Transcript BIOT 412: Medical Biotechnology

 Topic:
Stroke- Cerebrovascular Disease
Presented by:
Adeela Hussain
12-10403
Presented to:
Dr. Leslye Johnson
Due to blood clot or ruptured
artery if blood fails to reach
every cell then it lead to
failure of oxygen supply and
lasting as neurological
damage.
(1) Ischemic Stroke
 Blood
clot formation
 75-80%
Further two divisions
(a) Embolic Stroke---------------embolus
(b) Thrombotic Stroke ----------thrombosis

Stenosis---contraction of an artery due
to plaque formation
 TIA
is like a stroke, producing similar
symptoms, but usually lasting only a few
minutes and causing no permanent damage.

Mini stroke
A
transient ischemic attack can serve as both
a warning and an opportunity.
 Due
to rupturing of blood vessel
 Blood flows out; develops pressure on brain
and reduces the blood flow
 About 20%
Further two divisions:
 Intracerebral Hemorrhage: Bursting of
defective blood vessel within the brain itself.
 Subarachnoid Hemorrhage: Cracking of
blood vessel and blood flows between brain
and skull and affecting the cerebrospinal
fluid also.
 Sudden
severe headache
 Double vision
 Numbness, weakness or paralysis
 Speech problems
 Dizziness, trouble walking and loss of
balance and coordination
 Clumsiness
 Confusion or loss of memory
 Personality, mood or emotional changes
(Silent Strokes)
High Blood Pressure
 Diabetes
 Heart Disease
 High Cholesterol
 Atrial Fibrillation
 Family History of Stroke and Increasing Age
 Race (Black people get more effected)
 Smoking
 Use of Alcohol
 Birth Control Use or other Hormone Therapy
 High level of Homocysteine
 Cocaine Use

Magnetic Resonance Imaging
 Computerized Tomography (CT) Scan
 Arteriography
 Carotid duplex (ultrasound)
 Echocardiography
 CT and MRI with angiography
 Physical Assessment Tests as:
Cholesterol level
Blood sugar level
Amino acid level
Blood clotting tests
Complete blood count (CBC)

 Thrombolytic
Therapy-clot-busting drug-------Alteplase (Tissue Plasminogen Activator)
 Blood Thinners------- Aspirin, Clopidogrel
(Plavix), Heparin
 Radiology treatment
 Surgery
Preventation
Recent Research:
• Neuroprotective Agents
• Stem Cells Therapy
Impact of Stroke
WHO----- 5.5 million in 2002 casualties
60% females-----------------40% males
Stroke in Pakistan