Transcript Finally - Effective Treatment for Fatigue, Pain, CFS, and
Chronic Fatigue Syndrome and Fibromyalgia 2009 “State of the Union”
May 12, 2009 Jacob Teitelbaum MD
Statistics
Approximately
6 - 12 million
Americans(2-4-%) have severe Chronic Fatigue Syndrome (CFS) and/or Fibromyalgia (FMS) and another 6-12 million have a less severe form (intermediate Fibromyalgia) Only
15%
diagnosis of these have been given the correct Prevalence has more than DOUBLED in the last 10 years!
Our “ Gold-Standard ” Research Shows: Most people with pain and/or CFS/FMS can reclaim their vitality and be PAIN FREE!
Even Very Severely Ill People
Tired Achy Brain fog Can’t sleep?
Think CFS and Fibromyalgia which are now very treatable!
Pathophysiology of CFS/FM
• CFS/FM represent a mix of many different processes with a common endpoint • Each problem may trigger other problems • Like “blowing a fuse”, these syndromes reflect an energy crisis in your body, and can be triggered by anything that causes severe stress or prevents energy production
Causes of CFS & Fibromyalgia
• When ENERGY DEMAND is greater than ENERGY SUPPLY • Multiple causes and subsets—not the same disease from person to person
Hypothalamus
•
This circuit controls:
– Sleep – Hormonal function – Temperature – Autonomic function (B/P, pulse, sweats, etc.) • It requires an enormous amount of energy to do all this • which is why it acts as a circuit breaker protecting the person from further injury
Pain
Your muscles also need a lot of energy
When you run out, they get stuck in the shortened, rigid position and hurt – including by the joints where they attach (think about rigor mortis).
Chronic pain results in increased brain sensitivity to pain (Central Sensitization)
•
Why You “Blew Your Fuse”
Sudden Onset – think:
– Viral, parasitic or antibiotic sensitive infections – Injury – pregnancy •
Gradual Onset – think:
– Hormonal or nutritional deficiencies – Yeast/Candida infections – Auto-immune diseases – Sleep disorders – Severe stress
Causes &Triggers-Current research
• May be caused by over a dozen different infections • Multiple hormonal deficiencies (hypothalamic/pituitary) • Excessive stress • Sleep disorders • Nutritional deficiencies • Multiple neurotransmitter and cytokine abnormalities
Clinical Research
Earlier research examined the efficacy of an integrated treatment plan for the treatment of CFS/FMS compared to placebo.
91 percent of the CFS and fibromyalgia patients receiving active treatment experienced moderate to marked improvement in their symptoms of pain and fatigue compared to the placebo group.
Effective Treatment Of Chronic Fatigue Syndrome (CFIDS) & Fibromyalgia (FMS) - A Randomized, Double-Blind, Placebo- Controlled, Intent To Treat Study.
Journal Of Chronic Fatigue Syndrome Volume 8, Issue 2 - 2001
Study Design
• Randomized Double-Blind • Placebo-Controlled • Intent to Treat Analysis
Results
(p<.0001) Active Placebo Much Better Better Same Worse 16 13 2 0 3 9 11 6 Much Worse 1 3
Well Being (Analog) Index Score Average • (By Group) – Per Visit
Active Placebo 350 330 310 290 270 250 230 210 190 170 150
Average Analog Score per group by visit number
1. (p=.95) 2. (p=.0051) 3. (p=.0063) 4. (p=.0053) Final (p=.0002) (*p<.0001 adjusted for baseline score)
Long Term Effectiveness
• A 2-year follow up showed that patients continued to improve despite being able to wean off most treatments • They went from an average ~ 75% improvement in quality of life at 99 days to an average ~90% increase
New Research Data
• Follow up of ~ 15,000 CFS/Fibromyalgia patients treated at the Fibromyalgia and Fatigue Centers clinics is being readied for publication • ~85% of patients using the “SHINE Protocol” improved. “SHINE” restores both energy production and hypothalamic function —while markedly decreasing or eliminating pain
I had CFS/FMS in 1975 Since then, I’ve dedicated myself to creating effective treatment for everyone
You “blew a fuse” (the hypothalamus)!
To turn it back on and make your fatigue and pain go away, 5 main areas need to be treated…
Think “SHINE”
S
leep
H
ormonal deficiencies
I
nfections
N
utritional deficiencies
E
xercise as able
Avoid Writer’s Cramp
www.Vitality101.com
Do the Free Online Program to tailor a treatment protocol to your case (and sign up for a free e-mail newsletter to keep you up to date)
Good Quality Sleep
Getting A Good Night’s Sleep
To eliminate pain and restore energy production, it is critical to get eight to nine hours of deep sleep each night.
However, because of sleep center malfunction and pain, patients with CFS/FMS do not stay in deep stages of sleep.
Disordered Sleep in CFS & Fibromyalgia
• Studies have demonstrated that CFS/FMS patients are at risk for many sleep disorders (in addition to severe insomnia): • Restless Leg Syndrome—Treating the iron deficiency may be more effective than Requip • Sleep apnea • UARS- Upper Airway Resistance Syndrome
Healthy Sleep: Natural Support
•
Passionflower
and
Wild lettuce
induce and maintain sleep help to calm and • •
Jamaican dogwood
promotes muscle relaxation
Valerian
and
Hops
- shown in clinical studies to both help people fall asleep AND stay asleep •
L-theanine
(an amino acid found in green tea ) helps create a relaxed feeling, and also has muscle relaxing properties – while inducing deep sleep • These herbs help the body relax and move through all sleep stages - wake up calm and refreshed instead of groggy and tired
Revitalizing Sleep Formula
• Contains all 6 of these herbs • The
BEST
natural sleep aid available • Take 1 – 4 caps as needed (1 hour before bed time) • Excellent for anyone with insomnia, muscle pain and anxiety (even during the day)
Some Prescription Sleep Aids
• Ambien • Desyrel • Klonopin • Neurontin • Lyrica • Doxepin
HORMONES Your body’s communication and control system
Hormone Production
• Hormones are produced by glands,which are controlled by the hypothalamus. Multiple studies are showing Hypothalamic-Pituitary axis dysfunction • Thyroid – your body’s gas pedal • Adrenal (cortisol & DHEA) – the stress handler • Ovaries (estrogens and progesterone) and testes (testosterone)
Hormonal Deficiencies
• Even mild under-production of hormones (deficiency) can be associated with many health problems, and leave you sick, tired, “brain-fogged” and in pain!
• Hormonal deficiencies are common –
despite normal blood tests
• Treat with natural hormones
Low Thyroid Hormone
• Thyroid (the body’s gas pedal) • Symptoms of low thyroid include: – Fatigue – Weight gain – Joint/muscle pain (aches) – Cold intolerance – Thinning of lateral eyebrows – Poor memory and depression • Treat – Compounded or Armour Thyroid (Rx) and nutritional support
Weight Gain
• The average weight gain in CFS is 32 pounds (in 2 studies in our research center)! • Can help promote weight loss by: Addressing thyroid and adrenal hormone deficiency Taking acetyl-l-carnitine 1000 mg/day Treating fungal overgrowth Getting 8 hours sleep a night
Adrenal Burnout
• Too much time spent in a state of high stress can exhaust the adrenal gland. New research suggests “Adrenaline Overdrive” and exhaustion • Adrenal exhaustion is common and not recognized yet by traditional medicine • Symptoms: low blood pressure hypoglycemia crashing with stress
Natural Support of the Adrenal Gland ADRENAL STRESS-END
• Glandular adrenal extract contains supportive nutrients • Vitamin C and pantothenic acid (Vitamin B5) are critical to support adrenal gland function • Licorice - supports cortisol and acts as an antiviral
Also consider:
• DHEA if level is low and natural cortisol (cortef) in ultra low dosing
Infections
• Most important is yeast/fungal overgrowth • Suspect in all CFS/FMS patients. Markers include sinusitis and spastic colon • Rx –
Acidophilus Pearls
, low sugar (use stevia), antifungals (e.g.-
Anti-yeast
),
Diflucan
(Rx) • New research shows both increase in bowel yeast during flares of CFS and clinical improvement with probiotics
Chronic Infections in CFS/FM
• Dozens of Chronic Infections in CFS documented (several new ones this year) – Viral – Antibiotic sensitive – Yeast (Candida and others) – Parasites Shows that the immune suppression is primary, with the body picking up many infectious “hitch hikers”.
Nutritional Deficiencies-New Research
• Research showing multiple Amino Acid (protein) deficiencies • Low tyrosine-Can contribute to low dopamine, adrenaline and thyroid.
• May be caused by autonomic dysfunction with adrenaline/sympathetic nervous system overdrive • Multiple other amino acid deficiencies are also critical to treat (for glutathione, neurotransmitters, etc)
Nutritional Deficiencies-New Research
• Multiple nutritional deficiencies are likely • Which vitamin/mineral do you need? ALL OF THEM!
• New research shows: Vitamin D Deficiency (controversial) Iron helpful for RLS (Restless Legs) Iodine deficiency recurring in the USA
The Energy Revitalization System Makes It Easy
1 good tasting drink and 1 capsule Replaces 35 supplement tablets a day!
Contains 50 key nutrients!
Supplies optimal nutritional support for everyone easily and affordably
100% of my royalties go to charity as a teacher, to avoid a conflict of interest, I refuse to take money from any company whose products I recommend
Mitochondrial and Genetic Research
• 2 new studies documented defects in genetic energy production • Multiple studies showed a host of genetic predispositions to CFS. • Polymorphisms were found to correlate with gene expression and were strong predictors of CFS
D-Ribose-CORvalen
• This is an incredibly promising new nutrient for pain and fatigue patients • Ribose availability is a rate limiting issue in energy production-especially in people having an energy crisis I consider it to be the most important nutritional discovery of the decade!
D-Ribose-CORvalen
• ATP is composed of Ribose, adenine and phosphate groups • FAD is ribose plus riboflavin and adenine • Acetyl CoA is ribose plus pantothenic acid and adenine • DNA and RNA have ribose as a key component • Ribose deficiency in energy deficient states can be a critical piece of the puzzle
CORvalen Study
• 36 CFS/Fibromyalgia patients • 65.7% improved significantly(~20% dramatically) • Significant improvements were found in: – energy levels (+45%), – sleep patterns (+25%), – mental clarity (+16%), – pain (-14%), and the – patient’s overall state of well being (+30%)
Mind Body Connection
• There is no longer a question whether CFS is real and physical. It clearly is.
• All illnesses (e.g..-cancer, MS, heart attacks) have a psychodynamic • As with any illness, counseling should be used to support the patient if needed — not to invalidate the illness • Cognitive Behavioral Therapy (CBT) not effective by itself (75% drop out rate — more patients got worse than improved)
Medications
• 3 new medications approved by FDA for Fibromyalgia pain (Lyrica, Cymbalta, and Savella) • Though helpful, best to also treat the underlying causes of the pain with “SHINE”
From Fatigued To Fantastic!
The best-selling book on effective CFS/Fibromyalgia therapies It can teach you how to get your life back!
CFS & Fibromyalgia are treatable!
Remember SHINE !
“Teitelbaum’s treatment approach is an excellent and highly effective part of the standard of practice for treating Fibromyalgia and MPS” Editorial in the journal of the American Academy of Pain Management
Getting Well Now
• Do the free patented online program at www .Vitality101.com
It will analyze your symptoms (and labs if available), determine the underlying causes of your CFS & Fibromyalgia, and tailor a treatment protocol to your case
Fibromyalgia and Fatigue Centers
Physicians throughout the US who know how to effectively treat CFS & Fibromyalgia.
New-International program now available