Transcript Document

Inducción a:
Author Academy
David Mouriño
Gerente de Licenciamiento Digital Mexico
Springer Author Academy
www.springer.com/authoracademy
En esta inducción…
1. Selección de Journal
2. Estructura del manuscrito
3. Objetivo de la revista
4. Escritura efectiva
5. Cartas de presentación
6. Revisión por pares
Sección 1
Selección de Journal
Edanz:
Principales
dificultades
durante
la
Los autores tienen dificultades para elegir las revistas
preparación del manuscrito
Choosing a
journal
118
Expressing thoughts
clearly in English
Formatting according
to the guidelines
23.7%
79
Understanding the
author guidelines
73
63
35.4%
21.9%
18.9%
n = 333 published non-native English authors
Selección de
Journal
Cuándo
Eligirá el journal en el que publicará:
– Despúes de que ha decidido que tiene
suficientes resultados como para publicar
– Despúes de que ha decidido que tan alto y
amplio será el impacto de su publicación
– Despúes y de que ha decidido que tan
relevantes son los resultados
– Antes de escribir el título, resumen e
introducción del artículo
Selección de
Journal
Objetivos y
alcance
Acceso abierto
Tenga en cuenta los diferentes
factores de cada revista
Número de
lectores
Frecuencia de
publicación
Indexación
Factor de
impacto
Varies by field
¿Qué factor es más importante para usted?
Selección de
Journal
Eligiendo un Journal
Honestamente evalue la importancia
de su investigación
Significado
Objetivos y
alcance / impacto
Selección de
Journal
Evaluación
Autenticidad
¿Qué tan nuevos son sus descubrimientos?
Relevancia
¿Qué tan relevantes son?
Interés
¿Qué tanto se puede aplicar al mundo real?
Escritura efectiva
•
•
•
•
•
Tipos de publicaciones
científico-técnicas
Artículo en revistas (journal paper)
– journal (científico) / magazine (divulgación)
Ponencia
– Principal (keynote) –invitada– Ponencia (conference paper) –invitadaComunicación (contributed paper)
–libre versión escrita versión para presentar
Patente
– Contrato inventor-Estado que permite fabricar algo en exclusiva durante 20
años (luego pasa al dominio público)
Informe
– Memoria (proyecto)
– Libro blanco (informe oficial de situación, exhaustivo)
– Libro verde (libro de consulta, con propuestas)
Escritura efectiva
¿Dónde publicar?
Selección de
Journal
Journal Selector –
www.edanzediting.com/journal_selector
El Journal Selector ayuda a elegir
la publicacion más adecuada
Insert your proposed abstract
Selección de
Journal
Journal Selector –
www.edanzediting.com/journal_selector
Journals recomendados
Filtrar por:
Factor de impacto
Frecuencia de publicación
Acceso Abierto
Selección de
Journal
Journal Selector –
www.edanzediting.com/journal_selector
Términos semánticos que
encajan
Journals FI, Objetivos,
alcance y frecuencia
Artículos similares
¿Se han publicado artículos similares recientemente?
¿Ha citado algunos de estos artículos?
Selección de
Journal
Visite el sitio del journal
Selección de
Journal
Tips para identificar la
revista más adecuada
Identica los
intereses del
editor de la revista
Identifica los
intereses de los
lectores
•
•
•
S
Editoriales
Artículos en revisión
Fascículos especiales
• Más vistos
• Más citados
Identifica los intereses del editor de la revista y
de los lectores en cada publicación
Sección 2
Estructura del Manuscrito
Coverage and
Estructura
del
Staffing
Plan
Manuscrito
Títulos efectivos
Puntos
importantes
Evitar
Resuma las principales
conclusiones
Palabras clave
Menos de 20 palabras
Preguntas
Abreviaciones
“New” o “novel”
El título debe ser conciso y resumir su hallazgos clave
Coverage and
Estructura
del
Staffing
Plan
Manuscrito
Relevancia de
sus objetivos
Resúmen / Abstract
Importancia de
sus resultados
Validez de sus
conclusiones
Es la primera
impresión de su
documento
Juzgue su estilo
de escritura
Probablemente sea la
única parte que sea
leída
Coverage and
Estructura
del
Staffing
Plan
Manuscrito
Secciones del Resumen
Síntesis concisa de su investigación
Antecedentes
¿Porque se hizo el estudio?(20%)
Objetivos
Hipótesis (10%)
Métodos
Tecnicas (10%)
Resultados
Hallazgos más importantes(40%)
Conclusión
Conclusiones/implicaciones (20%)
Resúmenes
Escriba su reseña
Unstructured
abstract
en secciones
Our understanding of the mechanisms by which ducts and lobules develop is derived from model
organisms and three-dimensional (3D) cell culture models wherein mammalian epithelial cells undergo
morphogenesis to form multicellular spheres with a hollow central lumen. However, the
mechanophysical properties associated with epithelial morphogenesis are poorly understood.
Antecedentes
We performed multidimensional live-cell imaging analysis to track the morphogenetic process starting
from a single cell to the development of a multicellular, spherical structure composed of polarized
epithelial cells surrounding a hollow lumen.
Métodos
We report that in addition to actively maintaining apicobasal polarity, the structures underwent
rotational motions at rates of 15–20 μm/h and the structures rotated 360° every 4 h during the early
phase of morphogenesis. Rotational motion was independent of the cell cycle, but was blocked by loss
of the epithelial polarity proteins Scribble or Pard3, or by inhibition of dynein-based microtubule
motors. Interestingly, none of the structures derived from human cancer underwent rotational motion.
We found a direct relationship between rotational motion and assembly of endogenous basement
membrane matrix around the 3D structures, and that structures that failed to rotate were defective in
weaving exogenous laminin matrix. Dissolution of basement membrane around mature, nonrotating
acini restored rotational movement and the ability to assemble exogenous laminin.
Thus, coordinated rotational movement is a unique mechanophysical process observed during normal
3D morphogenesis that regulates laminin matrix assembly and is lost in cancer-derived epithelial cells.
Resultados
Conclusión
Wang et al. PNAS. 2013; 110: 163‒168.
Resúmenes
Escriba su Resumen
Our understanding of the mechanisms by which ducts and lobules develop is derived from model
organisms and three-dimensional (3D) cell culture models wherein mammalian epithelial cells
undergo morphogenesis to form multicellular spheres with a hollow central lumen. However, the
mechanophysical properties associated with epithelial morphogenesis are poorly understood. We
performed multidimensional live-cell imaging analysis to track the morphogenetic process starting
from a single cell to the development of a multicellular, spherical structure composed of polarized
epithelial cells surrounding a hollow lumen. We report that in addition to actively maintaining
apicobasal polarity, the structures underwent rotational motions at rates of 15–20 μm/h and the
structures rotated 360° every 4 h during the early phase of morphogenesis. Rotational motion was
independent of the cell cycle, but was blocked by loss of the epithelial polarity proteins Scribble or
Pard3, or by inhibition of dynein-based microtubule motors. Interestingly, none of the structures
derived from human cancer underwent rotational motion. We found a direct relationship between
rotational motion and assembly of endogenous basement membrane matrix around the 3D
structures, and that structures that failed to rotate were defective in weaving exogenous laminin
matrix. Dissolution of basement membrane around mature, nonrotating acini restored rotational
movement and the ability to assemble exogenous laminin. Thus, coordinated rotational movement is
a unique mechanophysical process observed during normal 3D morphogenesis that regulates
laminin matrix assembly and is lost in cancer-derived epithelial cells.
Wang et al. PNAS. 2013; 110: 163‒168.
Resúmenes
Escriba su Resumen
Our understanding of the mechanisms by which ducts and lobules develop is derived from model
organisms and three-dimensional (3D) cell culture models wherein mammalian epithelial cells
undergo morphogenesis to form multicellular spheres with a hollow central lumen. However, the
mechanophysical properties associated with epithelial morphogenesis are poorly understood. We
performed multidimensional live-cell imaging analysis to track the morphogenetic process starting
from a single cell to the development of a multicellular, spherical structure composed of polarized
epithelial cells surrounding a hollow lumen. We report that in addition to actively maintaining
apicobasal polarity, the structures underwent rotational motions at rates of 15–20 μm/h and the
structures rotated 360° every 4 h during the early phase of morphogenesis. Rotational motion was
independent of the cell cycle, but was blocked by loss of the epithelial polarity proteins Scribble or
Pard3, or by inhibition of dynein-based microtubule motors. Interestingly, none of the structures
derived from human cancer underwent rotational motion. We found a direct relationship between
rotational motion and assembly of endogenous basement membrane matrix around the 3D
structures, and that structures that failed to rotate were defective in weaving exogenous laminin
matrix. Dissolution of basement membrane around mature, nonrotating acini restored rotational
movement and the ability to assemble exogenous laminin. Thus, coordinated rotational movement is
a unique mechanophysical process observed during normal 3D morphogenesis that regulates
laminin matrix assembly and is lost in cancer-derived epithelial cells.
Antecedentes
Métodos
Resultados
Conclusiones
Wang et al. PNAS. 2013; 110: 163‒168.
Coverage
and
Estructura
del
Introduzca
su
Staffing
Plan
Manuscrito
tema de manera lógica
Introduction
de lo general a lo específico
Introducción General
Estado del arte del campo
Problemas en el campo
Objetivos
Objetivos específicos
Coverage and
Estructura
del
Staffing
Plan
Manuscrito
Métodos
Sus métodos reflejan su diseño experimental
Lo que fue
utilizado
Muestras o materiales
Cómo se hizo
Métodos generales
Técnicas específicas
(controles de discusión)
Cómo fue
analizado
Análisis de datos
Métodos de cuantificación
Pruebas estadísticas
Coverage and
Estructura
del
Staffing
Plan
Manuscrito
Resultados
Presente sus resultados en un orden lógico
Presentación lógica
1. Observación inicial
2. Caracterización
3. Aplicación
Subsecciones
Cada subsección
corresponde a
una figura
Descripción fáctica
Qué has encontrado,
no lo que significa
Coverage and
Estructura
del
Staffing
Plan
Manuscrito
Imágenes
Por lo general es lo
primer que los
lectores ven
Presentan muchos
datos de forma rápida
y eficiente
Figuras,
gráficos y
tablas
Que sean sencillas:
recuadros separados
si es necesario
Etiquetas claras y
leyendas de las
figuras
Coverage and
Estructura
del
Staffing
Plan
Manuscrito
Discusión
Comienzo
Resúmen de hallazgos clave
Estado de la conclusión principal
Medio
Interpretar los resultados en el
contexto de otros estudios
Describir limitaciones
Final
Replantear la conclusión principal
Aplicaciones/implicaciones
Proponer un futuro trabajo
Coverage and
Estructura
del
Staffing
Plan
Manuscrito
Referencias
Cite todas las declaraciones de los
trabajos publicados anteriormente
Cite ampliemente los diferentes
grupos en su campo
Utilice software de gestión de
referencias:
EndNote, Papers, RefWorks, Mendeley
Coverage and
Estructura
del
Staffing
Plan
Manuscrito
Vincule sus ideas
Antecedentes generales
Introducción
Estado del arte
Lagunas de conocimiento
Objectivos
Métodos
Resultados
Metodología
Resultados y cifras
Resumen de los resultados
Discusión
Relevancia del hallazgo
Implicaciones para el campo
Enlace lógicamente sus ideas en su investigación
Coverage and
Estructura
del
Staffing
Plan
Manuscrito
Vincule sus ideas
Introducción
New ways to treat or prevent lung cancer
are therefore needed.
Problema
This study explored the hypothesis that inhibition
of TNKS…would inhibit lung cancer growth…
Objetivos
Discusión
Pharmacological or genetic inhibition of TNKS1
and TNKS2…reduces lung cancer proliferation...
Conclusión
Busch et al. BMC Cancer. 2012;13:211.
Sección 3
Objetivo de la revista
Customer
Target
the Service
journal
Enfoque de la revista
Planta
The control of chlorophyll levels in maturing kiwifruit
Chlorophyll is present in many plant organs, including immature
fruit where it is usually degraded during ripening. Mature green
kiwifruit (Actinidia deliciosa) are an exception, with high
concentrations of chlorophyll remaining in the fruit flesh. In
gold-fleshed kiwifruit (A. chinensis), chlorophyll is degraded to
colourless catabolites upon fruit ripening, leaving yellow
carotenoids visible. We have identified candidate genes for the
control of chlorophyll degradation…
Pilkington et al. Planta. 2012; 236: 1615−1628.
Customer
Target
the Service
journal
Enfoque de la revista
Planta
The control of chlorophyll levels in maturing kiwifruit
De amplio
interés
Chlorophyll is present in many plant organs, including
immature
fruit where it is usually degraded during ripening. Mature green
kiwifruit (Actinidia deliciosa) are an exception, with high
concentrations of chlorophyll remaining in the fruit flesh. In
gold-fleshed kiwifruit (A. chinensis), chlorophyll is degraded to
colourless catabolites upon fruit ripening, leaving yellow
carotenoids visible. We have identified candidate genes for the
control of chlorophyll degradation…
Pilkington et al. Planta. 2012; 236: 1615−1628.
Customer
Target
the Service
journal
Publicación de amplio
enfoque
Planta
The control of chlorophyll levels in maturing kiwifruit
De amplio
interés
Chlorophyll is present in many plant organs, including
immature
fruit where it is usually degraded during ripening. Mature green
kiwifruit (Actinidia deliciosa) are an exception, with high
concentrations of chlorophyll remaining in the fruit flesh. In
gold-fleshed kiwifruit (A. chinensis), chlorophyll is degraded to
colourless catabolites upon fruit ripening, leaving yellow
carotenoids visible. We have identified candidate genes for the
control of chlorophyll degradation… De amplio interés
Pilkington et al. Planta. 2012; 236: 1615−1628.
Customer
Target
the Service
journal
Publicación de enfoque
específico
Paddy and Water Development
Effects of tillage and irrigation on the occurrence and establishment
of native wetland plant species in fallow paddy fields
Traditional weed management, such as tillage and irrigation, has led
to an enhanced maintenance of wetland plant species in fallow
paddy fields. Recent herbicide usage and improvements in irrigation
and drainage systems however have caused habitat loss of these
species, especially in fields on open lowlands…
Takanose et al. Paddy Water Environ. 2013; 11: 1−4.
Customer
Target
the Service
journal
Publicación de enfoque
específico
Paddy and Water Development
Effects of tillage and irrigation on the occurrence and establishment
of native wetland plant species in fallow paddy fields
Traditional weed management, such as tillage and irrigation, has led
to an enhanced maintenance of wetland plant species in fallow
paddy fields. Recent herbicide usage and improvements in irrigation
and drainage systems however have caused habitat loss of these
species, especially in fields on open lowlands…
Keywords from the Aims and Scope
Takanose et al. Paddy Water Environ. 2013; 11: 1−4.
Sección 4
Escritura efectiva
Escritura efectiva
Alta legibilidad
Su lector debería…
Leer sólo una vez
No tendría que leer despacio
Entender su lógica de manera
inmediata
Escritura efectiva
1. Frases cortas
The largest company, a Mexican corporation founded in 1916
outside of Puebla by Miguel Hernández, was considered to be
a model in the development of modern employee conditions
by economists.
30 palabras
Escritura efectiva
Frases cortas
The largest company, a Mexican corporation founded in 1916
outside of Puebla by Miguel Hernández, was considered to be
a model in the development of modern employee conditions
by economists.
30 palabras
Escritura efectiva
Frases cortas
16 words
Economists considered the largest company to be a model in
the development of modern employee conditions. This
company was a Mexican corporation founded in 1916 outside
of Puebla by Miguel Hernández.
15 words
Utilice sólo una idea por oracion
15–20 palabras
Escritura efectiva
2. Voz activa
Las oraciones escritas en voz activa son:
simples
directas
Claras
Fáciles de leer
Utilice la voz activa para ser más directos
Pasiva
The mechanisms regulating tumor growth were investigated.
Activa
We investigated the mechanisms regulating tumor growth.
Escritura efectiva
Se prefiere la voz activa
ACS Style Guide
“Use the active voice when it is less wordy and more
direct than the passive”. (3rd ed., pg. 42)
APA Style
“Use the active voice rather than the passive voice…”.
Chicago Style
Guide
“As a matter of style, passive voice is typically, but not
always, inferior to active voice”. (15th ed., pg. 177)
AMA Manual of
Style
“In general, authors should use the active voice…”.
www.apastyle.org/learn/faqs/effective-verb-use.aspx
(10th ed., pg. 320)
Escritura efectiva
3. Posición de tensión
¿Qué oración sugiere que conseguirá un
aumento de sueldo?
1. You deserve a raise, but the budget is tight.
2. The budget is tight, but you deserve a raise.
Los lectores se centran en el final de la oración
para identificar lo que es importante
http://writingcenter.unc.edu/handouts/flow/
Escritura efectiva
Posición de tensión
La posición de tensión debe introducir
el tema de la siguiente oracion
The budget is tight, but you deserve a raise. Your salary
will increase at the beginning of next year.
http://writingcenter.unc.edu/handouts/flow/
Escritura efectiva
Posición de estrés
La posición de tensión debe introducir
el tema de la siguiente oración
The budget is tight, but you deserve a raise. Your salary
Posición de tensión
will increase at the beginning of next year.
http://writingcenter.unc.edu/handouts/flow/
Escritura efectiva
Posición de tensión
La posición de tensión debe introducir
el tema de la siguiente oración
The budget is tight, but you deserve a raise. Your salary
Posición de tensión
Posición del tema
will increase at the beginning of next year.
La posición del tema identifica de qué trata la oración
http://writingcenter.unc.edu/handouts/flow/
Escritura efectiva
4. Posición del tema
oración
idea
idea
idea
idea
Tema enlace
The patient went to the hospital to see a
gastroenterologist. The doctor then performed a series
of diagnostic tests. The results showed the patient
suffered from a bacterial infection. Antibiotics were
prescribed to treat the infection before the patient
developed an ulcer.
Esta forma es mucho más común en inglés que en español
Simpson JM. J Second Lang Writ. 2000; 9: 293–309.
Escritura efectiva
Estructura del manuscrito
Lung cancer is the leading cause of cancer mortality for
men and women. Despite smoking prevention and
cessation programs… …New ways to treat or prevent lung
cancer are therefore needed.
One potential therapeutic target for lung cancer is the Wnt
signaling pathway. The canonical Wnt signaling pathway in
mammals consists of a…
Busch et al. BMC Cancer. 2012; 13: 211.
Escritura efectiva
Estructura del manuscrito
Oración temática
Lung cancer is the leading cause of cancer mortality for
men and women. Despite smoking prevention and
cessation programs… …New ways to treat or prevent lung
cancer are therefore needed.
One potential therapeutic target for lung cancer is the Wnt
signaling pathway. The canonical Wnt signaling pathway in
mammals consists of a…
Busch et al. BMC Cancer. 2012; 13: 211.
Escritura efectiva
Estructura del manuscrito
Oración temática
Lung cancer is the leading cause of cancer mortality for
men and women. Despite smoking prevention and
cessation programs… …New ways to treat or prevent lung
cancer are therefore needed. Stress sentence
One potential therapeutic target for lung cancer is the Wnt
signaling pathway. The canonical Wnt signaling pathway in
mammals consists of a…
Busch et al. BMC Cancer. 2012; 13: 211.
Escritura efectiva
Estructura del manuscrito
Oración temática
Lung cancer is the leading cause of cancer mortality for
men and women. Despite smoking prevention and
cessation programs… …New ways to treat or prevent lung
cancer are therefore needed. Stress sentence
Oración temática
One potential therapeutic target for lung cancer is the Wnt
signaling pathway. The canonical Wnt signaling pathway in
mammals consists of a…
Utilice la posicion de tensión y tema en su escrito de
manera lógica al presentar la información
Busch et al. BMC Cancer. 2012; 13: 211.
¡Los editores de revistas están ocupados!
Sección 5
Cartas de presentación
Coverage and
Cartas de
Staffing Plan
presentación
Significado
Relevancia
¿Es importante
su trabajo?
Las cartas de presentación
Resumen: son la primer
Primeradel
impresión
impresión
editor para
de lalectores
revista
¿Es interesante
para los
lectores?
Nivel de inglés
Coverage and
Cartas de
Staffing Plan
presentación
Dear Dr Graeber,
Una buena carta de presentación
Nombre del editor
Título del manuscrito
Please find enclosed our manuscript entitled “Amyloid-like inclusions in the brains of Huntington’s disease patients”, by
McGowan et al., which we would like to submit for publication as a Research Paper in Neurogenetics.
Tipo de publicación
Recent immunohistochemical studies have revealed the presence of neuronal inclusions containing an N-terminal portion of
the mutant huntingtin protein and ubiquitin in the brain tissues of Huntington’s disease (HD) patients; however, the role of
these inclusions in the disease process has remained unclear. One suspected disease-causing mechanism in Huntington’s
disease and other polyglutamine disorders is the potential for the mutant protein to undergo a conformational change to a
more stable anti-parallel β-sheet structure…
Antecedentes
de la
investigación
To confirm if the immunohistochemically observed huntingtin- and ubiquitin-containing inclusions display amyloid features, we
performed Congo red staining and both polarizing and confocal microscopy on post-mortem human brain tissues obtained
from five HD patients, two AD patients, and two normal controls. Congo red staining revealed a small number of amyloid-like
inclusions showing green birefringence by polarized microscopy, in a variety of cortical regions.... ….detected inclusions
observed in parallel sections, suggesting that only a relatively small proportion of inclusions in HD adopt an amyloid-like
structure.
¿Qué se hizo y
que se
encontro?
We believe our findings will be of particular interest to the readership of Neurogenetics, which includes researchers and
clinicians studying the genetic and molecular mechanisms underlying neurodegenerative diseases. Therefore, we feel that your
journal provides the most suitable platform for the dissemination of our work to the research community.
Razones de interés
para los lectores de la
revista
We would also like to suggest the following reviewers for our manuscript…
Revisores recomendados
“Hay que tener” declaraciones
Coverage and
Cartas de
Staffing Plan
presentación
Original y no
publicado
No enviado a
otras revistas
Los autores están
de acuerdo con
documento/revista
Ciertas declaraciones
que “Debe tener”
No existen
conflictos de interés
Fuentes de
financiamiento
Contibuciones
de autoría
Coverage and
Cartas de
Staffing Plan
presentación
Recomendando
evaluadores
“Authors are requested to provide the names and full
addresses (including e-mail address) of up to four potential
referees…”
“When submitting your paper, you must provide the
names, affiliations, and valid e-mail addresses of five (5)
reviewers. If you do not do so, your paper will be
returned, unreviewed.”
Verifique las directrices de la revista para
determinar cuántos revisores se recomiendan
Coverage and
Cartas de
Staffing Plan
presentación
Recomendando
evaluadores
¿Dónde
encontrarlos?
De sus lecturas / referencias, creación
de redes en las conferencias
¿De alto nivel?
Trate que los investigadores sean de
nivel medio
¿Qué evitar?
Colaboradores (últimos 5 años),
Investigadores de la misma institución
Lista internacional:
1 o 2 de Asia, 1 o 2 de Europe, y 1 o 2 de las Américas
Recomiende investigadores de nivel
medio de diferentes países
Seccion 6
La revisión por pares
La revisión por
pares
• Puede ser una experiencia positiva y valiosa
• Evaluadores confirman la validez de la ciencia
reportada.
• Expertos ofrecen su tiempo gratis para mejorar los
manuscritos revisarlos y dar consejo sin costo
• Manuscritos deben evolucionar hasta ser:
– Más impactantes
– Sencillos de leer
– Más útiles
Razones más comunes para el rechazo
• Carece de estructura adecuada
• Carece de los detalles necesarios para que los lectores comprendan
plenamente el análisis de los autores
• No tiene nueva ciencia
• No explica claramente qué partes de los hallazgos son ciencia nueva, frente a lo
que ya se conoce
• Carece de referencias
• Contiene teorías, conceptos o conclusiones que incompatibles con sus datos,
argumentos e información
• No proporciona suficiente información sobre los materiales y métodos para
permitir a otros científicos a repetir el experimento
• Carece descripciones claras o explicaciones de: Las hipótesis, el diseño
experimental, características de la muestra y las estadísticas descriptivas
• Describe poco el diseño experimental , o el análisis estadístico defectuoso o
insuficiente
• Tiene mala calidad lingüística
La revisión por
pares
Mejora su manuscrito
La revisión por pares es un proceso
positivo que mejorará su manuscito
Involúcrese en el
proceso de arbitraje
La revisión por
pares
¿Qué están buscando los
revisores?





La ciencia
El manuscrito
Hipótesis relevante
Buen diseño experimental
Metodología apropiada
Buen análisis de datos
Conclusiones válidas
 Flujo lógico de la información
 Estructura y formato del manuscrito
 Referencias apropiadas
Resultados
y cifras
Discusión
Alta legibilidad
Resumen
e introducción
Métodos
La revisión por
pares
Revisión
Responda claramente a cada
comentario de sus revisores
Carta de
respuesta
Refiérase a los números de línea y página
Fácil de ver los
cambios
Utilice un color de fuente diferente
Resalte el texto
La revisión por
pares
Marc Lippman, MD
Editor-in-Chief
Breast Cancer Research and Treatment
Escribiendo la carta de
respuesta
Datos personalizados del editor
3 September 2013
Número ID del manuscrito
Dear Dr Lippman,
Re: Resubmission of manuscript reference No. WJS-07-5739
Agradecimiento a los revisores
Please find attached a revised version of our manuscript originally entitled “Evaluation of the Glasgow prognostic
score in patients undergoing curative resection for breast cancer liver metastases,” which we would like to resubmit
for consideration for publication in the Breast Cancer Research and Treatment.
The reviewer’s comments were highly insightful and enabled us to greatly improve the quality of our manuscript. In
the following pages are our point-by-point responses to each of the comments.
Revisions in the manuscript are shown as highlighted text. In accordance with the first comment, the title has been
revised and the entire manuscript has undergone substantial English editing.
We hope that the revisions in the manuscript and our accompanying responses will be sufficient to make our
manuscript suitable for publication in the Breast Cancer Research and Treatment.
Resaltar los cambios
La revisión por
pares
Estando de acuerdo con
las revisiones
Reviewer Comment: In your analysis of the data you have chosen
to use a somewhat obscure fitting function (regression). In my
opinion, a simple Gaussian function would have sufficed.
Moreover, the results would be more instructive and easier to
compare to previous results.
Response: We agree with the reviewer’s assessment of the
analysis. Our tailored function, in its current form, makes it difficult
to tell that this measurement constitutes a significant
improvement over previously reported values. We describe our
new analysis using a Gaussian fitting function in our revised Results
section (Page 6, Lines 12–18).
La revisión por
pares
Estando de acuerdo con
los revisores
Reviewer Comment: In your analysis of the data you have chosen
to use a somewhat obscure fitting function (regression). In my
opinion, a simple Gaussian function would have sufficed.
Moreover, the results would be more instructive and easier to
compare to previous results.
Acuerdo
Response: We agree with the reviewer’s assessment of the
analysis. Our tailored function, in its current form, makes it difficult
to tell that this measurement constitutes a significant
improvement over previously reported values. We describe our
new analysis using a Gaussian fitting function in our revised Results
section (Page 6, Lines 12–18).
La revisión por
pares
Estando de acuerdo con
los revisores
Reviewer Comment: In your analysis of the data you have chosen
to use a somewhat obscure fitting function (regression). In my
opinion, a simple Gaussian function would have sufficed.
Moreover, the results would be more instructive and easier to
compare to previous results.
Acuerdo
Response: We agree with the reviewer’s assessment of the
analysis. Our tailored function, in its current form, makes it difficult
to tell that this measurement constitutes a significant
improvement over previously reported values. We describe our
new analysis using a Gaussian fitting function in our revised Results
section (Page 6, Lines 12–18).
Revisiones
La revisión por
pares
Estando de acuerdo con
los revisores
Reviewer Comment: In your analysis of the data you have chosen
to use a somewhat obscure fitting function (regression). In my
opinion, a simple Gaussian function would have sufficed.
Moreover, the results would be more instructive and easier to
compare to previous results.
Acuerdo
Response: We agree with the reviewer’s assessment of the
analysis. Our tailored function, in its current form, makes it difficult
to tell that this measurement constitutes a significant
improvement over previously reported values. We describe our
new analysis using a Gaussian fitting function in our revised Results
section (Page 6, Lines 12–18).
Revisiones
Ubicación
La revisión por
pares
En desacuerdo con los revisores
Reviewer Comment: In your analysis of the data you have chosen
to use a somewhat obscure fitting function (regression). In my
opinion, a simple Gaussian function would have sufficed.
Moreover, the results would be more instructive and easier to
compare to previous results.
Si no está de acuerdo con los comentarios de la
Response: Although a simple Gaussian fit would facilitate
revisión,
usted
tiene
el porfunction
qué
comparison
with
the results
of que
other demostrar
studies, our tailored
allows for the analysis of the data in terms of the Smith model
[Smith et al., 1998]. We have now explained the use of this
function and the Smith model in our revised Discussion section
(Page 12, Lines 2–6).
La revisión por
pares
En desacuerdo con los revisores
Reviewer Comment: In your analysis of the data you have chosen
to use a somewhat obscure fitting function (regression). In my
opinion, a simple Gaussian function would have sufficed.
Moreover, the results would be more instructive and easier to
compare to previous results.
Response: Although a simple Gaussian fit would facilitate
Evidencia
comparison with the results of other
studies, our tailored function
allows for the analysis of the data in terms of the Smith model
[Smith et al., 1998]. We have now explained the use of this
function and the Smith model in our revised Discussion section
(Page 12, Lines 2–6).
La revisión por
pares
En desacuerdo con los revisores
Reviewer Comment: In your analysis of the data you have chosen
to use a somewhat obscure fitting function (regression). In my
opinion, a simple Gaussian function would have sufficed.
Moreover, the results would be more instructive and easier to
compare to previous results.
Response: Although a simple Gaussian fit would facilitate
Evidencia
comparison with the results of other
studies, our tailored function
allows for the analysis of the data in terms of the Smith model
[Smith et al., 1998]. We have now explained the use of this
function and the Smith model inRevisiones
our revised Discussion section
(Page 12, Lines 2–6).
La revisión por
pares
En desacuerdo con los revisores
Reviewer Comment: In your analysis of the data you have chosen
to use a somewhat obscure fitting function (regression). In my
opinion, a simple Gaussian function would have sufficed.
Moreover, the results would be more instructive and easier to
compare to previous results.
Response: Although a simple Gaussian fit would facilitate
Evidencia
comparison with the results of other
studies, our tailored function
allows for the analysis of the data in terms of the Smith model
[Smith et al., 1998]. We have now explained the use of this
function and the Smith model inRevisiones
our revised Discussion section
(Page 12, Lines 2–6).
Ubicación
La revisión por
pares
Preguntas “Ocultas”
Reviewer comment: The authors looked for polymorphisms in the
promoter region of the gene; however, they didn't evaluate the
untranslated regions. That is one of my concerns about this
methodology.
¿Es una
pregunta?
Si un comentario del revisor no está
claro, pida ayuda de un colega
La revisión por
pares
Preguntas “Ocultas”
Reviewer comment: The authors looked for polymorphisms in the
promoter region of the gene; however, they didn't evaluate the
untranslated regions. That is one of my concerns about this
methodology.
Rephrased question: Why didn’t the authors evaluate
polymorphisms in the untranslated regions of the gene?
La revisión por
pares
Preguntas “Ocultas”
Reviewer comment: The authors looked for polymorphisms in the
promoter region of the gene; however, they didn't evaluate the
untranslated regions. That is one of my concerns about this
methodology.
Response: In this study, we decided to focus on the promoter
region of this gene because previous studies [Yajima et al., 2010;
Jackson et al., 2011] have shown that its transcription was
particularly affected. This has now been clarified in the
Discussion section of our manuscript (Page 16, Line 24–28).
La revisión por
pares
Preguntas “Ocultas”
Reviewer comment: The authors looked for polymorphisms in the
promoter region of the gene; however, they didn't evaluate the
untranslated regions. That is one of my concerns about this
methodology.
Response: In Evidencia
this study, we decided to focus on the promoter
region of this gene because previous studies [Yajima et al., 2010;
Jackson et al., 2011] have shown that its transcription was
particularly affected. This has now been clarified in the
Discussion section of our manuscript (Page 16, Line 24–28).
La revisión por
pares
Preguntas “Ocultas”
Reviewer comment: The authors looked for polymorphisms in the
promoter region of the gene; however, they didn't evaluate the
untranslated regions. That is one of my concerns about this
methodology.
Response: In Evidencia
this study, we decided to focus on the promoter
region of this gene because previous studies [Yajima et al., 2010;
Jackson et al., 2011] have shown that its transcription
was
Revisiones
particularly affected. This has now been clarified in the
Discussion section of our manuscript (Page 16, Line 24–28).
La revisión por
pares
Preguntas “Ocultas”
Reviewer comment: The authors looked for polymorphisms in the
promoter region of the gene; however, they didn't evaluate the
untranslated regions. That is one of my concerns about this
methodology.
Response: In Evidencia
this study, we decided to focus on the promoter
region of this gene because previous studies [Yajima et al., 2010;
Jackson et al., 2011] have shown that its transcription
was
Revisiones
particularly affected. This has now been clarified in the
Discussion section of our manuscript (Page 16, Line 24–28).
Ubicación
Resúmen
 Ventajas al publicar en inglés
 Seleccionar la revista más adecuada
 Presentar la información de manera lógica en su
manuscrito
 Comunicar las ideas claramente en Inglés
 Comunicación con los editores
 Peer review
¿Por qué publicar en inglés?
 Lenguaje internacional de la academia
 Construir reputación internacional
 Desarrollar colaboradores
internacionales
 Nuevas oportunidades de investigación
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