Transcript Percentage of Non-susceptible Sterile Site vs Non

Percentage of Penicillin Non-Susceptible
S. pneumoniae in Canada: 1988-2009
25
% intermediate resistance
20
% high-level resistance
15
10
5
19
93
19
94
19
95
19
96
19
97
19
98
19
99
20
00
20
01
20
02
20
03
20
04
20
05
20
06
20
07
20
08
20
09
19
88
0
*Non-meningitis, Oral pen breakpoints used
Canadian Bacterial Surveillance Network, Jun 2010
Percentage of Penicillin* Non-Susceptible
S. pneumoniae in Canada: 1993-2009
6
% intermediate resistance
5
% high-level resistance
4
3
2
1
19
93
19
94
19
95
19
96
19
97
19
98
19
99
20
00
20
01
20
02
20
03
20
04
20
05
20
06
20
07
20
08
20
09
0
*Non-meningitis, IV breakpoints used
Canadian Bacterial Surveillance Network, Jun 2010
Percentage of Non-susceptible Sterile Site vs Non-sterile
Site Isolates of S. pneumoniae, 2009
Percentage (%) Non-susceptible
30
Sterile
Non-sterile
25
20
15
10
5
0
Pen
Erythro
Clinda
*Non-meningitis breakpoints used, Non-meningitis (IV) for pen
Ceftriaxone
Cipro
Tetracycline
Tmp/Smx
Canadian Bacterial Surveillance Network, Jun 2010
Percentage of Amoxicillin Non-Susceptible
S. pneumoniae in Canada: 1988-2009
5
4.5
4
% low-level resistance
% resistance
3.5
3
2.5
2
1.5
1
0.5
19
93
19
94
19
95
19
96
19
97
19
98
19
99
20
00
20
01
20
02
20
03
20
04
20
05
20
06
20
07
20
08
20
09
19
88
0
Canadian Bacterial Surveillance Network, Jun 2010
Percentage of Non-susceptible Isolates of
S. pneumoniae in Ages <=15 and >64, 2009
30
Age <=15 yrs
Age >64 yrs
Percentage (%) non-susceptible
25
20
15
10
5
0
Pen
Erythro
Clinda
*Non-meningitis breakpoints used, Non-meningitis (IV) for pen
Ceftriaxone
Cipro
Tetracycline
Tmp/Smx
Canadian Bacterial Surveillance Network, Jun 2010
Percentage of Non-susceptible Isolates of
S. pneumoniae in Geographic Regions of Canada, 2009
30
25
20
15
10
5
0
PRAIRIES
BC
Levo
*Non-meningitis breakpoints used
Atlantic
ONT
Ceftri (Non-mening)
Pen
Clind
Eryth
Canadian Bacterial Surveillance Network, Jun 2010
Macrolide-Resistant Pneumococci:
Canadian Bacterial Surveillance Network, 1993-2009
20
15
10
5
20
09
20
08
20
07
20
06
20
05
20
04
20
03
20
02
20
01
20
00
19
99
19
98
19
97
19
96
19
95
19
94
19
93
0
19
88
Percentage of Isolates Resistant to
Erythromycin
25
Canadian Bacterial Surveillance Network, Jun 2010
Fluoroquinolone-Resistant Pneumococci:
Canadian Bacterial Surveillance Network, 1997-2009
% Resistant
2
1.5
Moxifloxacin
Levofloxacin
1
0.5
0
1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009
Canadian Bacterial Surveillance Network, Jun 2010
Fluoroquinolone-Resistant Pneumococci in Respiratory
Isolates from Adults >64 years: 1988-2009
Levo R
Moxi R
All quinolone Use
Cipro Use
Levo Use
Moxi
7
120
6
100
5
80
4
60
3
40
2
20
1
0
0
1993 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009
Serotype distribution by year: 1994-2009
80
70
% of isolates
60
50
40
30
20
10
0
1994
1995
1996
1997
1998
1999
2000
2001
2002
2003
2004
2005
2006
2007
2008
2009
Year
PCV7
PCV10 additional serotypes (1,5,7F)
PCV13 additional serotypes (3,6A,19A)
NPCV
Serotype distribution by year: 1994-2009
45
40
% of isolates
35
30
25
20
15
10
5
0
18C
14
9V
23F
9N
6B
4
19A
6A
11A
7F
3
19F
Other
Year
1994
2006
1995
2007
1996
2008
1997
2009
1998
1999
2000
2001
2002
2003
2004
2005