysport:a
• Doctor rating: 30 days after treatment, the majority (88%, 85%, and 86% in each of the 3 studies)
had their frown lines rated by a doctor as “mild” or “moderate” at maximum frown. For example, a
patient could improve from “severe” to “moderate” or from “moderate” to “mild.”
• Patient rating: 30 days after treatment, the majority (74%, 79%, and 82% in each of the 3 studies)
rated their own frown lines as “mild” or “moderate” at maximum frown. For example, a patient could
improve from “severe” to “moderate” or from “moderate” to “mild.”

a

Three double-blind, randomized, placebo-controlled, clinical studies evaluated the efficacy of Dysport for use in the temporary improvement of the appearance of moderate to severe
glabellar lines. These 3 studies enrolled healthy adults (ages 19-75) with glabellar lines of at least moderate severity at maximum frown. Subjects were excluded if they had marked
ptosis, deep dermal scarring, or a substantial inability to lessen glabellar lines, even by physically spreading them apart. The subjects in these studies received either Dysport or a
placebo. The total dose was delivered in equally divided aliquots to specified injection sites.

IMPORTANT SAFETY INFORMATION
Allergic Reaction to Injecting in the Skin
It is not known if an allergic reaction can be caused by injecting Dysport into the skin. The safety of
treating excessive sweating with Dysport is not known.
8

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Common Side Effects
The most common side effects are nose and throat irritation, headache, injection site pain, injection site skin
reaction, upper respiratory tract infection, eyelid swelling, eyelid drooping, sinus inflammation, and nausea.
9

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Tell your doctor about all the medicines you take, including prescription and nonprescription medicines,
vitamins and herbal and other natural products. Using Dysport with certain other medicines may cause
serious side effects.
Do not start any new medicines while taking Dysport without talking to your doctor first.
10

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Especially tell your doctor if you: have received any other botulinum toxin product in the last four
months, have received injections of botulinum toxin, such as Myobloc® (rimabotulinumtoxinB) or Botox®
(onabotulinumtoxinA) in the past (be sure your doctor knows exactly which product you received), have
recently received an antibiotic by injection, take muscle relaxants, take an allergy or cold medicine, or take
a sleep medicine.
11

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Use In Specific Populations
Dysport should not be used in children or in women who are pregnant or breastfeeding.
Ask your doctor if Dysport is right for you.
12

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What to expect with Dysport
A step-by-step guide to your treatment†

1

The Dysport treatment consultation
Discuss your expectations with your doctor and
whether you have any health conditions or
allergies that could interfere with your treatment.
† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

IMPORTANT SAFETY INFORMATION
What is the most important information you should know about Dysport?
Spread of Toxin Effects: In some cases, the effects of Dysport and all botulinum toxin products may affect
areas of the body away from the injection site. These effects can cause symptoms of a serious condition
called botulism. Symptoms of botulism can happen hours to weeks after injection and may include
swallowing and breathing problems, loss of strength and muscle weakness all over the body, double
vision, blurred vision and drooping eyelids, hoarseness or change or loss of voice, trouble saying words
clearly, or loss of bladder control. Swallowing and breathing problems can be life threatening and there
have been reports of death.
The risk of symptoms is probably greatest in children and adults treated for muscle spasms, particularly
in those patients who have underlying medical conditions that could make these symptoms more likely.
13

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What to expect with Dysport
A step-by-step guide to your treatment†

2

The Dysport treatment
Effective treatment requires 1 injection into each
of 5 points between and over the eyebrows.
Although office visit times may vary, the procedure
generally takes 10 to 20 minutes. Your healthcare
professional will determine the exact placement of
each injection to get results that are right for you.

IMPORTANT SAFETY INFORMATION
The toxic effects have been reported at doses similar to those used to treat muscle spasms in
the neck. Lower doses, in both approved and unapproved uses, have also caused toxic effects.
This includes treatment of children and adults for muscle spasms.
These effects could make it unsafe for you to drive a car, operate machinery, or do other
dangerous activities.
Do not have Dysport treatment if you: are allergic to Dysport or any of its ingredients (see the end
of the Medication Guide for a list of ingredients), are allergic to cow’s milk protein, had an allergic
reaction to any other botulinum toxin product, such as Myobloc® or Botox,® or have a skin infection at
the planned injection site.
14

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

What to expect with Dysport
A step-by-step guide to your treatment†

3

After your Dysport treatment
Ask your doctor about any precautions you
should take after your treatment. Call your doctor
or get medical help right away if you have any
problems swallowing, speaking, or breathing.
If this happens, do not drive a car, operate
machinery, or do other dangerous activities.

IMPORTANT SAFETY INFORMATION
The dose of Dysport is not the same as the dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to the dose of any other botulinum toxin
product you may have used.
Dysport may not be right for you if: you have surgical changes to your face, very weak
muscles in the treatment area, your face looks very different from side to side, the injection
site is inflamed, you have droopy eyelids or sagging eyelid folds, deep facial scars, thick oily
skin, or if your wrinkles can’t be smoothed by spreading them apart.
15

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

What to expect with Dysport
A step-by-step guide to your treatment†

4

Follow up
To maintain your improvements, you should
discuss a treatment schedule with your doctor.
As with any botulinum toxin product, you should
wait at least 90 days between treatments.

IMPORTANT SAFETY INFORMATION
Tell your doctor about all your medical conditions, including if you have: a disease that
affects your muscles and nerves (suchas amyotrophic lateral sclerosis [ALS or Lou Gehrig’s
disease], myasthenia gravis, or Lambert-Eaton syndrome), allergies to any botulinum toxin
product or had any side effect from any botulinum toxin product in the past, a breathing problem
(such as asthma or emphysema), swallowing problems, bleeding problems, diabetes, a slow
heart beat or other problem with your heart rate or rhythm, plans to have surgery, had surgery on
your face, weakness of your forehead muscles (such as trouble raising your eyebrows), drooping
eyelids, or any other change in the way your face normally looks. Patients with a disease that
affects muscles and nerves who are treated with typical doses of Dysport may have a higher risk
of serious side effects, including severe swallowing and breathing problems.
16

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

Why not start the Dysport
discussion with your doctor today?
Questions to ask your doctor:
• How soon will I see treatment results?
• How long does one treatment last?
• How often can I receive a Dysport treatment?
• Is there any way to save money on
my treatment?
• Can I have a treatment today?
• What are the risks associated with treatment?
IMPORTANT SAFETY INFORMATION
Human Albumin
This product contains albumin taken from human plasma. Steps taken during donor screening and product
manufacturing processes make the risk of spreading viral diseases extremely rare. In theory, there is also an
extremely rare risk of contracting Creutzfeldt-Jakob disease (CJD). No cases of spread of viral diseases or CJD
have ever been reported for albumin.
17

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Important Safety Information

What is the most important information you
should know about Dysport
(abobotulinumtoxinA) 300 Units for Injection?
Spread of Toxin Effects: In some cases, the
effects of Dysport and all botulinum toxin
products may affect areas of the body away
from the injection site. These effects can
cause symptoms of a serious condition called
botulism. Symptoms of botulism can happen
hours to weeks after injection and may
include swallowing and breathing problems,
loss of strength and muscle weakness all over
the body, double vision, blurred vision and
drooping eyelids, hoarseness or change or
loss of voice, trouble saying words clearly, or
loss of bladder control. Swallowing and
breathing problems can be life threatening
and there have been reports of death.

18

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

The risk of symptoms is probably greatest in
children and adults treated for muscle spasms,
particularly in those patients who have
underlying medical conditions that could make
these symptoms more likely.
The toxic effects have been reported at doses
similar to those used to treat muscle spasms in
the neck. Lower doses, in both approved and
unapproved uses, have also caused toxic
effects. This includes treatment of children and
adults for muscle spasms.
These effects could make it unsafe for you to
drive a car, operate machinery, or do other
dangerous activities.
Do not have Dysport treatment if you: are allergic
to Dysport or any of its ingredients (see the end of
the Medication Guide for a list of ingredients), are
allergic to cow’s milk protein, had an allergic
reaction to any other botulinum toxin product, such
as Myobloc® or Botox,® or have a skin infection at
the planned injection site.

Important Safety Information (cont.)

The dose of Dysport is not the same as the
dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to
the dose of any other botulinum toxin product
you may have used.
Dysport may not be right for you if: you have
surgical changes to your face, very weak muscles
in the treatment area, your face looks very
different from side to side, the injection site is
inflamed, you have droopy eyelids or sagging
eyelid folds, deep facial scars, thick oily skin, or if
your wrinkles can’t be smoothed by spreading
them apart.
Tell your doctor about all your medical
conditions, including if you have: a disease
that affects your muscles and nerves (such as
amyotrophic lateral sclerosis [ALS or Lou
Gehrig’s disease], myasthenia gravis, or LambertEaton syndrome), allergies to any botulinum toxin
product or had any side effect from any

19

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

botulinum toxin product in the past, a breathing
problem (such as asthma or emphysema),
swallowing problems, bleeding problems, diabetes,
a slow heart beat or other problem with your heart
rate or rhythm, plans to have surgery, had surgery
on your face, weakness of your forehead muscles
(such as trouble raising your eyebrows), drooping
eyelids, or any other change in the way your face
normally looks. Patients with a disease that affects
muscles and nerves who are treated with typical
doses of Dysport may have a higher risk of serious
side effects, including severe swallowing and
breathing problems.
Human Albumin
This product contains albumin taken from human
plasma. Steps taken during donor screening and
product manufacturing processes make the risk of
spreading viral diseases extremely rare. In theory,
there is also an extremely rare risk of contracting
Creutzfeldt-Jakob disease (CJD). No cases of
spread of viral diseases or CJD have ever been
reported for albumin.

Important Safety Information (cont.)

Allergic Reaction to Injecting in the Skin
It is not known if an allergic reaction can be
caused by injecting Dysport into the skin. The
safety of treating excessive sweating with Dysport
is not known.
Common Side Effects
The most common side effects are nose and
throat irritation, headache, injection site pain,
injection site skin reaction, upper respiratory tract
infection, eyelid swelling, eyelid drooping, sinus
inflammation, and nausea.
Tell your doctor about all the medicines you
take, including prescription and nonprescription
medicines, vitamins and herbal and other natural
products. Using Dysport with certain other
medicines may cause serious side effects.

20

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

Do not start any new medicines while taking
Dysport without talking to your doctor first.

Especially tell your doctor if you: have received
any other botulinum toxin product in the last four
months, have received injections of botulinum toxin,
such as Myobloc® (rimabotulinumtoxinB) or Botox®
(onabotulinumtoxinA) in the past (be sure your
doctor knows exactly which product you received),
have recently received an antibiotic by injection,
take muscle relaxants, take an allergy or cold
medicine, or take a sleep medicine.
Use In Specific Populations
Dysport should not be used in children or in women
who are pregnant or breastfeeding.
Ask your doctor if Dysport is right for you.

Medication Guide

21

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

22

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

23

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

24

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

25

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

26

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

27

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

28

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

29

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

30

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

31

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

32

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medicis Family
of Aesthetic Products

Products are not FDA approved for combination use.

www.DysportUSA.com

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.
33

The Dysport trademark is used under license. Restylane is a registered trademark of HA North American Sales AB. All other trademarks
are the property of their respective owners. DSP 11-060 10/31/12


Slide 18

Dysport ® is a prescription
injection for temporary
improvement in the look of
moderate to severe frown
lines between the eyebrows
(glabellar lines) in adults less
than 65 years of age.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.
The Dysport trademark is used under license. All other trademarks are the property of their respective owners. DSP 11-060 10/31/12

I do special things for myself,
and I’ll bet you do, too.
I work out, eat right, and take care of my
skin. Of course, cosmetic creams and lotions
will always have their place in my regimen—
but for my moderate to severe frown lines,
I was ready for a prescription treatment.
Maybe you are, too.

IMPORTANT SAFETY INFORMATION
What is the most important information you should know about Dysport?
Spread of Toxin Effects: In some cases, the effects of Dysport and all botulinum toxin products
may affect areas of the body away from the injection site. These effects can cause symptoms of
a serious condition called botulism. Symptoms of botulism can happen hours to weeks after
injection and may include swallowing and breathing problems, loss of strength and muscle
weakness all over the body, double vision, blurred vision and drooping eyelids, hoarseness or
change or loss of voice, trouble saying words clearly, or loss of bladder control.
PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

2

What is Dysport?
Prescription Dysport is an injection used to temporarily improve
the look of your moderate to severe frown lines without changing
the look of your whole face. The untreated facial muscles still
work normally, allowing you to freely show facial expressions,
such as smiling, in untreated areas.
Dysport is a formulation that has been shown to deliver temporary
improvement in moderate to severe frown lines, even with repeat
treatments. So, the effect of repeat treatment with Dysport may
be comparable to your first use.

IMPORTANT SAFETY INFORMATION
Swallowing and breathing problems can be life threatening and there have
been reports of death.
The risk of symptoms is probably greatest in children and adults treated for
muscle spasms, particularly in those patients who have underlying medical
conditions that could make these symptoms more likely.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

3

How does Dysport Work?
With just 1 injection into each of 5 points between and over
the eyebrows, Dysport blocks the signal from the nerve to the
muscles, ultimately resulting in a reduction of muscle activity
and temporarily preventing contraction of the muscles that
cause frown lines. You should not be treated with Dysport more
frequently than every 90 days.
Ask your doctor about your prescription treatment options for
temporarily improving the look of moderate to severe frown lines.
IMPORTANT SAFETY INFORMATION
The toxic effects have been reported at doses similar to those used to treat
muscle spasms in the neck. Lower doses, in both approved and unapproved
uses, have also caused toxic effects. This includes treatment of children and
adults for muscle spasms.

These effects could make it unsafe for you to drive a car, operate machinery,
or do other dangerous activities.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

4

What causes frown lines?
Over time, repeated movement of the facial skin by the
forehead muscles forms lines between the eyebrows.
Frown lines are “dynamic”—they happen because of
the way a person’s face moves.

IMPORTANT SAFETY INFORMATION
Do not have Dysport treatment if you: are allergic to Dysport or any of its ingredients
(see the end of the Medication Guide for a list of ingredients), are allergic to cow’s milk protein,
had an allergic reaction to any other botulinum toxin product (such as Myobloc® or Botox®),
or have a skin infection at the planned injection site.
The dose of Dysport is not the same as the dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to the dose of any other botulinum toxin
product you may have used.
Dysport may not be right for you if: you have surgical changes to your face, very weak
muscles in the treatment area, your face looks very different from side to side, the injection site
is inflamed, you have droopy eyelids or sagging eyelid folds, deep facial scars, thick oily skin, or
if your wrinkles can’t be smoothed by spreading them apart.
5

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Are frown lines always related to age?
No. Because frown lines are created by facial movements,
such as frowning or squinting, they may develop even in
younger adults.

IMPORTANT SAFETY INFORMATION
Tell your doctor about all your medical conditions, including if you have: a disease
that affects your muscles and nerves (such as amyotrophic lateral sclerosis [ALS or Lou
Gehrig’s disease], myasthenia gravis, or Lambert-Eaton syndrome), allergies to any
botulinum toxin product or had any side effect from any botulinum toxin product in the past,
a breathing problem (such as asthma or emphysema), swallowing problems, bleeding
problems, diabetes, a slow heart beat or other problem with your heart rate or rhythm, plans
to have surgery, had surgery on your face, weakness of your forehead muscles (such as
trouble raising your eyebrows), drooping eyelids, or any other change in the way your face
normally looks. Patients with a disease that affects muscles and nerves who are treated with
typical doses of Dysport may have a higher risk of serious side effects, including severe
swallowing and breathing problems.
6

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What can you do about frown lines?
Treatment with prescription Dysport can temporarily
improve the look of your moderate to severe frown lines.
Treatment generally takes just 10 to 20 minutes.
The most common side effects are nose and throat
irritation, headache, injection site pain, injection site skin
reaction, upper respiratory tract infection, eyelid swelling,
eyelid drooping, sinus inflammation, and nausea.

IMPORTANT SAFETY INFORMATION
Human Albumin
This product contains albumin taken from human plasma. Steps taken during donor
screening and product manufacturing processes make the risk of spreading viral diseases
extremely rare. In theory, there is also an extremely rare risk of contracting CreutzfeldtJakob disease (CJD). No cases of spread of viral diseases or CJD have ever been
reported for albumin.
7

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

How do you know if Dysport works?
Clinically proven results with 1 treatment
In 3 clinical studies of people whose frown lines were rated “moderate” or
“severe” by a doctor before their treatment with Dysport:a
• Doctor rating: 30 days after treatment, the majority (88%, 85%, and 86% in each of the 3 studies)
had their frown lines rated by a doctor as “mild” or “moderate” at maximum frown. For example, a
patient could improve from “severe” to “moderate” or from “moderate” to “mild.”
• Patient rating: 30 days after treatment, the majority (74%, 79%, and 82% in each of the 3 studies)
rated their own frown lines as “mild” or “moderate” at maximum frown. For example, a patient could
improve from “severe” to “moderate” or from “moderate” to “mild.”

a

Three double-blind, randomized, placebo-controlled, clinical studies evaluated the efficacy of Dysport for use in the temporary improvement of the appearance of moderate to severe
glabellar lines. These 3 studies enrolled healthy adults (ages 19-75) with glabellar lines of at least moderate severity at maximum frown. Subjects were excluded if they had marked
ptosis, deep dermal scarring, or a substantial inability to lessen glabellar lines, even by physically spreading them apart. The subjects in these studies received either Dysport or a
placebo. The total dose was delivered in equally divided aliquots to specified injection sites.

IMPORTANT SAFETY INFORMATION
Allergic Reaction to Injecting in the Skin
It is not known if an allergic reaction can be caused by injecting Dysport into the skin. The safety of
treating excessive sweating with Dysport is not known.
8

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Common Side Effects
The most common side effects are nose and throat irritation, headache, injection site pain, injection site skin
reaction, upper respiratory tract infection, eyelid swelling, eyelid drooping, sinus inflammation, and nausea.
9

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Tell your doctor about all the medicines you take, including prescription and nonprescription medicines,
vitamins and herbal and other natural products. Using Dysport with certain other medicines may cause
serious side effects.
Do not start any new medicines while taking Dysport without talking to your doctor first.
10

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Especially tell your doctor if you: have received any other botulinum toxin product in the last four
months, have received injections of botulinum toxin, such as Myobloc® (rimabotulinumtoxinB) or Botox®
(onabotulinumtoxinA) in the past (be sure your doctor knows exactly which product you received), have
recently received an antibiotic by injection, take muscle relaxants, take an allergy or cold medicine, or take
a sleep medicine.
11

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Use In Specific Populations
Dysport should not be used in children or in women who are pregnant or breastfeeding.
Ask your doctor if Dysport is right for you.
12

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What to expect with Dysport
A step-by-step guide to your treatment†

1

The Dysport treatment consultation
Discuss your expectations with your doctor and
whether you have any health conditions or
allergies that could interfere with your treatment.
† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

IMPORTANT SAFETY INFORMATION
What is the most important information you should know about Dysport?
Spread of Toxin Effects: In some cases, the effects of Dysport and all botulinum toxin products may affect
areas of the body away from the injection site. These effects can cause symptoms of a serious condition
called botulism. Symptoms of botulism can happen hours to weeks after injection and may include
swallowing and breathing problems, loss of strength and muscle weakness all over the body, double
vision, blurred vision and drooping eyelids, hoarseness or change or loss of voice, trouble saying words
clearly, or loss of bladder control. Swallowing and breathing problems can be life threatening and there
have been reports of death.
The risk of symptoms is probably greatest in children and adults treated for muscle spasms, particularly
in those patients who have underlying medical conditions that could make these symptoms more likely.
13

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What to expect with Dysport
A step-by-step guide to your treatment†

2

The Dysport treatment
Effective treatment requires 1 injection into each
of 5 points between and over the eyebrows.
Although office visit times may vary, the procedure
generally takes 10 to 20 minutes. Your healthcare
professional will determine the exact placement of
each injection to get results that are right for you.

IMPORTANT SAFETY INFORMATION
The toxic effects have been reported at doses similar to those used to treat muscle spasms in
the neck. Lower doses, in both approved and unapproved uses, have also caused toxic effects.
This includes treatment of children and adults for muscle spasms.
These effects could make it unsafe for you to drive a car, operate machinery, or do other
dangerous activities.
Do not have Dysport treatment if you: are allergic to Dysport or any of its ingredients (see the end
of the Medication Guide for a list of ingredients), are allergic to cow’s milk protein, had an allergic
reaction to any other botulinum toxin product, such as Myobloc® or Botox,® or have a skin infection at
the planned injection site.
14

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

What to expect with Dysport
A step-by-step guide to your treatment†

3

After your Dysport treatment
Ask your doctor about any precautions you
should take after your treatment. Call your doctor
or get medical help right away if you have any
problems swallowing, speaking, or breathing.
If this happens, do not drive a car, operate
machinery, or do other dangerous activities.

IMPORTANT SAFETY INFORMATION
The dose of Dysport is not the same as the dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to the dose of any other botulinum toxin
product you may have used.
Dysport may not be right for you if: you have surgical changes to your face, very weak
muscles in the treatment area, your face looks very different from side to side, the injection
site is inflamed, you have droopy eyelids or sagging eyelid folds, deep facial scars, thick oily
skin, or if your wrinkles can’t be smoothed by spreading them apart.
15

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

What to expect with Dysport
A step-by-step guide to your treatment†

4

Follow up
To maintain your improvements, you should
discuss a treatment schedule with your doctor.
As with any botulinum toxin product, you should
wait at least 90 days between treatments.

IMPORTANT SAFETY INFORMATION
Tell your doctor about all your medical conditions, including if you have: a disease that
affects your muscles and nerves (suchas amyotrophic lateral sclerosis [ALS or Lou Gehrig’s
disease], myasthenia gravis, or Lambert-Eaton syndrome), allergies to any botulinum toxin
product or had any side effect from any botulinum toxin product in the past, a breathing problem
(such as asthma or emphysema), swallowing problems, bleeding problems, diabetes, a slow
heart beat or other problem with your heart rate or rhythm, plans to have surgery, had surgery on
your face, weakness of your forehead muscles (such as trouble raising your eyebrows), drooping
eyelids, or any other change in the way your face normally looks. Patients with a disease that
affects muscles and nerves who are treated with typical doses of Dysport may have a higher risk
of serious side effects, including severe swallowing and breathing problems.
16

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

Why not start the Dysport
discussion with your doctor today?
Questions to ask your doctor:
• How soon will I see treatment results?
• How long does one treatment last?
• How often can I receive a Dysport treatment?
• Is there any way to save money on
my treatment?
• Can I have a treatment today?
• What are the risks associated with treatment?
IMPORTANT SAFETY INFORMATION
Human Albumin
This product contains albumin taken from human plasma. Steps taken during donor screening and product
manufacturing processes make the risk of spreading viral diseases extremely rare. In theory, there is also an
extremely rare risk of contracting Creutzfeldt-Jakob disease (CJD). No cases of spread of viral diseases or CJD
have ever been reported for albumin.
17

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Important Safety Information

What is the most important information you
should know about Dysport
(abobotulinumtoxinA) 300 Units for Injection?
Spread of Toxin Effects: In some cases, the
effects of Dysport and all botulinum toxin
products may affect areas of the body away
from the injection site. These effects can
cause symptoms of a serious condition called
botulism. Symptoms of botulism can happen
hours to weeks after injection and may
include swallowing and breathing problems,
loss of strength and muscle weakness all over
the body, double vision, blurred vision and
drooping eyelids, hoarseness or change or
loss of voice, trouble saying words clearly, or
loss of bladder control. Swallowing and
breathing problems can be life threatening
and there have been reports of death.

18

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

The risk of symptoms is probably greatest in
children and adults treated for muscle spasms,
particularly in those patients who have
underlying medical conditions that could make
these symptoms more likely.
The toxic effects have been reported at doses
similar to those used to treat muscle spasms in
the neck. Lower doses, in both approved and
unapproved uses, have also caused toxic
effects. This includes treatment of children and
adults for muscle spasms.
These effects could make it unsafe for you to
drive a car, operate machinery, or do other
dangerous activities.
Do not have Dysport treatment if you: are allergic
to Dysport or any of its ingredients (see the end of
the Medication Guide for a list of ingredients), are
allergic to cow’s milk protein, had an allergic
reaction to any other botulinum toxin product, such
as Myobloc® or Botox,® or have a skin infection at
the planned injection site.

Important Safety Information (cont.)

The dose of Dysport is not the same as the
dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to
the dose of any other botulinum toxin product
you may have used.
Dysport may not be right for you if: you have
surgical changes to your face, very weak muscles
in the treatment area, your face looks very
different from side to side, the injection site is
inflamed, you have droopy eyelids or sagging
eyelid folds, deep facial scars, thick oily skin, or if
your wrinkles can’t be smoothed by spreading
them apart.
Tell your doctor about all your medical
conditions, including if you have: a disease
that affects your muscles and nerves (such as
amyotrophic lateral sclerosis [ALS or Lou
Gehrig’s disease], myasthenia gravis, or LambertEaton syndrome), allergies to any botulinum toxin
product or had any side effect from any

19

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

botulinum toxin product in the past, a breathing
problem (such as asthma or emphysema),
swallowing problems, bleeding problems, diabetes,
a slow heart beat or other problem with your heart
rate or rhythm, plans to have surgery, had surgery
on your face, weakness of your forehead muscles
(such as trouble raising your eyebrows), drooping
eyelids, or any other change in the way your face
normally looks. Patients with a disease that affects
muscles and nerves who are treated with typical
doses of Dysport may have a higher risk of serious
side effects, including severe swallowing and
breathing problems.
Human Albumin
This product contains albumin taken from human
plasma. Steps taken during donor screening and
product manufacturing processes make the risk of
spreading viral diseases extremely rare. In theory,
there is also an extremely rare risk of contracting
Creutzfeldt-Jakob disease (CJD). No cases of
spread of viral diseases or CJD have ever been
reported for albumin.

Important Safety Information (cont.)

Allergic Reaction to Injecting in the Skin
It is not known if an allergic reaction can be
caused by injecting Dysport into the skin. The
safety of treating excessive sweating with Dysport
is not known.
Common Side Effects
The most common side effects are nose and
throat irritation, headache, injection site pain,
injection site skin reaction, upper respiratory tract
infection, eyelid swelling, eyelid drooping, sinus
inflammation, and nausea.
Tell your doctor about all the medicines you
take, including prescription and nonprescription
medicines, vitamins and herbal and other natural
products. Using Dysport with certain other
medicines may cause serious side effects.

20

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

Do not start any new medicines while taking
Dysport without talking to your doctor first.

Especially tell your doctor if you: have received
any other botulinum toxin product in the last four
months, have received injections of botulinum toxin,
such as Myobloc® (rimabotulinumtoxinB) or Botox®
(onabotulinumtoxinA) in the past (be sure your
doctor knows exactly which product you received),
have recently received an antibiotic by injection,
take muscle relaxants, take an allergy or cold
medicine, or take a sleep medicine.
Use In Specific Populations
Dysport should not be used in children or in women
who are pregnant or breastfeeding.
Ask your doctor if Dysport is right for you.

Medication Guide

21

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

22

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

23

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

24

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

25

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

26

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

27

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

28

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

29

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

30

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

31

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

32

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medicis Family
of Aesthetic Products

Products are not FDA approved for combination use.

www.DysportUSA.com

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.
33

The Dysport trademark is used under license. Restylane is a registered trademark of HA North American Sales AB. All other trademarks
are the property of their respective owners. DSP 11-060 10/31/12


Slide 19

Dysport ® is a prescription
injection for temporary
improvement in the look of
moderate to severe frown
lines between the eyebrows
(glabellar lines) in adults less
than 65 years of age.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.
The Dysport trademark is used under license. All other trademarks are the property of their respective owners. DSP 11-060 10/31/12

I do special things for myself,
and I’ll bet you do, too.
I work out, eat right, and take care of my
skin. Of course, cosmetic creams and lotions
will always have their place in my regimen—
but for my moderate to severe frown lines,
I was ready for a prescription treatment.
Maybe you are, too.

IMPORTANT SAFETY INFORMATION
What is the most important information you should know about Dysport?
Spread of Toxin Effects: In some cases, the effects of Dysport and all botulinum toxin products
may affect areas of the body away from the injection site. These effects can cause symptoms of
a serious condition called botulism. Symptoms of botulism can happen hours to weeks after
injection and may include swallowing and breathing problems, loss of strength and muscle
weakness all over the body, double vision, blurred vision and drooping eyelids, hoarseness or
change or loss of voice, trouble saying words clearly, or loss of bladder control.
PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

2

What is Dysport?
Prescription Dysport is an injection used to temporarily improve
the look of your moderate to severe frown lines without changing
the look of your whole face. The untreated facial muscles still
work normally, allowing you to freely show facial expressions,
such as smiling, in untreated areas.
Dysport is a formulation that has been shown to deliver temporary
improvement in moderate to severe frown lines, even with repeat
treatments. So, the effect of repeat treatment with Dysport may
be comparable to your first use.

IMPORTANT SAFETY INFORMATION
Swallowing and breathing problems can be life threatening and there have
been reports of death.
The risk of symptoms is probably greatest in children and adults treated for
muscle spasms, particularly in those patients who have underlying medical
conditions that could make these symptoms more likely.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

3

How does Dysport Work?
With just 1 injection into each of 5 points between and over
the eyebrows, Dysport blocks the signal from the nerve to the
muscles, ultimately resulting in a reduction of muscle activity
and temporarily preventing contraction of the muscles that
cause frown lines. You should not be treated with Dysport more
frequently than every 90 days.
Ask your doctor about your prescription treatment options for
temporarily improving the look of moderate to severe frown lines.
IMPORTANT SAFETY INFORMATION
The toxic effects have been reported at doses similar to those used to treat
muscle spasms in the neck. Lower doses, in both approved and unapproved
uses, have also caused toxic effects. This includes treatment of children and
adults for muscle spasms.

These effects could make it unsafe for you to drive a car, operate machinery,
or do other dangerous activities.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

4

What causes frown lines?
Over time, repeated movement of the facial skin by the
forehead muscles forms lines between the eyebrows.
Frown lines are “dynamic”—they happen because of
the way a person’s face moves.

IMPORTANT SAFETY INFORMATION
Do not have Dysport treatment if you: are allergic to Dysport or any of its ingredients
(see the end of the Medication Guide for a list of ingredients), are allergic to cow’s milk protein,
had an allergic reaction to any other botulinum toxin product (such as Myobloc® or Botox®),
or have a skin infection at the planned injection site.
The dose of Dysport is not the same as the dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to the dose of any other botulinum toxin
product you may have used.
Dysport may not be right for you if: you have surgical changes to your face, very weak
muscles in the treatment area, your face looks very different from side to side, the injection site
is inflamed, you have droopy eyelids or sagging eyelid folds, deep facial scars, thick oily skin, or
if your wrinkles can’t be smoothed by spreading them apart.
5

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Are frown lines always related to age?
No. Because frown lines are created by facial movements,
such as frowning or squinting, they may develop even in
younger adults.

IMPORTANT SAFETY INFORMATION
Tell your doctor about all your medical conditions, including if you have: a disease
that affects your muscles and nerves (such as amyotrophic lateral sclerosis [ALS or Lou
Gehrig’s disease], myasthenia gravis, or Lambert-Eaton syndrome), allergies to any
botulinum toxin product or had any side effect from any botulinum toxin product in the past,
a breathing problem (such as asthma or emphysema), swallowing problems, bleeding
problems, diabetes, a slow heart beat or other problem with your heart rate or rhythm, plans
to have surgery, had surgery on your face, weakness of your forehead muscles (such as
trouble raising your eyebrows), drooping eyelids, or any other change in the way your face
normally looks. Patients with a disease that affects muscles and nerves who are treated with
typical doses of Dysport may have a higher risk of serious side effects, including severe
swallowing and breathing problems.
6

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What can you do about frown lines?
Treatment with prescription Dysport can temporarily
improve the look of your moderate to severe frown lines.
Treatment generally takes just 10 to 20 minutes.
The most common side effects are nose and throat
irritation, headache, injection site pain, injection site skin
reaction, upper respiratory tract infection, eyelid swelling,
eyelid drooping, sinus inflammation, and nausea.

IMPORTANT SAFETY INFORMATION
Human Albumin
This product contains albumin taken from human plasma. Steps taken during donor
screening and product manufacturing processes make the risk of spreading viral diseases
extremely rare. In theory, there is also an extremely rare risk of contracting CreutzfeldtJakob disease (CJD). No cases of spread of viral diseases or CJD have ever been
reported for albumin.
7

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

How do you know if Dysport works?
Clinically proven results with 1 treatment
In 3 clinical studies of people whose frown lines were rated “moderate” or
“severe” by a doctor before their treatment with Dysport:a
• Doctor rating: 30 days after treatment, the majority (88%, 85%, and 86% in each of the 3 studies)
had their frown lines rated by a doctor as “mild” or “moderate” at maximum frown. For example, a
patient could improve from “severe” to “moderate” or from “moderate” to “mild.”
• Patient rating: 30 days after treatment, the majority (74%, 79%, and 82% in each of the 3 studies)
rated their own frown lines as “mild” or “moderate” at maximum frown. For example, a patient could
improve from “severe” to “moderate” or from “moderate” to “mild.”

a

Three double-blind, randomized, placebo-controlled, clinical studies evaluated the efficacy of Dysport for use in the temporary improvement of the appearance of moderate to severe
glabellar lines. These 3 studies enrolled healthy adults (ages 19-75) with glabellar lines of at least moderate severity at maximum frown. Subjects were excluded if they had marked
ptosis, deep dermal scarring, or a substantial inability to lessen glabellar lines, even by physically spreading them apart. The subjects in these studies received either Dysport or a
placebo. The total dose was delivered in equally divided aliquots to specified injection sites.

IMPORTANT SAFETY INFORMATION
Allergic Reaction to Injecting in the Skin
It is not known if an allergic reaction can be caused by injecting Dysport into the skin. The safety of
treating excessive sweating with Dysport is not known.
8

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Common Side Effects
The most common side effects are nose and throat irritation, headache, injection site pain, injection site skin
reaction, upper respiratory tract infection, eyelid swelling, eyelid drooping, sinus inflammation, and nausea.
9

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Tell your doctor about all the medicines you take, including prescription and nonprescription medicines,
vitamins and herbal and other natural products. Using Dysport with certain other medicines may cause
serious side effects.
Do not start any new medicines while taking Dysport without talking to your doctor first.
10

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Especially tell your doctor if you: have received any other botulinum toxin product in the last four
months, have received injections of botulinum toxin, such as Myobloc® (rimabotulinumtoxinB) or Botox®
(onabotulinumtoxinA) in the past (be sure your doctor knows exactly which product you received), have
recently received an antibiotic by injection, take muscle relaxants, take an allergy or cold medicine, or take
a sleep medicine.
11

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Use In Specific Populations
Dysport should not be used in children or in women who are pregnant or breastfeeding.
Ask your doctor if Dysport is right for you.
12

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What to expect with Dysport
A step-by-step guide to your treatment†

1

The Dysport treatment consultation
Discuss your expectations with your doctor and
whether you have any health conditions or
allergies that could interfere with your treatment.
† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

IMPORTANT SAFETY INFORMATION
What is the most important information you should know about Dysport?
Spread of Toxin Effects: In some cases, the effects of Dysport and all botulinum toxin products may affect
areas of the body away from the injection site. These effects can cause symptoms of a serious condition
called botulism. Symptoms of botulism can happen hours to weeks after injection and may include
swallowing and breathing problems, loss of strength and muscle weakness all over the body, double
vision, blurred vision and drooping eyelids, hoarseness or change or loss of voice, trouble saying words
clearly, or loss of bladder control. Swallowing and breathing problems can be life threatening and there
have been reports of death.
The risk of symptoms is probably greatest in children and adults treated for muscle spasms, particularly
in those patients who have underlying medical conditions that could make these symptoms more likely.
13

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What to expect with Dysport
A step-by-step guide to your treatment†

2

The Dysport treatment
Effective treatment requires 1 injection into each
of 5 points between and over the eyebrows.
Although office visit times may vary, the procedure
generally takes 10 to 20 minutes. Your healthcare
professional will determine the exact placement of
each injection to get results that are right for you.

IMPORTANT SAFETY INFORMATION
The toxic effects have been reported at doses similar to those used to treat muscle spasms in
the neck. Lower doses, in both approved and unapproved uses, have also caused toxic effects.
This includes treatment of children and adults for muscle spasms.
These effects could make it unsafe for you to drive a car, operate machinery, or do other
dangerous activities.
Do not have Dysport treatment if you: are allergic to Dysport or any of its ingredients (see the end
of the Medication Guide for a list of ingredients), are allergic to cow’s milk protein, had an allergic
reaction to any other botulinum toxin product, such as Myobloc® or Botox,® or have a skin infection at
the planned injection site.
14

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

What to expect with Dysport
A step-by-step guide to your treatment†

3

After your Dysport treatment
Ask your doctor about any precautions you
should take after your treatment. Call your doctor
or get medical help right away if you have any
problems swallowing, speaking, or breathing.
If this happens, do not drive a car, operate
machinery, or do other dangerous activities.

IMPORTANT SAFETY INFORMATION
The dose of Dysport is not the same as the dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to the dose of any other botulinum toxin
product you may have used.
Dysport may not be right for you if: you have surgical changes to your face, very weak
muscles in the treatment area, your face looks very different from side to side, the injection
site is inflamed, you have droopy eyelids or sagging eyelid folds, deep facial scars, thick oily
skin, or if your wrinkles can’t be smoothed by spreading them apart.
15

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

What to expect with Dysport
A step-by-step guide to your treatment†

4

Follow up
To maintain your improvements, you should
discuss a treatment schedule with your doctor.
As with any botulinum toxin product, you should
wait at least 90 days between treatments.

IMPORTANT SAFETY INFORMATION
Tell your doctor about all your medical conditions, including if you have: a disease that
affects your muscles and nerves (suchas amyotrophic lateral sclerosis [ALS or Lou Gehrig’s
disease], myasthenia gravis, or Lambert-Eaton syndrome), allergies to any botulinum toxin
product or had any side effect from any botulinum toxin product in the past, a breathing problem
(such as asthma or emphysema), swallowing problems, bleeding problems, diabetes, a slow
heart beat or other problem with your heart rate or rhythm, plans to have surgery, had surgery on
your face, weakness of your forehead muscles (such as trouble raising your eyebrows), drooping
eyelids, or any other change in the way your face normally looks. Patients with a disease that
affects muscles and nerves who are treated with typical doses of Dysport may have a higher risk
of serious side effects, including severe swallowing and breathing problems.
16

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

Why not start the Dysport
discussion with your doctor today?
Questions to ask your doctor:
• How soon will I see treatment results?
• How long does one treatment last?
• How often can I receive a Dysport treatment?
• Is there any way to save money on
my treatment?
• Can I have a treatment today?
• What are the risks associated with treatment?
IMPORTANT SAFETY INFORMATION
Human Albumin
This product contains albumin taken from human plasma. Steps taken during donor screening and product
manufacturing processes make the risk of spreading viral diseases extremely rare. In theory, there is also an
extremely rare risk of contracting Creutzfeldt-Jakob disease (CJD). No cases of spread of viral diseases or CJD
have ever been reported for albumin.
17

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Important Safety Information

What is the most important information you
should know about Dysport
(abobotulinumtoxinA) 300 Units for Injection?
Spread of Toxin Effects: In some cases, the
effects of Dysport and all botulinum toxin
products may affect areas of the body away
from the injection site. These effects can
cause symptoms of a serious condition called
botulism. Symptoms of botulism can happen
hours to weeks after injection and may
include swallowing and breathing problems,
loss of strength and muscle weakness all over
the body, double vision, blurred vision and
drooping eyelids, hoarseness or change or
loss of voice, trouble saying words clearly, or
loss of bladder control. Swallowing and
breathing problems can be life threatening
and there have been reports of death.

18

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

The risk of symptoms is probably greatest in
children and adults treated for muscle spasms,
particularly in those patients who have
underlying medical conditions that could make
these symptoms more likely.
The toxic effects have been reported at doses
similar to those used to treat muscle spasms in
the neck. Lower doses, in both approved and
unapproved uses, have also caused toxic
effects. This includes treatment of children and
adults for muscle spasms.
These effects could make it unsafe for you to
drive a car, operate machinery, or do other
dangerous activities.
Do not have Dysport treatment if you: are allergic
to Dysport or any of its ingredients (see the end of
the Medication Guide for a list of ingredients), are
allergic to cow’s milk protein, had an allergic
reaction to any other botulinum toxin product, such
as Myobloc® or Botox,® or have a skin infection at
the planned injection site.

Important Safety Information (cont.)

The dose of Dysport is not the same as the
dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to
the dose of any other botulinum toxin product
you may have used.
Dysport may not be right for you if: you have
surgical changes to your face, very weak muscles
in the treatment area, your face looks very
different from side to side, the injection site is
inflamed, you have droopy eyelids or sagging
eyelid folds, deep facial scars, thick oily skin, or if
your wrinkles can’t be smoothed by spreading
them apart.
Tell your doctor about all your medical
conditions, including if you have: a disease
that affects your muscles and nerves (such as
amyotrophic lateral sclerosis [ALS or Lou
Gehrig’s disease], myasthenia gravis, or LambertEaton syndrome), allergies to any botulinum toxin
product or had any side effect from any

19

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

botulinum toxin product in the past, a breathing
problem (such as asthma or emphysema),
swallowing problems, bleeding problems, diabetes,
a slow heart beat or other problem with your heart
rate or rhythm, plans to have surgery, had surgery
on your face, weakness of your forehead muscles
(such as trouble raising your eyebrows), drooping
eyelids, or any other change in the way your face
normally looks. Patients with a disease that affects
muscles and nerves who are treated with typical
doses of Dysport may have a higher risk of serious
side effects, including severe swallowing and
breathing problems.
Human Albumin
This product contains albumin taken from human
plasma. Steps taken during donor screening and
product manufacturing processes make the risk of
spreading viral diseases extremely rare. In theory,
there is also an extremely rare risk of contracting
Creutzfeldt-Jakob disease (CJD). No cases of
spread of viral diseases or CJD have ever been
reported for albumin.

Important Safety Information (cont.)

Allergic Reaction to Injecting in the Skin
It is not known if an allergic reaction can be
caused by injecting Dysport into the skin. The
safety of treating excessive sweating with Dysport
is not known.
Common Side Effects
The most common side effects are nose and
throat irritation, headache, injection site pain,
injection site skin reaction, upper respiratory tract
infection, eyelid swelling, eyelid drooping, sinus
inflammation, and nausea.
Tell your doctor about all the medicines you
take, including prescription and nonprescription
medicines, vitamins and herbal and other natural
products. Using Dysport with certain other
medicines may cause serious side effects.

20

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

Do not start any new medicines while taking
Dysport without talking to your doctor first.

Especially tell your doctor if you: have received
any other botulinum toxin product in the last four
months, have received injections of botulinum toxin,
such as Myobloc® (rimabotulinumtoxinB) or Botox®
(onabotulinumtoxinA) in the past (be sure your
doctor knows exactly which product you received),
have recently received an antibiotic by injection,
take muscle relaxants, take an allergy or cold
medicine, or take a sleep medicine.
Use In Specific Populations
Dysport should not be used in children or in women
who are pregnant or breastfeeding.
Ask your doctor if Dysport is right for you.

Medication Guide

21

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

22

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

23

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

24

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

25

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

26

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

27

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

28

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

29

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

30

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

31

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

32

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medicis Family
of Aesthetic Products

Products are not FDA approved for combination use.

www.DysportUSA.com

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.
33

The Dysport trademark is used under license. Restylane is a registered trademark of HA North American Sales AB. All other trademarks
are the property of their respective owners. DSP 11-060 10/31/12


Slide 20

Dysport ® is a prescription
injection for temporary
improvement in the look of
moderate to severe frown
lines between the eyebrows
(glabellar lines) in adults less
than 65 years of age.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.
The Dysport trademark is used under license. All other trademarks are the property of their respective owners. DSP 11-060 10/31/12

I do special things for myself,
and I’ll bet you do, too.
I work out, eat right, and take care of my
skin. Of course, cosmetic creams and lotions
will always have their place in my regimen—
but for my moderate to severe frown lines,
I was ready for a prescription treatment.
Maybe you are, too.

IMPORTANT SAFETY INFORMATION
What is the most important information you should know about Dysport?
Spread of Toxin Effects: In some cases, the effects of Dysport and all botulinum toxin products
may affect areas of the body away from the injection site. These effects can cause symptoms of
a serious condition called botulism. Symptoms of botulism can happen hours to weeks after
injection and may include swallowing and breathing problems, loss of strength and muscle
weakness all over the body, double vision, blurred vision and drooping eyelids, hoarseness or
change or loss of voice, trouble saying words clearly, or loss of bladder control.
PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

2

What is Dysport?
Prescription Dysport is an injection used to temporarily improve
the look of your moderate to severe frown lines without changing
the look of your whole face. The untreated facial muscles still
work normally, allowing you to freely show facial expressions,
such as smiling, in untreated areas.
Dysport is a formulation that has been shown to deliver temporary
improvement in moderate to severe frown lines, even with repeat
treatments. So, the effect of repeat treatment with Dysport may
be comparable to your first use.

IMPORTANT SAFETY INFORMATION
Swallowing and breathing problems can be life threatening and there have
been reports of death.
The risk of symptoms is probably greatest in children and adults treated for
muscle spasms, particularly in those patients who have underlying medical
conditions that could make these symptoms more likely.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

3

How does Dysport Work?
With just 1 injection into each of 5 points between and over
the eyebrows, Dysport blocks the signal from the nerve to the
muscles, ultimately resulting in a reduction of muscle activity
and temporarily preventing contraction of the muscles that
cause frown lines. You should not be treated with Dysport more
frequently than every 90 days.
Ask your doctor about your prescription treatment options for
temporarily improving the look of moderate to severe frown lines.
IMPORTANT SAFETY INFORMATION
The toxic effects have been reported at doses similar to those used to treat
muscle spasms in the neck. Lower doses, in both approved and unapproved
uses, have also caused toxic effects. This includes treatment of children and
adults for muscle spasms.

These effects could make it unsafe for you to drive a car, operate machinery,
or do other dangerous activities.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

4

What causes frown lines?
Over time, repeated movement of the facial skin by the
forehead muscles forms lines between the eyebrows.
Frown lines are “dynamic”—they happen because of
the way a person’s face moves.

IMPORTANT SAFETY INFORMATION
Do not have Dysport treatment if you: are allergic to Dysport or any of its ingredients
(see the end of the Medication Guide for a list of ingredients), are allergic to cow’s milk protein,
had an allergic reaction to any other botulinum toxin product (such as Myobloc® or Botox®),
or have a skin infection at the planned injection site.
The dose of Dysport is not the same as the dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to the dose of any other botulinum toxin
product you may have used.
Dysport may not be right for you if: you have surgical changes to your face, very weak
muscles in the treatment area, your face looks very different from side to side, the injection site
is inflamed, you have droopy eyelids or sagging eyelid folds, deep facial scars, thick oily skin, or
if your wrinkles can’t be smoothed by spreading them apart.
5

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Are frown lines always related to age?
No. Because frown lines are created by facial movements,
such as frowning or squinting, they may develop even in
younger adults.

IMPORTANT SAFETY INFORMATION
Tell your doctor about all your medical conditions, including if you have: a disease
that affects your muscles and nerves (such as amyotrophic lateral sclerosis [ALS or Lou
Gehrig’s disease], myasthenia gravis, or Lambert-Eaton syndrome), allergies to any
botulinum toxin product or had any side effect from any botulinum toxin product in the past,
a breathing problem (such as asthma or emphysema), swallowing problems, bleeding
problems, diabetes, a slow heart beat or other problem with your heart rate or rhythm, plans
to have surgery, had surgery on your face, weakness of your forehead muscles (such as
trouble raising your eyebrows), drooping eyelids, or any other change in the way your face
normally looks. Patients with a disease that affects muscles and nerves who are treated with
typical doses of Dysport may have a higher risk of serious side effects, including severe
swallowing and breathing problems.
6

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What can you do about frown lines?
Treatment with prescription Dysport can temporarily
improve the look of your moderate to severe frown lines.
Treatment generally takes just 10 to 20 minutes.
The most common side effects are nose and throat
irritation, headache, injection site pain, injection site skin
reaction, upper respiratory tract infection, eyelid swelling,
eyelid drooping, sinus inflammation, and nausea.

IMPORTANT SAFETY INFORMATION
Human Albumin
This product contains albumin taken from human plasma. Steps taken during donor
screening and product manufacturing processes make the risk of spreading viral diseases
extremely rare. In theory, there is also an extremely rare risk of contracting CreutzfeldtJakob disease (CJD). No cases of spread of viral diseases or CJD have ever been
reported for albumin.
7

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

How do you know if Dysport works?
Clinically proven results with 1 treatment
In 3 clinical studies of people whose frown lines were rated “moderate” or
“severe” by a doctor before their treatment with Dysport:a
• Doctor rating: 30 days after treatment, the majority (88%, 85%, and 86% in each of the 3 studies)
had their frown lines rated by a doctor as “mild” or “moderate” at maximum frown. For example, a
patient could improve from “severe” to “moderate” or from “moderate” to “mild.”
• Patient rating: 30 days after treatment, the majority (74%, 79%, and 82% in each of the 3 studies)
rated their own frown lines as “mild” or “moderate” at maximum frown. For example, a patient could
improve from “severe” to “moderate” or from “moderate” to “mild.”

a

Three double-blind, randomized, placebo-controlled, clinical studies evaluated the efficacy of Dysport for use in the temporary improvement of the appearance of moderate to severe
glabellar lines. These 3 studies enrolled healthy adults (ages 19-75) with glabellar lines of at least moderate severity at maximum frown. Subjects were excluded if they had marked
ptosis, deep dermal scarring, or a substantial inability to lessen glabellar lines, even by physically spreading them apart. The subjects in these studies received either Dysport or a
placebo. The total dose was delivered in equally divided aliquots to specified injection sites.

IMPORTANT SAFETY INFORMATION
Allergic Reaction to Injecting in the Skin
It is not known if an allergic reaction can be caused by injecting Dysport into the skin. The safety of
treating excessive sweating with Dysport is not known.
8

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Common Side Effects
The most common side effects are nose and throat irritation, headache, injection site pain, injection site skin
reaction, upper respiratory tract infection, eyelid swelling, eyelid drooping, sinus inflammation, and nausea.
9

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Tell your doctor about all the medicines you take, including prescription and nonprescription medicines,
vitamins and herbal and other natural products. Using Dysport with certain other medicines may cause
serious side effects.
Do not start any new medicines while taking Dysport without talking to your doctor first.
10

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Especially tell your doctor if you: have received any other botulinum toxin product in the last four
months, have received injections of botulinum toxin, such as Myobloc® (rimabotulinumtoxinB) or Botox®
(onabotulinumtoxinA) in the past (be sure your doctor knows exactly which product you received), have
recently received an antibiotic by injection, take muscle relaxants, take an allergy or cold medicine, or take
a sleep medicine.
11

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Use In Specific Populations
Dysport should not be used in children or in women who are pregnant or breastfeeding.
Ask your doctor if Dysport is right for you.
12

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What to expect with Dysport
A step-by-step guide to your treatment†

1

The Dysport treatment consultation
Discuss your expectations with your doctor and
whether you have any health conditions or
allergies that could interfere with your treatment.
† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

IMPORTANT SAFETY INFORMATION
What is the most important information you should know about Dysport?
Spread of Toxin Effects: In some cases, the effects of Dysport and all botulinum toxin products may affect
areas of the body away from the injection site. These effects can cause symptoms of a serious condition
called botulism. Symptoms of botulism can happen hours to weeks after injection and may include
swallowing and breathing problems, loss of strength and muscle weakness all over the body, double
vision, blurred vision and drooping eyelids, hoarseness or change or loss of voice, trouble saying words
clearly, or loss of bladder control. Swallowing and breathing problems can be life threatening and there
have been reports of death.
The risk of symptoms is probably greatest in children and adults treated for muscle spasms, particularly
in those patients who have underlying medical conditions that could make these symptoms more likely.
13

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What to expect with Dysport
A step-by-step guide to your treatment†

2

The Dysport treatment
Effective treatment requires 1 injection into each
of 5 points between and over the eyebrows.
Although office visit times may vary, the procedure
generally takes 10 to 20 minutes. Your healthcare
professional will determine the exact placement of
each injection to get results that are right for you.

IMPORTANT SAFETY INFORMATION
The toxic effects have been reported at doses similar to those used to treat muscle spasms in
the neck. Lower doses, in both approved and unapproved uses, have also caused toxic effects.
This includes treatment of children and adults for muscle spasms.
These effects could make it unsafe for you to drive a car, operate machinery, or do other
dangerous activities.
Do not have Dysport treatment if you: are allergic to Dysport or any of its ingredients (see the end
of the Medication Guide for a list of ingredients), are allergic to cow’s milk protein, had an allergic
reaction to any other botulinum toxin product, such as Myobloc® or Botox,® or have a skin infection at
the planned injection site.
14

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

What to expect with Dysport
A step-by-step guide to your treatment†

3

After your Dysport treatment
Ask your doctor about any precautions you
should take after your treatment. Call your doctor
or get medical help right away if you have any
problems swallowing, speaking, or breathing.
If this happens, do not drive a car, operate
machinery, or do other dangerous activities.

IMPORTANT SAFETY INFORMATION
The dose of Dysport is not the same as the dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to the dose of any other botulinum toxin
product you may have used.
Dysport may not be right for you if: you have surgical changes to your face, very weak
muscles in the treatment area, your face looks very different from side to side, the injection
site is inflamed, you have droopy eyelids or sagging eyelid folds, deep facial scars, thick oily
skin, or if your wrinkles can’t be smoothed by spreading them apart.
15

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

What to expect with Dysport
A step-by-step guide to your treatment†

4

Follow up
To maintain your improvements, you should
discuss a treatment schedule with your doctor.
As with any botulinum toxin product, you should
wait at least 90 days between treatments.

IMPORTANT SAFETY INFORMATION
Tell your doctor about all your medical conditions, including if you have: a disease that
affects your muscles and nerves (suchas amyotrophic lateral sclerosis [ALS or Lou Gehrig’s
disease], myasthenia gravis, or Lambert-Eaton syndrome), allergies to any botulinum toxin
product or had any side effect from any botulinum toxin product in the past, a breathing problem
(such as asthma or emphysema), swallowing problems, bleeding problems, diabetes, a slow
heart beat or other problem with your heart rate or rhythm, plans to have surgery, had surgery on
your face, weakness of your forehead muscles (such as trouble raising your eyebrows), drooping
eyelids, or any other change in the way your face normally looks. Patients with a disease that
affects muscles and nerves who are treated with typical doses of Dysport may have a higher risk
of serious side effects, including severe swallowing and breathing problems.
16

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

Why not start the Dysport
discussion with your doctor today?
Questions to ask your doctor:
• How soon will I see treatment results?
• How long does one treatment last?
• How often can I receive a Dysport treatment?
• Is there any way to save money on
my treatment?
• Can I have a treatment today?
• What are the risks associated with treatment?
IMPORTANT SAFETY INFORMATION
Human Albumin
This product contains albumin taken from human plasma. Steps taken during donor screening and product
manufacturing processes make the risk of spreading viral diseases extremely rare. In theory, there is also an
extremely rare risk of contracting Creutzfeldt-Jakob disease (CJD). No cases of spread of viral diseases or CJD
have ever been reported for albumin.
17

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Important Safety Information

What is the most important information you
should know about Dysport
(abobotulinumtoxinA) 300 Units for Injection?
Spread of Toxin Effects: In some cases, the
effects of Dysport and all botulinum toxin
products may affect areas of the body away
from the injection site. These effects can
cause symptoms of a serious condition called
botulism. Symptoms of botulism can happen
hours to weeks after injection and may
include swallowing and breathing problems,
loss of strength and muscle weakness all over
the body, double vision, blurred vision and
drooping eyelids, hoarseness or change or
loss of voice, trouble saying words clearly, or
loss of bladder control. Swallowing and
breathing problems can be life threatening
and there have been reports of death.

18

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

The risk of symptoms is probably greatest in
children and adults treated for muscle spasms,
particularly in those patients who have
underlying medical conditions that could make
these symptoms more likely.
The toxic effects have been reported at doses
similar to those used to treat muscle spasms in
the neck. Lower doses, in both approved and
unapproved uses, have also caused toxic
effects. This includes treatment of children and
adults for muscle spasms.
These effects could make it unsafe for you to
drive a car, operate machinery, or do other
dangerous activities.
Do not have Dysport treatment if you: are allergic
to Dysport or any of its ingredients (see the end of
the Medication Guide for a list of ingredients), are
allergic to cow’s milk protein, had an allergic
reaction to any other botulinum toxin product, such
as Myobloc® or Botox,® or have a skin infection at
the planned injection site.

Important Safety Information (cont.)

The dose of Dysport is not the same as the
dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to
the dose of any other botulinum toxin product
you may have used.
Dysport may not be right for you if: you have
surgical changes to your face, very weak muscles
in the treatment area, your face looks very
different from side to side, the injection site is
inflamed, you have droopy eyelids or sagging
eyelid folds, deep facial scars, thick oily skin, or if
your wrinkles can’t be smoothed by spreading
them apart.
Tell your doctor about all your medical
conditions, including if you have: a disease
that affects your muscles and nerves (such as
amyotrophic lateral sclerosis [ALS or Lou
Gehrig’s disease], myasthenia gravis, or LambertEaton syndrome), allergies to any botulinum toxin
product or had any side effect from any

19

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

botulinum toxin product in the past, a breathing
problem (such as asthma or emphysema),
swallowing problems, bleeding problems, diabetes,
a slow heart beat or other problem with your heart
rate or rhythm, plans to have surgery, had surgery
on your face, weakness of your forehead muscles
(such as trouble raising your eyebrows), drooping
eyelids, or any other change in the way your face
normally looks. Patients with a disease that affects
muscles and nerves who are treated with typical
doses of Dysport may have a higher risk of serious
side effects, including severe swallowing and
breathing problems.
Human Albumin
This product contains albumin taken from human
plasma. Steps taken during donor screening and
product manufacturing processes make the risk of
spreading viral diseases extremely rare. In theory,
there is also an extremely rare risk of contracting
Creutzfeldt-Jakob disease (CJD). No cases of
spread of viral diseases or CJD have ever been
reported for albumin.

Important Safety Information (cont.)

Allergic Reaction to Injecting in the Skin
It is not known if an allergic reaction can be
caused by injecting Dysport into the skin. The
safety of treating excessive sweating with Dysport
is not known.
Common Side Effects
The most common side effects are nose and
throat irritation, headache, injection site pain,
injection site skin reaction, upper respiratory tract
infection, eyelid swelling, eyelid drooping, sinus
inflammation, and nausea.
Tell your doctor about all the medicines you
take, including prescription and nonprescription
medicines, vitamins and herbal and other natural
products. Using Dysport with certain other
medicines may cause serious side effects.

20

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

Do not start any new medicines while taking
Dysport without talking to your doctor first.

Especially tell your doctor if you: have received
any other botulinum toxin product in the last four
months, have received injections of botulinum toxin,
such as Myobloc® (rimabotulinumtoxinB) or Botox®
(onabotulinumtoxinA) in the past (be sure your
doctor knows exactly which product you received),
have recently received an antibiotic by injection,
take muscle relaxants, take an allergy or cold
medicine, or take a sleep medicine.
Use In Specific Populations
Dysport should not be used in children or in women
who are pregnant or breastfeeding.
Ask your doctor if Dysport is right for you.

Medication Guide

21

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

22

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

23

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

24

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

25

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

26

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

27

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

28

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

29

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

30

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

31

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

32

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medicis Family
of Aesthetic Products

Products are not FDA approved for combination use.

www.DysportUSA.com

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.
33

The Dysport trademark is used under license. Restylane is a registered trademark of HA North American Sales AB. All other trademarks
are the property of their respective owners. DSP 11-060 10/31/12


Slide 21

Dysport ® is a prescription
injection for temporary
improvement in the look of
moderate to severe frown
lines between the eyebrows
(glabellar lines) in adults less
than 65 years of age.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.
The Dysport trademark is used under license. All other trademarks are the property of their respective owners. DSP 11-060 10/31/12

I do special things for myself,
and I’ll bet you do, too.
I work out, eat right, and take care of my
skin. Of course, cosmetic creams and lotions
will always have their place in my regimen—
but for my moderate to severe frown lines,
I was ready for a prescription treatment.
Maybe you are, too.

IMPORTANT SAFETY INFORMATION
What is the most important information you should know about Dysport?
Spread of Toxin Effects: In some cases, the effects of Dysport and all botulinum toxin products
may affect areas of the body away from the injection site. These effects can cause symptoms of
a serious condition called botulism. Symptoms of botulism can happen hours to weeks after
injection and may include swallowing and breathing problems, loss of strength and muscle
weakness all over the body, double vision, blurred vision and drooping eyelids, hoarseness or
change or loss of voice, trouble saying words clearly, or loss of bladder control.
PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

2

What is Dysport?
Prescription Dysport is an injection used to temporarily improve
the look of your moderate to severe frown lines without changing
the look of your whole face. The untreated facial muscles still
work normally, allowing you to freely show facial expressions,
such as smiling, in untreated areas.
Dysport is a formulation that has been shown to deliver temporary
improvement in moderate to severe frown lines, even with repeat
treatments. So, the effect of repeat treatment with Dysport may
be comparable to your first use.

IMPORTANT SAFETY INFORMATION
Swallowing and breathing problems can be life threatening and there have
been reports of death.
The risk of symptoms is probably greatest in children and adults treated for
muscle spasms, particularly in those patients who have underlying medical
conditions that could make these symptoms more likely.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

3

How does Dysport Work?
With just 1 injection into each of 5 points between and over
the eyebrows, Dysport blocks the signal from the nerve to the
muscles, ultimately resulting in a reduction of muscle activity
and temporarily preventing contraction of the muscles that
cause frown lines. You should not be treated with Dysport more
frequently than every 90 days.
Ask your doctor about your prescription treatment options for
temporarily improving the look of moderate to severe frown lines.
IMPORTANT SAFETY INFORMATION
The toxic effects have been reported at doses similar to those used to treat
muscle spasms in the neck. Lower doses, in both approved and unapproved
uses, have also caused toxic effects. This includes treatment of children and
adults for muscle spasms.

These effects could make it unsafe for you to drive a car, operate machinery,
or do other dangerous activities.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

4

What causes frown lines?
Over time, repeated movement of the facial skin by the
forehead muscles forms lines between the eyebrows.
Frown lines are “dynamic”—they happen because of
the way a person’s face moves.

IMPORTANT SAFETY INFORMATION
Do not have Dysport treatment if you: are allergic to Dysport or any of its ingredients
(see the end of the Medication Guide for a list of ingredients), are allergic to cow’s milk protein,
had an allergic reaction to any other botulinum toxin product (such as Myobloc® or Botox®),
or have a skin infection at the planned injection site.
The dose of Dysport is not the same as the dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to the dose of any other botulinum toxin
product you may have used.
Dysport may not be right for you if: you have surgical changes to your face, very weak
muscles in the treatment area, your face looks very different from side to side, the injection site
is inflamed, you have droopy eyelids or sagging eyelid folds, deep facial scars, thick oily skin, or
if your wrinkles can’t be smoothed by spreading them apart.
5

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Are frown lines always related to age?
No. Because frown lines are created by facial movements,
such as frowning or squinting, they may develop even in
younger adults.

IMPORTANT SAFETY INFORMATION
Tell your doctor about all your medical conditions, including if you have: a disease
that affects your muscles and nerves (such as amyotrophic lateral sclerosis [ALS or Lou
Gehrig’s disease], myasthenia gravis, or Lambert-Eaton syndrome), allergies to any
botulinum toxin product or had any side effect from any botulinum toxin product in the past,
a breathing problem (such as asthma or emphysema), swallowing problems, bleeding
problems, diabetes, a slow heart beat or other problem with your heart rate or rhythm, plans
to have surgery, had surgery on your face, weakness of your forehead muscles (such as
trouble raising your eyebrows), drooping eyelids, or any other change in the way your face
normally looks. Patients with a disease that affects muscles and nerves who are treated with
typical doses of Dysport may have a higher risk of serious side effects, including severe
swallowing and breathing problems.
6

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What can you do about frown lines?
Treatment with prescription Dysport can temporarily
improve the look of your moderate to severe frown lines.
Treatment generally takes just 10 to 20 minutes.
The most common side effects are nose and throat
irritation, headache, injection site pain, injection site skin
reaction, upper respiratory tract infection, eyelid swelling,
eyelid drooping, sinus inflammation, and nausea.

IMPORTANT SAFETY INFORMATION
Human Albumin
This product contains albumin taken from human plasma. Steps taken during donor
screening and product manufacturing processes make the risk of spreading viral diseases
extremely rare. In theory, there is also an extremely rare risk of contracting CreutzfeldtJakob disease (CJD). No cases of spread of viral diseases or CJD have ever been
reported for albumin.
7

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

How do you know if Dysport works?
Clinically proven results with 1 treatment
In 3 clinical studies of people whose frown lines were rated “moderate” or
“severe” by a doctor before their treatment with Dysport:a
• Doctor rating: 30 days after treatment, the majority (88%, 85%, and 86% in each of the 3 studies)
had their frown lines rated by a doctor as “mild” or “moderate” at maximum frown. For example, a
patient could improve from “severe” to “moderate” or from “moderate” to “mild.”
• Patient rating: 30 days after treatment, the majority (74%, 79%, and 82% in each of the 3 studies)
rated their own frown lines as “mild” or “moderate” at maximum frown. For example, a patient could
improve from “severe” to “moderate” or from “moderate” to “mild.”

a

Three double-blind, randomized, placebo-controlled, clinical studies evaluated the efficacy of Dysport for use in the temporary improvement of the appearance of moderate to severe
glabellar lines. These 3 studies enrolled healthy adults (ages 19-75) with glabellar lines of at least moderate severity at maximum frown. Subjects were excluded if they had marked
ptosis, deep dermal scarring, or a substantial inability to lessen glabellar lines, even by physically spreading them apart. The subjects in these studies received either Dysport or a
placebo. The total dose was delivered in equally divided aliquots to specified injection sites.

IMPORTANT SAFETY INFORMATION
Allergic Reaction to Injecting in the Skin
It is not known if an allergic reaction can be caused by injecting Dysport into the skin. The safety of
treating excessive sweating with Dysport is not known.
8

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Common Side Effects
The most common side effects are nose and throat irritation, headache, injection site pain, injection site skin
reaction, upper respiratory tract infection, eyelid swelling, eyelid drooping, sinus inflammation, and nausea.
9

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Tell your doctor about all the medicines you take, including prescription and nonprescription medicines,
vitamins and herbal and other natural products. Using Dysport with certain other medicines may cause
serious side effects.
Do not start any new medicines while taking Dysport without talking to your doctor first.
10

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Especially tell your doctor if you: have received any other botulinum toxin product in the last four
months, have received injections of botulinum toxin, such as Myobloc® (rimabotulinumtoxinB) or Botox®
(onabotulinumtoxinA) in the past (be sure your doctor knows exactly which product you received), have
recently received an antibiotic by injection, take muscle relaxants, take an allergy or cold medicine, or take
a sleep medicine.
11

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Use In Specific Populations
Dysport should not be used in children or in women who are pregnant or breastfeeding.
Ask your doctor if Dysport is right for you.
12

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What to expect with Dysport
A step-by-step guide to your treatment†

1

The Dysport treatment consultation
Discuss your expectations with your doctor and
whether you have any health conditions or
allergies that could interfere with your treatment.
† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

IMPORTANT SAFETY INFORMATION
What is the most important information you should know about Dysport?
Spread of Toxin Effects: In some cases, the effects of Dysport and all botulinum toxin products may affect
areas of the body away from the injection site. These effects can cause symptoms of a serious condition
called botulism. Symptoms of botulism can happen hours to weeks after injection and may include
swallowing and breathing problems, loss of strength and muscle weakness all over the body, double
vision, blurred vision and drooping eyelids, hoarseness or change or loss of voice, trouble saying words
clearly, or loss of bladder control. Swallowing and breathing problems can be life threatening and there
have been reports of death.
The risk of symptoms is probably greatest in children and adults treated for muscle spasms, particularly
in those patients who have underlying medical conditions that could make these symptoms more likely.
13

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What to expect with Dysport
A step-by-step guide to your treatment†

2

The Dysport treatment
Effective treatment requires 1 injection into each
of 5 points between and over the eyebrows.
Although office visit times may vary, the procedure
generally takes 10 to 20 minutes. Your healthcare
professional will determine the exact placement of
each injection to get results that are right for you.

IMPORTANT SAFETY INFORMATION
The toxic effects have been reported at doses similar to those used to treat muscle spasms in
the neck. Lower doses, in both approved and unapproved uses, have also caused toxic effects.
This includes treatment of children and adults for muscle spasms.
These effects could make it unsafe for you to drive a car, operate machinery, or do other
dangerous activities.
Do not have Dysport treatment if you: are allergic to Dysport or any of its ingredients (see the end
of the Medication Guide for a list of ingredients), are allergic to cow’s milk protein, had an allergic
reaction to any other botulinum toxin product, such as Myobloc® or Botox,® or have a skin infection at
the planned injection site.
14

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

What to expect with Dysport
A step-by-step guide to your treatment†

3

After your Dysport treatment
Ask your doctor about any precautions you
should take after your treatment. Call your doctor
or get medical help right away if you have any
problems swallowing, speaking, or breathing.
If this happens, do not drive a car, operate
machinery, or do other dangerous activities.

IMPORTANT SAFETY INFORMATION
The dose of Dysport is not the same as the dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to the dose of any other botulinum toxin
product you may have used.
Dysport may not be right for you if: you have surgical changes to your face, very weak
muscles in the treatment area, your face looks very different from side to side, the injection
site is inflamed, you have droopy eyelids or sagging eyelid folds, deep facial scars, thick oily
skin, or if your wrinkles can’t be smoothed by spreading them apart.
15

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

What to expect with Dysport
A step-by-step guide to your treatment†

4

Follow up
To maintain your improvements, you should
discuss a treatment schedule with your doctor.
As with any botulinum toxin product, you should
wait at least 90 days between treatments.

IMPORTANT SAFETY INFORMATION
Tell your doctor about all your medical conditions, including if you have: a disease that
affects your muscles and nerves (suchas amyotrophic lateral sclerosis [ALS or Lou Gehrig’s
disease], myasthenia gravis, or Lambert-Eaton syndrome), allergies to any botulinum toxin
product or had any side effect from any botulinum toxin product in the past, a breathing problem
(such as asthma or emphysema), swallowing problems, bleeding problems, diabetes, a slow
heart beat or other problem with your heart rate or rhythm, plans to have surgery, had surgery on
your face, weakness of your forehead muscles (such as trouble raising your eyebrows), drooping
eyelids, or any other change in the way your face normally looks. Patients with a disease that
affects muscles and nerves who are treated with typical doses of Dysport may have a higher risk
of serious side effects, including severe swallowing and breathing problems.
16

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

Why not start the Dysport
discussion with your doctor today?
Questions to ask your doctor:
• How soon will I see treatment results?
• How long does one treatment last?
• How often can I receive a Dysport treatment?
• Is there any way to save money on
my treatment?
• Can I have a treatment today?
• What are the risks associated with treatment?
IMPORTANT SAFETY INFORMATION
Human Albumin
This product contains albumin taken from human plasma. Steps taken during donor screening and product
manufacturing processes make the risk of spreading viral diseases extremely rare. In theory, there is also an
extremely rare risk of contracting Creutzfeldt-Jakob disease (CJD). No cases of spread of viral diseases or CJD
have ever been reported for albumin.
17

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Important Safety Information

What is the most important information you
should know about Dysport
(abobotulinumtoxinA) 300 Units for Injection?
Spread of Toxin Effects: In some cases, the
effects of Dysport and all botulinum toxin
products may affect areas of the body away
from the injection site. These effects can
cause symptoms of a serious condition called
botulism. Symptoms of botulism can happen
hours to weeks after injection and may
include swallowing and breathing problems,
loss of strength and muscle weakness all over
the body, double vision, blurred vision and
drooping eyelids, hoarseness or change or
loss of voice, trouble saying words clearly, or
loss of bladder control. Swallowing and
breathing problems can be life threatening
and there have been reports of death.

18

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

The risk of symptoms is probably greatest in
children and adults treated for muscle spasms,
particularly in those patients who have
underlying medical conditions that could make
these symptoms more likely.
The toxic effects have been reported at doses
similar to those used to treat muscle spasms in
the neck. Lower doses, in both approved and
unapproved uses, have also caused toxic
effects. This includes treatment of children and
adults for muscle spasms.
These effects could make it unsafe for you to
drive a car, operate machinery, or do other
dangerous activities.
Do not have Dysport treatment if you: are allergic
to Dysport or any of its ingredients (see the end of
the Medication Guide for a list of ingredients), are
allergic to cow’s milk protein, had an allergic
reaction to any other botulinum toxin product, such
as Myobloc® or Botox,® or have a skin infection at
the planned injection site.

Important Safety Information (cont.)

The dose of Dysport is not the same as the
dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to
the dose of any other botulinum toxin product
you may have used.
Dysport may not be right for you if: you have
surgical changes to your face, very weak muscles
in the treatment area, your face looks very
different from side to side, the injection site is
inflamed, you have droopy eyelids or sagging
eyelid folds, deep facial scars, thick oily skin, or if
your wrinkles can’t be smoothed by spreading
them apart.
Tell your doctor about all your medical
conditions, including if you have: a disease
that affects your muscles and nerves (such as
amyotrophic lateral sclerosis [ALS or Lou
Gehrig’s disease], myasthenia gravis, or LambertEaton syndrome), allergies to any botulinum toxin
product or had any side effect from any

19

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

botulinum toxin product in the past, a breathing
problem (such as asthma or emphysema),
swallowing problems, bleeding problems, diabetes,
a slow heart beat or other problem with your heart
rate or rhythm, plans to have surgery, had surgery
on your face, weakness of your forehead muscles
(such as trouble raising your eyebrows), drooping
eyelids, or any other change in the way your face
normally looks. Patients with a disease that affects
muscles and nerves who are treated with typical
doses of Dysport may have a higher risk of serious
side effects, including severe swallowing and
breathing problems.
Human Albumin
This product contains albumin taken from human
plasma. Steps taken during donor screening and
product manufacturing processes make the risk of
spreading viral diseases extremely rare. In theory,
there is also an extremely rare risk of contracting
Creutzfeldt-Jakob disease (CJD). No cases of
spread of viral diseases or CJD have ever been
reported for albumin.

Important Safety Information (cont.)

Allergic Reaction to Injecting in the Skin
It is not known if an allergic reaction can be
caused by injecting Dysport into the skin. The
safety of treating excessive sweating with Dysport
is not known.
Common Side Effects
The most common side effects are nose and
throat irritation, headache, injection site pain,
injection site skin reaction, upper respiratory tract
infection, eyelid swelling, eyelid drooping, sinus
inflammation, and nausea.
Tell your doctor about all the medicines you
take, including prescription and nonprescription
medicines, vitamins and herbal and other natural
products. Using Dysport with certain other
medicines may cause serious side effects.

20

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

Do not start any new medicines while taking
Dysport without talking to your doctor first.

Especially tell your doctor if you: have received
any other botulinum toxin product in the last four
months, have received injections of botulinum toxin,
such as Myobloc® (rimabotulinumtoxinB) or Botox®
(onabotulinumtoxinA) in the past (be sure your
doctor knows exactly which product you received),
have recently received an antibiotic by injection,
take muscle relaxants, take an allergy or cold
medicine, or take a sleep medicine.
Use In Specific Populations
Dysport should not be used in children or in women
who are pregnant or breastfeeding.
Ask your doctor if Dysport is right for you.

Medication Guide

21

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

22

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

23

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

24

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

25

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

26

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

27

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

28

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

29

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

30

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

31

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

32

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medicis Family
of Aesthetic Products

Products are not FDA approved for combination use.

www.DysportUSA.com

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.
33

The Dysport trademark is used under license. Restylane is a registered trademark of HA North American Sales AB. All other trademarks
are the property of their respective owners. DSP 11-060 10/31/12


Slide 22

Dysport ® is a prescription
injection for temporary
improvement in the look of
moderate to severe frown
lines between the eyebrows
(glabellar lines) in adults less
than 65 years of age.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.
The Dysport trademark is used under license. All other trademarks are the property of their respective owners. DSP 11-060 10/31/12

I do special things for myself,
and I’ll bet you do, too.
I work out, eat right, and take care of my
skin. Of course, cosmetic creams and lotions
will always have their place in my regimen—
but for my moderate to severe frown lines,
I was ready for a prescription treatment.
Maybe you are, too.

IMPORTANT SAFETY INFORMATION
What is the most important information you should know about Dysport?
Spread of Toxin Effects: In some cases, the effects of Dysport and all botulinum toxin products
may affect areas of the body away from the injection site. These effects can cause symptoms of
a serious condition called botulism. Symptoms of botulism can happen hours to weeks after
injection and may include swallowing and breathing problems, loss of strength and muscle
weakness all over the body, double vision, blurred vision and drooping eyelids, hoarseness or
change or loss of voice, trouble saying words clearly, or loss of bladder control.
PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

2

What is Dysport?
Prescription Dysport is an injection used to temporarily improve
the look of your moderate to severe frown lines without changing
the look of your whole face. The untreated facial muscles still
work normally, allowing you to freely show facial expressions,
such as smiling, in untreated areas.
Dysport is a formulation that has been shown to deliver temporary
improvement in moderate to severe frown lines, even with repeat
treatments. So, the effect of repeat treatment with Dysport may
be comparable to your first use.

IMPORTANT SAFETY INFORMATION
Swallowing and breathing problems can be life threatening and there have
been reports of death.
The risk of symptoms is probably greatest in children and adults treated for
muscle spasms, particularly in those patients who have underlying medical
conditions that could make these symptoms more likely.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

3

How does Dysport Work?
With just 1 injection into each of 5 points between and over
the eyebrows, Dysport blocks the signal from the nerve to the
muscles, ultimately resulting in a reduction of muscle activity
and temporarily preventing contraction of the muscles that
cause frown lines. You should not be treated with Dysport more
frequently than every 90 days.
Ask your doctor about your prescription treatment options for
temporarily improving the look of moderate to severe frown lines.
IMPORTANT SAFETY INFORMATION
The toxic effects have been reported at doses similar to those used to treat
muscle spasms in the neck. Lower doses, in both approved and unapproved
uses, have also caused toxic effects. This includes treatment of children and
adults for muscle spasms.

These effects could make it unsafe for you to drive a car, operate machinery,
or do other dangerous activities.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

4

What causes frown lines?
Over time, repeated movement of the facial skin by the
forehead muscles forms lines between the eyebrows.
Frown lines are “dynamic”—they happen because of
the way a person’s face moves.

IMPORTANT SAFETY INFORMATION
Do not have Dysport treatment if you: are allergic to Dysport or any of its ingredients
(see the end of the Medication Guide for a list of ingredients), are allergic to cow’s milk protein,
had an allergic reaction to any other botulinum toxin product (such as Myobloc® or Botox®),
or have a skin infection at the planned injection site.
The dose of Dysport is not the same as the dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to the dose of any other botulinum toxin
product you may have used.
Dysport may not be right for you if: you have surgical changes to your face, very weak
muscles in the treatment area, your face looks very different from side to side, the injection site
is inflamed, you have droopy eyelids or sagging eyelid folds, deep facial scars, thick oily skin, or
if your wrinkles can’t be smoothed by spreading them apart.
5

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Are frown lines always related to age?
No. Because frown lines are created by facial movements,
such as frowning or squinting, they may develop even in
younger adults.

IMPORTANT SAFETY INFORMATION
Tell your doctor about all your medical conditions, including if you have: a disease
that affects your muscles and nerves (such as amyotrophic lateral sclerosis [ALS or Lou
Gehrig’s disease], myasthenia gravis, or Lambert-Eaton syndrome), allergies to any
botulinum toxin product or had any side effect from any botulinum toxin product in the past,
a breathing problem (such as asthma or emphysema), swallowing problems, bleeding
problems, diabetes, a slow heart beat or other problem with your heart rate or rhythm, plans
to have surgery, had surgery on your face, weakness of your forehead muscles (such as
trouble raising your eyebrows), drooping eyelids, or any other change in the way your face
normally looks. Patients with a disease that affects muscles and nerves who are treated with
typical doses of Dysport may have a higher risk of serious side effects, including severe
swallowing and breathing problems.
6

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What can you do about frown lines?
Treatment with prescription Dysport can temporarily
improve the look of your moderate to severe frown lines.
Treatment generally takes just 10 to 20 minutes.
The most common side effects are nose and throat
irritation, headache, injection site pain, injection site skin
reaction, upper respiratory tract infection, eyelid swelling,
eyelid drooping, sinus inflammation, and nausea.

IMPORTANT SAFETY INFORMATION
Human Albumin
This product contains albumin taken from human plasma. Steps taken during donor
screening and product manufacturing processes make the risk of spreading viral diseases
extremely rare. In theory, there is also an extremely rare risk of contracting CreutzfeldtJakob disease (CJD). No cases of spread of viral diseases or CJD have ever been
reported for albumin.
7

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

How do you know if Dysport works?
Clinically proven results with 1 treatment
In 3 clinical studies of people whose frown lines were rated “moderate” or
“severe” by a doctor before their treatment with Dysport:a
• Doctor rating: 30 days after treatment, the majority (88%, 85%, and 86% in each of the 3 studies)
had their frown lines rated by a doctor as “mild” or “moderate” at maximum frown. For example, a
patient could improve from “severe” to “moderate” or from “moderate” to “mild.”
• Patient rating: 30 days after treatment, the majority (74%, 79%, and 82% in each of the 3 studies)
rated their own frown lines as “mild” or “moderate” at maximum frown. For example, a patient could
improve from “severe” to “moderate” or from “moderate” to “mild.”

a

Three double-blind, randomized, placebo-controlled, clinical studies evaluated the efficacy of Dysport for use in the temporary improvement of the appearance of moderate to severe
glabellar lines. These 3 studies enrolled healthy adults (ages 19-75) with glabellar lines of at least moderate severity at maximum frown. Subjects were excluded if they had marked
ptosis, deep dermal scarring, or a substantial inability to lessen glabellar lines, even by physically spreading them apart. The subjects in these studies received either Dysport or a
placebo. The total dose was delivered in equally divided aliquots to specified injection sites.

IMPORTANT SAFETY INFORMATION
Allergic Reaction to Injecting in the Skin
It is not known if an allergic reaction can be caused by injecting Dysport into the skin. The safety of
treating excessive sweating with Dysport is not known.
8

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Common Side Effects
The most common side effects are nose and throat irritation, headache, injection site pain, injection site skin
reaction, upper respiratory tract infection, eyelid swelling, eyelid drooping, sinus inflammation, and nausea.
9

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Tell your doctor about all the medicines you take, including prescription and nonprescription medicines,
vitamins and herbal and other natural products. Using Dysport with certain other medicines may cause
serious side effects.
Do not start any new medicines while taking Dysport without talking to your doctor first.
10

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Especially tell your doctor if you: have received any other botulinum toxin product in the last four
months, have received injections of botulinum toxin, such as Myobloc® (rimabotulinumtoxinB) or Botox®
(onabotulinumtoxinA) in the past (be sure your doctor knows exactly which product you received), have
recently received an antibiotic by injection, take muscle relaxants, take an allergy or cold medicine, or take
a sleep medicine.
11

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Use In Specific Populations
Dysport should not be used in children or in women who are pregnant or breastfeeding.
Ask your doctor if Dysport is right for you.
12

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What to expect with Dysport
A step-by-step guide to your treatment†

1

The Dysport treatment consultation
Discuss your expectations with your doctor and
whether you have any health conditions or
allergies that could interfere with your treatment.
† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

IMPORTANT SAFETY INFORMATION
What is the most important information you should know about Dysport?
Spread of Toxin Effects: In some cases, the effects of Dysport and all botulinum toxin products may affect
areas of the body away from the injection site. These effects can cause symptoms of a serious condition
called botulism. Symptoms of botulism can happen hours to weeks after injection and may include
swallowing and breathing problems, loss of strength and muscle weakness all over the body, double
vision, blurred vision and drooping eyelids, hoarseness or change or loss of voice, trouble saying words
clearly, or loss of bladder control. Swallowing and breathing problems can be life threatening and there
have been reports of death.
The risk of symptoms is probably greatest in children and adults treated for muscle spasms, particularly
in those patients who have underlying medical conditions that could make these symptoms more likely.
13

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What to expect with Dysport
A step-by-step guide to your treatment†

2

The Dysport treatment
Effective treatment requires 1 injection into each
of 5 points between and over the eyebrows.
Although office visit times may vary, the procedure
generally takes 10 to 20 minutes. Your healthcare
professional will determine the exact placement of
each injection to get results that are right for you.

IMPORTANT SAFETY INFORMATION
The toxic effects have been reported at doses similar to those used to treat muscle spasms in
the neck. Lower doses, in both approved and unapproved uses, have also caused toxic effects.
This includes treatment of children and adults for muscle spasms.
These effects could make it unsafe for you to drive a car, operate machinery, or do other
dangerous activities.
Do not have Dysport treatment if you: are allergic to Dysport or any of its ingredients (see the end
of the Medication Guide for a list of ingredients), are allergic to cow’s milk protein, had an allergic
reaction to any other botulinum toxin product, such as Myobloc® or Botox,® or have a skin infection at
the planned injection site.
14

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

What to expect with Dysport
A step-by-step guide to your treatment†

3

After your Dysport treatment
Ask your doctor about any precautions you
should take after your treatment. Call your doctor
or get medical help right away if you have any
problems swallowing, speaking, or breathing.
If this happens, do not drive a car, operate
machinery, or do other dangerous activities.

IMPORTANT SAFETY INFORMATION
The dose of Dysport is not the same as the dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to the dose of any other botulinum toxin
product you may have used.
Dysport may not be right for you if: you have surgical changes to your face, very weak
muscles in the treatment area, your face looks very different from side to side, the injection
site is inflamed, you have droopy eyelids or sagging eyelid folds, deep facial scars, thick oily
skin, or if your wrinkles can’t be smoothed by spreading them apart.
15

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

What to expect with Dysport
A step-by-step guide to your treatment†

4

Follow up
To maintain your improvements, you should
discuss a treatment schedule with your doctor.
As with any botulinum toxin product, you should
wait at least 90 days between treatments.

IMPORTANT SAFETY INFORMATION
Tell your doctor about all your medical conditions, including if you have: a disease that
affects your muscles and nerves (suchas amyotrophic lateral sclerosis [ALS or Lou Gehrig’s
disease], myasthenia gravis, or Lambert-Eaton syndrome), allergies to any botulinum toxin
product or had any side effect from any botulinum toxin product in the past, a breathing problem
(such as asthma or emphysema), swallowing problems, bleeding problems, diabetes, a slow
heart beat or other problem with your heart rate or rhythm, plans to have surgery, had surgery on
your face, weakness of your forehead muscles (such as trouble raising your eyebrows), drooping
eyelids, or any other change in the way your face normally looks. Patients with a disease that
affects muscles and nerves who are treated with typical doses of Dysport may have a higher risk
of serious side effects, including severe swallowing and breathing problems.
16

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

Why not start the Dysport
discussion with your doctor today?
Questions to ask your doctor:
• How soon will I see treatment results?
• How long does one treatment last?
• How often can I receive a Dysport treatment?
• Is there any way to save money on
my treatment?
• Can I have a treatment today?
• What are the risks associated with treatment?
IMPORTANT SAFETY INFORMATION
Human Albumin
This product contains albumin taken from human plasma. Steps taken during donor screening and product
manufacturing processes make the risk of spreading viral diseases extremely rare. In theory, there is also an
extremely rare risk of contracting Creutzfeldt-Jakob disease (CJD). No cases of spread of viral diseases or CJD
have ever been reported for albumin.
17

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Important Safety Information

What is the most important information you
should know about Dysport
(abobotulinumtoxinA) 300 Units for Injection?
Spread of Toxin Effects: In some cases, the
effects of Dysport and all botulinum toxin
products may affect areas of the body away
from the injection site. These effects can
cause symptoms of a serious condition called
botulism. Symptoms of botulism can happen
hours to weeks after injection and may
include swallowing and breathing problems,
loss of strength and muscle weakness all over
the body, double vision, blurred vision and
drooping eyelids, hoarseness or change or
loss of voice, trouble saying words clearly, or
loss of bladder control. Swallowing and
breathing problems can be life threatening
and there have been reports of death.

18

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

The risk of symptoms is probably greatest in
children and adults treated for muscle spasms,
particularly in those patients who have
underlying medical conditions that could make
these symptoms more likely.
The toxic effects have been reported at doses
similar to those used to treat muscle spasms in
the neck. Lower doses, in both approved and
unapproved uses, have also caused toxic
effects. This includes treatment of children and
adults for muscle spasms.
These effects could make it unsafe for you to
drive a car, operate machinery, or do other
dangerous activities.
Do not have Dysport treatment if you: are allergic
to Dysport or any of its ingredients (see the end of
the Medication Guide for a list of ingredients), are
allergic to cow’s milk protein, had an allergic
reaction to any other botulinum toxin product, such
as Myobloc® or Botox,® or have a skin infection at
the planned injection site.

Important Safety Information (cont.)

The dose of Dysport is not the same as the
dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to
the dose of any other botulinum toxin product
you may have used.
Dysport may not be right for you if: you have
surgical changes to your face, very weak muscles
in the treatment area, your face looks very
different from side to side, the injection site is
inflamed, you have droopy eyelids or sagging
eyelid folds, deep facial scars, thick oily skin, or if
your wrinkles can’t be smoothed by spreading
them apart.
Tell your doctor about all your medical
conditions, including if you have: a disease
that affects your muscles and nerves (such as
amyotrophic lateral sclerosis [ALS or Lou
Gehrig’s disease], myasthenia gravis, or LambertEaton syndrome), allergies to any botulinum toxin
product or had any side effect from any

19

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

botulinum toxin product in the past, a breathing
problem (such as asthma or emphysema),
swallowing problems, bleeding problems, diabetes,
a slow heart beat or other problem with your heart
rate or rhythm, plans to have surgery, had surgery
on your face, weakness of your forehead muscles
(such as trouble raising your eyebrows), drooping
eyelids, or any other change in the way your face
normally looks. Patients with a disease that affects
muscles and nerves who are treated with typical
doses of Dysport may have a higher risk of serious
side effects, including severe swallowing and
breathing problems.
Human Albumin
This product contains albumin taken from human
plasma. Steps taken during donor screening and
product manufacturing processes make the risk of
spreading viral diseases extremely rare. In theory,
there is also an extremely rare risk of contracting
Creutzfeldt-Jakob disease (CJD). No cases of
spread of viral diseases or CJD have ever been
reported for albumin.

Important Safety Information (cont.)

Allergic Reaction to Injecting in the Skin
It is not known if an allergic reaction can be
caused by injecting Dysport into the skin. The
safety of treating excessive sweating with Dysport
is not known.
Common Side Effects
The most common side effects are nose and
throat irritation, headache, injection site pain,
injection site skin reaction, upper respiratory tract
infection, eyelid swelling, eyelid drooping, sinus
inflammation, and nausea.
Tell your doctor about all the medicines you
take, including prescription and nonprescription
medicines, vitamins and herbal and other natural
products. Using Dysport with certain other
medicines may cause serious side effects.

20

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

Do not start any new medicines while taking
Dysport without talking to your doctor first.

Especially tell your doctor if you: have received
any other botulinum toxin product in the last four
months, have received injections of botulinum toxin,
such as Myobloc® (rimabotulinumtoxinB) or Botox®
(onabotulinumtoxinA) in the past (be sure your
doctor knows exactly which product you received),
have recently received an antibiotic by injection,
take muscle relaxants, take an allergy or cold
medicine, or take a sleep medicine.
Use In Specific Populations
Dysport should not be used in children or in women
who are pregnant or breastfeeding.
Ask your doctor if Dysport is right for you.

Medication Guide

21

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

22

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

23

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

24

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

25

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

26

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

27

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

28

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

29

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

30

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

31

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

32

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medicis Family
of Aesthetic Products

Products are not FDA approved for combination use.

www.DysportUSA.com

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.
33

The Dysport trademark is used under license. Restylane is a registered trademark of HA North American Sales AB. All other trademarks
are the property of their respective owners. DSP 11-060 10/31/12


Slide 23

Dysport ® is a prescription
injection for temporary
improvement in the look of
moderate to severe frown
lines between the eyebrows
(glabellar lines) in adults less
than 65 years of age.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.
The Dysport trademark is used under license. All other trademarks are the property of their respective owners. DSP 11-060 10/31/12

I do special things for myself,
and I’ll bet you do, too.
I work out, eat right, and take care of my
skin. Of course, cosmetic creams and lotions
will always have their place in my regimen—
but for my moderate to severe frown lines,
I was ready for a prescription treatment.
Maybe you are, too.

IMPORTANT SAFETY INFORMATION
What is the most important information you should know about Dysport?
Spread of Toxin Effects: In some cases, the effects of Dysport and all botulinum toxin products
may affect areas of the body away from the injection site. These effects can cause symptoms of
a serious condition called botulism. Symptoms of botulism can happen hours to weeks after
injection and may include swallowing and breathing problems, loss of strength and muscle
weakness all over the body, double vision, blurred vision and drooping eyelids, hoarseness or
change or loss of voice, trouble saying words clearly, or loss of bladder control.
PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

2

What is Dysport?
Prescription Dysport is an injection used to temporarily improve
the look of your moderate to severe frown lines without changing
the look of your whole face. The untreated facial muscles still
work normally, allowing you to freely show facial expressions,
such as smiling, in untreated areas.
Dysport is a formulation that has been shown to deliver temporary
improvement in moderate to severe frown lines, even with repeat
treatments. So, the effect of repeat treatment with Dysport may
be comparable to your first use.

IMPORTANT SAFETY INFORMATION
Swallowing and breathing problems can be life threatening and there have
been reports of death.
The risk of symptoms is probably greatest in children and adults treated for
muscle spasms, particularly in those patients who have underlying medical
conditions that could make these symptoms more likely.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

3

How does Dysport Work?
With just 1 injection into each of 5 points between and over
the eyebrows, Dysport blocks the signal from the nerve to the
muscles, ultimately resulting in a reduction of muscle activity
and temporarily preventing contraction of the muscles that
cause frown lines. You should not be treated with Dysport more
frequently than every 90 days.
Ask your doctor about your prescription treatment options for
temporarily improving the look of moderate to severe frown lines.
IMPORTANT SAFETY INFORMATION
The toxic effects have been reported at doses similar to those used to treat
muscle spasms in the neck. Lower doses, in both approved and unapproved
uses, have also caused toxic effects. This includes treatment of children and
adults for muscle spasms.

These effects could make it unsafe for you to drive a car, operate machinery,
or do other dangerous activities.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

4

What causes frown lines?
Over time, repeated movement of the facial skin by the
forehead muscles forms lines between the eyebrows.
Frown lines are “dynamic”—they happen because of
the way a person’s face moves.

IMPORTANT SAFETY INFORMATION
Do not have Dysport treatment if you: are allergic to Dysport or any of its ingredients
(see the end of the Medication Guide for a list of ingredients), are allergic to cow’s milk protein,
had an allergic reaction to any other botulinum toxin product (such as Myobloc® or Botox®),
or have a skin infection at the planned injection site.
The dose of Dysport is not the same as the dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to the dose of any other botulinum toxin
product you may have used.
Dysport may not be right for you if: you have surgical changes to your face, very weak
muscles in the treatment area, your face looks very different from side to side, the injection site
is inflamed, you have droopy eyelids or sagging eyelid folds, deep facial scars, thick oily skin, or
if your wrinkles can’t be smoothed by spreading them apart.
5

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Are frown lines always related to age?
No. Because frown lines are created by facial movements,
such as frowning or squinting, they may develop even in
younger adults.

IMPORTANT SAFETY INFORMATION
Tell your doctor about all your medical conditions, including if you have: a disease
that affects your muscles and nerves (such as amyotrophic lateral sclerosis [ALS or Lou
Gehrig’s disease], myasthenia gravis, or Lambert-Eaton syndrome), allergies to any
botulinum toxin product or had any side effect from any botulinum toxin product in the past,
a breathing problem (such as asthma or emphysema), swallowing problems, bleeding
problems, diabetes, a slow heart beat or other problem with your heart rate or rhythm, plans
to have surgery, had surgery on your face, weakness of your forehead muscles (such as
trouble raising your eyebrows), drooping eyelids, or any other change in the way your face
normally looks. Patients with a disease that affects muscles and nerves who are treated with
typical doses of Dysport may have a higher risk of serious side effects, including severe
swallowing and breathing problems.
6

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What can you do about frown lines?
Treatment with prescription Dysport can temporarily
improve the look of your moderate to severe frown lines.
Treatment generally takes just 10 to 20 minutes.
The most common side effects are nose and throat
irritation, headache, injection site pain, injection site skin
reaction, upper respiratory tract infection, eyelid swelling,
eyelid drooping, sinus inflammation, and nausea.

IMPORTANT SAFETY INFORMATION
Human Albumin
This product contains albumin taken from human plasma. Steps taken during donor
screening and product manufacturing processes make the risk of spreading viral diseases
extremely rare. In theory, there is also an extremely rare risk of contracting CreutzfeldtJakob disease (CJD). No cases of spread of viral diseases or CJD have ever been
reported for albumin.
7

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

How do you know if Dysport works?
Clinically proven results with 1 treatment
In 3 clinical studies of people whose frown lines were rated “moderate” or
“severe” by a doctor before their treatment with Dysport:a
• Doctor rating: 30 days after treatment, the majority (88%, 85%, and 86% in each of the 3 studies)
had their frown lines rated by a doctor as “mild” or “moderate” at maximum frown. For example, a
patient could improve from “severe” to “moderate” or from “moderate” to “mild.”
• Patient rating: 30 days after treatment, the majority (74%, 79%, and 82% in each of the 3 studies)
rated their own frown lines as “mild” or “moderate” at maximum frown. For example, a patient could
improve from “severe” to “moderate” or from “moderate” to “mild.”

a

Three double-blind, randomized, placebo-controlled, clinical studies evaluated the efficacy of Dysport for use in the temporary improvement of the appearance of moderate to severe
glabellar lines. These 3 studies enrolled healthy adults (ages 19-75) with glabellar lines of at least moderate severity at maximum frown. Subjects were excluded if they had marked
ptosis, deep dermal scarring, or a substantial inability to lessen glabellar lines, even by physically spreading them apart. The subjects in these studies received either Dysport or a
placebo. The total dose was delivered in equally divided aliquots to specified injection sites.

IMPORTANT SAFETY INFORMATION
Allergic Reaction to Injecting in the Skin
It is not known if an allergic reaction can be caused by injecting Dysport into the skin. The safety of
treating excessive sweating with Dysport is not known.
8

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Common Side Effects
The most common side effects are nose and throat irritation, headache, injection site pain, injection site skin
reaction, upper respiratory tract infection, eyelid swelling, eyelid drooping, sinus inflammation, and nausea.
9

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Tell your doctor about all the medicines you take, including prescription and nonprescription medicines,
vitamins and herbal and other natural products. Using Dysport with certain other medicines may cause
serious side effects.
Do not start any new medicines while taking Dysport without talking to your doctor first.
10

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Especially tell your doctor if you: have received any other botulinum toxin product in the last four
months, have received injections of botulinum toxin, such as Myobloc® (rimabotulinumtoxinB) or Botox®
(onabotulinumtoxinA) in the past (be sure your doctor knows exactly which product you received), have
recently received an antibiotic by injection, take muscle relaxants, take an allergy or cold medicine, or take
a sleep medicine.
11

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Use In Specific Populations
Dysport should not be used in children or in women who are pregnant or breastfeeding.
Ask your doctor if Dysport is right for you.
12

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What to expect with Dysport
A step-by-step guide to your treatment†

1

The Dysport treatment consultation
Discuss your expectations with your doctor and
whether you have any health conditions or
allergies that could interfere with your treatment.
† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

IMPORTANT SAFETY INFORMATION
What is the most important information you should know about Dysport?
Spread of Toxin Effects: In some cases, the effects of Dysport and all botulinum toxin products may affect
areas of the body away from the injection site. These effects can cause symptoms of a serious condition
called botulism. Symptoms of botulism can happen hours to weeks after injection and may include
swallowing and breathing problems, loss of strength and muscle weakness all over the body, double
vision, blurred vision and drooping eyelids, hoarseness or change or loss of voice, trouble saying words
clearly, or loss of bladder control. Swallowing and breathing problems can be life threatening and there
have been reports of death.
The risk of symptoms is probably greatest in children and adults treated for muscle spasms, particularly
in those patients who have underlying medical conditions that could make these symptoms more likely.
13

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What to expect with Dysport
A step-by-step guide to your treatment†

2

The Dysport treatment
Effective treatment requires 1 injection into each
of 5 points between and over the eyebrows.
Although office visit times may vary, the procedure
generally takes 10 to 20 minutes. Your healthcare
professional will determine the exact placement of
each injection to get results that are right for you.

IMPORTANT SAFETY INFORMATION
The toxic effects have been reported at doses similar to those used to treat muscle spasms in
the neck. Lower doses, in both approved and unapproved uses, have also caused toxic effects.
This includes treatment of children and adults for muscle spasms.
These effects could make it unsafe for you to drive a car, operate machinery, or do other
dangerous activities.
Do not have Dysport treatment if you: are allergic to Dysport or any of its ingredients (see the end
of the Medication Guide for a list of ingredients), are allergic to cow’s milk protein, had an allergic
reaction to any other botulinum toxin product, such as Myobloc® or Botox,® or have a skin infection at
the planned injection site.
14

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

What to expect with Dysport
A step-by-step guide to your treatment†

3

After your Dysport treatment
Ask your doctor about any precautions you
should take after your treatment. Call your doctor
or get medical help right away if you have any
problems swallowing, speaking, or breathing.
If this happens, do not drive a car, operate
machinery, or do other dangerous activities.

IMPORTANT SAFETY INFORMATION
The dose of Dysport is not the same as the dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to the dose of any other botulinum toxin
product you may have used.
Dysport may not be right for you if: you have surgical changes to your face, very weak
muscles in the treatment area, your face looks very different from side to side, the injection
site is inflamed, you have droopy eyelids or sagging eyelid folds, deep facial scars, thick oily
skin, or if your wrinkles can’t be smoothed by spreading them apart.
15

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

What to expect with Dysport
A step-by-step guide to your treatment†

4

Follow up
To maintain your improvements, you should
discuss a treatment schedule with your doctor.
As with any botulinum toxin product, you should
wait at least 90 days between treatments.

IMPORTANT SAFETY INFORMATION
Tell your doctor about all your medical conditions, including if you have: a disease that
affects your muscles and nerves (suchas amyotrophic lateral sclerosis [ALS or Lou Gehrig’s
disease], myasthenia gravis, or Lambert-Eaton syndrome), allergies to any botulinum toxin
product or had any side effect from any botulinum toxin product in the past, a breathing problem
(such as asthma or emphysema), swallowing problems, bleeding problems, diabetes, a slow
heart beat or other problem with your heart rate or rhythm, plans to have surgery, had surgery on
your face, weakness of your forehead muscles (such as trouble raising your eyebrows), drooping
eyelids, or any other change in the way your face normally looks. Patients with a disease that
affects muscles and nerves who are treated with typical doses of Dysport may have a higher risk
of serious side effects, including severe swallowing and breathing problems.
16

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

Why not start the Dysport
discussion with your doctor today?
Questions to ask your doctor:
• How soon will I see treatment results?
• How long does one treatment last?
• How often can I receive a Dysport treatment?
• Is there any way to save money on
my treatment?
• Can I have a treatment today?
• What are the risks associated with treatment?
IMPORTANT SAFETY INFORMATION
Human Albumin
This product contains albumin taken from human plasma. Steps taken during donor screening and product
manufacturing processes make the risk of spreading viral diseases extremely rare. In theory, there is also an
extremely rare risk of contracting Creutzfeldt-Jakob disease (CJD). No cases of spread of viral diseases or CJD
have ever been reported for albumin.
17

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Important Safety Information

What is the most important information you
should know about Dysport
(abobotulinumtoxinA) 300 Units for Injection?
Spread of Toxin Effects: In some cases, the
effects of Dysport and all botulinum toxin
products may affect areas of the body away
from the injection site. These effects can
cause symptoms of a serious condition called
botulism. Symptoms of botulism can happen
hours to weeks after injection and may
include swallowing and breathing problems,
loss of strength and muscle weakness all over
the body, double vision, blurred vision and
drooping eyelids, hoarseness or change or
loss of voice, trouble saying words clearly, or
loss of bladder control. Swallowing and
breathing problems can be life threatening
and there have been reports of death.

18

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

The risk of symptoms is probably greatest in
children and adults treated for muscle spasms,
particularly in those patients who have
underlying medical conditions that could make
these symptoms more likely.
The toxic effects have been reported at doses
similar to those used to treat muscle spasms in
the neck. Lower doses, in both approved and
unapproved uses, have also caused toxic
effects. This includes treatment of children and
adults for muscle spasms.
These effects could make it unsafe for you to
drive a car, operate machinery, or do other
dangerous activities.
Do not have Dysport treatment if you: are allergic
to Dysport or any of its ingredients (see the end of
the Medication Guide for a list of ingredients), are
allergic to cow’s milk protein, had an allergic
reaction to any other botulinum toxin product, such
as Myobloc® or Botox,® or have a skin infection at
the planned injection site.

Important Safety Information (cont.)

The dose of Dysport is not the same as the
dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to
the dose of any other botulinum toxin product
you may have used.
Dysport may not be right for you if: you have
surgical changes to your face, very weak muscles
in the treatment area, your face looks very
different from side to side, the injection site is
inflamed, you have droopy eyelids or sagging
eyelid folds, deep facial scars, thick oily skin, or if
your wrinkles can’t be smoothed by spreading
them apart.
Tell your doctor about all your medical
conditions, including if you have: a disease
that affects your muscles and nerves (such as
amyotrophic lateral sclerosis [ALS or Lou
Gehrig’s disease], myasthenia gravis, or LambertEaton syndrome), allergies to any botulinum toxin
product or had any side effect from any

19

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

botulinum toxin product in the past, a breathing
problem (such as asthma or emphysema),
swallowing problems, bleeding problems, diabetes,
a slow heart beat or other problem with your heart
rate or rhythm, plans to have surgery, had surgery
on your face, weakness of your forehead muscles
(such as trouble raising your eyebrows), drooping
eyelids, or any other change in the way your face
normally looks. Patients with a disease that affects
muscles and nerves who are treated with typical
doses of Dysport may have a higher risk of serious
side effects, including severe swallowing and
breathing problems.
Human Albumin
This product contains albumin taken from human
plasma. Steps taken during donor screening and
product manufacturing processes make the risk of
spreading viral diseases extremely rare. In theory,
there is also an extremely rare risk of contracting
Creutzfeldt-Jakob disease (CJD). No cases of
spread of viral diseases or CJD have ever been
reported for albumin.

Important Safety Information (cont.)

Allergic Reaction to Injecting in the Skin
It is not known if an allergic reaction can be
caused by injecting Dysport into the skin. The
safety of treating excessive sweating with Dysport
is not known.
Common Side Effects
The most common side effects are nose and
throat irritation, headache, injection site pain,
injection site skin reaction, upper respiratory tract
infection, eyelid swelling, eyelid drooping, sinus
inflammation, and nausea.
Tell your doctor about all the medicines you
take, including prescription and nonprescription
medicines, vitamins and herbal and other natural
products. Using Dysport with certain other
medicines may cause serious side effects.

20

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

Do not start any new medicines while taking
Dysport without talking to your doctor first.

Especially tell your doctor if you: have received
any other botulinum toxin product in the last four
months, have received injections of botulinum toxin,
such as Myobloc® (rimabotulinumtoxinB) or Botox®
(onabotulinumtoxinA) in the past (be sure your
doctor knows exactly which product you received),
have recently received an antibiotic by injection,
take muscle relaxants, take an allergy or cold
medicine, or take a sleep medicine.
Use In Specific Populations
Dysport should not be used in children or in women
who are pregnant or breastfeeding.
Ask your doctor if Dysport is right for you.

Medication Guide

21

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

22

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

23

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

24

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

25

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

26

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

27

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

28

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

29

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

30

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

31

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

32

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medicis Family
of Aesthetic Products

Products are not FDA approved for combination use.

www.DysportUSA.com

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.
33

The Dysport trademark is used under license. Restylane is a registered trademark of HA North American Sales AB. All other trademarks
are the property of their respective owners. DSP 11-060 10/31/12


Slide 24

Dysport ® is a prescription
injection for temporary
improvement in the look of
moderate to severe frown
lines between the eyebrows
(glabellar lines) in adults less
than 65 years of age.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.
The Dysport trademark is used under license. All other trademarks are the property of their respective owners. DSP 11-060 10/31/12

I do special things for myself,
and I’ll bet you do, too.
I work out, eat right, and take care of my
skin. Of course, cosmetic creams and lotions
will always have their place in my regimen—
but for my moderate to severe frown lines,
I was ready for a prescription treatment.
Maybe you are, too.

IMPORTANT SAFETY INFORMATION
What is the most important information you should know about Dysport?
Spread of Toxin Effects: In some cases, the effects of Dysport and all botulinum toxin products
may affect areas of the body away from the injection site. These effects can cause symptoms of
a serious condition called botulism. Symptoms of botulism can happen hours to weeks after
injection and may include swallowing and breathing problems, loss of strength and muscle
weakness all over the body, double vision, blurred vision and drooping eyelids, hoarseness or
change or loss of voice, trouble saying words clearly, or loss of bladder control.
PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

2

What is Dysport?
Prescription Dysport is an injection used to temporarily improve
the look of your moderate to severe frown lines without changing
the look of your whole face. The untreated facial muscles still
work normally, allowing you to freely show facial expressions,
such as smiling, in untreated areas.
Dysport is a formulation that has been shown to deliver temporary
improvement in moderate to severe frown lines, even with repeat
treatments. So, the effect of repeat treatment with Dysport may
be comparable to your first use.

IMPORTANT SAFETY INFORMATION
Swallowing and breathing problems can be life threatening and there have
been reports of death.
The risk of symptoms is probably greatest in children and adults treated for
muscle spasms, particularly in those patients who have underlying medical
conditions that could make these symptoms more likely.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

3

How does Dysport Work?
With just 1 injection into each of 5 points between and over
the eyebrows, Dysport blocks the signal from the nerve to the
muscles, ultimately resulting in a reduction of muscle activity
and temporarily preventing contraction of the muscles that
cause frown lines. You should not be treated with Dysport more
frequently than every 90 days.
Ask your doctor about your prescription treatment options for
temporarily improving the look of moderate to severe frown lines.
IMPORTANT SAFETY INFORMATION
The toxic effects have been reported at doses similar to those used to treat
muscle spasms in the neck. Lower doses, in both approved and unapproved
uses, have also caused toxic effects. This includes treatment of children and
adults for muscle spasms.

These effects could make it unsafe for you to drive a car, operate machinery,
or do other dangerous activities.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

4

What causes frown lines?
Over time, repeated movement of the facial skin by the
forehead muscles forms lines between the eyebrows.
Frown lines are “dynamic”—they happen because of
the way a person’s face moves.

IMPORTANT SAFETY INFORMATION
Do not have Dysport treatment if you: are allergic to Dysport or any of its ingredients
(see the end of the Medication Guide for a list of ingredients), are allergic to cow’s milk protein,
had an allergic reaction to any other botulinum toxin product (such as Myobloc® or Botox®),
or have a skin infection at the planned injection site.
The dose of Dysport is not the same as the dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to the dose of any other botulinum toxin
product you may have used.
Dysport may not be right for you if: you have surgical changes to your face, very weak
muscles in the treatment area, your face looks very different from side to side, the injection site
is inflamed, you have droopy eyelids or sagging eyelid folds, deep facial scars, thick oily skin, or
if your wrinkles can’t be smoothed by spreading them apart.
5

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Are frown lines always related to age?
No. Because frown lines are created by facial movements,
such as frowning or squinting, they may develop even in
younger adults.

IMPORTANT SAFETY INFORMATION
Tell your doctor about all your medical conditions, including if you have: a disease
that affects your muscles and nerves (such as amyotrophic lateral sclerosis [ALS or Lou
Gehrig’s disease], myasthenia gravis, or Lambert-Eaton syndrome), allergies to any
botulinum toxin product or had any side effect from any botulinum toxin product in the past,
a breathing problem (such as asthma or emphysema), swallowing problems, bleeding
problems, diabetes, a slow heart beat or other problem with your heart rate or rhythm, plans
to have surgery, had surgery on your face, weakness of your forehead muscles (such as
trouble raising your eyebrows), drooping eyelids, or any other change in the way your face
normally looks. Patients with a disease that affects muscles and nerves who are treated with
typical doses of Dysport may have a higher risk of serious side effects, including severe
swallowing and breathing problems.
6

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What can you do about frown lines?
Treatment with prescription Dysport can temporarily
improve the look of your moderate to severe frown lines.
Treatment generally takes just 10 to 20 minutes.
The most common side effects are nose and throat
irritation, headache, injection site pain, injection site skin
reaction, upper respiratory tract infection, eyelid swelling,
eyelid drooping, sinus inflammation, and nausea.

IMPORTANT SAFETY INFORMATION
Human Albumin
This product contains albumin taken from human plasma. Steps taken during donor
screening and product manufacturing processes make the risk of spreading viral diseases
extremely rare. In theory, there is also an extremely rare risk of contracting CreutzfeldtJakob disease (CJD). No cases of spread of viral diseases or CJD have ever been
reported for albumin.
7

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

How do you know if Dysport works?
Clinically proven results with 1 treatment
In 3 clinical studies of people whose frown lines were rated “moderate” or
“severe” by a doctor before their treatment with Dysport:a
• Doctor rating: 30 days after treatment, the majority (88%, 85%, and 86% in each of the 3 studies)
had their frown lines rated by a doctor as “mild” or “moderate” at maximum frown. For example, a
patient could improve from “severe” to “moderate” or from “moderate” to “mild.”
• Patient rating: 30 days after treatment, the majority (74%, 79%, and 82% in each of the 3 studies)
rated their own frown lines as “mild” or “moderate” at maximum frown. For example, a patient could
improve from “severe” to “moderate” or from “moderate” to “mild.”

a

Three double-blind, randomized, placebo-controlled, clinical studies evaluated the efficacy of Dysport for use in the temporary improvement of the appearance of moderate to severe
glabellar lines. These 3 studies enrolled healthy adults (ages 19-75) with glabellar lines of at least moderate severity at maximum frown. Subjects were excluded if they had marked
ptosis, deep dermal scarring, or a substantial inability to lessen glabellar lines, even by physically spreading them apart. The subjects in these studies received either Dysport or a
placebo. The total dose was delivered in equally divided aliquots to specified injection sites.

IMPORTANT SAFETY INFORMATION
Allergic Reaction to Injecting in the Skin
It is not known if an allergic reaction can be caused by injecting Dysport into the skin. The safety of
treating excessive sweating with Dysport is not known.
8

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Common Side Effects
The most common side effects are nose and throat irritation, headache, injection site pain, injection site skin
reaction, upper respiratory tract infection, eyelid swelling, eyelid drooping, sinus inflammation, and nausea.
9

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Tell your doctor about all the medicines you take, including prescription and nonprescription medicines,
vitamins and herbal and other natural products. Using Dysport with certain other medicines may cause
serious side effects.
Do not start any new medicines while taking Dysport without talking to your doctor first.
10

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Especially tell your doctor if you: have received any other botulinum toxin product in the last four
months, have received injections of botulinum toxin, such as Myobloc® (rimabotulinumtoxinB) or Botox®
(onabotulinumtoxinA) in the past (be sure your doctor knows exactly which product you received), have
recently received an antibiotic by injection, take muscle relaxants, take an allergy or cold medicine, or take
a sleep medicine.
11

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Use In Specific Populations
Dysport should not be used in children or in women who are pregnant or breastfeeding.
Ask your doctor if Dysport is right for you.
12

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What to expect with Dysport
A step-by-step guide to your treatment†

1

The Dysport treatment consultation
Discuss your expectations with your doctor and
whether you have any health conditions or
allergies that could interfere with your treatment.
† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

IMPORTANT SAFETY INFORMATION
What is the most important information you should know about Dysport?
Spread of Toxin Effects: In some cases, the effects of Dysport and all botulinum toxin products may affect
areas of the body away from the injection site. These effects can cause symptoms of a serious condition
called botulism. Symptoms of botulism can happen hours to weeks after injection and may include
swallowing and breathing problems, loss of strength and muscle weakness all over the body, double
vision, blurred vision and drooping eyelids, hoarseness or change or loss of voice, trouble saying words
clearly, or loss of bladder control. Swallowing and breathing problems can be life threatening and there
have been reports of death.
The risk of symptoms is probably greatest in children and adults treated for muscle spasms, particularly
in those patients who have underlying medical conditions that could make these symptoms more likely.
13

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What to expect with Dysport
A step-by-step guide to your treatment†

2

The Dysport treatment
Effective treatment requires 1 injection into each
of 5 points between and over the eyebrows.
Although office visit times may vary, the procedure
generally takes 10 to 20 minutes. Your healthcare
professional will determine the exact placement of
each injection to get results that are right for you.

IMPORTANT SAFETY INFORMATION
The toxic effects have been reported at doses similar to those used to treat muscle spasms in
the neck. Lower doses, in both approved and unapproved uses, have also caused toxic effects.
This includes treatment of children and adults for muscle spasms.
These effects could make it unsafe for you to drive a car, operate machinery, or do other
dangerous activities.
Do not have Dysport treatment if you: are allergic to Dysport or any of its ingredients (see the end
of the Medication Guide for a list of ingredients), are allergic to cow’s milk protein, had an allergic
reaction to any other botulinum toxin product, such as Myobloc® or Botox,® or have a skin infection at
the planned injection site.
14

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

What to expect with Dysport
A step-by-step guide to your treatment†

3

After your Dysport treatment
Ask your doctor about any precautions you
should take after your treatment. Call your doctor
or get medical help right away if you have any
problems swallowing, speaking, or breathing.
If this happens, do not drive a car, operate
machinery, or do other dangerous activities.

IMPORTANT SAFETY INFORMATION
The dose of Dysport is not the same as the dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to the dose of any other botulinum toxin
product you may have used.
Dysport may not be right for you if: you have surgical changes to your face, very weak
muscles in the treatment area, your face looks very different from side to side, the injection
site is inflamed, you have droopy eyelids or sagging eyelid folds, deep facial scars, thick oily
skin, or if your wrinkles can’t be smoothed by spreading them apart.
15

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

What to expect with Dysport
A step-by-step guide to your treatment†

4

Follow up
To maintain your improvements, you should
discuss a treatment schedule with your doctor.
As with any botulinum toxin product, you should
wait at least 90 days between treatments.

IMPORTANT SAFETY INFORMATION
Tell your doctor about all your medical conditions, including if you have: a disease that
affects your muscles and nerves (suchas amyotrophic lateral sclerosis [ALS or Lou Gehrig’s
disease], myasthenia gravis, or Lambert-Eaton syndrome), allergies to any botulinum toxin
product or had any side effect from any botulinum toxin product in the past, a breathing problem
(such as asthma or emphysema), swallowing problems, bleeding problems, diabetes, a slow
heart beat or other problem with your heart rate or rhythm, plans to have surgery, had surgery on
your face, weakness of your forehead muscles (such as trouble raising your eyebrows), drooping
eyelids, or any other change in the way your face normally looks. Patients with a disease that
affects muscles and nerves who are treated with typical doses of Dysport may have a higher risk
of serious side effects, including severe swallowing and breathing problems.
16

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

Why not start the Dysport
discussion with your doctor today?
Questions to ask your doctor:
• How soon will I see treatment results?
• How long does one treatment last?
• How often can I receive a Dysport treatment?
• Is there any way to save money on
my treatment?
• Can I have a treatment today?
• What are the risks associated with treatment?
IMPORTANT SAFETY INFORMATION
Human Albumin
This product contains albumin taken from human plasma. Steps taken during donor screening and product
manufacturing processes make the risk of spreading viral diseases extremely rare. In theory, there is also an
extremely rare risk of contracting Creutzfeldt-Jakob disease (CJD). No cases of spread of viral diseases or CJD
have ever been reported for albumin.
17

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Important Safety Information

What is the most important information you
should know about Dysport
(abobotulinumtoxinA) 300 Units for Injection?
Spread of Toxin Effects: In some cases, the
effects of Dysport and all botulinum toxin
products may affect areas of the body away
from the injection site. These effects can
cause symptoms of a serious condition called
botulism. Symptoms of botulism can happen
hours to weeks after injection and may
include swallowing and breathing problems,
loss of strength and muscle weakness all over
the body, double vision, blurred vision and
drooping eyelids, hoarseness or change or
loss of voice, trouble saying words clearly, or
loss of bladder control. Swallowing and
breathing problems can be life threatening
and there have been reports of death.

18

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

The risk of symptoms is probably greatest in
children and adults treated for muscle spasms,
particularly in those patients who have
underlying medical conditions that could make
these symptoms more likely.
The toxic effects have been reported at doses
similar to those used to treat muscle spasms in
the neck. Lower doses, in both approved and
unapproved uses, have also caused toxic
effects. This includes treatment of children and
adults for muscle spasms.
These effects could make it unsafe for you to
drive a car, operate machinery, or do other
dangerous activities.
Do not have Dysport treatment if you: are allergic
to Dysport or any of its ingredients (see the end of
the Medication Guide for a list of ingredients), are
allergic to cow’s milk protein, had an allergic
reaction to any other botulinum toxin product, such
as Myobloc® or Botox,® or have a skin infection at
the planned injection site.

Important Safety Information (cont.)

The dose of Dysport is not the same as the
dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to
the dose of any other botulinum toxin product
you may have used.
Dysport may not be right for you if: you have
surgical changes to your face, very weak muscles
in the treatment area, your face looks very
different from side to side, the injection site is
inflamed, you have droopy eyelids or sagging
eyelid folds, deep facial scars, thick oily skin, or if
your wrinkles can’t be smoothed by spreading
them apart.
Tell your doctor about all your medical
conditions, including if you have: a disease
that affects your muscles and nerves (such as
amyotrophic lateral sclerosis [ALS or Lou
Gehrig’s disease], myasthenia gravis, or LambertEaton syndrome), allergies to any botulinum toxin
product or had any side effect from any

19

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

botulinum toxin product in the past, a breathing
problem (such as asthma or emphysema),
swallowing problems, bleeding problems, diabetes,
a slow heart beat or other problem with your heart
rate or rhythm, plans to have surgery, had surgery
on your face, weakness of your forehead muscles
(such as trouble raising your eyebrows), drooping
eyelids, or any other change in the way your face
normally looks. Patients with a disease that affects
muscles and nerves who are treated with typical
doses of Dysport may have a higher risk of serious
side effects, including severe swallowing and
breathing problems.
Human Albumin
This product contains albumin taken from human
plasma. Steps taken during donor screening and
product manufacturing processes make the risk of
spreading viral diseases extremely rare. In theory,
there is also an extremely rare risk of contracting
Creutzfeldt-Jakob disease (CJD). No cases of
spread of viral diseases or CJD have ever been
reported for albumin.

Important Safety Information (cont.)

Allergic Reaction to Injecting in the Skin
It is not known if an allergic reaction can be
caused by injecting Dysport into the skin. The
safety of treating excessive sweating with Dysport
is not known.
Common Side Effects
The most common side effects are nose and
throat irritation, headache, injection site pain,
injection site skin reaction, upper respiratory tract
infection, eyelid swelling, eyelid drooping, sinus
inflammation, and nausea.
Tell your doctor about all the medicines you
take, including prescription and nonprescription
medicines, vitamins and herbal and other natural
products. Using Dysport with certain other
medicines may cause serious side effects.

20

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

Do not start any new medicines while taking
Dysport without talking to your doctor first.

Especially tell your doctor if you: have received
any other botulinum toxin product in the last four
months, have received injections of botulinum toxin,
such as Myobloc® (rimabotulinumtoxinB) or Botox®
(onabotulinumtoxinA) in the past (be sure your
doctor knows exactly which product you received),
have recently received an antibiotic by injection,
take muscle relaxants, take an allergy or cold
medicine, or take a sleep medicine.
Use In Specific Populations
Dysport should not be used in children or in women
who are pregnant or breastfeeding.
Ask your doctor if Dysport is right for you.

Medication Guide

21

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

22

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

23

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

24

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

25

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

26

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

27

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

28

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

29

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

30

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

31

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

32

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medicis Family
of Aesthetic Products

Products are not FDA approved for combination use.

www.DysportUSA.com

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.
33

The Dysport trademark is used under license. Restylane is a registered trademark of HA North American Sales AB. All other trademarks
are the property of their respective owners. DSP 11-060 10/31/12


Slide 25

Dysport ® is a prescription
injection for temporary
improvement in the look of
moderate to severe frown
lines between the eyebrows
(glabellar lines) in adults less
than 65 years of age.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.
The Dysport trademark is used under license. All other trademarks are the property of their respective owners. DSP 11-060 10/31/12

I do special things for myself,
and I’ll bet you do, too.
I work out, eat right, and take care of my
skin. Of course, cosmetic creams and lotions
will always have their place in my regimen—
but for my moderate to severe frown lines,
I was ready for a prescription treatment.
Maybe you are, too.

IMPORTANT SAFETY INFORMATION
What is the most important information you should know about Dysport?
Spread of Toxin Effects: In some cases, the effects of Dysport and all botulinum toxin products
may affect areas of the body away from the injection site. These effects can cause symptoms of
a serious condition called botulism. Symptoms of botulism can happen hours to weeks after
injection and may include swallowing and breathing problems, loss of strength and muscle
weakness all over the body, double vision, blurred vision and drooping eyelids, hoarseness or
change or loss of voice, trouble saying words clearly, or loss of bladder control.
PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

2

What is Dysport?
Prescription Dysport is an injection used to temporarily improve
the look of your moderate to severe frown lines without changing
the look of your whole face. The untreated facial muscles still
work normally, allowing you to freely show facial expressions,
such as smiling, in untreated areas.
Dysport is a formulation that has been shown to deliver temporary
improvement in moderate to severe frown lines, even with repeat
treatments. So, the effect of repeat treatment with Dysport may
be comparable to your first use.

IMPORTANT SAFETY INFORMATION
Swallowing and breathing problems can be life threatening and there have
been reports of death.
The risk of symptoms is probably greatest in children and adults treated for
muscle spasms, particularly in those patients who have underlying medical
conditions that could make these symptoms more likely.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

3

How does Dysport Work?
With just 1 injection into each of 5 points between and over
the eyebrows, Dysport blocks the signal from the nerve to the
muscles, ultimately resulting in a reduction of muscle activity
and temporarily preventing contraction of the muscles that
cause frown lines. You should not be treated with Dysport more
frequently than every 90 days.
Ask your doctor about your prescription treatment options for
temporarily improving the look of moderate to severe frown lines.
IMPORTANT SAFETY INFORMATION
The toxic effects have been reported at doses similar to those used to treat
muscle spasms in the neck. Lower doses, in both approved and unapproved
uses, have also caused toxic effects. This includes treatment of children and
adults for muscle spasms.

These effects could make it unsafe for you to drive a car, operate machinery,
or do other dangerous activities.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

4

What causes frown lines?
Over time, repeated movement of the facial skin by the
forehead muscles forms lines between the eyebrows.
Frown lines are “dynamic”—they happen because of
the way a person’s face moves.

IMPORTANT SAFETY INFORMATION
Do not have Dysport treatment if you: are allergic to Dysport or any of its ingredients
(see the end of the Medication Guide for a list of ingredients), are allergic to cow’s milk protein,
had an allergic reaction to any other botulinum toxin product (such as Myobloc® or Botox®),
or have a skin infection at the planned injection site.
The dose of Dysport is not the same as the dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to the dose of any other botulinum toxin
product you may have used.
Dysport may not be right for you if: you have surgical changes to your face, very weak
muscles in the treatment area, your face looks very different from side to side, the injection site
is inflamed, you have droopy eyelids or sagging eyelid folds, deep facial scars, thick oily skin, or
if your wrinkles can’t be smoothed by spreading them apart.
5

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Are frown lines always related to age?
No. Because frown lines are created by facial movements,
such as frowning or squinting, they may develop even in
younger adults.

IMPORTANT SAFETY INFORMATION
Tell your doctor about all your medical conditions, including if you have: a disease
that affects your muscles and nerves (such as amyotrophic lateral sclerosis [ALS or Lou
Gehrig’s disease], myasthenia gravis, or Lambert-Eaton syndrome), allergies to any
botulinum toxin product or had any side effect from any botulinum toxin product in the past,
a breathing problem (such as asthma or emphysema), swallowing problems, bleeding
problems, diabetes, a slow heart beat or other problem with your heart rate or rhythm, plans
to have surgery, had surgery on your face, weakness of your forehead muscles (such as
trouble raising your eyebrows), drooping eyelids, or any other change in the way your face
normally looks. Patients with a disease that affects muscles and nerves who are treated with
typical doses of Dysport may have a higher risk of serious side effects, including severe
swallowing and breathing problems.
6

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What can you do about frown lines?
Treatment with prescription Dysport can temporarily
improve the look of your moderate to severe frown lines.
Treatment generally takes just 10 to 20 minutes.
The most common side effects are nose and throat
irritation, headache, injection site pain, injection site skin
reaction, upper respiratory tract infection, eyelid swelling,
eyelid drooping, sinus inflammation, and nausea.

IMPORTANT SAFETY INFORMATION
Human Albumin
This product contains albumin taken from human plasma. Steps taken during donor
screening and product manufacturing processes make the risk of spreading viral diseases
extremely rare. In theory, there is also an extremely rare risk of contracting CreutzfeldtJakob disease (CJD). No cases of spread of viral diseases or CJD have ever been
reported for albumin.
7

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

How do you know if Dysport works?
Clinically proven results with 1 treatment
In 3 clinical studies of people whose frown lines were rated “moderate” or
“severe” by a doctor before their treatment with Dysport:a
• Doctor rating: 30 days after treatment, the majority (88%, 85%, and 86% in each of the 3 studies)
had their frown lines rated by a doctor as “mild” or “moderate” at maximum frown. For example, a
patient could improve from “severe” to “moderate” or from “moderate” to “mild.”
• Patient rating: 30 days after treatment, the majority (74%, 79%, and 82% in each of the 3 studies)
rated their own frown lines as “mild” or “moderate” at maximum frown. For example, a patient could
improve from “severe” to “moderate” or from “moderate” to “mild.”

a

Three double-blind, randomized, placebo-controlled, clinical studies evaluated the efficacy of Dysport for use in the temporary improvement of the appearance of moderate to severe
glabellar lines. These 3 studies enrolled healthy adults (ages 19-75) with glabellar lines of at least moderate severity at maximum frown. Subjects were excluded if they had marked
ptosis, deep dermal scarring, or a substantial inability to lessen glabellar lines, even by physically spreading them apart. The subjects in these studies received either Dysport or a
placebo. The total dose was delivered in equally divided aliquots to specified injection sites.

IMPORTANT SAFETY INFORMATION
Allergic Reaction to Injecting in the Skin
It is not known if an allergic reaction can be caused by injecting Dysport into the skin. The safety of
treating excessive sweating with Dysport is not known.
8

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Common Side Effects
The most common side effects are nose and throat irritation, headache, injection site pain, injection site skin
reaction, upper respiratory tract infection, eyelid swelling, eyelid drooping, sinus inflammation, and nausea.
9

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Tell your doctor about all the medicines you take, including prescription and nonprescription medicines,
vitamins and herbal and other natural products. Using Dysport with certain other medicines may cause
serious side effects.
Do not start any new medicines while taking Dysport without talking to your doctor first.
10

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Especially tell your doctor if you: have received any other botulinum toxin product in the last four
months, have received injections of botulinum toxin, such as Myobloc® (rimabotulinumtoxinB) or Botox®
(onabotulinumtoxinA) in the past (be sure your doctor knows exactly which product you received), have
recently received an antibiotic by injection, take muscle relaxants, take an allergy or cold medicine, or take
a sleep medicine.
11

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Use In Specific Populations
Dysport should not be used in children or in women who are pregnant or breastfeeding.
Ask your doctor if Dysport is right for you.
12

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What to expect with Dysport
A step-by-step guide to your treatment†

1

The Dysport treatment consultation
Discuss your expectations with your doctor and
whether you have any health conditions or
allergies that could interfere with your treatment.
† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

IMPORTANT SAFETY INFORMATION
What is the most important information you should know about Dysport?
Spread of Toxin Effects: In some cases, the effects of Dysport and all botulinum toxin products may affect
areas of the body away from the injection site. These effects can cause symptoms of a serious condition
called botulism. Symptoms of botulism can happen hours to weeks after injection and may include
swallowing and breathing problems, loss of strength and muscle weakness all over the body, double
vision, blurred vision and drooping eyelids, hoarseness or change or loss of voice, trouble saying words
clearly, or loss of bladder control. Swallowing and breathing problems can be life threatening and there
have been reports of death.
The risk of symptoms is probably greatest in children and adults treated for muscle spasms, particularly
in those patients who have underlying medical conditions that could make these symptoms more likely.
13

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What to expect with Dysport
A step-by-step guide to your treatment†

2

The Dysport treatment
Effective treatment requires 1 injection into each
of 5 points between and over the eyebrows.
Although office visit times may vary, the procedure
generally takes 10 to 20 minutes. Your healthcare
professional will determine the exact placement of
each injection to get results that are right for you.

IMPORTANT SAFETY INFORMATION
The toxic effects have been reported at doses similar to those used to treat muscle spasms in
the neck. Lower doses, in both approved and unapproved uses, have also caused toxic effects.
This includes treatment of children and adults for muscle spasms.
These effects could make it unsafe for you to drive a car, operate machinery, or do other
dangerous activities.
Do not have Dysport treatment if you: are allergic to Dysport or any of its ingredients (see the end
of the Medication Guide for a list of ingredients), are allergic to cow’s milk protein, had an allergic
reaction to any other botulinum toxin product, such as Myobloc® or Botox,® or have a skin infection at
the planned injection site.
14

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

What to expect with Dysport
A step-by-step guide to your treatment†

3

After your Dysport treatment
Ask your doctor about any precautions you
should take after your treatment. Call your doctor
or get medical help right away if you have any
problems swallowing, speaking, or breathing.
If this happens, do not drive a car, operate
machinery, or do other dangerous activities.

IMPORTANT SAFETY INFORMATION
The dose of Dysport is not the same as the dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to the dose of any other botulinum toxin
product you may have used.
Dysport may not be right for you if: you have surgical changes to your face, very weak
muscles in the treatment area, your face looks very different from side to side, the injection
site is inflamed, you have droopy eyelids or sagging eyelid folds, deep facial scars, thick oily
skin, or if your wrinkles can’t be smoothed by spreading them apart.
15

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

What to expect with Dysport
A step-by-step guide to your treatment†

4

Follow up
To maintain your improvements, you should
discuss a treatment schedule with your doctor.
As with any botulinum toxin product, you should
wait at least 90 days between treatments.

IMPORTANT SAFETY INFORMATION
Tell your doctor about all your medical conditions, including if you have: a disease that
affects your muscles and nerves (suchas amyotrophic lateral sclerosis [ALS or Lou Gehrig’s
disease], myasthenia gravis, or Lambert-Eaton syndrome), allergies to any botulinum toxin
product or had any side effect from any botulinum toxin product in the past, a breathing problem
(such as asthma or emphysema), swallowing problems, bleeding problems, diabetes, a slow
heart beat or other problem with your heart rate or rhythm, plans to have surgery, had surgery on
your face, weakness of your forehead muscles (such as trouble raising your eyebrows), drooping
eyelids, or any other change in the way your face normally looks. Patients with a disease that
affects muscles and nerves who are treated with typical doses of Dysport may have a higher risk
of serious side effects, including severe swallowing and breathing problems.
16

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

Why not start the Dysport
discussion with your doctor today?
Questions to ask your doctor:
• How soon will I see treatment results?
• How long does one treatment last?
• How often can I receive a Dysport treatment?
• Is there any way to save money on
my treatment?
• Can I have a treatment today?
• What are the risks associated with treatment?
IMPORTANT SAFETY INFORMATION
Human Albumin
This product contains albumin taken from human plasma. Steps taken during donor screening and product
manufacturing processes make the risk of spreading viral diseases extremely rare. In theory, there is also an
extremely rare risk of contracting Creutzfeldt-Jakob disease (CJD). No cases of spread of viral diseases or CJD
have ever been reported for albumin.
17

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Important Safety Information

What is the most important information you
should know about Dysport
(abobotulinumtoxinA) 300 Units for Injection?
Spread of Toxin Effects: In some cases, the
effects of Dysport and all botulinum toxin
products may affect areas of the body away
from the injection site. These effects can
cause symptoms of a serious condition called
botulism. Symptoms of botulism can happen
hours to weeks after injection and may
include swallowing and breathing problems,
loss of strength and muscle weakness all over
the body, double vision, blurred vision and
drooping eyelids, hoarseness or change or
loss of voice, trouble saying words clearly, or
loss of bladder control. Swallowing and
breathing problems can be life threatening
and there have been reports of death.

18

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

The risk of symptoms is probably greatest in
children and adults treated for muscle spasms,
particularly in those patients who have
underlying medical conditions that could make
these symptoms more likely.
The toxic effects have been reported at doses
similar to those used to treat muscle spasms in
the neck. Lower doses, in both approved and
unapproved uses, have also caused toxic
effects. This includes treatment of children and
adults for muscle spasms.
These effects could make it unsafe for you to
drive a car, operate machinery, or do other
dangerous activities.
Do not have Dysport treatment if you: are allergic
to Dysport or any of its ingredients (see the end of
the Medication Guide for a list of ingredients), are
allergic to cow’s milk protein, had an allergic
reaction to any other botulinum toxin product, such
as Myobloc® or Botox,® or have a skin infection at
the planned injection site.

Important Safety Information (cont.)

The dose of Dysport is not the same as the
dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to
the dose of any other botulinum toxin product
you may have used.
Dysport may not be right for you if: you have
surgical changes to your face, very weak muscles
in the treatment area, your face looks very
different from side to side, the injection site is
inflamed, you have droopy eyelids or sagging
eyelid folds, deep facial scars, thick oily skin, or if
your wrinkles can’t be smoothed by spreading
them apart.
Tell your doctor about all your medical
conditions, including if you have: a disease
that affects your muscles and nerves (such as
amyotrophic lateral sclerosis [ALS or Lou
Gehrig’s disease], myasthenia gravis, or LambertEaton syndrome), allergies to any botulinum toxin
product or had any side effect from any

19

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

botulinum toxin product in the past, a breathing
problem (such as asthma or emphysema),
swallowing problems, bleeding problems, diabetes,
a slow heart beat or other problem with your heart
rate or rhythm, plans to have surgery, had surgery
on your face, weakness of your forehead muscles
(such as trouble raising your eyebrows), drooping
eyelids, or any other change in the way your face
normally looks. Patients with a disease that affects
muscles and nerves who are treated with typical
doses of Dysport may have a higher risk of serious
side effects, including severe swallowing and
breathing problems.
Human Albumin
This product contains albumin taken from human
plasma. Steps taken during donor screening and
product manufacturing processes make the risk of
spreading viral diseases extremely rare. In theory,
there is also an extremely rare risk of contracting
Creutzfeldt-Jakob disease (CJD). No cases of
spread of viral diseases or CJD have ever been
reported for albumin.

Important Safety Information (cont.)

Allergic Reaction to Injecting in the Skin
It is not known if an allergic reaction can be
caused by injecting Dysport into the skin. The
safety of treating excessive sweating with Dysport
is not known.
Common Side Effects
The most common side effects are nose and
throat irritation, headache, injection site pain,
injection site skin reaction, upper respiratory tract
infection, eyelid swelling, eyelid drooping, sinus
inflammation, and nausea.
Tell your doctor about all the medicines you
take, including prescription and nonprescription
medicines, vitamins and herbal and other natural
products. Using Dysport with certain other
medicines may cause serious side effects.

20

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

Do not start any new medicines while taking
Dysport without talking to your doctor first.

Especially tell your doctor if you: have received
any other botulinum toxin product in the last four
months, have received injections of botulinum toxin,
such as Myobloc® (rimabotulinumtoxinB) or Botox®
(onabotulinumtoxinA) in the past (be sure your
doctor knows exactly which product you received),
have recently received an antibiotic by injection,
take muscle relaxants, take an allergy or cold
medicine, or take a sleep medicine.
Use In Specific Populations
Dysport should not be used in children or in women
who are pregnant or breastfeeding.
Ask your doctor if Dysport is right for you.

Medication Guide

21

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

22

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

23

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

24

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

25

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

26

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

27

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

28

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

29

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

30

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

31

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

32

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medicis Family
of Aesthetic Products

Products are not FDA approved for combination use.

www.DysportUSA.com

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.
33

The Dysport trademark is used under license. Restylane is a registered trademark of HA North American Sales AB. All other trademarks
are the property of their respective owners. DSP 11-060 10/31/12


Slide 26

Dysport ® is a prescription
injection for temporary
improvement in the look of
moderate to severe frown
lines between the eyebrows
(glabellar lines) in adults less
than 65 years of age.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.
The Dysport trademark is used under license. All other trademarks are the property of their respective owners. DSP 11-060 10/31/12

I do special things for myself,
and I’ll bet you do, too.
I work out, eat right, and take care of my
skin. Of course, cosmetic creams and lotions
will always have their place in my regimen—
but for my moderate to severe frown lines,
I was ready for a prescription treatment.
Maybe you are, too.

IMPORTANT SAFETY INFORMATION
What is the most important information you should know about Dysport?
Spread of Toxin Effects: In some cases, the effects of Dysport and all botulinum toxin products
may affect areas of the body away from the injection site. These effects can cause symptoms of
a serious condition called botulism. Symptoms of botulism can happen hours to weeks after
injection and may include swallowing and breathing problems, loss of strength and muscle
weakness all over the body, double vision, blurred vision and drooping eyelids, hoarseness or
change or loss of voice, trouble saying words clearly, or loss of bladder control.
PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

2

What is Dysport?
Prescription Dysport is an injection used to temporarily improve
the look of your moderate to severe frown lines without changing
the look of your whole face. The untreated facial muscles still
work normally, allowing you to freely show facial expressions,
such as smiling, in untreated areas.
Dysport is a formulation that has been shown to deliver temporary
improvement in moderate to severe frown lines, even with repeat
treatments. So, the effect of repeat treatment with Dysport may
be comparable to your first use.

IMPORTANT SAFETY INFORMATION
Swallowing and breathing problems can be life threatening and there have
been reports of death.
The risk of symptoms is probably greatest in children and adults treated for
muscle spasms, particularly in those patients who have underlying medical
conditions that could make these symptoms more likely.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

3

How does Dysport Work?
With just 1 injection into each of 5 points between and over
the eyebrows, Dysport blocks the signal from the nerve to the
muscles, ultimately resulting in a reduction of muscle activity
and temporarily preventing contraction of the muscles that
cause frown lines. You should not be treated with Dysport more
frequently than every 90 days.
Ask your doctor about your prescription treatment options for
temporarily improving the look of moderate to severe frown lines.
IMPORTANT SAFETY INFORMATION
The toxic effects have been reported at doses similar to those used to treat
muscle spasms in the neck. Lower doses, in both approved and unapproved
uses, have also caused toxic effects. This includes treatment of children and
adults for muscle spasms.

These effects could make it unsafe for you to drive a car, operate machinery,
or do other dangerous activities.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

4

What causes frown lines?
Over time, repeated movement of the facial skin by the
forehead muscles forms lines between the eyebrows.
Frown lines are “dynamic”—they happen because of
the way a person’s face moves.

IMPORTANT SAFETY INFORMATION
Do not have Dysport treatment if you: are allergic to Dysport or any of its ingredients
(see the end of the Medication Guide for a list of ingredients), are allergic to cow’s milk protein,
had an allergic reaction to any other botulinum toxin product (such as Myobloc® or Botox®),
or have a skin infection at the planned injection site.
The dose of Dysport is not the same as the dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to the dose of any other botulinum toxin
product you may have used.
Dysport may not be right for you if: you have surgical changes to your face, very weak
muscles in the treatment area, your face looks very different from side to side, the injection site
is inflamed, you have droopy eyelids or sagging eyelid folds, deep facial scars, thick oily skin, or
if your wrinkles can’t be smoothed by spreading them apart.
5

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Are frown lines always related to age?
No. Because frown lines are created by facial movements,
such as frowning or squinting, they may develop even in
younger adults.

IMPORTANT SAFETY INFORMATION
Tell your doctor about all your medical conditions, including if you have: a disease
that affects your muscles and nerves (such as amyotrophic lateral sclerosis [ALS or Lou
Gehrig’s disease], myasthenia gravis, or Lambert-Eaton syndrome), allergies to any
botulinum toxin product or had any side effect from any botulinum toxin product in the past,
a breathing problem (such as asthma or emphysema), swallowing problems, bleeding
problems, diabetes, a slow heart beat or other problem with your heart rate or rhythm, plans
to have surgery, had surgery on your face, weakness of your forehead muscles (such as
trouble raising your eyebrows), drooping eyelids, or any other change in the way your face
normally looks. Patients with a disease that affects muscles and nerves who are treated with
typical doses of Dysport may have a higher risk of serious side effects, including severe
swallowing and breathing problems.
6

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What can you do about frown lines?
Treatment with prescription Dysport can temporarily
improve the look of your moderate to severe frown lines.
Treatment generally takes just 10 to 20 minutes.
The most common side effects are nose and throat
irritation, headache, injection site pain, injection site skin
reaction, upper respiratory tract infection, eyelid swelling,
eyelid drooping, sinus inflammation, and nausea.

IMPORTANT SAFETY INFORMATION
Human Albumin
This product contains albumin taken from human plasma. Steps taken during donor
screening and product manufacturing processes make the risk of spreading viral diseases
extremely rare. In theory, there is also an extremely rare risk of contracting CreutzfeldtJakob disease (CJD). No cases of spread of viral diseases or CJD have ever been
reported for albumin.
7

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

How do you know if Dysport works?
Clinically proven results with 1 treatment
In 3 clinical studies of people whose frown lines were rated “moderate” or
“severe” by a doctor before their treatment with Dysport:a
• Doctor rating: 30 days after treatment, the majority (88%, 85%, and 86% in each of the 3 studies)
had their frown lines rated by a doctor as “mild” or “moderate” at maximum frown. For example, a
patient could improve from “severe” to “moderate” or from “moderate” to “mild.”
• Patient rating: 30 days after treatment, the majority (74%, 79%, and 82% in each of the 3 studies)
rated their own frown lines as “mild” or “moderate” at maximum frown. For example, a patient could
improve from “severe” to “moderate” or from “moderate” to “mild.”

a

Three double-blind, randomized, placebo-controlled, clinical studies evaluated the efficacy of Dysport for use in the temporary improvement of the appearance of moderate to severe
glabellar lines. These 3 studies enrolled healthy adults (ages 19-75) with glabellar lines of at least moderate severity at maximum frown. Subjects were excluded if they had marked
ptosis, deep dermal scarring, or a substantial inability to lessen glabellar lines, even by physically spreading them apart. The subjects in these studies received either Dysport or a
placebo. The total dose was delivered in equally divided aliquots to specified injection sites.

IMPORTANT SAFETY INFORMATION
Allergic Reaction to Injecting in the Skin
It is not known if an allergic reaction can be caused by injecting Dysport into the skin. The safety of
treating excessive sweating with Dysport is not known.
8

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Common Side Effects
The most common side effects are nose and throat irritation, headache, injection site pain, injection site skin
reaction, upper respiratory tract infection, eyelid swelling, eyelid drooping, sinus inflammation, and nausea.
9

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Tell your doctor about all the medicines you take, including prescription and nonprescription medicines,
vitamins and herbal and other natural products. Using Dysport with certain other medicines may cause
serious side effects.
Do not start any new medicines while taking Dysport without talking to your doctor first.
10

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Especially tell your doctor if you: have received any other botulinum toxin product in the last four
months, have received injections of botulinum toxin, such as Myobloc® (rimabotulinumtoxinB) or Botox®
(onabotulinumtoxinA) in the past (be sure your doctor knows exactly which product you received), have
recently received an antibiotic by injection, take muscle relaxants, take an allergy or cold medicine, or take
a sleep medicine.
11

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Use In Specific Populations
Dysport should not be used in children or in women who are pregnant or breastfeeding.
Ask your doctor if Dysport is right for you.
12

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What to expect with Dysport
A step-by-step guide to your treatment†

1

The Dysport treatment consultation
Discuss your expectations with your doctor and
whether you have any health conditions or
allergies that could interfere with your treatment.
† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

IMPORTANT SAFETY INFORMATION
What is the most important information you should know about Dysport?
Spread of Toxin Effects: In some cases, the effects of Dysport and all botulinum toxin products may affect
areas of the body away from the injection site. These effects can cause symptoms of a serious condition
called botulism. Symptoms of botulism can happen hours to weeks after injection and may include
swallowing and breathing problems, loss of strength and muscle weakness all over the body, double
vision, blurred vision and drooping eyelids, hoarseness or change or loss of voice, trouble saying words
clearly, or loss of bladder control. Swallowing and breathing problems can be life threatening and there
have been reports of death.
The risk of symptoms is probably greatest in children and adults treated for muscle spasms, particularly
in those patients who have underlying medical conditions that could make these symptoms more likely.
13

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What to expect with Dysport
A step-by-step guide to your treatment†

2

The Dysport treatment
Effective treatment requires 1 injection into each
of 5 points between and over the eyebrows.
Although office visit times may vary, the procedure
generally takes 10 to 20 minutes. Your healthcare
professional will determine the exact placement of
each injection to get results that are right for you.

IMPORTANT SAFETY INFORMATION
The toxic effects have been reported at doses similar to those used to treat muscle spasms in
the neck. Lower doses, in both approved and unapproved uses, have also caused toxic effects.
This includes treatment of children and adults for muscle spasms.
These effects could make it unsafe for you to drive a car, operate machinery, or do other
dangerous activities.
Do not have Dysport treatment if you: are allergic to Dysport or any of its ingredients (see the end
of the Medication Guide for a list of ingredients), are allergic to cow’s milk protein, had an allergic
reaction to any other botulinum toxin product, such as Myobloc® or Botox,® or have a skin infection at
the planned injection site.
14

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

What to expect with Dysport
A step-by-step guide to your treatment†

3

After your Dysport treatment
Ask your doctor about any precautions you
should take after your treatment. Call your doctor
or get medical help right away if you have any
problems swallowing, speaking, or breathing.
If this happens, do not drive a car, operate
machinery, or do other dangerous activities.

IMPORTANT SAFETY INFORMATION
The dose of Dysport is not the same as the dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to the dose of any other botulinum toxin
product you may have used.
Dysport may not be right for you if: you have surgical changes to your face, very weak
muscles in the treatment area, your face looks very different from side to side, the injection
site is inflamed, you have droopy eyelids or sagging eyelid folds, deep facial scars, thick oily
skin, or if your wrinkles can’t be smoothed by spreading them apart.
15

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

What to expect with Dysport
A step-by-step guide to your treatment†

4

Follow up
To maintain your improvements, you should
discuss a treatment schedule with your doctor.
As with any botulinum toxin product, you should
wait at least 90 days between treatments.

IMPORTANT SAFETY INFORMATION
Tell your doctor about all your medical conditions, including if you have: a disease that
affects your muscles and nerves (suchas amyotrophic lateral sclerosis [ALS or Lou Gehrig’s
disease], myasthenia gravis, or Lambert-Eaton syndrome), allergies to any botulinum toxin
product or had any side effect from any botulinum toxin product in the past, a breathing problem
(such as asthma or emphysema), swallowing problems, bleeding problems, diabetes, a slow
heart beat or other problem with your heart rate or rhythm, plans to have surgery, had surgery on
your face, weakness of your forehead muscles (such as trouble raising your eyebrows), drooping
eyelids, or any other change in the way your face normally looks. Patients with a disease that
affects muscles and nerves who are treated with typical doses of Dysport may have a higher risk
of serious side effects, including severe swallowing and breathing problems.
16

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

Why not start the Dysport
discussion with your doctor today?
Questions to ask your doctor:
• How soon will I see treatment results?
• How long does one treatment last?
• How often can I receive a Dysport treatment?
• Is there any way to save money on
my treatment?
• Can I have a treatment today?
• What are the risks associated with treatment?
IMPORTANT SAFETY INFORMATION
Human Albumin
This product contains albumin taken from human plasma. Steps taken during donor screening and product
manufacturing processes make the risk of spreading viral diseases extremely rare. In theory, there is also an
extremely rare risk of contracting Creutzfeldt-Jakob disease (CJD). No cases of spread of viral diseases or CJD
have ever been reported for albumin.
17

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Important Safety Information

What is the most important information you
should know about Dysport
(abobotulinumtoxinA) 300 Units for Injection?
Spread of Toxin Effects: In some cases, the
effects of Dysport and all botulinum toxin
products may affect areas of the body away
from the injection site. These effects can
cause symptoms of a serious condition called
botulism. Symptoms of botulism can happen
hours to weeks after injection and may
include swallowing and breathing problems,
loss of strength and muscle weakness all over
the body, double vision, blurred vision and
drooping eyelids, hoarseness or change or
loss of voice, trouble saying words clearly, or
loss of bladder control. Swallowing and
breathing problems can be life threatening
and there have been reports of death.

18

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

The risk of symptoms is probably greatest in
children and adults treated for muscle spasms,
particularly in those patients who have
underlying medical conditions that could make
these symptoms more likely.
The toxic effects have been reported at doses
similar to those used to treat muscle spasms in
the neck. Lower doses, in both approved and
unapproved uses, have also caused toxic
effects. This includes treatment of children and
adults for muscle spasms.
These effects could make it unsafe for you to
drive a car, operate machinery, or do other
dangerous activities.
Do not have Dysport treatment if you: are allergic
to Dysport or any of its ingredients (see the end of
the Medication Guide for a list of ingredients), are
allergic to cow’s milk protein, had an allergic
reaction to any other botulinum toxin product, such
as Myobloc® or Botox,® or have a skin infection at
the planned injection site.

Important Safety Information (cont.)

The dose of Dysport is not the same as the
dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to
the dose of any other botulinum toxin product
you may have used.
Dysport may not be right for you if: you have
surgical changes to your face, very weak muscles
in the treatment area, your face looks very
different from side to side, the injection site is
inflamed, you have droopy eyelids or sagging
eyelid folds, deep facial scars, thick oily skin, or if
your wrinkles can’t be smoothed by spreading
them apart.
Tell your doctor about all your medical
conditions, including if you have: a disease
that affects your muscles and nerves (such as
amyotrophic lateral sclerosis [ALS or Lou
Gehrig’s disease], myasthenia gravis, or LambertEaton syndrome), allergies to any botulinum toxin
product or had any side effect from any

19

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

botulinum toxin product in the past, a breathing
problem (such as asthma or emphysema),
swallowing problems, bleeding problems, diabetes,
a slow heart beat or other problem with your heart
rate or rhythm, plans to have surgery, had surgery
on your face, weakness of your forehead muscles
(such as trouble raising your eyebrows), drooping
eyelids, or any other change in the way your face
normally looks. Patients with a disease that affects
muscles and nerves who are treated with typical
doses of Dysport may have a higher risk of serious
side effects, including severe swallowing and
breathing problems.
Human Albumin
This product contains albumin taken from human
plasma. Steps taken during donor screening and
product manufacturing processes make the risk of
spreading viral diseases extremely rare. In theory,
there is also an extremely rare risk of contracting
Creutzfeldt-Jakob disease (CJD). No cases of
spread of viral diseases or CJD have ever been
reported for albumin.

Important Safety Information (cont.)

Allergic Reaction to Injecting in the Skin
It is not known if an allergic reaction can be
caused by injecting Dysport into the skin. The
safety of treating excessive sweating with Dysport
is not known.
Common Side Effects
The most common side effects are nose and
throat irritation, headache, injection site pain,
injection site skin reaction, upper respiratory tract
infection, eyelid swelling, eyelid drooping, sinus
inflammation, and nausea.
Tell your doctor about all the medicines you
take, including prescription and nonprescription
medicines, vitamins and herbal and other natural
products. Using Dysport with certain other
medicines may cause serious side effects.

20

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

Do not start any new medicines while taking
Dysport without talking to your doctor first.

Especially tell your doctor if you: have received
any other botulinum toxin product in the last four
months, have received injections of botulinum toxin,
such as Myobloc® (rimabotulinumtoxinB) or Botox®
(onabotulinumtoxinA) in the past (be sure your
doctor knows exactly which product you received),
have recently received an antibiotic by injection,
take muscle relaxants, take an allergy or cold
medicine, or take a sleep medicine.
Use In Specific Populations
Dysport should not be used in children or in women
who are pregnant or breastfeeding.
Ask your doctor if Dysport is right for you.

Medication Guide

21

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

22

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

23

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

24

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

25

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

26

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

27

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

28

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

29

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

30

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

31

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

32

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medicis Family
of Aesthetic Products

Products are not FDA approved for combination use.

www.DysportUSA.com

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.
33

The Dysport trademark is used under license. Restylane is a registered trademark of HA North American Sales AB. All other trademarks
are the property of their respective owners. DSP 11-060 10/31/12


Slide 27

Dysport ® is a prescription
injection for temporary
improvement in the look of
moderate to severe frown
lines between the eyebrows
(glabellar lines) in adults less
than 65 years of age.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.
The Dysport trademark is used under license. All other trademarks are the property of their respective owners. DSP 11-060 10/31/12

I do special things for myself,
and I’ll bet you do, too.
I work out, eat right, and take care of my
skin. Of course, cosmetic creams and lotions
will always have their place in my regimen—
but for my moderate to severe frown lines,
I was ready for a prescription treatment.
Maybe you are, too.

IMPORTANT SAFETY INFORMATION
What is the most important information you should know about Dysport?
Spread of Toxin Effects: In some cases, the effects of Dysport and all botulinum toxin products
may affect areas of the body away from the injection site. These effects can cause symptoms of
a serious condition called botulism. Symptoms of botulism can happen hours to weeks after
injection and may include swallowing and breathing problems, loss of strength and muscle
weakness all over the body, double vision, blurred vision and drooping eyelids, hoarseness or
change or loss of voice, trouble saying words clearly, or loss of bladder control.
PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

2

What is Dysport?
Prescription Dysport is an injection used to temporarily improve
the look of your moderate to severe frown lines without changing
the look of your whole face. The untreated facial muscles still
work normally, allowing you to freely show facial expressions,
such as smiling, in untreated areas.
Dysport is a formulation that has been shown to deliver temporary
improvement in moderate to severe frown lines, even with repeat
treatments. So, the effect of repeat treatment with Dysport may
be comparable to your first use.

IMPORTANT SAFETY INFORMATION
Swallowing and breathing problems can be life threatening and there have
been reports of death.
The risk of symptoms is probably greatest in children and adults treated for
muscle spasms, particularly in those patients who have underlying medical
conditions that could make these symptoms more likely.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

3

How does Dysport Work?
With just 1 injection into each of 5 points between and over
the eyebrows, Dysport blocks the signal from the nerve to the
muscles, ultimately resulting in a reduction of muscle activity
and temporarily preventing contraction of the muscles that
cause frown lines. You should not be treated with Dysport more
frequently than every 90 days.
Ask your doctor about your prescription treatment options for
temporarily improving the look of moderate to severe frown lines.
IMPORTANT SAFETY INFORMATION
The toxic effects have been reported at doses similar to those used to treat
muscle spasms in the neck. Lower doses, in both approved and unapproved
uses, have also caused toxic effects. This includes treatment of children and
adults for muscle spasms.

These effects could make it unsafe for you to drive a car, operate machinery,
or do other dangerous activities.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

4

What causes frown lines?
Over time, repeated movement of the facial skin by the
forehead muscles forms lines between the eyebrows.
Frown lines are “dynamic”—they happen because of
the way a person’s face moves.

IMPORTANT SAFETY INFORMATION
Do not have Dysport treatment if you: are allergic to Dysport or any of its ingredients
(see the end of the Medication Guide for a list of ingredients), are allergic to cow’s milk protein,
had an allergic reaction to any other botulinum toxin product (such as Myobloc® or Botox®),
or have a skin infection at the planned injection site.
The dose of Dysport is not the same as the dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to the dose of any other botulinum toxin
product you may have used.
Dysport may not be right for you if: you have surgical changes to your face, very weak
muscles in the treatment area, your face looks very different from side to side, the injection site
is inflamed, you have droopy eyelids or sagging eyelid folds, deep facial scars, thick oily skin, or
if your wrinkles can’t be smoothed by spreading them apart.
5

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Are frown lines always related to age?
No. Because frown lines are created by facial movements,
such as frowning or squinting, they may develop even in
younger adults.

IMPORTANT SAFETY INFORMATION
Tell your doctor about all your medical conditions, including if you have: a disease
that affects your muscles and nerves (such as amyotrophic lateral sclerosis [ALS or Lou
Gehrig’s disease], myasthenia gravis, or Lambert-Eaton syndrome), allergies to any
botulinum toxin product or had any side effect from any botulinum toxin product in the past,
a breathing problem (such as asthma or emphysema), swallowing problems, bleeding
problems, diabetes, a slow heart beat or other problem with your heart rate or rhythm, plans
to have surgery, had surgery on your face, weakness of your forehead muscles (such as
trouble raising your eyebrows), drooping eyelids, or any other change in the way your face
normally looks. Patients with a disease that affects muscles and nerves who are treated with
typical doses of Dysport may have a higher risk of serious side effects, including severe
swallowing and breathing problems.
6

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What can you do about frown lines?
Treatment with prescription Dysport can temporarily
improve the look of your moderate to severe frown lines.
Treatment generally takes just 10 to 20 minutes.
The most common side effects are nose and throat
irritation, headache, injection site pain, injection site skin
reaction, upper respiratory tract infection, eyelid swelling,
eyelid drooping, sinus inflammation, and nausea.

IMPORTANT SAFETY INFORMATION
Human Albumin
This product contains albumin taken from human plasma. Steps taken during donor
screening and product manufacturing processes make the risk of spreading viral diseases
extremely rare. In theory, there is also an extremely rare risk of contracting CreutzfeldtJakob disease (CJD). No cases of spread of viral diseases or CJD have ever been
reported for albumin.
7

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

How do you know if Dysport works?
Clinically proven results with 1 treatment
In 3 clinical studies of people whose frown lines were rated “moderate” or
“severe” by a doctor before their treatment with Dysport:a
• Doctor rating: 30 days after treatment, the majority (88%, 85%, and 86% in each of the 3 studies)
had their frown lines rated by a doctor as “mild” or “moderate” at maximum frown. For example, a
patient could improve from “severe” to “moderate” or from “moderate” to “mild.”
• Patient rating: 30 days after treatment, the majority (74%, 79%, and 82% in each of the 3 studies)
rated their own frown lines as “mild” or “moderate” at maximum frown. For example, a patient could
improve from “severe” to “moderate” or from “moderate” to “mild.”

a

Three double-blind, randomized, placebo-controlled, clinical studies evaluated the efficacy of Dysport for use in the temporary improvement of the appearance of moderate to severe
glabellar lines. These 3 studies enrolled healthy adults (ages 19-75) with glabellar lines of at least moderate severity at maximum frown. Subjects were excluded if they had marked
ptosis, deep dermal scarring, or a substantial inability to lessen glabellar lines, even by physically spreading them apart. The subjects in these studies received either Dysport or a
placebo. The total dose was delivered in equally divided aliquots to specified injection sites.

IMPORTANT SAFETY INFORMATION
Allergic Reaction to Injecting in the Skin
It is not known if an allergic reaction can be caused by injecting Dysport into the skin. The safety of
treating excessive sweating with Dysport is not known.
8

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Common Side Effects
The most common side effects are nose and throat irritation, headache, injection site pain, injection site skin
reaction, upper respiratory tract infection, eyelid swelling, eyelid drooping, sinus inflammation, and nausea.
9

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Tell your doctor about all the medicines you take, including prescription and nonprescription medicines,
vitamins and herbal and other natural products. Using Dysport with certain other medicines may cause
serious side effects.
Do not start any new medicines while taking Dysport without talking to your doctor first.
10

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Especially tell your doctor if you: have received any other botulinum toxin product in the last four
months, have received injections of botulinum toxin, such as Myobloc® (rimabotulinumtoxinB) or Botox®
(onabotulinumtoxinA) in the past (be sure your doctor knows exactly which product you received), have
recently received an antibiotic by injection, take muscle relaxants, take an allergy or cold medicine, or take
a sleep medicine.
11

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Use In Specific Populations
Dysport should not be used in children or in women who are pregnant or breastfeeding.
Ask your doctor if Dysport is right for you.
12

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What to expect with Dysport
A step-by-step guide to your treatment†

1

The Dysport treatment consultation
Discuss your expectations with your doctor and
whether you have any health conditions or
allergies that could interfere with your treatment.
† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

IMPORTANT SAFETY INFORMATION
What is the most important information you should know about Dysport?
Spread of Toxin Effects: In some cases, the effects of Dysport and all botulinum toxin products may affect
areas of the body away from the injection site. These effects can cause symptoms of a serious condition
called botulism. Symptoms of botulism can happen hours to weeks after injection and may include
swallowing and breathing problems, loss of strength and muscle weakness all over the body, double
vision, blurred vision and drooping eyelids, hoarseness or change or loss of voice, trouble saying words
clearly, or loss of bladder control. Swallowing and breathing problems can be life threatening and there
have been reports of death.
The risk of symptoms is probably greatest in children and adults treated for muscle spasms, particularly
in those patients who have underlying medical conditions that could make these symptoms more likely.
13

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What to expect with Dysport
A step-by-step guide to your treatment†

2

The Dysport treatment
Effective treatment requires 1 injection into each
of 5 points between and over the eyebrows.
Although office visit times may vary, the procedure
generally takes 10 to 20 minutes. Your healthcare
professional will determine the exact placement of
each injection to get results that are right for you.

IMPORTANT SAFETY INFORMATION
The toxic effects have been reported at doses similar to those used to treat muscle spasms in
the neck. Lower doses, in both approved and unapproved uses, have also caused toxic effects.
This includes treatment of children and adults for muscle spasms.
These effects could make it unsafe for you to drive a car, operate machinery, or do other
dangerous activities.
Do not have Dysport treatment if you: are allergic to Dysport or any of its ingredients (see the end
of the Medication Guide for a list of ingredients), are allergic to cow’s milk protein, had an allergic
reaction to any other botulinum toxin product, such as Myobloc® or Botox,® or have a skin infection at
the planned injection site.
14

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

What to expect with Dysport
A step-by-step guide to your treatment†

3

After your Dysport treatment
Ask your doctor about any precautions you
should take after your treatment. Call your doctor
or get medical help right away if you have any
problems swallowing, speaking, or breathing.
If this happens, do not drive a car, operate
machinery, or do other dangerous activities.

IMPORTANT SAFETY INFORMATION
The dose of Dysport is not the same as the dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to the dose of any other botulinum toxin
product you may have used.
Dysport may not be right for you if: you have surgical changes to your face, very weak
muscles in the treatment area, your face looks very different from side to side, the injection
site is inflamed, you have droopy eyelids or sagging eyelid folds, deep facial scars, thick oily
skin, or if your wrinkles can’t be smoothed by spreading them apart.
15

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

What to expect with Dysport
A step-by-step guide to your treatment†

4

Follow up
To maintain your improvements, you should
discuss a treatment schedule with your doctor.
As with any botulinum toxin product, you should
wait at least 90 days between treatments.

IMPORTANT SAFETY INFORMATION
Tell your doctor about all your medical conditions, including if you have: a disease that
affects your muscles and nerves (suchas amyotrophic lateral sclerosis [ALS or Lou Gehrig’s
disease], myasthenia gravis, or Lambert-Eaton syndrome), allergies to any botulinum toxin
product or had any side effect from any botulinum toxin product in the past, a breathing problem
(such as asthma or emphysema), swallowing problems, bleeding problems, diabetes, a slow
heart beat or other problem with your heart rate or rhythm, plans to have surgery, had surgery on
your face, weakness of your forehead muscles (such as trouble raising your eyebrows), drooping
eyelids, or any other change in the way your face normally looks. Patients with a disease that
affects muscles and nerves who are treated with typical doses of Dysport may have a higher risk
of serious side effects, including severe swallowing and breathing problems.
16

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

Why not start the Dysport
discussion with your doctor today?
Questions to ask your doctor:
• How soon will I see treatment results?
• How long does one treatment last?
• How often can I receive a Dysport treatment?
• Is there any way to save money on
my treatment?
• Can I have a treatment today?
• What are the risks associated with treatment?
IMPORTANT SAFETY INFORMATION
Human Albumin
This product contains albumin taken from human plasma. Steps taken during donor screening and product
manufacturing processes make the risk of spreading viral diseases extremely rare. In theory, there is also an
extremely rare risk of contracting Creutzfeldt-Jakob disease (CJD). No cases of spread of viral diseases or CJD
have ever been reported for albumin.
17

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Important Safety Information

What is the most important information you
should know about Dysport
(abobotulinumtoxinA) 300 Units for Injection?
Spread of Toxin Effects: In some cases, the
effects of Dysport and all botulinum toxin
products may affect areas of the body away
from the injection site. These effects can
cause symptoms of a serious condition called
botulism. Symptoms of botulism can happen
hours to weeks after injection and may
include swallowing and breathing problems,
loss of strength and muscle weakness all over
the body, double vision, blurred vision and
drooping eyelids, hoarseness or change or
loss of voice, trouble saying words clearly, or
loss of bladder control. Swallowing and
breathing problems can be life threatening
and there have been reports of death.

18

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

The risk of symptoms is probably greatest in
children and adults treated for muscle spasms,
particularly in those patients who have
underlying medical conditions that could make
these symptoms more likely.
The toxic effects have been reported at doses
similar to those used to treat muscle spasms in
the neck. Lower doses, in both approved and
unapproved uses, have also caused toxic
effects. This includes treatment of children and
adults for muscle spasms.
These effects could make it unsafe for you to
drive a car, operate machinery, or do other
dangerous activities.
Do not have Dysport treatment if you: are allergic
to Dysport or any of its ingredients (see the end of
the Medication Guide for a list of ingredients), are
allergic to cow’s milk protein, had an allergic
reaction to any other botulinum toxin product, such
as Myobloc® or Botox,® or have a skin infection at
the planned injection site.

Important Safety Information (cont.)

The dose of Dysport is not the same as the
dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to
the dose of any other botulinum toxin product
you may have used.
Dysport may not be right for you if: you have
surgical changes to your face, very weak muscles
in the treatment area, your face looks very
different from side to side, the injection site is
inflamed, you have droopy eyelids or sagging
eyelid folds, deep facial scars, thick oily skin, or if
your wrinkles can’t be smoothed by spreading
them apart.
Tell your doctor about all your medical
conditions, including if you have: a disease
that affects your muscles and nerves (such as
amyotrophic lateral sclerosis [ALS or Lou
Gehrig’s disease], myasthenia gravis, or LambertEaton syndrome), allergies to any botulinum toxin
product or had any side effect from any

19

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

botulinum toxin product in the past, a breathing
problem (such as asthma or emphysema),
swallowing problems, bleeding problems, diabetes,
a slow heart beat or other problem with your heart
rate or rhythm, plans to have surgery, had surgery
on your face, weakness of your forehead muscles
(such as trouble raising your eyebrows), drooping
eyelids, or any other change in the way your face
normally looks. Patients with a disease that affects
muscles and nerves who are treated with typical
doses of Dysport may have a higher risk of serious
side effects, including severe swallowing and
breathing problems.
Human Albumin
This product contains albumin taken from human
plasma. Steps taken during donor screening and
product manufacturing processes make the risk of
spreading viral diseases extremely rare. In theory,
there is also an extremely rare risk of contracting
Creutzfeldt-Jakob disease (CJD). No cases of
spread of viral diseases or CJD have ever been
reported for albumin.

Important Safety Information (cont.)

Allergic Reaction to Injecting in the Skin
It is not known if an allergic reaction can be
caused by injecting Dysport into the skin. The
safety of treating excessive sweating with Dysport
is not known.
Common Side Effects
The most common side effects are nose and
throat irritation, headache, injection site pain,
injection site skin reaction, upper respiratory tract
infection, eyelid swelling, eyelid drooping, sinus
inflammation, and nausea.
Tell your doctor about all the medicines you
take, including prescription and nonprescription
medicines, vitamins and herbal and other natural
products. Using Dysport with certain other
medicines may cause serious side effects.

20

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

Do not start any new medicines while taking
Dysport without talking to your doctor first.

Especially tell your doctor if you: have received
any other botulinum toxin product in the last four
months, have received injections of botulinum toxin,
such as Myobloc® (rimabotulinumtoxinB) or Botox®
(onabotulinumtoxinA) in the past (be sure your
doctor knows exactly which product you received),
have recently received an antibiotic by injection,
take muscle relaxants, take an allergy or cold
medicine, or take a sleep medicine.
Use In Specific Populations
Dysport should not be used in children or in women
who are pregnant or breastfeeding.
Ask your doctor if Dysport is right for you.

Medication Guide

21

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

22

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

23

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

24

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

25

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

26

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

27

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

28

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

29

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

30

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

31

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

32

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medicis Family
of Aesthetic Products

Products are not FDA approved for combination use.

www.DysportUSA.com

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.
33

The Dysport trademark is used under license. Restylane is a registered trademark of HA North American Sales AB. All other trademarks
are the property of their respective owners. DSP 11-060 10/31/12


Slide 28

Dysport ® is a prescription
injection for temporary
improvement in the look of
moderate to severe frown
lines between the eyebrows
(glabellar lines) in adults less
than 65 years of age.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.
The Dysport trademark is used under license. All other trademarks are the property of their respective owners. DSP 11-060 10/31/12

I do special things for myself,
and I’ll bet you do, too.
I work out, eat right, and take care of my
skin. Of course, cosmetic creams and lotions
will always have their place in my regimen—
but for my moderate to severe frown lines,
I was ready for a prescription treatment.
Maybe you are, too.

IMPORTANT SAFETY INFORMATION
What is the most important information you should know about Dysport?
Spread of Toxin Effects: In some cases, the effects of Dysport and all botulinum toxin products
may affect areas of the body away from the injection site. These effects can cause symptoms of
a serious condition called botulism. Symptoms of botulism can happen hours to weeks after
injection and may include swallowing and breathing problems, loss of strength and muscle
weakness all over the body, double vision, blurred vision and drooping eyelids, hoarseness or
change or loss of voice, trouble saying words clearly, or loss of bladder control.
PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

2

What is Dysport?
Prescription Dysport is an injection used to temporarily improve
the look of your moderate to severe frown lines without changing
the look of your whole face. The untreated facial muscles still
work normally, allowing you to freely show facial expressions,
such as smiling, in untreated areas.
Dysport is a formulation that has been shown to deliver temporary
improvement in moderate to severe frown lines, even with repeat
treatments. So, the effect of repeat treatment with Dysport may
be comparable to your first use.

IMPORTANT SAFETY INFORMATION
Swallowing and breathing problems can be life threatening and there have
been reports of death.
The risk of symptoms is probably greatest in children and adults treated for
muscle spasms, particularly in those patients who have underlying medical
conditions that could make these symptoms more likely.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

3

How does Dysport Work?
With just 1 injection into each of 5 points between and over
the eyebrows, Dysport blocks the signal from the nerve to the
muscles, ultimately resulting in a reduction of muscle activity
and temporarily preventing contraction of the muscles that
cause frown lines. You should not be treated with Dysport more
frequently than every 90 days.
Ask your doctor about your prescription treatment options for
temporarily improving the look of moderate to severe frown lines.
IMPORTANT SAFETY INFORMATION
The toxic effects have been reported at doses similar to those used to treat
muscle spasms in the neck. Lower doses, in both approved and unapproved
uses, have also caused toxic effects. This includes treatment of children and
adults for muscle spasms.

These effects could make it unsafe for you to drive a car, operate machinery,
or do other dangerous activities.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

4

What causes frown lines?
Over time, repeated movement of the facial skin by the
forehead muscles forms lines between the eyebrows.
Frown lines are “dynamic”—they happen because of
the way a person’s face moves.

IMPORTANT SAFETY INFORMATION
Do not have Dysport treatment if you: are allergic to Dysport or any of its ingredients
(see the end of the Medication Guide for a list of ingredients), are allergic to cow’s milk protein,
had an allergic reaction to any other botulinum toxin product (such as Myobloc® or Botox®),
or have a skin infection at the planned injection site.
The dose of Dysport is not the same as the dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to the dose of any other botulinum toxin
product you may have used.
Dysport may not be right for you if: you have surgical changes to your face, very weak
muscles in the treatment area, your face looks very different from side to side, the injection site
is inflamed, you have droopy eyelids or sagging eyelid folds, deep facial scars, thick oily skin, or
if your wrinkles can’t be smoothed by spreading them apart.
5

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Are frown lines always related to age?
No. Because frown lines are created by facial movements,
such as frowning or squinting, they may develop even in
younger adults.

IMPORTANT SAFETY INFORMATION
Tell your doctor about all your medical conditions, including if you have: a disease
that affects your muscles and nerves (such as amyotrophic lateral sclerosis [ALS or Lou
Gehrig’s disease], myasthenia gravis, or Lambert-Eaton syndrome), allergies to any
botulinum toxin product or had any side effect from any botulinum toxin product in the past,
a breathing problem (such as asthma or emphysema), swallowing problems, bleeding
problems, diabetes, a slow heart beat or other problem with your heart rate or rhythm, plans
to have surgery, had surgery on your face, weakness of your forehead muscles (such as
trouble raising your eyebrows), drooping eyelids, or any other change in the way your face
normally looks. Patients with a disease that affects muscles and nerves who are treated with
typical doses of Dysport may have a higher risk of serious side effects, including severe
swallowing and breathing problems.
6

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What can you do about frown lines?
Treatment with prescription Dysport can temporarily
improve the look of your moderate to severe frown lines.
Treatment generally takes just 10 to 20 minutes.
The most common side effects are nose and throat
irritation, headache, injection site pain, injection site skin
reaction, upper respiratory tract infection, eyelid swelling,
eyelid drooping, sinus inflammation, and nausea.

IMPORTANT SAFETY INFORMATION
Human Albumin
This product contains albumin taken from human plasma. Steps taken during donor
screening and product manufacturing processes make the risk of spreading viral diseases
extremely rare. In theory, there is also an extremely rare risk of contracting CreutzfeldtJakob disease (CJD). No cases of spread of viral diseases or CJD have ever been
reported for albumin.
7

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

How do you know if Dysport works?
Clinically proven results with 1 treatment
In 3 clinical studies of people whose frown lines were rated “moderate” or
“severe” by a doctor before their treatment with Dysport:a
• Doctor rating: 30 days after treatment, the majority (88%, 85%, and 86% in each of the 3 studies)
had their frown lines rated by a doctor as “mild” or “moderate” at maximum frown. For example, a
patient could improve from “severe” to “moderate” or from “moderate” to “mild.”
• Patient rating: 30 days after treatment, the majority (74%, 79%, and 82% in each of the 3 studies)
rated their own frown lines as “mild” or “moderate” at maximum frown. For example, a patient could
improve from “severe” to “moderate” or from “moderate” to “mild.”

a

Three double-blind, randomized, placebo-controlled, clinical studies evaluated the efficacy of Dysport for use in the temporary improvement of the appearance of moderate to severe
glabellar lines. These 3 studies enrolled healthy adults (ages 19-75) with glabellar lines of at least moderate severity at maximum frown. Subjects were excluded if they had marked
ptosis, deep dermal scarring, or a substantial inability to lessen glabellar lines, even by physically spreading them apart. The subjects in these studies received either Dysport or a
placebo. The total dose was delivered in equally divided aliquots to specified injection sites.

IMPORTANT SAFETY INFORMATION
Allergic Reaction to Injecting in the Skin
It is not known if an allergic reaction can be caused by injecting Dysport into the skin. The safety of
treating excessive sweating with Dysport is not known.
8

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Common Side Effects
The most common side effects are nose and throat irritation, headache, injection site pain, injection site skin
reaction, upper respiratory tract infection, eyelid swelling, eyelid drooping, sinus inflammation, and nausea.
9

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Tell your doctor about all the medicines you take, including prescription and nonprescription medicines,
vitamins and herbal and other natural products. Using Dysport with certain other medicines may cause
serious side effects.
Do not start any new medicines while taking Dysport without talking to your doctor first.
10

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Especially tell your doctor if you: have received any other botulinum toxin product in the last four
months, have received injections of botulinum toxin, such as Myobloc® (rimabotulinumtoxinB) or Botox®
(onabotulinumtoxinA) in the past (be sure your doctor knows exactly which product you received), have
recently received an antibiotic by injection, take muscle relaxants, take an allergy or cold medicine, or take
a sleep medicine.
11

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Use In Specific Populations
Dysport should not be used in children or in women who are pregnant or breastfeeding.
Ask your doctor if Dysport is right for you.
12

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What to expect with Dysport
A step-by-step guide to your treatment†

1

The Dysport treatment consultation
Discuss your expectations with your doctor and
whether you have any health conditions or
allergies that could interfere with your treatment.
† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

IMPORTANT SAFETY INFORMATION
What is the most important information you should know about Dysport?
Spread of Toxin Effects: In some cases, the effects of Dysport and all botulinum toxin products may affect
areas of the body away from the injection site. These effects can cause symptoms of a serious condition
called botulism. Symptoms of botulism can happen hours to weeks after injection and may include
swallowing and breathing problems, loss of strength and muscle weakness all over the body, double
vision, blurred vision and drooping eyelids, hoarseness or change or loss of voice, trouble saying words
clearly, or loss of bladder control. Swallowing and breathing problems can be life threatening and there
have been reports of death.
The risk of symptoms is probably greatest in children and adults treated for muscle spasms, particularly
in those patients who have underlying medical conditions that could make these symptoms more likely.
13

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What to expect with Dysport
A step-by-step guide to your treatment†

2

The Dysport treatment
Effective treatment requires 1 injection into each
of 5 points between and over the eyebrows.
Although office visit times may vary, the procedure
generally takes 10 to 20 minutes. Your healthcare
professional will determine the exact placement of
each injection to get results that are right for you.

IMPORTANT SAFETY INFORMATION
The toxic effects have been reported at doses similar to those used to treat muscle spasms in
the neck. Lower doses, in both approved and unapproved uses, have also caused toxic effects.
This includes treatment of children and adults for muscle spasms.
These effects could make it unsafe for you to drive a car, operate machinery, or do other
dangerous activities.
Do not have Dysport treatment if you: are allergic to Dysport or any of its ingredients (see the end
of the Medication Guide for a list of ingredients), are allergic to cow’s milk protein, had an allergic
reaction to any other botulinum toxin product, such as Myobloc® or Botox,® or have a skin infection at
the planned injection site.
14

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

What to expect with Dysport
A step-by-step guide to your treatment†

3

After your Dysport treatment
Ask your doctor about any precautions you
should take after your treatment. Call your doctor
or get medical help right away if you have any
problems swallowing, speaking, or breathing.
If this happens, do not drive a car, operate
machinery, or do other dangerous activities.

IMPORTANT SAFETY INFORMATION
The dose of Dysport is not the same as the dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to the dose of any other botulinum toxin
product you may have used.
Dysport may not be right for you if: you have surgical changes to your face, very weak
muscles in the treatment area, your face looks very different from side to side, the injection
site is inflamed, you have droopy eyelids or sagging eyelid folds, deep facial scars, thick oily
skin, or if your wrinkles can’t be smoothed by spreading them apart.
15

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

What to expect with Dysport
A step-by-step guide to your treatment†

4

Follow up
To maintain your improvements, you should
discuss a treatment schedule with your doctor.
As with any botulinum toxin product, you should
wait at least 90 days between treatments.

IMPORTANT SAFETY INFORMATION
Tell your doctor about all your medical conditions, including if you have: a disease that
affects your muscles and nerves (suchas amyotrophic lateral sclerosis [ALS or Lou Gehrig’s
disease], myasthenia gravis, or Lambert-Eaton syndrome), allergies to any botulinum toxin
product or had any side effect from any botulinum toxin product in the past, a breathing problem
(such as asthma or emphysema), swallowing problems, bleeding problems, diabetes, a slow
heart beat or other problem with your heart rate or rhythm, plans to have surgery, had surgery on
your face, weakness of your forehead muscles (such as trouble raising your eyebrows), drooping
eyelids, or any other change in the way your face normally looks. Patients with a disease that
affects muscles and nerves who are treated with typical doses of Dysport may have a higher risk
of serious side effects, including severe swallowing and breathing problems.
16

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

Why not start the Dysport
discussion with your doctor today?
Questions to ask your doctor:
• How soon will I see treatment results?
• How long does one treatment last?
• How often can I receive a Dysport treatment?
• Is there any way to save money on
my treatment?
• Can I have a treatment today?
• What are the risks associated with treatment?
IMPORTANT SAFETY INFORMATION
Human Albumin
This product contains albumin taken from human plasma. Steps taken during donor screening and product
manufacturing processes make the risk of spreading viral diseases extremely rare. In theory, there is also an
extremely rare risk of contracting Creutzfeldt-Jakob disease (CJD). No cases of spread of viral diseases or CJD
have ever been reported for albumin.
17

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Important Safety Information

What is the most important information you
should know about Dysport
(abobotulinumtoxinA) 300 Units for Injection?
Spread of Toxin Effects: In some cases, the
effects of Dysport and all botulinum toxin
products may affect areas of the body away
from the injection site. These effects can
cause symptoms of a serious condition called
botulism. Symptoms of botulism can happen
hours to weeks after injection and may
include swallowing and breathing problems,
loss of strength and muscle weakness all over
the body, double vision, blurred vision and
drooping eyelids, hoarseness or change or
loss of voice, trouble saying words clearly, or
loss of bladder control. Swallowing and
breathing problems can be life threatening
and there have been reports of death.

18

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

The risk of symptoms is probably greatest in
children and adults treated for muscle spasms,
particularly in those patients who have
underlying medical conditions that could make
these symptoms more likely.
The toxic effects have been reported at doses
similar to those used to treat muscle spasms in
the neck. Lower doses, in both approved and
unapproved uses, have also caused toxic
effects. This includes treatment of children and
adults for muscle spasms.
These effects could make it unsafe for you to
drive a car, operate machinery, or do other
dangerous activities.
Do not have Dysport treatment if you: are allergic
to Dysport or any of its ingredients (see the end of
the Medication Guide for a list of ingredients), are
allergic to cow’s milk protein, had an allergic
reaction to any other botulinum toxin product, such
as Myobloc® or Botox,® or have a skin infection at
the planned injection site.

Important Safety Information (cont.)

The dose of Dysport is not the same as the
dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to
the dose of any other botulinum toxin product
you may have used.
Dysport may not be right for you if: you have
surgical changes to your face, very weak muscles
in the treatment area, your face looks very
different from side to side, the injection site is
inflamed, you have droopy eyelids or sagging
eyelid folds, deep facial scars, thick oily skin, or if
your wrinkles can’t be smoothed by spreading
them apart.
Tell your doctor about all your medical
conditions, including if you have: a disease
that affects your muscles and nerves (such as
amyotrophic lateral sclerosis [ALS or Lou
Gehrig’s disease], myasthenia gravis, or LambertEaton syndrome), allergies to any botulinum toxin
product or had any side effect from any

19

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

botulinum toxin product in the past, a breathing
problem (such as asthma or emphysema),
swallowing problems, bleeding problems, diabetes,
a slow heart beat or other problem with your heart
rate or rhythm, plans to have surgery, had surgery
on your face, weakness of your forehead muscles
(such as trouble raising your eyebrows), drooping
eyelids, or any other change in the way your face
normally looks. Patients with a disease that affects
muscles and nerves who are treated with typical
doses of Dysport may have a higher risk of serious
side effects, including severe swallowing and
breathing problems.
Human Albumin
This product contains albumin taken from human
plasma. Steps taken during donor screening and
product manufacturing processes make the risk of
spreading viral diseases extremely rare. In theory,
there is also an extremely rare risk of contracting
Creutzfeldt-Jakob disease (CJD). No cases of
spread of viral diseases or CJD have ever been
reported for albumin.

Important Safety Information (cont.)

Allergic Reaction to Injecting in the Skin
It is not known if an allergic reaction can be
caused by injecting Dysport into the skin. The
safety of treating excessive sweating with Dysport
is not known.
Common Side Effects
The most common side effects are nose and
throat irritation, headache, injection site pain,
injection site skin reaction, upper respiratory tract
infection, eyelid swelling, eyelid drooping, sinus
inflammation, and nausea.
Tell your doctor about all the medicines you
take, including prescription and nonprescription
medicines, vitamins and herbal and other natural
products. Using Dysport with certain other
medicines may cause serious side effects.

20

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

Do not start any new medicines while taking
Dysport without talking to your doctor first.

Especially tell your doctor if you: have received
any other botulinum toxin product in the last four
months, have received injections of botulinum toxin,
such as Myobloc® (rimabotulinumtoxinB) or Botox®
(onabotulinumtoxinA) in the past (be sure your
doctor knows exactly which product you received),
have recently received an antibiotic by injection,
take muscle relaxants, take an allergy or cold
medicine, or take a sleep medicine.
Use In Specific Populations
Dysport should not be used in children or in women
who are pregnant or breastfeeding.
Ask your doctor if Dysport is right for you.

Medication Guide

21

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

22

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

23

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

24

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

25

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

26

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

27

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

28

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

29

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

30

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

31

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

32

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medicis Family
of Aesthetic Products

Products are not FDA approved for combination use.

www.DysportUSA.com

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.
33

The Dysport trademark is used under license. Restylane is a registered trademark of HA North American Sales AB. All other trademarks
are the property of their respective owners. DSP 11-060 10/31/12


Slide 29

Dysport ® is a prescription
injection for temporary
improvement in the look of
moderate to severe frown
lines between the eyebrows
(glabellar lines) in adults less
than 65 years of age.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.
The Dysport trademark is used under license. All other trademarks are the property of their respective owners. DSP 11-060 10/31/12

I do special things for myself,
and I’ll bet you do, too.
I work out, eat right, and take care of my
skin. Of course, cosmetic creams and lotions
will always have their place in my regimen—
but for my moderate to severe frown lines,
I was ready for a prescription treatment.
Maybe you are, too.

IMPORTANT SAFETY INFORMATION
What is the most important information you should know about Dysport?
Spread of Toxin Effects: In some cases, the effects of Dysport and all botulinum toxin products
may affect areas of the body away from the injection site. These effects can cause symptoms of
a serious condition called botulism. Symptoms of botulism can happen hours to weeks after
injection and may include swallowing and breathing problems, loss of strength and muscle
weakness all over the body, double vision, blurred vision and drooping eyelids, hoarseness or
change or loss of voice, trouble saying words clearly, or loss of bladder control.
PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

2

What is Dysport?
Prescription Dysport is an injection used to temporarily improve
the look of your moderate to severe frown lines without changing
the look of your whole face. The untreated facial muscles still
work normally, allowing you to freely show facial expressions,
such as smiling, in untreated areas.
Dysport is a formulation that has been shown to deliver temporary
improvement in moderate to severe frown lines, even with repeat
treatments. So, the effect of repeat treatment with Dysport may
be comparable to your first use.

IMPORTANT SAFETY INFORMATION
Swallowing and breathing problems can be life threatening and there have
been reports of death.
The risk of symptoms is probably greatest in children and adults treated for
muscle spasms, particularly in those patients who have underlying medical
conditions that could make these symptoms more likely.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

3

How does Dysport Work?
With just 1 injection into each of 5 points between and over
the eyebrows, Dysport blocks the signal from the nerve to the
muscles, ultimately resulting in a reduction of muscle activity
and temporarily preventing contraction of the muscles that
cause frown lines. You should not be treated with Dysport more
frequently than every 90 days.
Ask your doctor about your prescription treatment options for
temporarily improving the look of moderate to severe frown lines.
IMPORTANT SAFETY INFORMATION
The toxic effects have been reported at doses similar to those used to treat
muscle spasms in the neck. Lower doses, in both approved and unapproved
uses, have also caused toxic effects. This includes treatment of children and
adults for muscle spasms.

These effects could make it unsafe for you to drive a car, operate machinery,
or do other dangerous activities.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

4

What causes frown lines?
Over time, repeated movement of the facial skin by the
forehead muscles forms lines between the eyebrows.
Frown lines are “dynamic”—they happen because of
the way a person’s face moves.

IMPORTANT SAFETY INFORMATION
Do not have Dysport treatment if you: are allergic to Dysport or any of its ingredients
(see the end of the Medication Guide for a list of ingredients), are allergic to cow’s milk protein,
had an allergic reaction to any other botulinum toxin product (such as Myobloc® or Botox®),
or have a skin infection at the planned injection site.
The dose of Dysport is not the same as the dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to the dose of any other botulinum toxin
product you may have used.
Dysport may not be right for you if: you have surgical changes to your face, very weak
muscles in the treatment area, your face looks very different from side to side, the injection site
is inflamed, you have droopy eyelids or sagging eyelid folds, deep facial scars, thick oily skin, or
if your wrinkles can’t be smoothed by spreading them apart.
5

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Are frown lines always related to age?
No. Because frown lines are created by facial movements,
such as frowning or squinting, they may develop even in
younger adults.

IMPORTANT SAFETY INFORMATION
Tell your doctor about all your medical conditions, including if you have: a disease
that affects your muscles and nerves (such as amyotrophic lateral sclerosis [ALS or Lou
Gehrig’s disease], myasthenia gravis, or Lambert-Eaton syndrome), allergies to any
botulinum toxin product or had any side effect from any botulinum toxin product in the past,
a breathing problem (such as asthma or emphysema), swallowing problems, bleeding
problems, diabetes, a slow heart beat or other problem with your heart rate or rhythm, plans
to have surgery, had surgery on your face, weakness of your forehead muscles (such as
trouble raising your eyebrows), drooping eyelids, or any other change in the way your face
normally looks. Patients with a disease that affects muscles and nerves who are treated with
typical doses of Dysport may have a higher risk of serious side effects, including severe
swallowing and breathing problems.
6

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What can you do about frown lines?
Treatment with prescription Dysport can temporarily
improve the look of your moderate to severe frown lines.
Treatment generally takes just 10 to 20 minutes.
The most common side effects are nose and throat
irritation, headache, injection site pain, injection site skin
reaction, upper respiratory tract infection, eyelid swelling,
eyelid drooping, sinus inflammation, and nausea.

IMPORTANT SAFETY INFORMATION
Human Albumin
This product contains albumin taken from human plasma. Steps taken during donor
screening and product manufacturing processes make the risk of spreading viral diseases
extremely rare. In theory, there is also an extremely rare risk of contracting CreutzfeldtJakob disease (CJD). No cases of spread of viral diseases or CJD have ever been
reported for albumin.
7

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

How do you know if Dysport works?
Clinically proven results with 1 treatment
In 3 clinical studies of people whose frown lines were rated “moderate” or
“severe” by a doctor before their treatment with Dysport:a
• Doctor rating: 30 days after treatment, the majority (88%, 85%, and 86% in each of the 3 studies)
had their frown lines rated by a doctor as “mild” or “moderate” at maximum frown. For example, a
patient could improve from “severe” to “moderate” or from “moderate” to “mild.”
• Patient rating: 30 days after treatment, the majority (74%, 79%, and 82% in each of the 3 studies)
rated their own frown lines as “mild” or “moderate” at maximum frown. For example, a patient could
improve from “severe” to “moderate” or from “moderate” to “mild.”

a

Three double-blind, randomized, placebo-controlled, clinical studies evaluated the efficacy of Dysport for use in the temporary improvement of the appearance of moderate to severe
glabellar lines. These 3 studies enrolled healthy adults (ages 19-75) with glabellar lines of at least moderate severity at maximum frown. Subjects were excluded if they had marked
ptosis, deep dermal scarring, or a substantial inability to lessen glabellar lines, even by physically spreading them apart. The subjects in these studies received either Dysport or a
placebo. The total dose was delivered in equally divided aliquots to specified injection sites.

IMPORTANT SAFETY INFORMATION
Allergic Reaction to Injecting in the Skin
It is not known if an allergic reaction can be caused by injecting Dysport into the skin. The safety of
treating excessive sweating with Dysport is not known.
8

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Common Side Effects
The most common side effects are nose and throat irritation, headache, injection site pain, injection site skin
reaction, upper respiratory tract infection, eyelid swelling, eyelid drooping, sinus inflammation, and nausea.
9

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Tell your doctor about all the medicines you take, including prescription and nonprescription medicines,
vitamins and herbal and other natural products. Using Dysport with certain other medicines may cause
serious side effects.
Do not start any new medicines while taking Dysport without talking to your doctor first.
10

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Especially tell your doctor if you: have received any other botulinum toxin product in the last four
months, have received injections of botulinum toxin, such as Myobloc® (rimabotulinumtoxinB) or Botox®
(onabotulinumtoxinA) in the past (be sure your doctor knows exactly which product you received), have
recently received an antibiotic by injection, take muscle relaxants, take an allergy or cold medicine, or take
a sleep medicine.
11

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Use In Specific Populations
Dysport should not be used in children or in women who are pregnant or breastfeeding.
Ask your doctor if Dysport is right for you.
12

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What to expect with Dysport
A step-by-step guide to your treatment†

1

The Dysport treatment consultation
Discuss your expectations with your doctor and
whether you have any health conditions or
allergies that could interfere with your treatment.
† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

IMPORTANT SAFETY INFORMATION
What is the most important information you should know about Dysport?
Spread of Toxin Effects: In some cases, the effects of Dysport and all botulinum toxin products may affect
areas of the body away from the injection site. These effects can cause symptoms of a serious condition
called botulism. Symptoms of botulism can happen hours to weeks after injection and may include
swallowing and breathing problems, loss of strength and muscle weakness all over the body, double
vision, blurred vision and drooping eyelids, hoarseness or change or loss of voice, trouble saying words
clearly, or loss of bladder control. Swallowing and breathing problems can be life threatening and there
have been reports of death.
The risk of symptoms is probably greatest in children and adults treated for muscle spasms, particularly
in those patients who have underlying medical conditions that could make these symptoms more likely.
13

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What to expect with Dysport
A step-by-step guide to your treatment†

2

The Dysport treatment
Effective treatment requires 1 injection into each
of 5 points between and over the eyebrows.
Although office visit times may vary, the procedure
generally takes 10 to 20 minutes. Your healthcare
professional will determine the exact placement of
each injection to get results that are right for you.

IMPORTANT SAFETY INFORMATION
The toxic effects have been reported at doses similar to those used to treat muscle spasms in
the neck. Lower doses, in both approved and unapproved uses, have also caused toxic effects.
This includes treatment of children and adults for muscle spasms.
These effects could make it unsafe for you to drive a car, operate machinery, or do other
dangerous activities.
Do not have Dysport treatment if you: are allergic to Dysport or any of its ingredients (see the end
of the Medication Guide for a list of ingredients), are allergic to cow’s milk protein, had an allergic
reaction to any other botulinum toxin product, such as Myobloc® or Botox,® or have a skin infection at
the planned injection site.
14

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

What to expect with Dysport
A step-by-step guide to your treatment†

3

After your Dysport treatment
Ask your doctor about any precautions you
should take after your treatment. Call your doctor
or get medical help right away if you have any
problems swallowing, speaking, or breathing.
If this happens, do not drive a car, operate
machinery, or do other dangerous activities.

IMPORTANT SAFETY INFORMATION
The dose of Dysport is not the same as the dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to the dose of any other botulinum toxin
product you may have used.
Dysport may not be right for you if: you have surgical changes to your face, very weak
muscles in the treatment area, your face looks very different from side to side, the injection
site is inflamed, you have droopy eyelids or sagging eyelid folds, deep facial scars, thick oily
skin, or if your wrinkles can’t be smoothed by spreading them apart.
15

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

What to expect with Dysport
A step-by-step guide to your treatment†

4

Follow up
To maintain your improvements, you should
discuss a treatment schedule with your doctor.
As with any botulinum toxin product, you should
wait at least 90 days between treatments.

IMPORTANT SAFETY INFORMATION
Tell your doctor about all your medical conditions, including if you have: a disease that
affects your muscles and nerves (suchas amyotrophic lateral sclerosis [ALS or Lou Gehrig’s
disease], myasthenia gravis, or Lambert-Eaton syndrome), allergies to any botulinum toxin
product or had any side effect from any botulinum toxin product in the past, a breathing problem
(such as asthma or emphysema), swallowing problems, bleeding problems, diabetes, a slow
heart beat or other problem with your heart rate or rhythm, plans to have surgery, had surgery on
your face, weakness of your forehead muscles (such as trouble raising your eyebrows), drooping
eyelids, or any other change in the way your face normally looks. Patients with a disease that
affects muscles and nerves who are treated with typical doses of Dysport may have a higher risk
of serious side effects, including severe swallowing and breathing problems.
16

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

Why not start the Dysport
discussion with your doctor today?
Questions to ask your doctor:
• How soon will I see treatment results?
• How long does one treatment last?
• How often can I receive a Dysport treatment?
• Is there any way to save money on
my treatment?
• Can I have a treatment today?
• What are the risks associated with treatment?
IMPORTANT SAFETY INFORMATION
Human Albumin
This product contains albumin taken from human plasma. Steps taken during donor screening and product
manufacturing processes make the risk of spreading viral diseases extremely rare. In theory, there is also an
extremely rare risk of contracting Creutzfeldt-Jakob disease (CJD). No cases of spread of viral diseases or CJD
have ever been reported for albumin.
17

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Important Safety Information

What is the most important information you
should know about Dysport
(abobotulinumtoxinA) 300 Units for Injection?
Spread of Toxin Effects: In some cases, the
effects of Dysport and all botulinum toxin
products may affect areas of the body away
from the injection site. These effects can
cause symptoms of a serious condition called
botulism. Symptoms of botulism can happen
hours to weeks after injection and may
include swallowing and breathing problems,
loss of strength and muscle weakness all over
the body, double vision, blurred vision and
drooping eyelids, hoarseness or change or
loss of voice, trouble saying words clearly, or
loss of bladder control. Swallowing and
breathing problems can be life threatening
and there have been reports of death.

18

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

The risk of symptoms is probably greatest in
children and adults treated for muscle spasms,
particularly in those patients who have
underlying medical conditions that could make
these symptoms more likely.
The toxic effects have been reported at doses
similar to those used to treat muscle spasms in
the neck. Lower doses, in both approved and
unapproved uses, have also caused toxic
effects. This includes treatment of children and
adults for muscle spasms.
These effects could make it unsafe for you to
drive a car, operate machinery, or do other
dangerous activities.
Do not have Dysport treatment if you: are allergic
to Dysport or any of its ingredients (see the end of
the Medication Guide for a list of ingredients), are
allergic to cow’s milk protein, had an allergic
reaction to any other botulinum toxin product, such
as Myobloc® or Botox,® or have a skin infection at
the planned injection site.

Important Safety Information (cont.)

The dose of Dysport is not the same as the
dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to
the dose of any other botulinum toxin product
you may have used.
Dysport may not be right for you if: you have
surgical changes to your face, very weak muscles
in the treatment area, your face looks very
different from side to side, the injection site is
inflamed, you have droopy eyelids or sagging
eyelid folds, deep facial scars, thick oily skin, or if
your wrinkles can’t be smoothed by spreading
them apart.
Tell your doctor about all your medical
conditions, including if you have: a disease
that affects your muscles and nerves (such as
amyotrophic lateral sclerosis [ALS or Lou
Gehrig’s disease], myasthenia gravis, or LambertEaton syndrome), allergies to any botulinum toxin
product or had any side effect from any

19

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

botulinum toxin product in the past, a breathing
problem (such as asthma or emphysema),
swallowing problems, bleeding problems, diabetes,
a slow heart beat or other problem with your heart
rate or rhythm, plans to have surgery, had surgery
on your face, weakness of your forehead muscles
(such as trouble raising your eyebrows), drooping
eyelids, or any other change in the way your face
normally looks. Patients with a disease that affects
muscles and nerves who are treated with typical
doses of Dysport may have a higher risk of serious
side effects, including severe swallowing and
breathing problems.
Human Albumin
This product contains albumin taken from human
plasma. Steps taken during donor screening and
product manufacturing processes make the risk of
spreading viral diseases extremely rare. In theory,
there is also an extremely rare risk of contracting
Creutzfeldt-Jakob disease (CJD). No cases of
spread of viral diseases or CJD have ever been
reported for albumin.

Important Safety Information (cont.)

Allergic Reaction to Injecting in the Skin
It is not known if an allergic reaction can be
caused by injecting Dysport into the skin. The
safety of treating excessive sweating with Dysport
is not known.
Common Side Effects
The most common side effects are nose and
throat irritation, headache, injection site pain,
injection site skin reaction, upper respiratory tract
infection, eyelid swelling, eyelid drooping, sinus
inflammation, and nausea.
Tell your doctor about all the medicines you
take, including prescription and nonprescription
medicines, vitamins and herbal and other natural
products. Using Dysport with certain other
medicines may cause serious side effects.

20

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

Do not start any new medicines while taking
Dysport without talking to your doctor first.

Especially tell your doctor if you: have received
any other botulinum toxin product in the last four
months, have received injections of botulinum toxin,
such as Myobloc® (rimabotulinumtoxinB) or Botox®
(onabotulinumtoxinA) in the past (be sure your
doctor knows exactly which product you received),
have recently received an antibiotic by injection,
take muscle relaxants, take an allergy or cold
medicine, or take a sleep medicine.
Use In Specific Populations
Dysport should not be used in children or in women
who are pregnant or breastfeeding.
Ask your doctor if Dysport is right for you.

Medication Guide

21

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

22

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

23

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

24

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

25

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

26

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

27

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

28

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

29

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

30

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

31

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

32

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medicis Family
of Aesthetic Products

Products are not FDA approved for combination use.

www.DysportUSA.com

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.
33

The Dysport trademark is used under license. Restylane is a registered trademark of HA North American Sales AB. All other trademarks
are the property of their respective owners. DSP 11-060 10/31/12


Slide 30

Dysport ® is a prescription
injection for temporary
improvement in the look of
moderate to severe frown
lines between the eyebrows
(glabellar lines) in adults less
than 65 years of age.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.
The Dysport trademark is used under license. All other trademarks are the property of their respective owners. DSP 11-060 10/31/12

I do special things for myself,
and I’ll bet you do, too.
I work out, eat right, and take care of my
skin. Of course, cosmetic creams and lotions
will always have their place in my regimen—
but for my moderate to severe frown lines,
I was ready for a prescription treatment.
Maybe you are, too.

IMPORTANT SAFETY INFORMATION
What is the most important information you should know about Dysport?
Spread of Toxin Effects: In some cases, the effects of Dysport and all botulinum toxin products
may affect areas of the body away from the injection site. These effects can cause symptoms of
a serious condition called botulism. Symptoms of botulism can happen hours to weeks after
injection and may include swallowing and breathing problems, loss of strength and muscle
weakness all over the body, double vision, blurred vision and drooping eyelids, hoarseness or
change or loss of voice, trouble saying words clearly, or loss of bladder control.
PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

2

What is Dysport?
Prescription Dysport is an injection used to temporarily improve
the look of your moderate to severe frown lines without changing
the look of your whole face. The untreated facial muscles still
work normally, allowing you to freely show facial expressions,
such as smiling, in untreated areas.
Dysport is a formulation that has been shown to deliver temporary
improvement in moderate to severe frown lines, even with repeat
treatments. So, the effect of repeat treatment with Dysport may
be comparable to your first use.

IMPORTANT SAFETY INFORMATION
Swallowing and breathing problems can be life threatening and there have
been reports of death.
The risk of symptoms is probably greatest in children and adults treated for
muscle spasms, particularly in those patients who have underlying medical
conditions that could make these symptoms more likely.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

3

How does Dysport Work?
With just 1 injection into each of 5 points between and over
the eyebrows, Dysport blocks the signal from the nerve to the
muscles, ultimately resulting in a reduction of muscle activity
and temporarily preventing contraction of the muscles that
cause frown lines. You should not be treated with Dysport more
frequently than every 90 days.
Ask your doctor about your prescription treatment options for
temporarily improving the look of moderate to severe frown lines.
IMPORTANT SAFETY INFORMATION
The toxic effects have been reported at doses similar to those used to treat
muscle spasms in the neck. Lower doses, in both approved and unapproved
uses, have also caused toxic effects. This includes treatment of children and
adults for muscle spasms.

These effects could make it unsafe for you to drive a car, operate machinery,
or do other dangerous activities.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

4

What causes frown lines?
Over time, repeated movement of the facial skin by the
forehead muscles forms lines between the eyebrows.
Frown lines are “dynamic”—they happen because of
the way a person’s face moves.

IMPORTANT SAFETY INFORMATION
Do not have Dysport treatment if you: are allergic to Dysport or any of its ingredients
(see the end of the Medication Guide for a list of ingredients), are allergic to cow’s milk protein,
had an allergic reaction to any other botulinum toxin product (such as Myobloc® or Botox®),
or have a skin infection at the planned injection site.
The dose of Dysport is not the same as the dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to the dose of any other botulinum toxin
product you may have used.
Dysport may not be right for you if: you have surgical changes to your face, very weak
muscles in the treatment area, your face looks very different from side to side, the injection site
is inflamed, you have droopy eyelids or sagging eyelid folds, deep facial scars, thick oily skin, or
if your wrinkles can’t be smoothed by spreading them apart.
5

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Are frown lines always related to age?
No. Because frown lines are created by facial movements,
such as frowning or squinting, they may develop even in
younger adults.

IMPORTANT SAFETY INFORMATION
Tell your doctor about all your medical conditions, including if you have: a disease
that affects your muscles and nerves (such as amyotrophic lateral sclerosis [ALS or Lou
Gehrig’s disease], myasthenia gravis, or Lambert-Eaton syndrome), allergies to any
botulinum toxin product or had any side effect from any botulinum toxin product in the past,
a breathing problem (such as asthma or emphysema), swallowing problems, bleeding
problems, diabetes, a slow heart beat or other problem with your heart rate or rhythm, plans
to have surgery, had surgery on your face, weakness of your forehead muscles (such as
trouble raising your eyebrows), drooping eyelids, or any other change in the way your face
normally looks. Patients with a disease that affects muscles and nerves who are treated with
typical doses of Dysport may have a higher risk of serious side effects, including severe
swallowing and breathing problems.
6

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What can you do about frown lines?
Treatment with prescription Dysport can temporarily
improve the look of your moderate to severe frown lines.
Treatment generally takes just 10 to 20 minutes.
The most common side effects are nose and throat
irritation, headache, injection site pain, injection site skin
reaction, upper respiratory tract infection, eyelid swelling,
eyelid drooping, sinus inflammation, and nausea.

IMPORTANT SAFETY INFORMATION
Human Albumin
This product contains albumin taken from human plasma. Steps taken during donor
screening and product manufacturing processes make the risk of spreading viral diseases
extremely rare. In theory, there is also an extremely rare risk of contracting CreutzfeldtJakob disease (CJD). No cases of spread of viral diseases or CJD have ever been
reported for albumin.
7

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

How do you know if Dysport works?
Clinically proven results with 1 treatment
In 3 clinical studies of people whose frown lines were rated “moderate” or
“severe” by a doctor before their treatment with Dysport:a
• Doctor rating: 30 days after treatment, the majority (88%, 85%, and 86% in each of the 3 studies)
had their frown lines rated by a doctor as “mild” or “moderate” at maximum frown. For example, a
patient could improve from “severe” to “moderate” or from “moderate” to “mild.”
• Patient rating: 30 days after treatment, the majority (74%, 79%, and 82% in each of the 3 studies)
rated their own frown lines as “mild” or “moderate” at maximum frown. For example, a patient could
improve from “severe” to “moderate” or from “moderate” to “mild.”

a

Three double-blind, randomized, placebo-controlled, clinical studies evaluated the efficacy of Dysport for use in the temporary improvement of the appearance of moderate to severe
glabellar lines. These 3 studies enrolled healthy adults (ages 19-75) with glabellar lines of at least moderate severity at maximum frown. Subjects were excluded if they had marked
ptosis, deep dermal scarring, or a substantial inability to lessen glabellar lines, even by physically spreading them apart. The subjects in these studies received either Dysport or a
placebo. The total dose was delivered in equally divided aliquots to specified injection sites.

IMPORTANT SAFETY INFORMATION
Allergic Reaction to Injecting in the Skin
It is not known if an allergic reaction can be caused by injecting Dysport into the skin. The safety of
treating excessive sweating with Dysport is not known.
8

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Common Side Effects
The most common side effects are nose and throat irritation, headache, injection site pain, injection site skin
reaction, upper respiratory tract infection, eyelid swelling, eyelid drooping, sinus inflammation, and nausea.
9

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Tell your doctor about all the medicines you take, including prescription and nonprescription medicines,
vitamins and herbal and other natural products. Using Dysport with certain other medicines may cause
serious side effects.
Do not start any new medicines while taking Dysport without talking to your doctor first.
10

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Especially tell your doctor if you: have received any other botulinum toxin product in the last four
months, have received injections of botulinum toxin, such as Myobloc® (rimabotulinumtoxinB) or Botox®
(onabotulinumtoxinA) in the past (be sure your doctor knows exactly which product you received), have
recently received an antibiotic by injection, take muscle relaxants, take an allergy or cold medicine, or take
a sleep medicine.
11

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Use In Specific Populations
Dysport should not be used in children or in women who are pregnant or breastfeeding.
Ask your doctor if Dysport is right for you.
12

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What to expect with Dysport
A step-by-step guide to your treatment†

1

The Dysport treatment consultation
Discuss your expectations with your doctor and
whether you have any health conditions or
allergies that could interfere with your treatment.
† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

IMPORTANT SAFETY INFORMATION
What is the most important information you should know about Dysport?
Spread of Toxin Effects: In some cases, the effects of Dysport and all botulinum toxin products may affect
areas of the body away from the injection site. These effects can cause symptoms of a serious condition
called botulism. Symptoms of botulism can happen hours to weeks after injection and may include
swallowing and breathing problems, loss of strength and muscle weakness all over the body, double
vision, blurred vision and drooping eyelids, hoarseness or change or loss of voice, trouble saying words
clearly, or loss of bladder control. Swallowing and breathing problems can be life threatening and there
have been reports of death.
The risk of symptoms is probably greatest in children and adults treated for muscle spasms, particularly
in those patients who have underlying medical conditions that could make these symptoms more likely.
13

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What to expect with Dysport
A step-by-step guide to your treatment†

2

The Dysport treatment
Effective treatment requires 1 injection into each
of 5 points between and over the eyebrows.
Although office visit times may vary, the procedure
generally takes 10 to 20 minutes. Your healthcare
professional will determine the exact placement of
each injection to get results that are right for you.

IMPORTANT SAFETY INFORMATION
The toxic effects have been reported at doses similar to those used to treat muscle spasms in
the neck. Lower doses, in both approved and unapproved uses, have also caused toxic effects.
This includes treatment of children and adults for muscle spasms.
These effects could make it unsafe for you to drive a car, operate machinery, or do other
dangerous activities.
Do not have Dysport treatment if you: are allergic to Dysport or any of its ingredients (see the end
of the Medication Guide for a list of ingredients), are allergic to cow’s milk protein, had an allergic
reaction to any other botulinum toxin product, such as Myobloc® or Botox,® or have a skin infection at
the planned injection site.
14

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

What to expect with Dysport
A step-by-step guide to your treatment†

3

After your Dysport treatment
Ask your doctor about any precautions you
should take after your treatment. Call your doctor
or get medical help right away if you have any
problems swallowing, speaking, or breathing.
If this happens, do not drive a car, operate
machinery, or do other dangerous activities.

IMPORTANT SAFETY INFORMATION
The dose of Dysport is not the same as the dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to the dose of any other botulinum toxin
product you may have used.
Dysport may not be right for you if: you have surgical changes to your face, very weak
muscles in the treatment area, your face looks very different from side to side, the injection
site is inflamed, you have droopy eyelids or sagging eyelid folds, deep facial scars, thick oily
skin, or if your wrinkles can’t be smoothed by spreading them apart.
15

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

What to expect with Dysport
A step-by-step guide to your treatment†

4

Follow up
To maintain your improvements, you should
discuss a treatment schedule with your doctor.
As with any botulinum toxin product, you should
wait at least 90 days between treatments.

IMPORTANT SAFETY INFORMATION
Tell your doctor about all your medical conditions, including if you have: a disease that
affects your muscles and nerves (suchas amyotrophic lateral sclerosis [ALS or Lou Gehrig’s
disease], myasthenia gravis, or Lambert-Eaton syndrome), allergies to any botulinum toxin
product or had any side effect from any botulinum toxin product in the past, a breathing problem
(such as asthma or emphysema), swallowing problems, bleeding problems, diabetes, a slow
heart beat or other problem with your heart rate or rhythm, plans to have surgery, had surgery on
your face, weakness of your forehead muscles (such as trouble raising your eyebrows), drooping
eyelids, or any other change in the way your face normally looks. Patients with a disease that
affects muscles and nerves who are treated with typical doses of Dysport may have a higher risk
of serious side effects, including severe swallowing and breathing problems.
16

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

Why not start the Dysport
discussion with your doctor today?
Questions to ask your doctor:
• How soon will I see treatment results?
• How long does one treatment last?
• How often can I receive a Dysport treatment?
• Is there any way to save money on
my treatment?
• Can I have a treatment today?
• What are the risks associated with treatment?
IMPORTANT SAFETY INFORMATION
Human Albumin
This product contains albumin taken from human plasma. Steps taken during donor screening and product
manufacturing processes make the risk of spreading viral diseases extremely rare. In theory, there is also an
extremely rare risk of contracting Creutzfeldt-Jakob disease (CJD). No cases of spread of viral diseases or CJD
have ever been reported for albumin.
17

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Important Safety Information

What is the most important information you
should know about Dysport
(abobotulinumtoxinA) 300 Units for Injection?
Spread of Toxin Effects: In some cases, the
effects of Dysport and all botulinum toxin
products may affect areas of the body away
from the injection site. These effects can
cause symptoms of a serious condition called
botulism. Symptoms of botulism can happen
hours to weeks after injection and may
include swallowing and breathing problems,
loss of strength and muscle weakness all over
the body, double vision, blurred vision and
drooping eyelids, hoarseness or change or
loss of voice, trouble saying words clearly, or
loss of bladder control. Swallowing and
breathing problems can be life threatening
and there have been reports of death.

18

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

The risk of symptoms is probably greatest in
children and adults treated for muscle spasms,
particularly in those patients who have
underlying medical conditions that could make
these symptoms more likely.
The toxic effects have been reported at doses
similar to those used to treat muscle spasms in
the neck. Lower doses, in both approved and
unapproved uses, have also caused toxic
effects. This includes treatment of children and
adults for muscle spasms.
These effects could make it unsafe for you to
drive a car, operate machinery, or do other
dangerous activities.
Do not have Dysport treatment if you: are allergic
to Dysport or any of its ingredients (see the end of
the Medication Guide for a list of ingredients), are
allergic to cow’s milk protein, had an allergic
reaction to any other botulinum toxin product, such
as Myobloc® or Botox,® or have a skin infection at
the planned injection site.

Important Safety Information (cont.)

The dose of Dysport is not the same as the
dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to
the dose of any other botulinum toxin product
you may have used.
Dysport may not be right for you if: you have
surgical changes to your face, very weak muscles
in the treatment area, your face looks very
different from side to side, the injection site is
inflamed, you have droopy eyelids or sagging
eyelid folds, deep facial scars, thick oily skin, or if
your wrinkles can’t be smoothed by spreading
them apart.
Tell your doctor about all your medical
conditions, including if you have: a disease
that affects your muscles and nerves (such as
amyotrophic lateral sclerosis [ALS or Lou
Gehrig’s disease], myasthenia gravis, or LambertEaton syndrome), allergies to any botulinum toxin
product or had any side effect from any

19

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

botulinum toxin product in the past, a breathing
problem (such as asthma or emphysema),
swallowing problems, bleeding problems, diabetes,
a slow heart beat or other problem with your heart
rate or rhythm, plans to have surgery, had surgery
on your face, weakness of your forehead muscles
(such as trouble raising your eyebrows), drooping
eyelids, or any other change in the way your face
normally looks. Patients with a disease that affects
muscles and nerves who are treated with typical
doses of Dysport may have a higher risk of serious
side effects, including severe swallowing and
breathing problems.
Human Albumin
This product contains albumin taken from human
plasma. Steps taken during donor screening and
product manufacturing processes make the risk of
spreading viral diseases extremely rare. In theory,
there is also an extremely rare risk of contracting
Creutzfeldt-Jakob disease (CJD). No cases of
spread of viral diseases or CJD have ever been
reported for albumin.

Important Safety Information (cont.)

Allergic Reaction to Injecting in the Skin
It is not known if an allergic reaction can be
caused by injecting Dysport into the skin. The
safety of treating excessive sweating with Dysport
is not known.
Common Side Effects
The most common side effects are nose and
throat irritation, headache, injection site pain,
injection site skin reaction, upper respiratory tract
infection, eyelid swelling, eyelid drooping, sinus
inflammation, and nausea.
Tell your doctor about all the medicines you
take, including prescription and nonprescription
medicines, vitamins and herbal and other natural
products. Using Dysport with certain other
medicines may cause serious side effects.

20

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

Do not start any new medicines while taking
Dysport without talking to your doctor first.

Especially tell your doctor if you: have received
any other botulinum toxin product in the last four
months, have received injections of botulinum toxin,
such as Myobloc® (rimabotulinumtoxinB) or Botox®
(onabotulinumtoxinA) in the past (be sure your
doctor knows exactly which product you received),
have recently received an antibiotic by injection,
take muscle relaxants, take an allergy or cold
medicine, or take a sleep medicine.
Use In Specific Populations
Dysport should not be used in children or in women
who are pregnant or breastfeeding.
Ask your doctor if Dysport is right for you.

Medication Guide

21

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

22

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

23

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

24

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

25

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

26

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

27

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

28

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

29

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

30

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

31

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

32

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medicis Family
of Aesthetic Products

Products are not FDA approved for combination use.

www.DysportUSA.com

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.
33

The Dysport trademark is used under license. Restylane is a registered trademark of HA North American Sales AB. All other trademarks
are the property of their respective owners. DSP 11-060 10/31/12


Slide 31

Dysport ® is a prescription
injection for temporary
improvement in the look of
moderate to severe frown
lines between the eyebrows
(glabellar lines) in adults less
than 65 years of age.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.
The Dysport trademark is used under license. All other trademarks are the property of their respective owners. DSP 11-060 10/31/12

I do special things for myself,
and I’ll bet you do, too.
I work out, eat right, and take care of my
skin. Of course, cosmetic creams and lotions
will always have their place in my regimen—
but for my moderate to severe frown lines,
I was ready for a prescription treatment.
Maybe you are, too.

IMPORTANT SAFETY INFORMATION
What is the most important information you should know about Dysport?
Spread of Toxin Effects: In some cases, the effects of Dysport and all botulinum toxin products
may affect areas of the body away from the injection site. These effects can cause symptoms of
a serious condition called botulism. Symptoms of botulism can happen hours to weeks after
injection and may include swallowing and breathing problems, loss of strength and muscle
weakness all over the body, double vision, blurred vision and drooping eyelids, hoarseness or
change or loss of voice, trouble saying words clearly, or loss of bladder control.
PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

2

What is Dysport?
Prescription Dysport is an injection used to temporarily improve
the look of your moderate to severe frown lines without changing
the look of your whole face. The untreated facial muscles still
work normally, allowing you to freely show facial expressions,
such as smiling, in untreated areas.
Dysport is a formulation that has been shown to deliver temporary
improvement in moderate to severe frown lines, even with repeat
treatments. So, the effect of repeat treatment with Dysport may
be comparable to your first use.

IMPORTANT SAFETY INFORMATION
Swallowing and breathing problems can be life threatening and there have
been reports of death.
The risk of symptoms is probably greatest in children and adults treated for
muscle spasms, particularly in those patients who have underlying medical
conditions that could make these symptoms more likely.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

3

How does Dysport Work?
With just 1 injection into each of 5 points between and over
the eyebrows, Dysport blocks the signal from the nerve to the
muscles, ultimately resulting in a reduction of muscle activity
and temporarily preventing contraction of the muscles that
cause frown lines. You should not be treated with Dysport more
frequently than every 90 days.
Ask your doctor about your prescription treatment options for
temporarily improving the look of moderate to severe frown lines.
IMPORTANT SAFETY INFORMATION
The toxic effects have been reported at doses similar to those used to treat
muscle spasms in the neck. Lower doses, in both approved and unapproved
uses, have also caused toxic effects. This includes treatment of children and
adults for muscle spasms.

These effects could make it unsafe for you to drive a car, operate machinery,
or do other dangerous activities.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

4

What causes frown lines?
Over time, repeated movement of the facial skin by the
forehead muscles forms lines between the eyebrows.
Frown lines are “dynamic”—they happen because of
the way a person’s face moves.

IMPORTANT SAFETY INFORMATION
Do not have Dysport treatment if you: are allergic to Dysport or any of its ingredients
(see the end of the Medication Guide for a list of ingredients), are allergic to cow’s milk protein,
had an allergic reaction to any other botulinum toxin product (such as Myobloc® or Botox®),
or have a skin infection at the planned injection site.
The dose of Dysport is not the same as the dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to the dose of any other botulinum toxin
product you may have used.
Dysport may not be right for you if: you have surgical changes to your face, very weak
muscles in the treatment area, your face looks very different from side to side, the injection site
is inflamed, you have droopy eyelids or sagging eyelid folds, deep facial scars, thick oily skin, or
if your wrinkles can’t be smoothed by spreading them apart.
5

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Are frown lines always related to age?
No. Because frown lines are created by facial movements,
such as frowning or squinting, they may develop even in
younger adults.

IMPORTANT SAFETY INFORMATION
Tell your doctor about all your medical conditions, including if you have: a disease
that affects your muscles and nerves (such as amyotrophic lateral sclerosis [ALS or Lou
Gehrig’s disease], myasthenia gravis, or Lambert-Eaton syndrome), allergies to any
botulinum toxin product or had any side effect from any botulinum toxin product in the past,
a breathing problem (such as asthma or emphysema), swallowing problems, bleeding
problems, diabetes, a slow heart beat or other problem with your heart rate or rhythm, plans
to have surgery, had surgery on your face, weakness of your forehead muscles (such as
trouble raising your eyebrows), drooping eyelids, or any other change in the way your face
normally looks. Patients with a disease that affects muscles and nerves who are treated with
typical doses of Dysport may have a higher risk of serious side effects, including severe
swallowing and breathing problems.
6

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What can you do about frown lines?
Treatment with prescription Dysport can temporarily
improve the look of your moderate to severe frown lines.
Treatment generally takes just 10 to 20 minutes.
The most common side effects are nose and throat
irritation, headache, injection site pain, injection site skin
reaction, upper respiratory tract infection, eyelid swelling,
eyelid drooping, sinus inflammation, and nausea.

IMPORTANT SAFETY INFORMATION
Human Albumin
This product contains albumin taken from human plasma. Steps taken during donor
screening and product manufacturing processes make the risk of spreading viral diseases
extremely rare. In theory, there is also an extremely rare risk of contracting CreutzfeldtJakob disease (CJD). No cases of spread of viral diseases or CJD have ever been
reported for albumin.
7

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

How do you know if Dysport works?
Clinically proven results with 1 treatment
In 3 clinical studies of people whose frown lines were rated “moderate” or
“severe” by a doctor before their treatment with Dysport:a
• Doctor rating: 30 days after treatment, the majority (88%, 85%, and 86% in each of the 3 studies)
had their frown lines rated by a doctor as “mild” or “moderate” at maximum frown. For example, a
patient could improve from “severe” to “moderate” or from “moderate” to “mild.”
• Patient rating: 30 days after treatment, the majority (74%, 79%, and 82% in each of the 3 studies)
rated their own frown lines as “mild” or “moderate” at maximum frown. For example, a patient could
improve from “severe” to “moderate” or from “moderate” to “mild.”

a

Three double-blind, randomized, placebo-controlled, clinical studies evaluated the efficacy of Dysport for use in the temporary improvement of the appearance of moderate to severe
glabellar lines. These 3 studies enrolled healthy adults (ages 19-75) with glabellar lines of at least moderate severity at maximum frown. Subjects were excluded if they had marked
ptosis, deep dermal scarring, or a substantial inability to lessen glabellar lines, even by physically spreading them apart. The subjects in these studies received either Dysport or a
placebo. The total dose was delivered in equally divided aliquots to specified injection sites.

IMPORTANT SAFETY INFORMATION
Allergic Reaction to Injecting in the Skin
It is not known if an allergic reaction can be caused by injecting Dysport into the skin. The safety of
treating excessive sweating with Dysport is not known.
8

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Common Side Effects
The most common side effects are nose and throat irritation, headache, injection site pain, injection site skin
reaction, upper respiratory tract infection, eyelid swelling, eyelid drooping, sinus inflammation, and nausea.
9

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Tell your doctor about all the medicines you take, including prescription and nonprescription medicines,
vitamins and herbal and other natural products. Using Dysport with certain other medicines may cause
serious side effects.
Do not start any new medicines while taking Dysport without talking to your doctor first.
10

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Especially tell your doctor if you: have received any other botulinum toxin product in the last four
months, have received injections of botulinum toxin, such as Myobloc® (rimabotulinumtoxinB) or Botox®
(onabotulinumtoxinA) in the past (be sure your doctor knows exactly which product you received), have
recently received an antibiotic by injection, take muscle relaxants, take an allergy or cold medicine, or take
a sleep medicine.
11

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Use In Specific Populations
Dysport should not be used in children or in women who are pregnant or breastfeeding.
Ask your doctor if Dysport is right for you.
12

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What to expect with Dysport
A step-by-step guide to your treatment†

1

The Dysport treatment consultation
Discuss your expectations with your doctor and
whether you have any health conditions or
allergies that could interfere with your treatment.
† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

IMPORTANT SAFETY INFORMATION
What is the most important information you should know about Dysport?
Spread of Toxin Effects: In some cases, the effects of Dysport and all botulinum toxin products may affect
areas of the body away from the injection site. These effects can cause symptoms of a serious condition
called botulism. Symptoms of botulism can happen hours to weeks after injection and may include
swallowing and breathing problems, loss of strength and muscle weakness all over the body, double
vision, blurred vision and drooping eyelids, hoarseness or change or loss of voice, trouble saying words
clearly, or loss of bladder control. Swallowing and breathing problems can be life threatening and there
have been reports of death.
The risk of symptoms is probably greatest in children and adults treated for muscle spasms, particularly
in those patients who have underlying medical conditions that could make these symptoms more likely.
13

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What to expect with Dysport
A step-by-step guide to your treatment†

2

The Dysport treatment
Effective treatment requires 1 injection into each
of 5 points between and over the eyebrows.
Although office visit times may vary, the procedure
generally takes 10 to 20 minutes. Your healthcare
professional will determine the exact placement of
each injection to get results that are right for you.

IMPORTANT SAFETY INFORMATION
The toxic effects have been reported at doses similar to those used to treat muscle spasms in
the neck. Lower doses, in both approved and unapproved uses, have also caused toxic effects.
This includes treatment of children and adults for muscle spasms.
These effects could make it unsafe for you to drive a car, operate machinery, or do other
dangerous activities.
Do not have Dysport treatment if you: are allergic to Dysport or any of its ingredients (see the end
of the Medication Guide for a list of ingredients), are allergic to cow’s milk protein, had an allergic
reaction to any other botulinum toxin product, such as Myobloc® or Botox,® or have a skin infection at
the planned injection site.
14

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

What to expect with Dysport
A step-by-step guide to your treatment†

3

After your Dysport treatment
Ask your doctor about any precautions you
should take after your treatment. Call your doctor
or get medical help right away if you have any
problems swallowing, speaking, or breathing.
If this happens, do not drive a car, operate
machinery, or do other dangerous activities.

IMPORTANT SAFETY INFORMATION
The dose of Dysport is not the same as the dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to the dose of any other botulinum toxin
product you may have used.
Dysport may not be right for you if: you have surgical changes to your face, very weak
muscles in the treatment area, your face looks very different from side to side, the injection
site is inflamed, you have droopy eyelids or sagging eyelid folds, deep facial scars, thick oily
skin, or if your wrinkles can’t be smoothed by spreading them apart.
15

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

What to expect with Dysport
A step-by-step guide to your treatment†

4

Follow up
To maintain your improvements, you should
discuss a treatment schedule with your doctor.
As with any botulinum toxin product, you should
wait at least 90 days between treatments.

IMPORTANT SAFETY INFORMATION
Tell your doctor about all your medical conditions, including if you have: a disease that
affects your muscles and nerves (suchas amyotrophic lateral sclerosis [ALS or Lou Gehrig’s
disease], myasthenia gravis, or Lambert-Eaton syndrome), allergies to any botulinum toxin
product or had any side effect from any botulinum toxin product in the past, a breathing problem
(such as asthma or emphysema), swallowing problems, bleeding problems, diabetes, a slow
heart beat or other problem with your heart rate or rhythm, plans to have surgery, had surgery on
your face, weakness of your forehead muscles (such as trouble raising your eyebrows), drooping
eyelids, or any other change in the way your face normally looks. Patients with a disease that
affects muscles and nerves who are treated with typical doses of Dysport may have a higher risk
of serious side effects, including severe swallowing and breathing problems.
16

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

Why not start the Dysport
discussion with your doctor today?
Questions to ask your doctor:
• How soon will I see treatment results?
• How long does one treatment last?
• How often can I receive a Dysport treatment?
• Is there any way to save money on
my treatment?
• Can I have a treatment today?
• What are the risks associated with treatment?
IMPORTANT SAFETY INFORMATION
Human Albumin
This product contains albumin taken from human plasma. Steps taken during donor screening and product
manufacturing processes make the risk of spreading viral diseases extremely rare. In theory, there is also an
extremely rare risk of contracting Creutzfeldt-Jakob disease (CJD). No cases of spread of viral diseases or CJD
have ever been reported for albumin.
17

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Important Safety Information

What is the most important information you
should know about Dysport
(abobotulinumtoxinA) 300 Units for Injection?
Spread of Toxin Effects: In some cases, the
effects of Dysport and all botulinum toxin
products may affect areas of the body away
from the injection site. These effects can
cause symptoms of a serious condition called
botulism. Symptoms of botulism can happen
hours to weeks after injection and may
include swallowing and breathing problems,
loss of strength and muscle weakness all over
the body, double vision, blurred vision and
drooping eyelids, hoarseness or change or
loss of voice, trouble saying words clearly, or
loss of bladder control. Swallowing and
breathing problems can be life threatening
and there have been reports of death.

18

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

The risk of symptoms is probably greatest in
children and adults treated for muscle spasms,
particularly in those patients who have
underlying medical conditions that could make
these symptoms more likely.
The toxic effects have been reported at doses
similar to those used to treat muscle spasms in
the neck. Lower doses, in both approved and
unapproved uses, have also caused toxic
effects. This includes treatment of children and
adults for muscle spasms.
These effects could make it unsafe for you to
drive a car, operate machinery, or do other
dangerous activities.
Do not have Dysport treatment if you: are allergic
to Dysport or any of its ingredients (see the end of
the Medication Guide for a list of ingredients), are
allergic to cow’s milk protein, had an allergic
reaction to any other botulinum toxin product, such
as Myobloc® or Botox,® or have a skin infection at
the planned injection site.

Important Safety Information (cont.)

The dose of Dysport is not the same as the
dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to
the dose of any other botulinum toxin product
you may have used.
Dysport may not be right for you if: you have
surgical changes to your face, very weak muscles
in the treatment area, your face looks very
different from side to side, the injection site is
inflamed, you have droopy eyelids or sagging
eyelid folds, deep facial scars, thick oily skin, or if
your wrinkles can’t be smoothed by spreading
them apart.
Tell your doctor about all your medical
conditions, including if you have: a disease
that affects your muscles and nerves (such as
amyotrophic lateral sclerosis [ALS or Lou
Gehrig’s disease], myasthenia gravis, or LambertEaton syndrome), allergies to any botulinum toxin
product or had any side effect from any

19

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

botulinum toxin product in the past, a breathing
problem (such as asthma or emphysema),
swallowing problems, bleeding problems, diabetes,
a slow heart beat or other problem with your heart
rate or rhythm, plans to have surgery, had surgery
on your face, weakness of your forehead muscles
(such as trouble raising your eyebrows), drooping
eyelids, or any other change in the way your face
normally looks. Patients with a disease that affects
muscles and nerves who are treated with typical
doses of Dysport may have a higher risk of serious
side effects, including severe swallowing and
breathing problems.
Human Albumin
This product contains albumin taken from human
plasma. Steps taken during donor screening and
product manufacturing processes make the risk of
spreading viral diseases extremely rare. In theory,
there is also an extremely rare risk of contracting
Creutzfeldt-Jakob disease (CJD). No cases of
spread of viral diseases or CJD have ever been
reported for albumin.

Important Safety Information (cont.)

Allergic Reaction to Injecting in the Skin
It is not known if an allergic reaction can be
caused by injecting Dysport into the skin. The
safety of treating excessive sweating with Dysport
is not known.
Common Side Effects
The most common side effects are nose and
throat irritation, headache, injection site pain,
injection site skin reaction, upper respiratory tract
infection, eyelid swelling, eyelid drooping, sinus
inflammation, and nausea.
Tell your doctor about all the medicines you
take, including prescription and nonprescription
medicines, vitamins and herbal and other natural
products. Using Dysport with certain other
medicines may cause serious side effects.

20

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

Do not start any new medicines while taking
Dysport without talking to your doctor first.

Especially tell your doctor if you: have received
any other botulinum toxin product in the last four
months, have received injections of botulinum toxin,
such as Myobloc® (rimabotulinumtoxinB) or Botox®
(onabotulinumtoxinA) in the past (be sure your
doctor knows exactly which product you received),
have recently received an antibiotic by injection,
take muscle relaxants, take an allergy or cold
medicine, or take a sleep medicine.
Use In Specific Populations
Dysport should not be used in children or in women
who are pregnant or breastfeeding.
Ask your doctor if Dysport is right for you.

Medication Guide

21

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

22

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

23

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

24

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

25

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

26

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

27

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

28

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

29

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

30

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

31

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

32

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medicis Family
of Aesthetic Products

Products are not FDA approved for combination use.

www.DysportUSA.com

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.
33

The Dysport trademark is used under license. Restylane is a registered trademark of HA North American Sales AB. All other trademarks
are the property of their respective owners. DSP 11-060 10/31/12


Slide 32

Dysport ® is a prescription
injection for temporary
improvement in the look of
moderate to severe frown
lines between the eyebrows
(glabellar lines) in adults less
than 65 years of age.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.
The Dysport trademark is used under license. All other trademarks are the property of their respective owners. DSP 11-060 10/31/12

I do special things for myself,
and I’ll bet you do, too.
I work out, eat right, and take care of my
skin. Of course, cosmetic creams and lotions
will always have their place in my regimen—
but for my moderate to severe frown lines,
I was ready for a prescription treatment.
Maybe you are, too.

IMPORTANT SAFETY INFORMATION
What is the most important information you should know about Dysport?
Spread of Toxin Effects: In some cases, the effects of Dysport and all botulinum toxin products
may affect areas of the body away from the injection site. These effects can cause symptoms of
a serious condition called botulism. Symptoms of botulism can happen hours to weeks after
injection and may include swallowing and breathing problems, loss of strength and muscle
weakness all over the body, double vision, blurred vision and drooping eyelids, hoarseness or
change or loss of voice, trouble saying words clearly, or loss of bladder control.
PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

2

What is Dysport?
Prescription Dysport is an injection used to temporarily improve
the look of your moderate to severe frown lines without changing
the look of your whole face. The untreated facial muscles still
work normally, allowing you to freely show facial expressions,
such as smiling, in untreated areas.
Dysport is a formulation that has been shown to deliver temporary
improvement in moderate to severe frown lines, even with repeat
treatments. So, the effect of repeat treatment with Dysport may
be comparable to your first use.

IMPORTANT SAFETY INFORMATION
Swallowing and breathing problems can be life threatening and there have
been reports of death.
The risk of symptoms is probably greatest in children and adults treated for
muscle spasms, particularly in those patients who have underlying medical
conditions that could make these symptoms more likely.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

3

How does Dysport Work?
With just 1 injection into each of 5 points between and over
the eyebrows, Dysport blocks the signal from the nerve to the
muscles, ultimately resulting in a reduction of muscle activity
and temporarily preventing contraction of the muscles that
cause frown lines. You should not be treated with Dysport more
frequently than every 90 days.
Ask your doctor about your prescription treatment options for
temporarily improving the look of moderate to severe frown lines.
IMPORTANT SAFETY INFORMATION
The toxic effects have been reported at doses similar to those used to treat
muscle spasms in the neck. Lower doses, in both approved and unapproved
uses, have also caused toxic effects. This includes treatment of children and
adults for muscle spasms.

These effects could make it unsafe for you to drive a car, operate machinery,
or do other dangerous activities.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

4

What causes frown lines?
Over time, repeated movement of the facial skin by the
forehead muscles forms lines between the eyebrows.
Frown lines are “dynamic”—they happen because of
the way a person’s face moves.

IMPORTANT SAFETY INFORMATION
Do not have Dysport treatment if you: are allergic to Dysport or any of its ingredients
(see the end of the Medication Guide for a list of ingredients), are allergic to cow’s milk protein,
had an allergic reaction to any other botulinum toxin product (such as Myobloc® or Botox®),
or have a skin infection at the planned injection site.
The dose of Dysport is not the same as the dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to the dose of any other botulinum toxin
product you may have used.
Dysport may not be right for you if: you have surgical changes to your face, very weak
muscles in the treatment area, your face looks very different from side to side, the injection site
is inflamed, you have droopy eyelids or sagging eyelid folds, deep facial scars, thick oily skin, or
if your wrinkles can’t be smoothed by spreading them apart.
5

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Are frown lines always related to age?
No. Because frown lines are created by facial movements,
such as frowning or squinting, they may develop even in
younger adults.

IMPORTANT SAFETY INFORMATION
Tell your doctor about all your medical conditions, including if you have: a disease
that affects your muscles and nerves (such as amyotrophic lateral sclerosis [ALS or Lou
Gehrig’s disease], myasthenia gravis, or Lambert-Eaton syndrome), allergies to any
botulinum toxin product or had any side effect from any botulinum toxin product in the past,
a breathing problem (such as asthma or emphysema), swallowing problems, bleeding
problems, diabetes, a slow heart beat or other problem with your heart rate or rhythm, plans
to have surgery, had surgery on your face, weakness of your forehead muscles (such as
trouble raising your eyebrows), drooping eyelids, or any other change in the way your face
normally looks. Patients with a disease that affects muscles and nerves who are treated with
typical doses of Dysport may have a higher risk of serious side effects, including severe
swallowing and breathing problems.
6

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What can you do about frown lines?
Treatment with prescription Dysport can temporarily
improve the look of your moderate to severe frown lines.
Treatment generally takes just 10 to 20 minutes.
The most common side effects are nose and throat
irritation, headache, injection site pain, injection site skin
reaction, upper respiratory tract infection, eyelid swelling,
eyelid drooping, sinus inflammation, and nausea.

IMPORTANT SAFETY INFORMATION
Human Albumin
This product contains albumin taken from human plasma. Steps taken during donor
screening and product manufacturing processes make the risk of spreading viral diseases
extremely rare. In theory, there is also an extremely rare risk of contracting CreutzfeldtJakob disease (CJD). No cases of spread of viral diseases or CJD have ever been
reported for albumin.
7

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

How do you know if Dysport works?
Clinically proven results with 1 treatment
In 3 clinical studies of people whose frown lines were rated “moderate” or
“severe” by a doctor before their treatment with Dysport:a
• Doctor rating: 30 days after treatment, the majority (88%, 85%, and 86% in each of the 3 studies)
had their frown lines rated by a doctor as “mild” or “moderate” at maximum frown. For example, a
patient could improve from “severe” to “moderate” or from “moderate” to “mild.”
• Patient rating: 30 days after treatment, the majority (74%, 79%, and 82% in each of the 3 studies)
rated their own frown lines as “mild” or “moderate” at maximum frown. For example, a patient could
improve from “severe” to “moderate” or from “moderate” to “mild.”

a

Three double-blind, randomized, placebo-controlled, clinical studies evaluated the efficacy of Dysport for use in the temporary improvement of the appearance of moderate to severe
glabellar lines. These 3 studies enrolled healthy adults (ages 19-75) with glabellar lines of at least moderate severity at maximum frown. Subjects were excluded if they had marked
ptosis, deep dermal scarring, or a substantial inability to lessen glabellar lines, even by physically spreading them apart. The subjects in these studies received either Dysport or a
placebo. The total dose was delivered in equally divided aliquots to specified injection sites.

IMPORTANT SAFETY INFORMATION
Allergic Reaction to Injecting in the Skin
It is not known if an allergic reaction can be caused by injecting Dysport into the skin. The safety of
treating excessive sweating with Dysport is not known.
8

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Common Side Effects
The most common side effects are nose and throat irritation, headache, injection site pain, injection site skin
reaction, upper respiratory tract infection, eyelid swelling, eyelid drooping, sinus inflammation, and nausea.
9

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Tell your doctor about all the medicines you take, including prescription and nonprescription medicines,
vitamins and herbal and other natural products. Using Dysport with certain other medicines may cause
serious side effects.
Do not start any new medicines while taking Dysport without talking to your doctor first.
10

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Especially tell your doctor if you: have received any other botulinum toxin product in the last four
months, have received injections of botulinum toxin, such as Myobloc® (rimabotulinumtoxinB) or Botox®
(onabotulinumtoxinA) in the past (be sure your doctor knows exactly which product you received), have
recently received an antibiotic by injection, take muscle relaxants, take an allergy or cold medicine, or take
a sleep medicine.
11

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Use In Specific Populations
Dysport should not be used in children or in women who are pregnant or breastfeeding.
Ask your doctor if Dysport is right for you.
12

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What to expect with Dysport
A step-by-step guide to your treatment†

1

The Dysport treatment consultation
Discuss your expectations with your doctor and
whether you have any health conditions or
allergies that could interfere with your treatment.
† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

IMPORTANT SAFETY INFORMATION
What is the most important information you should know about Dysport?
Spread of Toxin Effects: In some cases, the effects of Dysport and all botulinum toxin products may affect
areas of the body away from the injection site. These effects can cause symptoms of a serious condition
called botulism. Symptoms of botulism can happen hours to weeks after injection and may include
swallowing and breathing problems, loss of strength and muscle weakness all over the body, double
vision, blurred vision and drooping eyelids, hoarseness or change or loss of voice, trouble saying words
clearly, or loss of bladder control. Swallowing and breathing problems can be life threatening and there
have been reports of death.
The risk of symptoms is probably greatest in children and adults treated for muscle spasms, particularly
in those patients who have underlying medical conditions that could make these symptoms more likely.
13

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What to expect with Dysport
A step-by-step guide to your treatment†

2

The Dysport treatment
Effective treatment requires 1 injection into each
of 5 points between and over the eyebrows.
Although office visit times may vary, the procedure
generally takes 10 to 20 minutes. Your healthcare
professional will determine the exact placement of
each injection to get results that are right for you.

IMPORTANT SAFETY INFORMATION
The toxic effects have been reported at doses similar to those used to treat muscle spasms in
the neck. Lower doses, in both approved and unapproved uses, have also caused toxic effects.
This includes treatment of children and adults for muscle spasms.
These effects could make it unsafe for you to drive a car, operate machinery, or do other
dangerous activities.
Do not have Dysport treatment if you: are allergic to Dysport or any of its ingredients (see the end
of the Medication Guide for a list of ingredients), are allergic to cow’s milk protein, had an allergic
reaction to any other botulinum toxin product, such as Myobloc® or Botox,® or have a skin infection at
the planned injection site.
14

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

What to expect with Dysport
A step-by-step guide to your treatment†

3

After your Dysport treatment
Ask your doctor about any precautions you
should take after your treatment. Call your doctor
or get medical help right away if you have any
problems swallowing, speaking, or breathing.
If this happens, do not drive a car, operate
machinery, or do other dangerous activities.

IMPORTANT SAFETY INFORMATION
The dose of Dysport is not the same as the dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to the dose of any other botulinum toxin
product you may have used.
Dysport may not be right for you if: you have surgical changes to your face, very weak
muscles in the treatment area, your face looks very different from side to side, the injection
site is inflamed, you have droopy eyelids or sagging eyelid folds, deep facial scars, thick oily
skin, or if your wrinkles can’t be smoothed by spreading them apart.
15

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

What to expect with Dysport
A step-by-step guide to your treatment†

4

Follow up
To maintain your improvements, you should
discuss a treatment schedule with your doctor.
As with any botulinum toxin product, you should
wait at least 90 days between treatments.

IMPORTANT SAFETY INFORMATION
Tell your doctor about all your medical conditions, including if you have: a disease that
affects your muscles and nerves (suchas amyotrophic lateral sclerosis [ALS or Lou Gehrig’s
disease], myasthenia gravis, or Lambert-Eaton syndrome), allergies to any botulinum toxin
product or had any side effect from any botulinum toxin product in the past, a breathing problem
(such as asthma or emphysema), swallowing problems, bleeding problems, diabetes, a slow
heart beat or other problem with your heart rate or rhythm, plans to have surgery, had surgery on
your face, weakness of your forehead muscles (such as trouble raising your eyebrows), drooping
eyelids, or any other change in the way your face normally looks. Patients with a disease that
affects muscles and nerves who are treated with typical doses of Dysport may have a higher risk
of serious side effects, including severe swallowing and breathing problems.
16

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

Why not start the Dysport
discussion with your doctor today?
Questions to ask your doctor:
• How soon will I see treatment results?
• How long does one treatment last?
• How often can I receive a Dysport treatment?
• Is there any way to save money on
my treatment?
• Can I have a treatment today?
• What are the risks associated with treatment?
IMPORTANT SAFETY INFORMATION
Human Albumin
This product contains albumin taken from human plasma. Steps taken during donor screening and product
manufacturing processes make the risk of spreading viral diseases extremely rare. In theory, there is also an
extremely rare risk of contracting Creutzfeldt-Jakob disease (CJD). No cases of spread of viral diseases or CJD
have ever been reported for albumin.
17

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Important Safety Information

What is the most important information you
should know about Dysport
(abobotulinumtoxinA) 300 Units for Injection?
Spread of Toxin Effects: In some cases, the
effects of Dysport and all botulinum toxin
products may affect areas of the body away
from the injection site. These effects can
cause symptoms of a serious condition called
botulism. Symptoms of botulism can happen
hours to weeks after injection and may
include swallowing and breathing problems,
loss of strength and muscle weakness all over
the body, double vision, blurred vision and
drooping eyelids, hoarseness or change or
loss of voice, trouble saying words clearly, or
loss of bladder control. Swallowing and
breathing problems can be life threatening
and there have been reports of death.

18

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

The risk of symptoms is probably greatest in
children and adults treated for muscle spasms,
particularly in those patients who have
underlying medical conditions that could make
these symptoms more likely.
The toxic effects have been reported at doses
similar to those used to treat muscle spasms in
the neck. Lower doses, in both approved and
unapproved uses, have also caused toxic
effects. This includes treatment of children and
adults for muscle spasms.
These effects could make it unsafe for you to
drive a car, operate machinery, or do other
dangerous activities.
Do not have Dysport treatment if you: are allergic
to Dysport or any of its ingredients (see the end of
the Medication Guide for a list of ingredients), are
allergic to cow’s milk protein, had an allergic
reaction to any other botulinum toxin product, such
as Myobloc® or Botox,® or have a skin infection at
the planned injection site.

Important Safety Information (cont.)

The dose of Dysport is not the same as the
dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to
the dose of any other botulinum toxin product
you may have used.
Dysport may not be right for you if: you have
surgical changes to your face, very weak muscles
in the treatment area, your face looks very
different from side to side, the injection site is
inflamed, you have droopy eyelids or sagging
eyelid folds, deep facial scars, thick oily skin, or if
your wrinkles can’t be smoothed by spreading
them apart.
Tell your doctor about all your medical
conditions, including if you have: a disease
that affects your muscles and nerves (such as
amyotrophic lateral sclerosis [ALS or Lou
Gehrig’s disease], myasthenia gravis, or LambertEaton syndrome), allergies to any botulinum toxin
product or had any side effect from any

19

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

botulinum toxin product in the past, a breathing
problem (such as asthma or emphysema),
swallowing problems, bleeding problems, diabetes,
a slow heart beat or other problem with your heart
rate or rhythm, plans to have surgery, had surgery
on your face, weakness of your forehead muscles
(such as trouble raising your eyebrows), drooping
eyelids, or any other change in the way your face
normally looks. Patients with a disease that affects
muscles and nerves who are treated with typical
doses of Dysport may have a higher risk of serious
side effects, including severe swallowing and
breathing problems.
Human Albumin
This product contains albumin taken from human
plasma. Steps taken during donor screening and
product manufacturing processes make the risk of
spreading viral diseases extremely rare. In theory,
there is also an extremely rare risk of contracting
Creutzfeldt-Jakob disease (CJD). No cases of
spread of viral diseases or CJD have ever been
reported for albumin.

Important Safety Information (cont.)

Allergic Reaction to Injecting in the Skin
It is not known if an allergic reaction can be
caused by injecting Dysport into the skin. The
safety of treating excessive sweating with Dysport
is not known.
Common Side Effects
The most common side effects are nose and
throat irritation, headache, injection site pain,
injection site skin reaction, upper respiratory tract
infection, eyelid swelling, eyelid drooping, sinus
inflammation, and nausea.
Tell your doctor about all the medicines you
take, including prescription and nonprescription
medicines, vitamins and herbal and other natural
products. Using Dysport with certain other
medicines may cause serious side effects.

20

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

Do not start any new medicines while taking
Dysport without talking to your doctor first.

Especially tell your doctor if you: have received
any other botulinum toxin product in the last four
months, have received injections of botulinum toxin,
such as Myobloc® (rimabotulinumtoxinB) or Botox®
(onabotulinumtoxinA) in the past (be sure your
doctor knows exactly which product you received),
have recently received an antibiotic by injection,
take muscle relaxants, take an allergy or cold
medicine, or take a sleep medicine.
Use In Specific Populations
Dysport should not be used in children or in women
who are pregnant or breastfeeding.
Ask your doctor if Dysport is right for you.

Medication Guide

21

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

22

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

23

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

24

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

25

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

26

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

27

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

28

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

29

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

30

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

31

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

32

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medicis Family
of Aesthetic Products

Products are not FDA approved for combination use.

www.DysportUSA.com

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.
33

The Dysport trademark is used under license. Restylane is a registered trademark of HA North American Sales AB. All other trademarks
are the property of their respective owners. DSP 11-060 10/31/12


Slide 33

Dysport ® is a prescription
injection for temporary
improvement in the look of
moderate to severe frown
lines between the eyebrows
(glabellar lines) in adults less
than 65 years of age.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.
The Dysport trademark is used under license. All other trademarks are the property of their respective owners. DSP 11-060 10/31/12

I do special things for myself,
and I’ll bet you do, too.
I work out, eat right, and take care of my
skin. Of course, cosmetic creams and lotions
will always have their place in my regimen—
but for my moderate to severe frown lines,
I was ready for a prescription treatment.
Maybe you are, too.

IMPORTANT SAFETY INFORMATION
What is the most important information you should know about Dysport?
Spread of Toxin Effects: In some cases, the effects of Dysport and all botulinum toxin products
may affect areas of the body away from the injection site. These effects can cause symptoms of
a serious condition called botulism. Symptoms of botulism can happen hours to weeks after
injection and may include swallowing and breathing problems, loss of strength and muscle
weakness all over the body, double vision, blurred vision and drooping eyelids, hoarseness or
change or loss of voice, trouble saying words clearly, or loss of bladder control.
PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

2

What is Dysport?
Prescription Dysport is an injection used to temporarily improve
the look of your moderate to severe frown lines without changing
the look of your whole face. The untreated facial muscles still
work normally, allowing you to freely show facial expressions,
such as smiling, in untreated areas.
Dysport is a formulation that has been shown to deliver temporary
improvement in moderate to severe frown lines, even with repeat
treatments. So, the effect of repeat treatment with Dysport may
be comparable to your first use.

IMPORTANT SAFETY INFORMATION
Swallowing and breathing problems can be life threatening and there have
been reports of death.
The risk of symptoms is probably greatest in children and adults treated for
muscle spasms, particularly in those patients who have underlying medical
conditions that could make these symptoms more likely.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

3

How does Dysport Work?
With just 1 injection into each of 5 points between and over
the eyebrows, Dysport blocks the signal from the nerve to the
muscles, ultimately resulting in a reduction of muscle activity
and temporarily preventing contraction of the muscles that
cause frown lines. You should not be treated with Dysport more
frequently than every 90 days.
Ask your doctor about your prescription treatment options for
temporarily improving the look of moderate to severe frown lines.
IMPORTANT SAFETY INFORMATION
The toxic effects have been reported at doses similar to those used to treat
muscle spasms in the neck. Lower doses, in both approved and unapproved
uses, have also caused toxic effects. This includes treatment of children and
adults for muscle spasms.

These effects could make it unsafe for you to drive a car, operate machinery,
or do other dangerous activities.

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

4

What causes frown lines?
Over time, repeated movement of the facial skin by the
forehead muscles forms lines between the eyebrows.
Frown lines are “dynamic”—they happen because of
the way a person’s face moves.

IMPORTANT SAFETY INFORMATION
Do not have Dysport treatment if you: are allergic to Dysport or any of its ingredients
(see the end of the Medication Guide for a list of ingredients), are allergic to cow’s milk protein,
had an allergic reaction to any other botulinum toxin product (such as Myobloc® or Botox®),
or have a skin infection at the planned injection site.
The dose of Dysport is not the same as the dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to the dose of any other botulinum toxin
product you may have used.
Dysport may not be right for you if: you have surgical changes to your face, very weak
muscles in the treatment area, your face looks very different from side to side, the injection site
is inflamed, you have droopy eyelids or sagging eyelid folds, deep facial scars, thick oily skin, or
if your wrinkles can’t be smoothed by spreading them apart.
5

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Are frown lines always related to age?
No. Because frown lines are created by facial movements,
such as frowning or squinting, they may develop even in
younger adults.

IMPORTANT SAFETY INFORMATION
Tell your doctor about all your medical conditions, including if you have: a disease
that affects your muscles and nerves (such as amyotrophic lateral sclerosis [ALS or Lou
Gehrig’s disease], myasthenia gravis, or Lambert-Eaton syndrome), allergies to any
botulinum toxin product or had any side effect from any botulinum toxin product in the past,
a breathing problem (such as asthma or emphysema), swallowing problems, bleeding
problems, diabetes, a slow heart beat or other problem with your heart rate or rhythm, plans
to have surgery, had surgery on your face, weakness of your forehead muscles (such as
trouble raising your eyebrows), drooping eyelids, or any other change in the way your face
normally looks. Patients with a disease that affects muscles and nerves who are treated with
typical doses of Dysport may have a higher risk of serious side effects, including severe
swallowing and breathing problems.
6

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What can you do about frown lines?
Treatment with prescription Dysport can temporarily
improve the look of your moderate to severe frown lines.
Treatment generally takes just 10 to 20 minutes.
The most common side effects are nose and throat
irritation, headache, injection site pain, injection site skin
reaction, upper respiratory tract infection, eyelid swelling,
eyelid drooping, sinus inflammation, and nausea.

IMPORTANT SAFETY INFORMATION
Human Albumin
This product contains albumin taken from human plasma. Steps taken during donor
screening and product manufacturing processes make the risk of spreading viral diseases
extremely rare. In theory, there is also an extremely rare risk of contracting CreutzfeldtJakob disease (CJD). No cases of spread of viral diseases or CJD have ever been
reported for albumin.
7

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

How do you know if Dysport works?
Clinically proven results with 1 treatment
In 3 clinical studies of people whose frown lines were rated “moderate” or
“severe” by a doctor before their treatment with Dysport:a
• Doctor rating: 30 days after treatment, the majority (88%, 85%, and 86% in each of the 3 studies)
had their frown lines rated by a doctor as “mild” or “moderate” at maximum frown. For example, a
patient could improve from “severe” to “moderate” or from “moderate” to “mild.”
• Patient rating: 30 days after treatment, the majority (74%, 79%, and 82% in each of the 3 studies)
rated their own frown lines as “mild” or “moderate” at maximum frown. For example, a patient could
improve from “severe” to “moderate” or from “moderate” to “mild.”

a

Three double-blind, randomized, placebo-controlled, clinical studies evaluated the efficacy of Dysport for use in the temporary improvement of the appearance of moderate to severe
glabellar lines. These 3 studies enrolled healthy adults (ages 19-75) with glabellar lines of at least moderate severity at maximum frown. Subjects were excluded if they had marked
ptosis, deep dermal scarring, or a substantial inability to lessen glabellar lines, even by physically spreading them apart. The subjects in these studies received either Dysport or a
placebo. The total dose was delivered in equally divided aliquots to specified injection sites.

IMPORTANT SAFETY INFORMATION
Allergic Reaction to Injecting in the Skin
It is not known if an allergic reaction can be caused by injecting Dysport into the skin. The safety of
treating excessive sweating with Dysport is not known.
8

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Common Side Effects
The most common side effects are nose and throat irritation, headache, injection site pain, injection site skin
reaction, upper respiratory tract infection, eyelid swelling, eyelid drooping, sinus inflammation, and nausea.
9

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Tell your doctor about all the medicines you take, including prescription and nonprescription medicines,
vitamins and herbal and other natural products. Using Dysport with certain other medicines may cause
serious side effects.
Do not start any new medicines while taking Dysport without talking to your doctor first.
10

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Especially tell your doctor if you: have received any other botulinum toxin product in the last four
months, have received injections of botulinum toxin, such as Myobloc® (rimabotulinumtoxinB) or Botox®
(onabotulinumtoxinA) in the past (be sure your doctor knows exactly which product you received), have
recently received an antibiotic by injection, take muscle relaxants, take an allergy or cold medicine, or take
a sleep medicine.
11

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Unretouched images of patients at maximum frown

IMPORTANT SAFETY INFORMATION
Use In Specific Populations
Dysport should not be used in children or in women who are pregnant or breastfeeding.
Ask your doctor if Dysport is right for you.
12

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What to expect with Dysport
A step-by-step guide to your treatment†

1

The Dysport treatment consultation
Discuss your expectations with your doctor and
whether you have any health conditions or
allergies that could interfere with your treatment.
† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

IMPORTANT SAFETY INFORMATION
What is the most important information you should know about Dysport?
Spread of Toxin Effects: In some cases, the effects of Dysport and all botulinum toxin products may affect
areas of the body away from the injection site. These effects can cause symptoms of a serious condition
called botulism. Symptoms of botulism can happen hours to weeks after injection and may include
swallowing and breathing problems, loss of strength and muscle weakness all over the body, double
vision, blurred vision and drooping eyelids, hoarseness or change or loss of voice, trouble saying words
clearly, or loss of bladder control. Swallowing and breathing problems can be life threatening and there
have been reports of death.
The risk of symptoms is probably greatest in children and adults treated for muscle spasms, particularly
in those patients who have underlying medical conditions that could make these symptoms more likely.
13

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

What to expect with Dysport
A step-by-step guide to your treatment†

2

The Dysport treatment
Effective treatment requires 1 injection into each
of 5 points between and over the eyebrows.
Although office visit times may vary, the procedure
generally takes 10 to 20 minutes. Your healthcare
professional will determine the exact placement of
each injection to get results that are right for you.

IMPORTANT SAFETY INFORMATION
The toxic effects have been reported at doses similar to those used to treat muscle spasms in
the neck. Lower doses, in both approved and unapproved uses, have also caused toxic effects.
This includes treatment of children and adults for muscle spasms.
These effects could make it unsafe for you to drive a car, operate machinery, or do other
dangerous activities.
Do not have Dysport treatment if you: are allergic to Dysport or any of its ingredients (see the end
of the Medication Guide for a list of ingredients), are allergic to cow’s milk protein, had an allergic
reaction to any other botulinum toxin product, such as Myobloc® or Botox,® or have a skin infection at
the planned injection site.
14

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

What to expect with Dysport
A step-by-step guide to your treatment†

3

After your Dysport treatment
Ask your doctor about any precautions you
should take after your treatment. Call your doctor
or get medical help right away if you have any
problems swallowing, speaking, or breathing.
If this happens, do not drive a car, operate
machinery, or do other dangerous activities.

IMPORTANT SAFETY INFORMATION
The dose of Dysport is not the same as the dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to the dose of any other botulinum toxin
product you may have used.
Dysport may not be right for you if: you have surgical changes to your face, very weak
muscles in the treatment area, your face looks very different from side to side, the injection
site is inflamed, you have droopy eyelids or sagging eyelid folds, deep facial scars, thick oily
skin, or if your wrinkles can’t be smoothed by spreading them apart.
15

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

What to expect with Dysport
A step-by-step guide to your treatment†

4

Follow up
To maintain your improvements, you should
discuss a treatment schedule with your doctor.
As with any botulinum toxin product, you should
wait at least 90 days between treatments.

IMPORTANT SAFETY INFORMATION
Tell your doctor about all your medical conditions, including if you have: a disease that
affects your muscles and nerves (suchas amyotrophic lateral sclerosis [ALS or Lou Gehrig’s
disease], myasthenia gravis, or Lambert-Eaton syndrome), allergies to any botulinum toxin
product or had any side effect from any botulinum toxin product in the past, a breathing problem
(such as asthma or emphysema), swallowing problems, bleeding problems, diabetes, a slow
heart beat or other problem with your heart rate or rhythm, plans to have surgery, had surgery on
your face, weakness of your forehead muscles (such as trouble raising your eyebrows), drooping
eyelids, or any other change in the way your face normally looks. Patients with a disease that
affects muscles and nerves who are treated with typical doses of Dysport may have a higher risk
of serious side effects, including severe swallowing and breathing problems.
16

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

† Although the experience
described is typical, the
general routine at your
doctor’s office may differ,
and individual results
may vary.

Why not start the Dysport
discussion with your doctor today?
Questions to ask your doctor:
• How soon will I see treatment results?
• How long does one treatment last?
• How often can I receive a Dysport treatment?
• Is there any way to save money on
my treatment?
• Can I have a treatment today?
• What are the risks associated with treatment?
IMPORTANT SAFETY INFORMATION
Human Albumin
This product contains albumin taken from human plasma. Steps taken during donor screening and product
manufacturing processes make the risk of spreading viral diseases extremely rare. In theory, there is also an
extremely rare risk of contracting Creutzfeldt-Jakob disease (CJD). No cases of spread of viral diseases or CJD
have ever been reported for albumin.
17

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.

Important Safety Information

What is the most important information you
should know about Dysport
(abobotulinumtoxinA) 300 Units for Injection?
Spread of Toxin Effects: In some cases, the
effects of Dysport and all botulinum toxin
products may affect areas of the body away
from the injection site. These effects can
cause symptoms of a serious condition called
botulism. Symptoms of botulism can happen
hours to weeks after injection and may
include swallowing and breathing problems,
loss of strength and muscle weakness all over
the body, double vision, blurred vision and
drooping eyelids, hoarseness or change or
loss of voice, trouble saying words clearly, or
loss of bladder control. Swallowing and
breathing problems can be life threatening
and there have been reports of death.

18

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

The risk of symptoms is probably greatest in
children and adults treated for muscle spasms,
particularly in those patients who have
underlying medical conditions that could make
these symptoms more likely.
The toxic effects have been reported at doses
similar to those used to treat muscle spasms in
the neck. Lower doses, in both approved and
unapproved uses, have also caused toxic
effects. This includes treatment of children and
adults for muscle spasms.
These effects could make it unsafe for you to
drive a car, operate machinery, or do other
dangerous activities.
Do not have Dysport treatment if you: are allergic
to Dysport or any of its ingredients (see the end of
the Medication Guide for a list of ingredients), are
allergic to cow’s milk protein, had an allergic
reaction to any other botulinum toxin product, such
as Myobloc® or Botox,® or have a skin infection at
the planned injection site.

Important Safety Information (cont.)

The dose of Dysport is not the same as the
dose of any other botulinum toxin product.
The dose of Dysport cannot be compared to
the dose of any other botulinum toxin product
you may have used.
Dysport may not be right for you if: you have
surgical changes to your face, very weak muscles
in the treatment area, your face looks very
different from side to side, the injection site is
inflamed, you have droopy eyelids or sagging
eyelid folds, deep facial scars, thick oily skin, or if
your wrinkles can’t be smoothed by spreading
them apart.
Tell your doctor about all your medical
conditions, including if you have: a disease
that affects your muscles and nerves (such as
amyotrophic lateral sclerosis [ALS or Lou
Gehrig’s disease], myasthenia gravis, or LambertEaton syndrome), allergies to any botulinum toxin
product or had any side effect from any

19

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

botulinum toxin product in the past, a breathing
problem (such as asthma or emphysema),
swallowing problems, bleeding problems, diabetes,
a slow heart beat or other problem with your heart
rate or rhythm, plans to have surgery, had surgery
on your face, weakness of your forehead muscles
(such as trouble raising your eyebrows), drooping
eyelids, or any other change in the way your face
normally looks. Patients with a disease that affects
muscles and nerves who are treated with typical
doses of Dysport may have a higher risk of serious
side effects, including severe swallowing and
breathing problems.
Human Albumin
This product contains albumin taken from human
plasma. Steps taken during donor screening and
product manufacturing processes make the risk of
spreading viral diseases extremely rare. In theory,
there is also an extremely rare risk of contracting
Creutzfeldt-Jakob disease (CJD). No cases of
spread of viral diseases or CJD have ever been
reported for albumin.

Important Safety Information (cont.)

Allergic Reaction to Injecting in the Skin
It is not known if an allergic reaction can be
caused by injecting Dysport into the skin. The
safety of treating excessive sweating with Dysport
is not known.
Common Side Effects
The most common side effects are nose and
throat irritation, headache, injection site pain,
injection site skin reaction, upper respiratory tract
infection, eyelid swelling, eyelid drooping, sinus
inflammation, and nausea.
Tell your doctor about all the medicines you
take, including prescription and nonprescription
medicines, vitamins and herbal and other natural
products. Using Dysport with certain other
medicines may cause serious side effects.

20

PLEASE SEE MEDICATION GUIDE ON SLIDES 21–32.

Do not start any new medicines while taking
Dysport without talking to your doctor first.

Especially tell your doctor if you: have received
any other botulinum toxin product in the last four
months, have received injections of botulinum toxin,
such as Myobloc® (rimabotulinumtoxinB) or Botox®
(onabotulinumtoxinA) in the past (be sure your
doctor knows exactly which product you received),
have recently received an antibiotic by injection,
take muscle relaxants, take an allergy or cold
medicine, or take a sleep medicine.
Use In Specific Populations
Dysport should not be used in children or in women
who are pregnant or breastfeeding.
Ask your doctor if Dysport is right for you.

Medication Guide

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PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

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PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

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PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

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PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

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PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

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PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

27

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

28

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

29

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

30

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

31

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medication Guide (cont.)

32

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON SLIDES 18–20.

Medicis Family
of Aesthetic Products

Products are not FDA approved for combination use.

www.DysportUSA.com

PLEASE SEE IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING
ON SLIDES 18–20, AND MEDICATION GUIDE ON SLIDES 21–32.
33

The Dysport trademark is used under license. Restylane is a registered trademark of HA North American Sales AB. All other trademarks
are the property of their respective owners. DSP 11-060 10/31/12