Transcript XenoBiosis International B.V.

Life Science, what?
 Products which serve human health care
 Product’s source is Asian herbal traditional medicine
 Herbs
unique technology
extract
 The extract is marketed to end-stage companies in the
pharmaceutical, cosmetic or food supplement market
Products
 95% pure extract from the leaves of the Ginkgo biloba
tree; GinkgoTerp®
 R&D:
 Immune stimulators
 Anti-oxidizing agents
 Anticancer steroïds
GinkgoTerp®
 Because of the different constituents, this extract can affect
various systems in the human body
 In general, GinkgoTerp® is a perfect prophylaxis for the
body under strain or where the body is decreasingly able to
recover from it, such as
 Sports
 Stress
 Ageing
 Atherosclerosis
 Memory impairment
 Alzheimer’s disease
 Parkinson’s disease
Bioactivity: flavonoïds and
terpenelactones
 Flavonoïds are free-radical scavengers. Since
flavonoïds are also available in dietary products, the
additional effect of the amount in the normal extract is
considered to be not significant.
 Terpene trilactones are known to block three receptors
(GABA -, Glycine – and Platelet Activating Factor
receptors) and act on mitochondria throughout the
whole body. Effects of GBE are largely attributed to
these compounds
Mode of action
Gk
A
Bil
GABA
Bil
GLY
Gk
B
PAF
Gk
A+B
Alzheimer’s disease
Parkinson’s disease
Mood/anxiety
Cancer progression
Cognitive function
Neuronal damage
Cardiovascular
Atherosclerosis
Erectile dysfunction
Disappointing results of Ginkgo
studies
 Ginkgo shows a clear positive effect on vascular
disorders with 240mg a day
 Intermittent claudation
 Vascular dementia
 No positive results from clinical studies regarding
Alzheimer’s disease
 An inadequate dosage regimen could be the cause
Estimation of the correct dosage regimen is a must!
Dosage regimen(1)
 Tablets/capsules have to be taken 0.5h before the
meal to obtain a desired blood-level
have to be taken
at two or three
different time
points per day
 Tablets/capsules
have to be nonenteric coated
40
30
20
10
ng/ml
 Tablets/ capsules
50
0
0
10
Ginkgolide B i.v.
Ginkgolide B oral, fasting
20
T(hr)
30
Ginkgolide B oral, breakfas
Dosage regimen(2)
Based on the pharmacology of the active constituents,
following doses are advised:
 vascular disorders:
120/7.5 mg, twice a day*
 memory impairment:
240/15 mg, twice a day*
 neurodegenerative diseases: 360/22.5 mg, thrice a day*
* EGb761/GinkgoTerp®
GinkgoTerp® vs. EGb761
 95% terpenelactones
 6% terpenelactones
 NO flavonoids
 24% flavonoids
 5% undefined
 70% undefined
 7.5 mg extract to
 120 mg extract to
achieve effect
16 times less
achieve effect
Why are we the best?
Competitors produce a 30% pure product, GinkgoTerp®
is a 95% pure product of the active compounds
 Based on terpenelactones-content, we produce 16 times purer extract
than competitors
EGB 761
SGBE-T
GinkgoTerp®
bilobalide
1%
EGB 761
3%
Competitors
3%
5%
3%
ginkgolides
45%
bilobalide
24%
ginkgolides
bilobalide
3%
24%
ginkgolides
flavonoidglycosides
flavonoidglycosides
flavonoidglycosides
variable and/or to be
variable
70% and/or to be
determined
variable and/or to be
determined
70%
49%
determined
Co-formulations
Since GinkoTerp® is added in much less mg’s as
competitive extracts, co-formulation is an excellent option
For instance with:
 Sports: Magnesium, Potassium, Zinc
 Stress/Concentration: Vitamin B1 and 3
 Ageing: Vitamins (B1,3,9, C, E)
Principle of production
 Excellent quality of raw material
 continuity, method of harvesting and drying
 A unique production process for extract with high
purity level
What’s in it for you?
A 16x purer extract/new formula means:
 You get your money’s worth
95% instead of 6% terpenelactones-content
 Competitive price setting which creates a win-win situation
 Less side effects
less undefined compounds, 5% vs. 70% undefined
 Smaller dose needed in formulation
16 times less mg’s needed e.g. 7.5mg GinkgoTerp® vs. 120mg EGb761
 Increasing convenience for consumer
smaller tablets/capsules; easier to swallow
 Excellent to use in co-formulations
16 times less mg’s needed
 No colorization
snow-white appearance