Transcript Catalogue_biotherapy_2014_08

Product Guide
Biotherapy
2014-2015
As a French company with an international dimension, Macopharma
has become one of the leaders in the field of Transfusion
medicine.
Our products are used in more than 70 countries. Within the last
three decades, we have become one of the largest suppliers
of blood bags and in-line systems for leucodepletion worldwide.
We are now focusing on developing innovative concepts
to support the processes involved in transfusion medicine,
such as pathogen reduction technologies, prion removal
and automation...
Thanks to our customers and to the creativity of our R&D and
Marketing teams, we have created a new « Biotherapy » division
in order to speed up our development, to be more innovative while
offering the best products and services to our customers in cell/tissue therapy, regenerative
medicine and transplant.
To our existing customers, we hope that this new 2014 catalogue will provide a useful
overview of what Macopharma has to offer. To our new customers, we sincerely hope
that you will enjoy reading this document and that you will find exciting products for your
specific applications in Biotherapy.
Ronald de Lagrange-Chancel, CEO
p°1
MACOPHARMA - BIOTHERAPY
As Transfusion medicine evolves towards new cell therapies, Macopharma has also started to
diversify into biotherapies and has developed a wide range of products to assist its customers
in the fields of cell & tissue therapy, regenerative
medicine and transplant.
Thus, the Biotherapy range of products
provides solutions for every step of
the cellular therapy process from
the collection, processing and
expansion of stem cells, to the
treatment and transplant
of cells or organs to patients:
. Cord Blood: Devices and
bags for collection, processing,
freezing and expansion of cord
blood Hematopoietic stem
cells.
. Bio Banking: Medical devices for
for cell & tissue transport and
storage at very low temperatures.
. Cell culture: Innovative closed
systems and media for expansion
& preservation of stem cells in GMP
conditions for clinical application.
. Photopheresis: Flexible process to efficiently
treat patients with the Macopharma ECP
technique: THERAFLEX-ECP. . Transplant: Solution and medical devices to optimize organ retrieval,
preservation and transplantation.
* Macopharma products that are available in the USA are identified with an asterisk.
p°2
TABLE OF CONTENTS
> Welcome from the CEO......................................................................................p°1
> Introduction on Biotherapy at Macopharma..............................................p°2
>Cord Blood................................................................................................................p°4
Collection
Processing
Freezing
Expansion/preservation
>Bio Banking................................................................................................................p°18
Tissues
Cells
Equipments
>Cell Culture...............................................................................................................p°31
Mesenchymal stem cells
Hematopoietic stem cells
Pancreatic islets
>Photopheresis...........................................................................................................p°49
Theraflex-ECP
>Transplant .................................................................................................................p°51
>Transfer sets..............................................................................................................p°54
p°3
CORD BLOOD
Macopharma offers a complete range
to save cord blood cells, with an
efficient process to achieve an
optimal collection volume and
maximise cell recovery.
Today, most
Netcord accredited bank
members use
Macopharma’s systems to
collect cord blood.
Macopharma remains a
privileged partner for all your leading
developments, from the collection to
the expansion of Cord Blood.
These products are designed to enter the
operating theatre and provide the user with
a high quality product with optimal
performance.
p°4
MACOPHARMA
CORD BLOOD COLLECTION
Preventing needlestick
injuries with a needle
guard on each line
One-way pemanent clamp
to secure the collection unit
at the end of collection
Making sampling easier
with an integrated
injection site
Ensuring optimal collection
with a double-needle system
(12-gauge needle)
and back-eye needles*
Increasing cell recovery
with an in-line
rinsing pouch
* See focus next page
p°5
MACOPHARMA’S CORD BLOOD COLLECTION
BAGS: STEAM STERILISATION,
A UNIQUE FEATURE ON THE MARKET!
Due to the increase of cord blood collection during caesarean deliveries, cord blood collection
kits must be sterilised in order to enter operating theatres.
Macopharma ‘s collection bags undergo steam sterilisation, providing them with a unique
feature on the collection kit market, responding to a large need from both public and private
cord blood banks.
The packaged cord blood collection
bag undergoes steam sterilisation and
is then overwrapped (2) in Class 10
000. The overwrapped collection kit is
then pasteurised, to ensure minimal
contamination on the outside of the
inner package (1).
For safety reasons, and to bring the best
product quality to our customers, a
visual system has been implemented to
check sterilisation. A patch on the bag
enables a quick and easy look at the
sterilisation status of the bag. This patch
changes colour when sterilisation has
been performed.
2
Quarantine, delivery
in a non sterile
environment
3
Before sterilisation, the patch
is pink.
1
After sterilisation, the
patch is black.
Non sterile
Packagedin
Class 10 000 and
pasteurised
Sterile
p°6
CORD BLOOD
COLLECTION
For vaginal births
Cord blood collection bag - Ref. MSC1201DU
Specifications
30 cm
70 cm
50 cm
Collection
volume
Anticoagulant
solution
Needle size
Additional
features
Collection
Shelf life
Up to
200 mL
21 mL CPD +
8 mL CPD
(rinsing bag)
12 G
Protection
sachet
2 needles
1 year
30 cm
Cord blood collection bag - Ref. MSC1202PU
Specifications
27 cm
Collection
volume
Up to
200 mL
Anticoagulant
solution
21 mL CPD +
8 mL CPD
(rinsing bag)
Needle size
12 G
Additional
features
Protection
sachet
Vacuvam
for sampling
Collection
5 cm
Shelf life
120 cm
27 cm
2 needles
1 year
p°7
CORD BLOOD
COLLECTION
For vaginal births and caesarean section deliveries
Cord blood collection bag - Ref. MSC1205DU
Specifications
27 cm
5 cm
Collection
volume
Anticoagulant
solution
Up to
200 mL
21 mL CPD +
8 mL CPD
(rinsing bag)
120 cm
27 cm
Needle size
Additional
features
Collection
Shelf life
12 G
Suitable for
caesarean
section
deliveries
2 needles
1 year
Cord blood collection bag - Ref. MSC1206DU
Specifications
p°8
Collection
volume
Anticoagulant
solution
Up to
200 mL
21 mL CPD +
8 mL CPD
(rinsing bag)
30 cm
Needle size
Additional
features
Collection
Shelf life
12 G
Suitable for
caesarean
section
deliveries
1 needle
1 year
120 cm
CORD BLOOD
Collection
,
information
For additional
brochure
see our
Equipment
DOCON - Ref. 9DCN000
State of the art intuitive Cord Blood Collection mixer
Suitable for cord blood collection
Specifications
Dimensions
Weight
Options
205 x 460 x 215 mm (width x
depth x height)
3.3 kg (without
batteries)
9DCN200: Docon battery pack
9MSC10014596: Macoscan QSI
9DCN420: Transport case
p°9
CORD BLOOD
Collection & Processing
Top&Bottom technique
Cord blood collection and T&B volume reduction bag - Ref. MQT2205PU
Specifications
5 cm
50 cm
120 cm
65 cm
Collection
volume
Anticoagulant
solution
Needle size
Additional
features
Collection
Shelf life
Up to
250 mL
21 mL CPD +
8 mL CPD
(rinsing bag)
12 G
Protection
sachet
2 needles
1 year
27 cm
35 cm
p°10
CORD BLOOD
Processing
Top&Bottom technique
T&B volume reduction bag - Ref. VRT0000XU
Specifications
Fill collection
Connections
Shelf life
Up to
250 mL
1 spike
1 pigtail for sterile docking
5 years
50 cm
30 cm
35 cm
65 cm
p°11
CORD BLOOD
PROCESSING
Top&Top technique
Volume reduction bag - Ref. VDC1002XU
Specifications
Fill collection
Connections
Shelf life
Up to
200 mL
1 spike
1 female luer
2 injection sites
5 years
Volume reduction bag - Ref. VDC1001XU
Specifications
p°12
Fill collection
Connections
Shelf life
Up to
200 mL
1 spike
1 female luer
1 male luer
5 years
CORD BLOOD
Processing
,
information
brochure
For additional
dedicated
our
see
Equipment
Macopress® Smart (MPS)
Automatic Cord Blood separator
According to the type of communication
Ref. 9MPSBRLAN - 9MPSBRWIFI - 9MPSBR485
Specifications
Reference
Features
Accessories
9MPSBRLAN
9MPSBRWIFI
9MPSBR485
4 integrated balances
Lateral press
Electronic motion
DMS+ bi-directional communication
Additional external balance: 9MPS040
Additional sealing handle: 9MPS050
Barcode reader
Maco Scan QS i: 9MSC10014596
or 9MSC10014621(with support)
or 9MSC10014493 (Macoscan mobile+base)
p°13
CORD BLOOD
Processing
Accessories
Foam bags for centrifugation of cord blood bags - Ref. H97IMC systems
Specifications
p°14
Product code
Dimensions
Material
H97IMC01
Length: 160 mm
Width: 90 mm
Thickness: 10 mm
Standard PVC
H97IMC02
Length: 140 mm
Width: 90 mm
Thickness: 10 mm
Standard PVC
CORD BLOOD
FREEZING
3D Mini and Overwrap
EVA cell freezing and storage bag - Ref. GSR0501AU
Specifications
Product
code
Freezing
volume
Dimensions
Temperature
width (mm) Thickness Connections
range
Shelf life
length (mm)
for storage
25 mL
57 mm
GSR0501AU A : 20 mL +/- 2x86 mm 0.5 mm
B : 5 mL
+/- 3
A
1 spike
1 male luer
2 needleless
access ports
-196°C
to +40°C
5 years
B
Com
ing so
on
EVA overwrap for cell freezing bag GSR0501AU - Ref. GSR0010AU
Dimensions
Thickness
Suitable with cell
freezing bag
Shelf life
GSR0010AU
See drawing
0.35 mm
GSR0501AU
5 years
100
Product
code
69
Specifications
Storage temperature: Down to -196°C
89
p°15
CORD BLOOD
EXPANSION
Hematopoietic stem cells Media
HP01 in EVA bag and in bottle - Ref. BC0100030
Specifications
Volume of
medium
Use
Storage
Temperature
1000 mL
GMP
PRODUCT
for clinical
applications
Between
2°C and 8°C
PRESERVATION
HP02 in bottle
Product
p°16
available
on demand
Shelf life
Connections
12 months
1 female luer
1 injection site
1 male luer
1 twist off
Bio Banking
Over 20 years ago Macopharma developed
EVA freezing bags suitable for cell
cryopreservation at very low temperatures.
Made of EVA (Ethyl Vinyl Acetate),
these freezing bags are designed
to tolerate long term storage at
temperatures down to -196°C (the
condensation point of nitrogen),
facilitating optimal storage of
cells and tissues. Both bag and
connection have been designed to
match users’ needs.
In addition to this, our range of products
has been enlarged to encompass
storage pots and aluminium bags for tissue
collection, transportation and storage to
provide users with a broad choice depending
on their internal procedures.
p°17
Bio Banking:
Tissues
p°18
Bio Banking
Tissue banking
Processing and cryopreservation
Pots for tissue collection, transport and freezing - Ref. CDR systems
Specifications
Product
code
Volume (mL)
Diameter (mm)
Internal / External
Height
Optical specifications
Internal
External
Internal
External
Internal
External
Internal
External
CDR1000AU
40
80
34.8/41.4
48.6/55.4
53.5
59.1
Transparent
Transparent
CDR1005AU
40
34.8/41.4
53.5
Transparent
CDR2005AU
80
48.6/55.4
59.1
Transparent
CDR7000AU
250
500
72/80.2
86.5/95.2
81.5
105.3
Transparent
Transparent
CDR8000AU
500
1000
86.5/95.2
108.7/118.2
105.3
123.8
Transparent
White
Shelf life
4 years
p°19
Bio Banking
Freez
ing h
old
Com
ing so er
on
Tissue banking
EVA freezing bag
EVA bags for tissue freezing - Ref. GSR systems
Specifications
Product
code
Width (mm)
Length (mm)
Connections
Shelf life
GSR7002AU
ext=150
274
1 male luer - 1 spike
2 needleless access ports
5 years
Connections
Shelf life
Specifications
Product
code
Width (mm)
Length (mm)
GSR5020AU
int=140
ext=150
318
GSR7010AU
int=160
ext=170
318
5 years
GSR7010AU could also be used as an overwrap for the GSR7002AU
p°20
Bio banking
Tissue banking
Large
b
Com one bag
ing so
s
on
Aluminium bags
Aluminium bags for tissue freezing - Ref. XSR systems
Specifications
Product code
Length (mm)
Width (mm)
XSR1010ZU
120
155
XSR2010ZU
180
220
XSR3010ZU
210
305
Additional
specifications
Shelf life
5 interpolated sheets
5 years
Products are double overwrapped in peelable sachets.
p°21
Bio Banking
Tissue banking
Solutions
Vascular graft SCOT30 solution for storage (+4°C) and cryopreservation
(-80°C or -150°C) – Ref. BF0200060
Specifications
Storage
Temperature of preservation in its overwrap:
between 2°C and 25°C. It must be stored
for at least 24 hours before use between
3°C and 5°C.
AMM PTA N°: TA 07.05.69
Produit Thérapeutique Annexe (PTA)
Marketing Authorisation in France
p°22
Volume
Material
Shelf life
350 mL
Flexible EVA bag
protected by a
polyethylene/
polyethylene
terephthalate
overwrap
12 months
Bio Banking:
Cells
Connector
Outlet ports
Needleless
access port
(NAC)
Overwrap
Needleless
access port
(NAC)
Male luer
EVA
Freezing
bag
Spike
Label
Labelling
window
p°23
Bio Banking
CELL BANKING
EVA freezing bags
EVA cell freezing and storage bag - Ref. GSR systems
Specifications
Product code
Recommended
Nominal volume
Freezing
(mL)
volume (mL)
Total length*
(mm)
External width
(mm)
GSR1000AU
10-30
110
230
75
GSR2001AU
30-70
215
180
130
GSR5001AU
60-100
400
225
130
GSR7000AU
100-180
820
274
150
GSR7001AU
80-150
570
256
130
GSR8000AU
140-280
1920
431
150
GSR8001AU
120-250
940
313
130
Connections
Shelf life
1 spike
1 male luer
2 needleless
access ports
5 years
Storage temperature: Down to -196°C
*with the outlet ports
Freez
ing
comi cassette
ng so
s
on
p°24
Bio Banking
CELL BANKING
EVA Overwraps
Ref. GSR systems - EVA overwraps for cell freezing bags
Specifications
Product code
Width (mm)
Length (mm)
Suitable with cell freezing bag
Shelf life
GSR5020AU
int=140
ext=150
318
GSR2001AU
GSR5001AU
GSR7001AU
5 years
GSR7010AU
int=160
ext=170
318
Storage temperature: Down to -196°C
p°25
GSR7001AU
BIO BANKING
CELL BANKING
Cord Blood Freezing
EVA cell freezing and storage bags - Ref. GDR1000AK
Specifications
Recommended
Freezing volume (mL)
2x (10-30 mL)
Length
(mm)
230
Width
(mm)
Connections
Shelf life
75
3 female luers
1 injection site
(latex free)
2 clamps
5 years
Storage temperature: Down to -196°C
p°26
bio banking
ACCESSORIES
For cell processing and manipulation
Cardboard boxes - Ref. H01FCB systems
Specifications
Dimensions
Suitable for
Included
H01FCB01
Length: 280 mm
Width: 155 mm
Thickness: 25mm
GSR5001AU
GSR7000AU
GSR7001AU
GSR7002AU
- 2 compartments to contain 2 sampling cryotubes
- 2 identification windows for the control of freezing
bag labels
H01FCB02
Length: 471 mm
Width: 152 mm
Thickness: 17 mm
GSR8000AU
/
H01FCB03
Length: 276 mm
Width: 155 mm
Thickness: 22mm
GSR2001AU
GSR5001AU
- 2 compartments to contain 2 sampling cryotubes
- 4 identification windows for the control of freezing bag
labels
Sampling coupler
Ref. EPE1016AU
Sampling coupler with needleless access
Ref. EPE2000AU
Specifications
Specifications
Connections
p°27
Reference
spike - female luer - injection site
Connections
spike + needleless access port
equipmentS
SEALER
Thermal impulse sealer for EVA or Aluminium bags for cell and tissue freezing
Ref. 9HPL4500
Specifications
Dimensions
& weight
520 (L) x 300
(W) x 220 (H)
18 kg
Cutting length
Seal
width
Sealing features
. Thermal impulse
via 2 heated jaws
360 mm
. Seal triggering:
(integrated
3 mm
cutting device)
Electrical foot (pad,
electromagnetic
closure)
Option:
9HPL4501
Bench-adaptable table
in front of sealing jaws to
maintain the Freezing
EVA bags at the correct
height during sealing
Adapted table: 9HPL4501
p°28
EQUIPMENTS
SEALER
Ref. 9MSL3622 - Macoseal TWIN EVA Mini 3D
Superior high frequency sealer for EVA tubes and EVA cell freezing and storage bag
Specifications
Generator
dimensions
232 mm x
91 mm x 91 mm
(L x W x H)
Generator
weight
Hand sealer
2.1 kg
Weight: 0.32 kg
Dimensions:
200 mm x 28 mm
(L x W)
Tubes diameter
EVA Tube 1: 3.9 mm (inner) – 5.4 mm (outer) /
separation with decontaminated scissors
EVA Tube 2: 2.95 mm (inner) – 4.15 mm (outer) /
separation with decontaminated scissors
Option
Reference 9MSL3630, Additional PVC
hand sealer (PVC tube: from 2.5 to 5 mm,
max 0.75 mm wall thickness)
Possible to connect 2 hand sealers:
The top port on the generator is dedicated to sealing EVA tubes (without precut) and Mini 3D bag with a specific EVA hand sealer. A
second hand sealer for PVC tubes can be added.
Ref. 9MSL3621 - Macoseal TWIN EVA
Superior high frequency sealer for EVA tubes
Specifications
Generator
dimensions
232 mm x 91
mm x 91 mm
(L x W x H)
p°29
Generator
weight
Hand sealer
Tubes diameter
2.1 kg
Weight: 0.32 kg
Dimensions:
200 mm x 28 mm
(L x W)
EVA Tube 1: 3.9 mm (inner) 5.4 mm (outer) /
separation with decontaminated scissors
EVA Tube 2: 2.95 mm (inner) – 4.15 mm (outer)
PVC from 2.5 to 5 mm, max 0.75 mm wall thickness
Superior high frequency generator with one hand sealer for EVA tubes (with precut) and an additional
hand sealer for PVC tubes in option.
Option
Additional PVC handle:
9MSL3630
CELL CULTURE
Bruno Delorme obtained his PhD in cellular and molecular biology in 1997.
Bruno acquired a strong background in the field of stem cell biology and tissue regeneration.
He completed a post-doctoral placement in the field of skeletal muscle differentiation and
regeneration before joining the INSERM to work on human blood circulating endothelial
progenitor cells and their potential application for ischemic pathologies; he then focused
on the use of human bone marrow’s mesenchymal stem cells for connective tissue
disorders.
MacoPharma Biotherapy.
Bruno Delorme, PhD.
R&D Biotherapy Director.
He gained a strong experience in project coordination and published scientific
papers on adult stem cell research in peer-reviewed journals.
Today, Bruno Delorme is the R&D Biotherapy Director at Maco Productions’
SAS Laboratory, where he is managing the development of scientific research
projects for innovative technologies, as well as the dissemination of scientific
publications and communications and being in charge of academic partnerships.
Macopharma’s Biotherapy division is specialised in cell therapy and tissue engineering.
Working in collaboration with cell therapy centres, biobanks, research teams and hospitals, we
have developed a whole range of disposables and media for stem cell collection, processing
and expansion. To cope with this challenge we developed a secure cell culture concept
with clinical grade serum-free and xeno-free culture media dedicated to specific stem cell
populations (such as hematopoietic and mesenchymal stem cells) and easy to manipulate
closed systems.
We also developed innovative solutions and medical devices for the preservation of cells, tissues
and organs before transplantation. These products enhance safety, traceability and standardisation
for stem cell research and clinical applications.
We also provide technology for extracorporeal photochemotherapy (THERAFLEX-ECP), a cell therapy technique designed
to induce a modulation of the immune response and especially for the treatment of skin lymphomas.
p°30
MESENCHYMAL STEM CELLS
MC3 System: Macopharma Closed Cell Culture system
Macopharma and Corning Life Sciences are working together to provide their customers with the MC3 system, a unique solution adapted to each step of adherent stem cell
culture in closed system.
Cell Seeding
Medium Exchange
Cell Harvesting
. Large surface of culture with Corning®
CellSTACK® (636 cm² to 3180 cm²)
. Closed system decreasing
contamination risks
. Reduced handling
time
. Products equipped with
needleless access
ports
. Adapted to each step of
adherent cell culture
. Single use products to
ensure product quality
and safety
. Ready and easy to use
. Adapted medium and
buffer bags
p°31
CELL CULTURE
MESENCHYMAL STEM CELLS
MC3 system: Seeding
Seeding kit - Ref. BC0400011
Specifications
Connections
1 MPC connector
2 needleless access ports
1 spike
p°32
CELL CULTURE
MESENCHYMAL STEM CELLS
MC3 system: Seeding packages
Seeding packages with CellSTACK®
Specifications
Seeding kit BC0400011
+
Ref
Included items
Cell culture
surface
BC0600011
1 kit BC0400011
1 CORNING® CellSTACK®
1 chamber
1 MPC connector
636 cm2
1 kit BC0400011
2 CORNING® CellSTACK®
1 chamber
2 MPC connectors
2 x 636 cm2
1 kit BC0400011
1 CORNING® CellSTACK®
2 chambers
1 MPC connector
1272 cm2
1 kit BC0400011
1 CORNING® CellSTACK®
5 chambers
1 MPC connector
3180 cm2
BC0600021
BC0600031
MPC connector
+
BC0600041
p°33
CORNING® CellSTACK®
CORNING® CellSTACK®
one chamber
CORNING® CellSTACK®
one chamber
CORNING® CellSTACK®
two chambers
CORNING® CellSTACK®
five chambers
CELL CULTURE
MESENCHYMAL STEM CELLS
MC3 system: Medium exchange
Medium exchange kits
Specifications
Ref
Volume
Use with:
BC0400021
500 mL
CORNING® CellSTACK®
1 or 2 chambers
BC0400041
1000 mL
CORNING® CellSTACK®
5 chambers
Connections
1 MPC connector
1 needleless
access port
1 spike
p°34
CELL CULTURE
MESENCHYMAL STEM CELLS
MC3 system: Medium exchange packages
Medium exchange packages with MPC connectors
Specifications
Ref
Included items
BC0601011
1 kit BC0400021 (500 mL)
1 MPC connector
BC0601021
1 kit BC0400021 (500 mL)
2 MPC connectors
BC0601031
1 kit BC0400041 (1000 mL)
1 MPC connector
+
p°35
CELL CULTURE
MESENCHYMAL STEM CELLS
MC3 system: Harvesting
Harvesting kits
Specifications
Ref
Volume
Use with:
Connections
CORNING® CellSTACK®
1 MPC connector
1 or 2 chambers
3 needleless
access ports
CORNING® CellSTACK®
1 spike
BC0400051 1000 mL
5 chambers
BC0400031
500 mL
p°36
CELL CULTURE
MESENCHYMAL STEM CELLS
MC3 system: Harvesting packages
Harvesting packages with MPC connectors
Specifications
+
p°37
Ref
Use with:
BC0602011
1 kit BC0400031 (500 mL)
1 MPC connector
BC0602021
1 kit BC0400031 (500 mL)
2 MPC connectors
BC0602031
1 kit BC0400051 (1000 mL)
1 MPC connector
CELL CULTURE
MESENCHYMAL STEM CELLS
MC3 system: Media
MEM alpha medium in EVA bag
Specifications
Ref
Volume
BC0110010
270 mL
CellSTACK®
one or two chambers
BC0110020
675 mL
CellSTACK®
five chambers
1L
connections
1 female luer / 1 male
luer / 1 twist-off, 1 injection site
BC0110021
Use with:
GMP
PRODUCT
for clinical
applications
Storage
Temperature
Shelf life
Between
2°C and 8°C
12 months
Connections: 2 outlet ports
DMEM medium in EVA bag
Specifications
Ref
Volume
Use with:
CellSTACK®
BC0110060 240 mL
one or two chambers
Storage
Temperature
Shelf life
GMP
PRODUCT
Between
for clinical 2°C and 8°C
applications
8 months
p°38
CELL CULTURE
MESENCHYMAL STEM CELLS
MC3 system: Buffer
Phosphate Buffered Saline solution (PBS) in EVA bag
Specifications
Ref
Volume
BC0120020
400 mL
CellSTACK®
one or two chambers
1L
CellSTACK
five chambers
BC0120030
p°39
Use with:
®
Connections
GMP
PRODUCT
for clinical
applications
Storage
Temperature
Shelf life
Between
2°C and 25°C
12 months
2 outlet ports
1 female luer
1 injection site
1 male luer
1 twist off
CELL CULTURE
MESENCHYMAL STEM CELLS
MC3 system: Transfer bags
Transfer EVA bags
Specifications
Ref
Volume
BC0300011
150 mL
BC0300021
350 mL
BC0300031
500 mL
BC0300041
1000 mL
Ref BC0300041
Connections
2 twist off
1spike
1 needleless
access port
1 injection site
1 male luer
Ref BC0300031
Ref BC0300021
Ref BC0300011
p°40
CELL CULTURE
MESENCHYMAL STEM CELLS
Platelet lysate preparation kit
Macopharma has developed in collaboration with a French blood centre a system dedicated to
the preparation of platelet lysate in 3 steps.
STEP 1
STEP 2
Freezing and
Centrifugation
Ref. BC0800010
Filtration
STEP 3
Distribution
Ref. GNR1000AU
Ref. GSR5050AU
Specifications
Ref
p°41
Volume
GSR5050AU
500 mL
Ref
Volume
BC0800010
500 mL
Ref
Bags
GNR1000AU
9 EVA
bags
Temperature
of storage
Connections
Shelf life
1 spike
1 male luer
-80°C to +40°C
1 outlet
1 injection site
1 needleless access port
Filtration
Connections
Porosity of the Sterile connection
filter: 0.65 µm
1 spike
Volume
Temperature
of storage
10 mL to 30 mL -80°C to +40°C
per bag
Shelf life
1 year
Shelf life
5 years
2 years
. Ready and easy to use
. Closed system decreasing
contamination risks
. Adapted to GMP production
. Cost effective technique
Cell culture
MESENCHYMAL STEM CELLS
Bone Marrow collection
For collection and transfer in the operating theatre
Bone marrow transfer / collection bag - Ref. MSE0100Q
Specifications
35 cm
Volume of
collection
Anticoagulant
solution
Connection
Shelf life
Up to
450 mL
50 mL ACD
Female luer
1 year
Bone marrow transfer / collection bag - Ref. VSE6002Q
Specifications
Fill
collection
Connection
Shelf life
Up to
1000 mL
Female luer
5 years
30 cm
p°42
Cell culture
MESENCHYMAL STEM CELLS
Bone Marrow collection
For collection and transfer in the operating theatre
Bone marrow container / collection bag - Ref. MSM0000XU
Specifications
p°43
Volume
of collection
Connections
Shelf life
Up to 40 mL
2 female luers
1 male luer
1 one-way permanent
clamp
5 years
CELL CULTURE
HEMATOPOIETIC STEM CELLS
Media
HP01 in bottle - Ref. BC0100010
Specifications
Volume of
medium
500 mL
Packaging
Use
Storage
Temperature
Shelf life
PET bottle
GMP
PRODUCT
for clinical
applications
Between
2°C and 8°C
12 months
HP01 in EVA bag - Ref. BC0100030
Specifications
Volume of
medium
Use
Storage
Temperature
Shelf life
Connections
1000 mL
GMP
PRODUCT
for clinical
applications
Between
2°C and 8°C
12 months
1 female luer
1 injection site
1 male luer
1 twist off
p°44
CELL CULTURE
CO-CULTURE BAG
New generation of culture bag
Co-Culture bag - Ref. BC0900010
Specifications
Volume
2 compartments
Top : 400 mL for medium
Bottom : 20 mL for cells
Discontinuous welding for
exchanges
. 3D Bag
. GMP product
. Closed system
. User friendly
p°45
CELL CULTURE
COMING SOON IN 2014
NEW
!
CELL CULTURE: PANCREATIC ISLETS
PRISM SYSTEM
PRISMd
Device to work
in a closed system
and to improve
pancreatic
islet preservation
PRISMa
Automated system
designed to control
medium perfusion,
medium exchange
and islet harvesting
PRISMm
Defined and
ready-to-use medium
dedicated to islet
preservation
• Closed system with specific medical device
• Automated medium exchange
• Temperature control and oxygenation system
• Touch screen graphical user interface
• GMP medium for islet preservation
p°46
CELL CULTURE
PANCREATIC ISLETS
Media
PrisM in EVA bag Ref. BC0130020
Specifications
Volume of
medium
Use
Storage
Temperature
Shelf life
1500 mL
GMP
PRODUCT
for clinical
applications
Between
2°C and 8°C
8 months
PrisM in bottle
Specifications
Ref
Volume of
medium
BC0130030
500 mL
BC0130010
p°47
1000 mL
Packaging
Use
Storage
Temperature
Shelf life
PET bottle
GMP
PRODUCT
for clinical
applications
Between
2°C and 8°C
8 months
PHOTOPHERESIS
Extracorporeal Photochemotherapy (ECP) has been recognised by the scientific community as a therapeutic option to
treat various disorders, such as:
. Cutaneous T-cell lymphoma (Sezary syndrome)
. GVHD (acute and chronic)
. Organ transplant rejection
. Autoimmune disorders
Macopharma has developed a complete product range for the off-line treatment of ECP: THERAFLEX - ECP.
Theraflex ECP Procedure
Extracorporeal photochemotherapy
(ECP) is based on the exposure
of peripheral blood mononuclear
cells to the photosensitizing agent
(8-methoxypsoralen or 8-MOP) and
UVA illumination.
Mononuclear cells are harvested by
cytapheresis and reinfused to the
patient after cell illumination.
MNC collection
UVA illumination
+
+
8-MOP addition
p°48
PHOTOPHERESIS
THERAFLEX-ECP
Extracorporeal Photochemotherapy
UVA illumination EVA bag - Ref. XUV8501Q
Specifications
Nominal volume
Volume
Connections
Shelf Life
3L
300 mL
1 spike
1 injection site
5 years inside the
overwrap
8-MOP solution - Ref. CSL1800XA
Specifications
Volume
Composition
Chemical composition for 100 mL of solution:
5 mL
Produit Thérapeutique Annexe (PTA)
Marketing Authorisation in France
AMM PTA N°: TA 07.10.109
Methoxalen...............................................2 mg
Ethanol (96%)......................................3230 mg
Glacial acetic acid...............................230 mg
Sodium acetate thrihydrate...................860 mg
Sodium chloride......................................40 mg
Water for injections.................................100 mL
Macogenic G2 UVA illumination device - Ref. 9MG2000
Specifications
Dimensions
Included items
and options
Weight
87 cm (width)
x 64 cm (depth)
x 37 cm (height)
Printers, scanner,
LCD colour touch
screen
65 kg
p°49
TRANSPLANT
The current worldwide need to improve graft
performance after organ and tissue transplant
is still unmet.
In partnership with academic research teams in France,
Macopharma has developed organ preservation solutions
and medical devices designed to support transplant teams in
obtaining better patients’ outcomes.
Our preservation solutions contain innovative compounds
that minimise graft injury during transportation, storage
and preservation. Our ergonomic and sterile medical
devices are designed and adapted
to facilitate organ and tissue collection in
operating theatres.
p°50
TRANSPLANT
Organ conservation solution
SCOT 15 solution for abdominal multi-organs
Description
AMM PTA N°: TA 08.11.129
Storage
Extracellular-type solution
Temperature of preservation in its overwrap:
between 2°C and 25°C. It must be stored
between 3°C and 5°C for at least 24 hours
before use
Hypothermic infusion and preservation of organs
Colloid: Polyethylene glycol (PEG) 20 kD at 15 g/L
Produit Thérapeutique Annexe (PTA)
Marketing Authorisation in France
SCOT 15 Multi-organ abdominal in bottle - Ref. BT0200070
Specifications
Volume
Usage
Shelf life
1000 mL
Solution to infuse, preserve and transport
abdominal organs at low temperature
12 months
SCOT 15 Multi-organ abdominal in EVA bag - Ref. BT0200080
Specifications
Volume
Usage
Shelf life
1500 mL
Solution to infuse, preserve and transport
abdominal organs at low temperature
12 months
p°51
TRANSPLANT
Organ RETRIEVAL
Exsanguination line / bag for multi-organ retrieval - Ref. BT0700040
Specifications
p°52
Volume of use
Connections
15 L
Filling by gravity
Cannula with 2.5 m tubing
+ 1 clamp
transfert set*
* On-demand production
p°53
transfert set
SAMPLING SET
Sample collection (PVC)
Specifications
Reference
Volume
Language
VSE0000A
VSE0000Y
VSE0000YK
Shelf Life
Packaging
5 years
20
FR
FR
40 mL
EN
VSE0000YL
PT
Specifications
Reference
Volume
Language
Shelf life
VSE0001Y
100 mL
En
5 years
Packaging
20
p°54
transfert set
Simple Transfer Set
300 mL (PVC)
Specifications
Reference
Volume
Language
VSE2001L
PT - ISBT
VSE2001XA
VSE2001XL
PT - ISBT
VSE4001Q
VSE4001XA
VSE4001XB
Spike
VSE4001XP
VSE4002XB
Bung
VSE4101XR
VSE6003QS
VSE8000XL
Spike
VSE8001XL
VSE8001XQ
p°55
Female Luer
30
5 years
40
VSE2001XQ
EN - FR
60
VSE2001XR
IT - ISBT
40
Specifications
Composition
Packaging
40
FR
Spike
600 mL (PVC)
Reference
Shelf life
Language
Shelf life
(year)
Packaging
EN - FR
5
35
FR
5
30
EN
5
35
PL - ISBT
5
35
UNIVERSAL
5
35
IT - ISBT
5
30
ES
5
15
PT - ISBT
5
15
PT - ISBT
5
35
EN - FR - GER
- DUT
5
30
transfert set
Simple Transfer Set
1000 mL (PVC)
Specifications
Reference
Volume
Composition
Language
Shelf life
Packaging
VSE6001Q
1000 mL
Spike
EN-FR
5
35
VSE6041XA
1000 mL
Luer
FR
5
15
p°56
transfert set
Pooling Bag
Specifications
600 mL (PVC)
Reference
composition
Language
Shelf life
Packaging
VSE3010XD
6 bungs
EN
5
20
VSE4002XA
2 Spikes
FR
5
30
VSE4011A
6 bungs
FR
5
20
VSE4110XA
6 Spikes
FR
5
15
VSE8003XQ
8 Spikes
EN - FR - GER - DUT
5
15
VSE8004XB
6 bungs
EN
5
20
VSE8004XQ
6 bungs
EN - FR - ISBT
5
20
1000 mL and more (PVC)
Specifications
p°57
Reference
Volume
Composition
Language
Packaging
Shelf life
VSE6002XR
1000
2 Spikes
IT - ISBT
30
5
VSE6002Z
1000
2 Spikes
FR
25
5
VSE8001XB
1000
2 bungs
EN - ISBT
25
5
VSE8014xa
3000
4 spikes
FR
15
5
transfert set
Distribution set
Double set for distribution (PVC)
Specifications
Reference
Volume
Composition
Language
Packaging
VDE3011XA
400
Spike
FR
25
VDE4003XA
500
2 bungs
FR
25
Shelf life
5
1000 mL and more (PVC)
Specifications
Reference
Volume
VRE4001XA
500
VRE7000XQ
500
Composition
Spike
Language
Packaging
FR
20
FR
25
Shelf life
5
p°58
transfert set
Distribution set
Quadruple bags (PVC)
Specifications
Reference
Volume
Composition
Language
Packaging
VQE2001A
300
Spike
FR
15
VQE2001XQ
300
Spike
EN-FR
15
VQE6001XB
600
Bung
EN
20
VQL0001XC
150
Bung
FR
25
25
VQL0001XU
150
Bung
UNIVERSAL +
ISBT
VQX0001XU
150
Spike
FR
25
VQX0002XU
150
Spike
EN
15
VQX0003XU
100
Spike
EN
20
Sextuple set (PVC)
Specifications
p°59
Reference
Volume
Composition
Language
Packaging
VXX2001XB
300
Spike
EN
15
VXX6001XB
600
Bung
EN
15
VXX6002XB
600
Bung
EN
15
Shelf life
5
Shelf life
5
4
transfert set
Phlebotomy set
Collection volume : 600 mL (PVC)
Specifications
Reference
Language
Packaging
Shelf life
20
5
VSL7000PQ
VSL7000YQ
VSL7000YD
FR
VSL7001PQ
VSL7001PD
EN
p°60
transfert set
TRANSFER CONNECTIONS AND SYSTEMS
Specifications
Reference
Language
Packaging
EPE1017A
9S-1S
EN
20
EPE1018A
12 S - 1 L
FR
15
EFL0002XU
5S-1S
EN
30
Shelf life
5
Simple transfer set
Specifications
Reference
EPF0004C
1 N - 1S
Language
Packaging
GER
125
EPF0005A
1 N - 1S
FR
125
EPP0002A
1S-1S
FR
30
EFL0003XU
1S-1S
FR
300
EFL0006XD
1S-1L
EN
20
EFL0006XU
1S-1L
EN
20
Shelf life
5
3
Pooling Systems
Tubings
Collection Line
Specifications
Specifications
Reference
ESL0001GU
EFL0001DU
p°61
Language
EN
Packaging
300
500
Shelf life
5
Reference
Compostion
Language
EFL0000XC
20 m Tubing
GER
EFL0000XD
20 m Tubing
EN
10
5
FR
100
5
EFL0000Y
Packaging Shelf life
10
2
EFL0001XC
20 m Tubing
GER
10
2
EFL0007XU
12 m Tubing
EN
15
5
BIOTHERAPY
Maco Productions
200 Chaussée Fernand Forest
59200 Tourcoing
France
Tel : + 33 (0) 320 11 84 00
Maco Productions Polonia
Ul. Szwajcarska 22
54-405 Wroclaw
Polska
Tel : + 48 71 37 60 110
MACO MD (Tunisia)
Zone Industrielle de Chotrana
2056 Raoued, ARIANA
TUNISIA
Tel : + 216 70 946 233
Macopharma UK
8th Floor - Regal House
70 London Road
Twickenham - Middlesex
TW1 3QS
United Kingdom
Tel : + 44 (0) 20 8892 2922
Macopharma International
GmbH
Robert-Bosch-Strasse 11
D-63225 Langen
Germany
Tel : + 49 (0) 61 03 900 800
Macopharma BeNelux sprl
88, avenue Royale
B-7700 Mouscron
Belgium
Tel : + 32 (0) 56 84 12 86
Macopharma Nordic AB
Södra Strandvägen 4
252 24 Helsingborg
Sweden
Tel : + 46 (0) 42 176 340
Macopharma USA
3675 Crestwood Parkway,
#260 Duluth, GA 30096
USA
Tel : + 1 770 270 6867
Maco spania
Avenida de la Vega, 1
Edificio 3 - Planta 3
28108 Alcobendas, Madrid
Spain
Tel : + 34 91 521 48 56
Macopharma Italia
Galleria Gandhi, 2/A
20017 Rho MI, Milan
Italy
Tel : +39 02 93 909 531
Macopharma Australia PTY
Level 9, Tower B
799 Pacific Highways, Chastwood
Australia
Tel : + 61 2 9904 7303
Macopharma Nederland B.V.
Orteliuslaan 850
3528 BB Utrecht
Nederland
Tel : + 31 30 265 1739
Macopharma Canada
1080 Beaver Hall, Suite GR-002
Montreal (QC) H2Z 1S8
Canada
Tel : + 1 514 868 2222
Macopharma Middle East
JAFZA, Office LB15412,
PO Box 263304 - Dubaï
United Arab emirates
Tel : + 971 4 88 76 732
www.macopharma.com
[email protected]
Macopharma transfusion
solution Pvt Ltd
DSM#006, DLF Commercial
center Shivaji Marg, Moti Nagar,
New Delhi, 110015
INDIA
Tel : +91 981 056 5080
Macopharma russia
Shumkina st.20-1, office 202
107113 Moscow
RUSSIA
Tel : +7 495 221 0040
Macopharma International
GmbH
Fribourg branch, Rue St-Pierre
18,
CH-1701 Fribourg
SWITZERLAND
Tel : +41 44 730 2540
Macopharma Nordic
P.O Box 3015 Elisenberg
0207 Oslo
NORWAY
Tel : +47 23 277 050
Macopharma NEW ZEALAND
BDO Auckland, Level 8,
120 Albert Street
1010 Auckland
NEW ZEALAND
XB1GA01C - July 2014
Macopharma
rue Lorthiois
59420 Mouvaux
France
Tel : + 33 (0) 320 11 84 30