Transcript SciFinder: An Essential Part of the Research Process

Preview
2006 Edition
SciFinder®:
Part of the process™
SciFinder® 2006 provides new,
powerful capabilities for scientists
• New structure searching capabilities
• New reaction display capabilities
• New navigation and usability
improvements
2006 Edition
SciFinder®:
Part of the process™
SciFinder 2006 provides outstanding
new capabilities for scientists
• New structure searching capabilities
• New reaction display capabilities
• New navigation and usability
improvements
2006 Edition
SciFinder®:
Part of the process™
Several new structure search
capabilities are available
• Similarity Searching
• Powerful new query tools
• New and improved structure search
options
2006 Edition
SciFinder®:
Part of the process™
Similarity searching allows
scientists to find new types of
answers to their structure questions
• Similarity search ranks all
compounds in the CAS RegistrySM
database via the Tanimoto algorithm
• Compounds with highest scores
included in results
• Similarity search is complementary
to substructure search
2006 Edition
SciFinder®:
Part of the process™
The Tanimoto algorithm utilizes
various chemical descriptors
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Atoms and their direct attachments
Atom sequences
Bond sequences
Degree of connectivity
Type of ring fusion
Element counts
Atom counts
Ring counts
2006 Edition
SciFinder®:
Part of the process™
An example of a Tanimoto score
calculation
• QS = Number of query descriptors = 143
• FS = Number of file substance descriptors = 169
• C = Number of descriptors common to both = 139
Score =
100 * C
=
100 * 139
= 80
(QS + FS – C) (143 + 169 – 139)
2006 Edition
SciFinder®:
Part of the process™
The fewer the differences between
query and answer, the higher the
score
Query
2006 Edition
SciFinder®:
Part of the process™
Similarity searching is accessed via
Get Substances
2006 Edition
SciFinder®:
Part of the process™
An analysis is performed based on
similarity scores
2006 Edition
SciFinder®:
Part of the process™
Selected answers are presented in
similarity score order
2006 Edition
SciFinder®:
Part of the process™
Substances with lower scores show
increasing variance with the query
2006 Edition
SciFinder®:
Part of the process™
Substances with lower scores show
increasing variance with the query
2006 Edition
SciFinder®:
Part of the process™
New structure query tools are
available in SciFinder 2006
• Draw a variable attachment point
• Draw a repeating group
2006 Edition
SciFinder®:
Part of the process™
These new tools are available in the
structure editor tool palette
New Repeating
group tool
New Variable
Attachment
Position tool
2006 Edition
SciFinder®:
Part of the process™
New search options allow scientists
to control the relevancy of their
answer set
Control the type of substance
retrieved by its chemical classification
Only retrieve commercially available
substances
Eliminate substances with no
literature references
Describe literature roles of resulting
substances
2006 Edition
SciFinder®:
Part of the process™
SciFinder 2006 provides
outstanding new capabilities for
scientists
• New structure searching capabilities
• New reaction capabilities
• New navigation and usability
improvements
2006 Edition
SciFinder®:
Part of the process™
Reaction searching is being
enriched with new content and new
features
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Enhanced access to RXN linking
Query highlighting
Reaction conditions
Elucidation of interim RXN steps
Improved search options, including
limit by number of steps
2006 Edition
SciFinder®:
Part of the process™
New Reaction search options allow
scientists to control the relevancy of
their answer set
2006 Edition
SciFinder®:
Part of the process™
Reaction conditions show time,
temperature and other parameters
2006 Edition
SciFinder®:
Part of the process™
Intermediate reactions in a multi-step
reaction can be conveniently reviewed
Click on any substance to
check substance details,
commercial availability or
other reactions where this
compound is the product
or starting material
2006 Edition
SciFinder®:
Part of the process™
Click any substance in the reaction to
get additional information, including
retro-synthetic pathways
Reactions
►
2006 Edition
SciFinder®:
Part of the process™
Click any substance in the reaction to
get additional information, including
retro-synthetic pathways
2006 Edition
SciFinder®:
Part of the process™
SciFinder 2006 provides outstanding
new capabilities for scientists
• New structure searching capabilities
• New reaction display capabilities
• New navigation and usability
improvements
2006 Edition
SciFinder®:
Part of the process™
New navigation and usability
improvements make SciFinder a
better research tool
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Duplicate detection and removal
Direct to document/Direct to Library
Mouse-wheel enabled!
New user assistance
New navigation windows
Quick reference lookup with Locate by
Bibliographic Information
2006 Edition
SciFinder®:
Part of the process™
Duplicate detection and removal are
useful when searching in both
CAplussm and MEDLINE®
Duplicate
references are
removed with
the click of a
mouse!
2006 Edition
SciFinder®:
Part of the process™
Convenient access to source
documents is provided by links from
every reference, direct to the document
or your library!
2006 Edition
SciFinder®:
Part of the process™
New user assistance options will
provide in-context help
Launched
via user
assistance
button
2006 Edition
SciFinder®:
Part of the process™
New task navigation windows will
reduce mouse clicks for scientists
All explore
options in one
window!
SciFinder®: Part of the process™
New Locate
capability when
looking up
something
specific 2006 Edition
The Locate feature allows quick
access to specific references
Journal references or patents can
be obtained
Input as much or as little of what
you know about the reference
Journal names, author names, title
words and publication date can be
combined
2006 Edition
SciFinder®:
Part of the process™
SciFinder has become an essential
part of the research process!
• Convenient access to CAS content
– enriched over time with vital content to support
discovery research
• An array of powerful search technologies
– supporting a variety of scientists across the
research enterprise
• Enabled with an easy-to-use interface
– designed to maximize efficiency for scientists
2006 Edition
SciFinder®:
Part of the process™
2006 Edition
SciFinder®:
Part of the process™