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Biosciences in Michigan: A High-Tech, Multi-Sector, Growth Industry Stephen Rapundalo, PhD President and CEO MichBio Introducing the Biosciences Agricultural Drugs & Medical Devices & Feedstock & Chemicals Pharmaceuticals Equipment Agricultural processing Medicinal & Basic organic chemicals Pharmaceutical preparations Ethyl alcohol mfg. Organic fiber mfg. Fertilizers Pesticides and other agricultural chemicals botanicals Diagnostic substances Biological products Laboratory apparatus & furniture Surgical, medical, dental, ophthalmic & analytical instruments & equipment Irradiation apparatus & electromedical equipment Product-Oriented Hospitals Research, Testing, & Medical Laboratories Specialty hospitals Biological research University medical research hospitals Commercial medical research Clinical research institutions Testing laboratories Medical laboratories & diagnostic imaging centers Service-Oriented A High-Growth Global Industry Biosciences has a strong performance record, even in difficult economic and political times; – outperformed Dow and NASDAQ $85 billion in U.S. revenues – Europe = $12 billion – Asia/Pacific = $3 billion – Canada = $2 billion Pharma remains “king” – twenty products have sales >$ 1B; >100 products total – 350 biotech drugs in late stage clinical trials U.S.-made ag-bio products now grown on 200 million acres worldwide and growing at 20% per year; over 1 billion acres have been planted Proven applications in healthcare (cure & prevention), food/agriculture, and industrial (chemicals, fuels & materials) U.S. BioPharma, Biotech, Devices & Diagnostics growth is assured and sustainable on a demographics basis alone. Biosciences in the U.S. Biosciences are key driver of modern economic progress All states and regions are investing to create a business climate that supports specific needs of biosciences sector FierceBiotech 2009 Top Regions Targeting Biotechnology MN, MA, NY, ON, CO Academic R&D expenditures = $28 billion in FY06 VC investments in bio companies = $11.6 billion in 2007 Total U.S. employment of 1.3 million in 2006 Total impact (direct, indirect, induced jobs) = 7.5 million – Direct-effect employment multiplier = 5.8 Biosciences in Michigan Biosciences is “big” business in Michigan > 550 bioscience companies 40,086 direct jobs 33,873 private sector jobs 6,213 jobs in academia 58,721 spinoff jobs direct+spinoff earnings = $6.6 B private sector payroll = $2.5B private sector tax revenues = $0.5 B $9.3 B to state’s GRP $73,930 avg. bio salary $11.1 B in sales for MI companies w/ HQs four Fortune 500 bioscience companies (Dow, Delphi, Kellogg, Stryker) Global Bio-Industry Leaders in MI Abbott – owns Abbott Nutrition (formerly Ross Labs) in Sturgis Amway – nutraceuticals in Grand Rapids Bayer – owns Bayer Crop Science facility in Muskegon Beckman-Coulter – owns Lumigen in Southfield Becton Dickinson – own facility in Detroit Bristol-Myers Squibb – owns Mead Johnson Nutrition in Zeeland Dow – bio-based technologies and chemicals in Midland Johnson & Johnson – owns Healthmedia in Ann Arbor Kellogg – Battle Creek Nestlé Company – owns Gerber Products in Fremont Perrigo – world’s #1 OTC manufacturer in Allegan Pfizer – largest global manufacturing facility in Portage; Animal Health R&D HQ in Kalamazoo Stryker – Portage; Kalamazoo Terumo – owns Terumo CVS and Terumo Heart in Ann Arbor MI’s Bio-Industry – A Full Spectrum Prototype Development Center School of Engineering & Technology Entrepreneurship in MI’s Biosciences MI’s Biosciences Stats & Rankings $323 million in state bio investment from 1999-2008 (MLLC, 21st CJF) $46 million in state VC investment #10 in academic bio R&D FY06 = $910 million #8 in bioscience degrees AY 2006 = 4,782 #13 in bioscience-related employment #21 in VC bio investments 2002-2007 = $269 million; $74 million FY 2007 #21 in bioscience patents 2002-2007 = 2,225 Kalamazoo is one of only 14 regions specialized in 3 out four bio sub-sectors Pharma – Kalamazoo =#1 mMSA in employment conc. and #10 in size Medical devices – conc. – – – – – Kalamazoo = #2 mMSA Saginaw = #9 mMSA Ann Arbor = #12 mMSA Benton Harbor = #7 sMSA Jackson = #9 sMSA Research, Med/Lab Testing – Detroit = #10 size MSA – Ann Arbor = #6 conc. mMSA – Bay City = #9 conc. mMSA MSA’s with 10,000+ Employees Factors for Success Ingredients for building a critical mass in the biosciences in states and regions include: Engaged universities with active leadership Building entrepreneurial cultures with intensive networking across sectors and with industry Available capital covering all stages of business cycle Discretionary federal or other R&D funding Workforce and talent pool Access to specialized facilities and equipment Supportive business, tax and regulatory policies Patience and a long-term perspective An Action Plan for MI’s Biosciences Opportunities for Michigan Formal strategy for development of the biosciences sector State legislative committee and/or caucus focused on biosciences Program or initiative to support bioscience research infrastructure projects Funding to attract “star” executive/management and faculty to state Enhance pre-seed funding and other investment sourcing for companies Entrepreneurial support program focused on biosciences Program or initiative to finance fit-out costs for bioscience incubators Novel approaches to address bioscience talent needs Tax incentives specific to bioscience companies and sector strengths Favorable regulatory policies