Transcript SciFinder 2006

Tubitak: MAM Research Center
Introduction and benefits
Paul Peters
31 Jan 2007
Strategies & challenges within
pharma & biotech
• Companies searching for more complex
solutions in healthcare
• Need to develop strong clinical candidates
– adopt best practices from both traditional
pharmaceutical as well as modern biotechnology
– Major attrition in development, especially Phase 2
• Chemistry and biology merging as sciences
(genomics, proteomics)
• Freedom-to-operate and other intellectual
property issues are key drivers of R&D
• Strategic information has become a critical
business factor to innovate
2006 Edition
Chemical Abstracts Service, CAS
• CAS... we are scientists, creating and
delivering the most complete and
effective digital information
environment for scientific research
and discovery
• CAS is a self-sustaining division of the
American Chemical Society
• CAS employs 1250 staff members in
Columbus, Ohio
2006 Edition
Chemical Abstracts Service, CAS
• CAS Content... the world’s
largest collection of chemical and
related scientific information for
the research community
including:
• Most authoritative collection of
substance information available
• Worldwide coverage of current
and comprehensive journals and
patents
2006 Edition
2006 Edition
2006 Edition
2006 Edition
SciFinder content
• CAplus from CAS with 27.6 mil references,
abstracts and detailed indexing from 1907– Sources: 9,500 journals, patents from 50 offices,
internet journals and preprint servers, conferences,
theses and report
– Citations from journals and patents 1997-
• Registry from CAS with ~88.5 mil substances
– Small molecules, biosequences, polymers,
inorganics, alloys, complexes
– Single compounds have experimental data from
InfoChem and CAS and have calculated data from
ACDlabs
2006 Edition
SciFinder content
• CASREACT from CAS with 12.0 mil single
and multi-step reactions
– From journals and patents, 1907-
• ChemCats from CAS with supplier data from
>955 catalogues
– Screening compounds, fine chemicals and some
bulk for 12 mil compounds
• Chemlist from CAS with regulatory
information
• Medline from NLM with 16.5 mil records
from 1950– Sources: 3200 journals
2006 Edition
Unique and comprehensive
databases: Creating Content
2006 Edition
Sample record (i)
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Sample record (ii)
2006 Edition
Sample record (iii)
2006 Edition
Sample record (v)
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Sample record in SciFinder
• Shows bibliographic details of the patent
• Includes patent family data
• The CAS abstract for this invention
– much more informative than the original
abstract
• Deep indexing of the relevant subjects and
substances by CAS Registry numbers and
their respective roles
• Examiner citation for this patent
2006 Edition
SciFinder functions
• Explore literature and patents by:
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Substance name, formula or (sub)structure
Topic search with a natural language query
Author name or organization name
Reaction path or functional group transformation
BLAST search for biosequences
List of patent numbers
Specific bibliographic reference
Numerous ways to refine and analyze results
• Setting up alerts (Keep me Posted)
• Browse table of contents
2006 Edition
SciFinder: more than a search
• SciFinder has implemented several smart
search processes to improve recall of
relevant hits:
– Research Topic Explore will use automatic
searching of different spelling, word endings,
word order and synonyms from a dictionary
– Author Explore will provide candidates with
similar spelling as provided
– Structure Explore will automatically find
tautomers and metal-containing complexes
2006 Edition
Full Text links to Chemport
• 374 Publishers
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ACS
RSC
Academic Press
Springer Link
Am. Inst. Phys.
Highwire Publ.
• US Patent Office
• MicroPatent
• 6500+ Journals
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Elsevier
Kluwer Acad. Publ.
Karger Publ.
Wiley
Marcel Dekker
Inst. of Physics
• EBSCO
• EPO’s Esp@cenet
2006 Edition
The true power of SciFinder
• SciFinder is the preferred research tool
for scientists in industry and academia
– Unmatched content and currency
– Ease of use of the interface
– Analysis tools that provide additional
insights and creativity
– Analysis tools that let the user handle
larger answer sets effectively
2006 Edition
Analysis features for references
2006 Edition
Analysis features for references
2006 Edition
Analyze feature
• Good for analyzing basic document
information, for instance
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Analyze by most listed author
Analyze by publication year
Analyze by document type
Analyze by company/ organization name
• More convenient than Refine, since we
see what is available in the answers
– Find unexpected terms
2006 Edition
Categorize feature
• Very useful to organize indexing terms
– Controlled terms for processes, biological
entities, diseases, technologies, methods, etc.
– Substance names in the context of their role
in the documents
• List all catalysts, reactants, industrial
manufactured compounds, compounds with
therapeutic use
2006 Edition
Categorize on RC metathesis
Reactants /
Reagents
2006 Edition
Categorize on RC metathesis
Catalysts
2006 Edition
Panorama feature
• Based on the same concept of organizing
index terms in science categories
• Exports two categorize tables to Excel for
cross-tabulation of terms
• Shows the number of references indexed
with terms from the two categories
– Choose them wisely to get the most out of
Panorama’s data mining capabilities
– SF2002 has some pre-worked Panorama sheets
2006 Edition
RC metathesis: Panorama of
catalysts versus reactants/reagents
Select different option from the
2006 Edition
drop down menus
RC metathesis: Panorama of
catalysts versus reactants/reagents
2006 Edition
RC metathesis: Panorama of
catalysts versus reactants/reagents
• Allows you to identify main compounds
in ring-closure metathesis reactions
• But also combinations that have few or no
references
• Double-click a cell to get those references
• Click the charts button to create a variety
of charts and trend lines
• Panorama sheet can be saved and re-used
2006 Edition
RC metathesis: Publication year
trend lines for 5 catalysts
2006 Edition
SciFinder benefits
• Easy access to largest database covering
chemistry and related sciences relevant to drug
discovery
– Solid look at IP status for substances and processes
– Advanced analysis tools to handle larger answer sets in
a creative way
– Powerful alerting due to high currency of the
information
– Content and interface designed by scientists for
scientists
– Big time save not having to run experiments that are
well documented in the literature
– Big money save not having to continue projects that
have already received patent protection by competition 2006 Edition
SciFinder for Govt Research
• Price structure based on a commitment in a
12 month period
• Access at a concurrent user level, each
with a maximum number of individual
users
– 1 ccu up to 40 users; 2 ccu up to 70 users
– 3 ccu up to 110 users; 5 ccu up to 200 users
• Pricing starts at $66,240 in 2007
– 1 ccu $66,240; 2 ccu $106,200;
3 ccu $159,300; 5 ccu $265,500
2006 Edition
SciFinder Govt Research
• Usage restrictions
– Sharing of loginids is not allowed
– Not allowed to do searches for others
– Not allowed to do searches for commercial
research, including patentability searching
– A scientist may not have more than 5,000
records saved on his/her PC
– Inactivity timeout of 20 minutes
• Access can be limited by IP address
2006 Edition
Questions?