Transcript PSYCHOPHARMACOLOGY

PSYCHOPHARMACOLOGY
PSYCHOPHARMACOLOGY






Antipsychotics
Antiparkinsonisms
Antidepressants
Mood stabilizers
Sedative Hypnotics
Others
Principles of
psychopharmacotherapy
The diagnostic assessment is fundamental to our
model
Pharmacotherapy is insufficient for complete
recovery.
The phase of an illness is of critical importance in
terms of the initial intervention and the duration of
treatment
The risks to benefit ratio must always be
considered when developing a treatment strategy
Principles of
psychopharmacotherapy
Prior personal history of good and bad
response to a specific agent usually dictates
the first line of choice for a subsequent
episode.
It is important to target specific symptoms
that serves as a marker for the underlying
psychopathology.
Observe the development of adverse side
effects.
Indications of antipsychotics
Brief psychotic disorders
Schizophreniform
Schizophrenia
Schizoaffective Disorders
Delusional disorders
Psychotic mood disorders
Organic psychoses
Antipsychotics
Phenothiazines
Aliphatic
Chlorpromazine ( Thorazine 25, 50,100mg)
Piperidines
Thioridazine ( Melleril 50, 100mg )
Piperazines
Fluphenazine
Perphenazine ( Trilafon 4, & 8 mg.)
Trifluoperazine ( Stelazine 5 mg.)
Mesoridazine ( serentil 10mg.)
Antipsychotics
THIOXANTHENES
Thiothexenes – Navane
Zuclophentixol HCl – Clopixol 10, 25mg tab
Zuclophentixol decanoate – Clopixol depot
Zuclophentixol acetate – Clopixol Acuphase
Antipsychotics
Butyrophenones
Haloperidol ( Haldol, 1, 2, 5, 10 mg/tab)
( Serenace 5, 10, 20mg/tab )
( Serenace 5mg/ampule )
Antipsychotics
Benzamides
Sulpiride – Dogmatil
Amisulpiride - Solian
Antipsychotics
Serotonin-Dopamine Antagonists
Dibenzodiazepines
Clozapine - Leponex
Thiobenzodiazepines
Olanzapine - Zyprexa
Benzothiazepines
Quetiapine - seroquel
Benzisoxasoles
Risperidone - Risperdal
Benzisothiasole piperazine
Ziprasidone - Zeldox
Antiparkinsonism
Biperidin HCl – Akineton 2mg.
Diphenhydramine – Benadryl 50mg
Amantadine – Symmetrel 100mg
Benztropine mesylate – Cogentin 2mg
Trihexyphenidyl HCl – Artane 2mg
Antidepressants
Heterocyclics
MAOI’s
RIMA
Dopamine Agonists
SSRI
SNRI
Antidepressants
Heterocyclics
Tricyclics
Imipramine - Tofranil
Clomipramine - Anafranil
Tetracyclics
Maprotiline - Ludiomil
Dothiepine – Prothiaden
Mirtazapine - Remeron
Antidepressants
Monoamine Oxidase Inhibitors (MAOI)
Increases biogenic amines by inhibiting their
degradation
Should not be taken with foods w/ tyramine
Examples
Tranylcypromine ( Parnate )
Phenelzine ( Nardil )
Iproniazid ( Marsilid )
Antidepressants
Reuptake Inhibitor of Monoamine Oxidase Inhibitor
type A (RIMA)
Moclobemide – Aurorix 150 mg
Brofaromine
Antidepressants
Dopamine Agonists
Amineptine HCl – Survector 100mg/tab
Antidepressants
Selective Serotonin Reuptake Inhibitors (SSRI)
Paroxetine – Paxil, Seroxat 20/tab
Fluovoxamine – Luvox, Faverin 50mg/tab
Fluoxetine – Prozac 20mg/pulvules
Sertraline – Zoloft 50mg/tab
Antidepressants
Serotonin-Norepinephrine Reuptake Inhibitors
Venlafaxine – Effexor 50mg./tab
Mood Stabilizers
Lithium carbonate – Quilonium R 450mg/tab
Carbamazepine – Tegretol 200mg/tab
Oxcarbazepine – Trileptal 300 & 600mg
Depakene – Valproic Acid
Divalproate sodium – Epival 250mg/tab
Sedative - Hypnotics
Benzodiazepines
Imidazopyridines
Cyclopyrrolone derivatives
Benzodiazepines
Long Acting
Intermediate
Short-acting
Diazepam
Midazolam
Triazolam
Flurazepam
Clonazepam
alprazolam
Clorazepate
dipotassium
Clobazam
Lorazepam
Estazolam
Imidazopyridines
 Zolpidem – Stilnox 10mg/tab
Cyclopyrrolone derivative
Zopiclone – Imovane 7.5mg/tab