Transcript Colloidal silver - College of Engineering

Colloidal silver
IE497B
Spring 2009
Dr. R. A. Wysk
Colloidal Silver
– Colloidal silver is a colloid of silver particles in water.
It has antimicrobial properties and was, in the past,
used on external wounds and burns to prevent
infection. Some claim that it is a beneficial nutritional
supplement and a powerful antibiotic[1], although this
is disputed[2]. As with many of the claims made for
this product, there is no scientific proof of its efficacy
as a treatment for illnesses such as anthrax following
bio-terror alerts.[citation needed] The ingestion of
colloidal silver in large quantities or over a long period
of time carries a high risk of argyria, a condition in
which the skin turns permanently blue-gray[3][4][5][6].
Colloidal Silver – properties
• Colloidal silver can be used to keep drinkable water
potable over a long period. [1] It is also used externally
for health benefits.
• Silver has been used as a topical antiseptic for minor
burns for more than 100 years [7]. High concentrations
of colloidal silver kill bacteria and the topical, or external,
use of colloidal silver to kill microbes is well established.
Though colloidal silver was a prescribed treatment in the
U.S. Navy's corpsman's manual until 1973, the use of
colloidal silver was discontinued due to the rare but
serious risk of argyria, a non-reversible condition. For
this reason and others—the extraordinarily broad claims
made for the product—its use as an ingested medication
remains controversial.
So what
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Colloidal silver is toxic. Oral LD50 values for mice reported for colloidal silver are 100
mg/kg.[8]
Continued ingestion of high doses (more than 1 gram of accumulated silver, or 5 mg
per day) of colloidal silver may result in argyria, a rare condition causing a permanent
discoloration of the skin.[3][4][5]
Argyria is not a serious or fatal condition.[9] While the skin discoloration may be
confused for other conditions, there are no physiologic implications for the patient.[10]
Almost all known cases of argyria resulted from exposure to or use of silver oxide or
silver nitrate.[citation needed] One of the few confirmed cases of argyria caused by
colloidal silver is that of Stan Jones, a Montana Libertarian candidate for the U.S.
Senate in 2002 and 2006, who overdosed on colloidal silver. Mr. Jones' colloidal silver
was a home-prepared solution which he began taking in 1999 due to fears of
antibiotics being unavailable due to "Y2K" bug problems.[6]
Advocates of colloidal silver claim it to be a useful supplement to their diet, providing
them with improved health and well being and (among other things) a low incidence
of colds and flu.[citation needed] They also assert that, under careful use (one
teaspoon of 5ppm concentrate every 1 to 3 days) of properly produced (5parts per
million) colloidal silver, argyria is virtually impossible. [11] These claims are anecdotal,
and have not been confirmed by scientific study.
Making Colloidal silver
• Colloidal Silver (CS) is generally produced by an
electrolysis process. The making of colloidal silver
requires 2 silver electrodes to be placed in a glass
container of water and the appropriate electric current
applied. The vast majority of CS generators being
offered today use batteries in a series wired
arrangement which supply DC voltage and current. With
battery voltage potential applied, the water acts as a
conductive medium as tiny particles of silver sinter off
one of the silver electrodes and go into the water. Ideally,
the silver particles should remain suspended in the water
as a colloid solution due to the positive electric charge
on each silver particle which allows the particles to repel
each other and remain suspended.
A Colloidal silver generator
Argyria
Commercial Developments
• Nanover
• Nanohorizons
Bactericidal action of Silver
• Silver interferes with the metabolisms of bacteria.
• Active oxygen made by silver destroys membranes
of bacteria
• Silver causes mutation of bacteria by combining with
particular parts of proteins
Functions of Silver
• Bactericidal rate : over 93.9 %
• Bacteriostatic rate : over 99.9 %
• Deodorization rate : over 95 %
Red blood cells before and after wearing “On Silverunderwear” :
Massed red blood cells get scattered and clarified (immune
bodies are increased)
Applications and Trends
• Trends : the beginning of the silver-bactericidal market has been passed and its
applications are being disseminated.
• Applications of NANOVERTM
- special fields : cell phone, health care, cosmetics
- fiber industry : Daewoo international Inc., fiber post processing companies, etc.
- paper manufacturer : Shinho Inc., Shinmoolim Inc., etc.
- film: Kuemyang Chemical Inc.
- resin (M/B chip): Songwon Chemical Inc., SK-UCB Inc., Woori Comtech Inc., etc.
- bactericidal rubber glove : Cleanwarp Inc.
- Paints : Byouksan Inc.
- ETC. : stones(charnel houses), wallpapers, etc.
SK Teletech launches silver-nano coated well-being cell
phones.
SK Teletech(CEO Y.J. Kim, www.skteletech.com) is the first handset
maker in the world to launch silver-nano coated mobile phones with
sterilizing function, the company announced on 5th.
‘Silver-nano coating‘ technology is to coat materials with nanometer
(1 billionth of a meter) sized silver particles that are effective at
attacking pathogens. Its applications are home appliances such as
TV sets, laundry machines, vacuum cleaners, etc.
The company’s new model IM-7400 is a semi-automatic slide phone
which has a rotating 1.1-megapixel CCD camera, 100MB internal
memory, MP3, radio, GPS, etc.
A person concerned with SK Teletech said, “ after it is announced
that a cell phone contains about 25,000 bacteria, the customers’
need for bactericidal cell phone gets higher” and “ we will provide
silver-nano coated mobile phone for all models, so that we will let our
customers have a good image for our company that provides ‘wellbeing phones’
S.J. Park@The Electric Times, [email protected]
besides, reported in Korea Economic Daily, The Hankyoreh, etc.
NANOVER
TM
application to Mobile phones
SKTT- SKY IM-7400
LG-LP5200 LGT
Bactericidal function of NANOVERTM
• sterilizing within a few minutes
• much lower MIC (MIC; minimal inhibitory
concentration)
: lower than 10 PPM for most germs including Esherichia coli
(O157), Staphylococcus aureus ATCC 29213, Salmonella, MRSA,
etc
• great bactericidal function in applications for fibers
and plastics
• maintaining its bactericidal function after 20 times
washing
Minimal Inhibitory Concentration (MIC) of NANOVERTM
 Strong antimicrobial efficacy
Microbe (bacteria)
(g/mL)
E-coli
10
ATCC 25922
E-coli
10
Characteristics
MIC
pollution of foods and drinks
main reason of food poisoning
and enteritis
food poisoning by producing velo toxin
O157
Staphylococcus Aureus
10
ATCC 29213
Salmonella Typhimurium
10
infections including food poisoning
vomiting, diarrhea
causing typhoid fever
Catholic Medical School, the 54th Fall the Korean Association
of Internal
Medicine
Conference proceedings, Oct 25, 2003
stomachache,
vomiting,
fever,
Test method: Agar-dilution method defined by NCCLS
MRSA
10
headache, general paralysis
causing secondary infection
Bactericidal rate of textile
Method : KS K 0693 test for measuring bactericidal rate of textile
Specimen : SCV-WA702 (10 ppm) ; dipping textile in the
solution for 30 minutes
Used auxotroph : Staphylococcus aureus ATCC 6538
blank
(bactericidal rate : 99.9%)
NanoHorizons – State College, PA
• NanoHorizons is a custom nanoscale
materials engineering company. The
company's SmartSilver™ brand is
recognized worldwide as a leader in
providing anti-odor/antimicrobial protection
to natural and synthetic fibers and fabrics.
SmartSilver additives, along with
NanoHorizons' other technologies, solve
real-world challenges through nanoscale
engineering, in industries ranging from
performance apparel to medical
instrumentation.
SmartSilver
•
Figure 2: SmartSilver-enhanced polyester fiber is virtually
indistinguishable from regular polyester fiber.
A single SmartSilver
nanoparticle.
Silver-coated nylon fiber shows
signs of flaking in the left image.
The rough and flaky surface in the
right image shows how the silver
coating could easily come off.
To use colloidal silver or not to use colloidal silver
IE497
Biomed