Transcript Application Rapid push method in praxis
Immunology nursing in the Czech republic today
Teplá Ilona
Králíčková Pavlína Institute of Allergy and Clinical Immunology University Hospital Hradec Kralove Czech Republic
sources: foto oficial pages in the Internet
Introduction
sources : oficial pages in the Internet / foto learning centre of the University Hospital Hradec Kralove
The main points
• • • • • •
Statistical survey of our patients in the Czech PID database Practical aspects in the administration Immunoglobulin supplementation therapy and comparison IVIG x SCIG Most frequent questions/difficulties with the administration Conclusion Discussion
Statistical survey of PID patients
/Czech republic/
Actual status
• general descriptions of database / immunoglobulin therapy/ • comparison of status in particular centres /referential values/ Czech PID registry, export of data 09/2014
Statistical survey of PID patients /Czech republic
Total evidence
Actual monitored number of patients
684 664
Centre
FNUSA Brno - Ústav klin. imunolog. a alergolog.
FN Motol - Ústav imunologie FNHK - ÚKIA VFN Praha - Ústav imunologie a mikrobiologie FN Plzeň - Ústav imunologie a alergologie ZÚ ÚnL - Odd. klin. imunologie a alergologie IKEM Praha - Klinická a transplantační medicína FN Olomouc - Odd. alergologie a klin. imunologie Nemocnice České Budějovice - Imunologické oddělení Zlín - Plicní oddělení, KNTB a.s.
ZÚ Ostrava - Oddělení imunologie a alergologie FN Brno - Pediatrická klinika FNHK - Klinika dětského lékařství FNKV Praha - Odd.alergologie a klin. imunologie FN Olomouc a LF UP - Dětská klinika Tábor-Kasmed s.r.o., alerg., imunolog, neurolog.
FN Ostrava - Alergologie Krnov SSZ - interní oddělení
% of valid cases
88,6% 88,7%
Number of patients
156 35 29 21 18 151 79 59 43 14 14 13 11 11 3 3 2 2
valid
98,0% 92,4% 93,7% 100,0% 64,3% 97,0% 86,2% 100,0% 88,9% 100,0% 100,0% 91,7% 100,0% 90,9% 66,7% 100,0% 50,0% 100,0%
Statistical survey of PID patients
/Czech republic/
Male (N=300) Female (N=364)
N=664 (Currently monitored)
Basic characteristics
Replacement therapy
Practical aspects in the administration
•
Optimal IgG doses and target trough levels are individual (clinical symptoms, comorbidities, genetic factors)
•
The route of administration could be the result of discussion (patient X nurse X doctor)
Negative influence
- financial conditions in hospital - statement of insurance company - economical tender of immunoglobulin preparation
Practical aspects in the administration
IVIG therapy Advantages
cheaper in the Czech Rep.
- administration ones/twice a month - more often checking of clinical status and laboratory results Disadvantages - administration at outpatient department (traveling, day off work) - higher risk of adverse events - more often intolerance of administered preparation - necessary good venous access
Practical aspects in the administration
SCIG therapy Advantages
- home therapy with independence - comfort, flexibility - less frequent visits at the doctor - better tolerance of Ig preparations - low side effect profile (no severe systemic) - alternative for patients with poor venous access - benefit in case of gastrointestinal losses, malnutrition - flexibility of dosing and ease of administration
Disadvantages/limitations
- fear from the inject or the needle - administrations 1-3 times a week - intolerance (local skin reactions, scars, stretch marks) - risk of lower compliance
SCIG therapy
It is important to doing difference between methods of subcutaneous administrations, preparations
• •
Individual approach to each patient Choose areas from recommended sites for the administration /abdomen, outer/
•
inner thighs, hips, upper arms/
Specific role of trained nurses in the education of patients
It depends on the constitution of the patient, the thickness of the subcutis and type of needles
SCIG therapy
Subcutaneous administration
•
method rapid push /patient can adjust the rate of the infusion according to his tolerance without using the infusion pump/ ….Rapid push significantly higher infusion rate (60ml/h x 20ml/h) ….Patients with 10ml and less per one site prefer rapid push
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by the infusion pump /there should keep recommended rate of the infusion/ ….Infusion pumps provide pharmaceutical firms ….Comparable efficacy and tolerability
Our own experience – centre Hradec Kralove, Czech Rep.
•
47 patients regularly on Ig substitution therapy
• •
27/47 20/47 IVIG SCIG
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SCIG with pump since … 2007 to Oct 2014: 9 patients (3 died, 1 switched to IVIG – medication intolerance)
•
Rapid push since …2012 to Oct 2014: 11 patients (2 switched to IVIG – 1 case patient preference, one case unsatisfactory IgG level and patients reluctance to increase Ig doses)
Side effects – pump x rapid push
No serious systemic reaction
• including patient experienced moderate systemic reaction - IgA antibodies • 1 case - intolerance of two different preparations (fatigue) Local reactions: Pump: infrequently haematoma
Rapid push:
→ 2/11 mild itching, erythema → 2/11 pain during administration (change of the injection site to the inner thigh)
Often problems with administration / by patients and nurse´s view
a view on our daily centre /outpatient ward/
Practical experience
•
Giving enough practical information to the patient by a nurse specialist
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Explanation of the whole procedure (initiation of SCIG therapy) or providing an instructional video
•
Demonstration of administration
•
Reassurance of the patient (patient in home therapy after regaining certainty in the administration)
Question 1
:
There are enlarged pores, which are usually disappear for a day, the area is painful. Shall I continue with the application
?
There is the skin apparently attenuated (stretch marks, etc.) … You will try to change the site. We choose a different area from the recommended injection sites. Mainly it depends on the tolerance of the patient ..
We had same patient in our department with this problem and she solved it just changing of the injection site. She started to administer to the inner side of thigh and she was satisfy .
Practical experience
-
possibility of the administration
Question/difficulties 2
:
There are stretch marks around the abdomen and it is very limited the choice to other site.
• •
outside stretch marks (scars) it depends again on the constitution of the patient, the thickness of the subcutis
Question 3
:
The injection site is after the infusion leakage or wet
…
There was probably made too shallow the introducing of the needle. The needle was only a little bent or it was just a poor implementation. We have tested for example bending the needle to the angle of 90 degrees /method rapid push/, the introduction of the needle is deep enough to the preparation is well absorbed and well tolerated by the patient .
the bending of the needle to 90 the subcutis ° degrees is recommended in the administration to the abdomen (special type of the needle) and there is stronger thickness of
Practical experience
-
possibilty of administration
Question 4
:
The injection site is after administration indurated and painful and it has been disappear for a long time..…
The dose of the liquid is probably too large on the thickness of the subcutis. We will try to divide the dose into two or more administrations. New sites should be at lest 2 inches apart.
We should have been always consulted with the doctor.
Conclusion
Immunoglobulin supplementation therapy represents a corner stone in the treatment of patients with disturbance of specific antibody production. The correctly guided treatment leads to decrease of severe illnesses and im prove the quality of life. I am glad that I can participate in it.
There were used information from the official websites www. hizentra.com and the Internet .
Discussion
Immunology nursing in the Czech republic today
Thank you for your attention .
sources : foto oficial pages in the Internet