Transcript LifePak Marketing Information

®
LifePak
Technical Training for Medical
Representative Certification
Written by:
Carsten R. Smidt, Ph.D., F.A.C.N.
The LifePak Family
The LifePak Family
Study Materials
Copy of these slides
Draft, LifePak® Monograph
For internal use only.
Do not copy!
Nutrition 101
Present Knowledge in Nutrition
Seventh Edition
E. E. Ziegler and L. J. Filer, Jr.
1996, 684 pages, $50.00
ILSI Press, 202-659-0074 x123
[email protected]
Don’t fall asleep!
Possible Exam Items:
What you will learn:
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Why take multivitamins?
Concept of optimum supplementation
LifePak’s 5-in-1 concept
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antioxidants, free radicals & heart health
B-vitamins & homocysteine
bone nutrients & osteoporosis
trace elements & bioavailability
phytonutrients
What you will learn:
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LifePak & Cardiovascular Health,
Glucose & Insulin Metabolism, and
Immune Function
Key features of other LifePak products
LifePak Directions
LifePak Safety
LifePak Precautions
In other words...
LifePak is the best
multivitamin/mineral
supplement -worldwide!
Why take multivitamins?
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To meet the RDAs, I.e., prevent nutrient
deficiencies
To improve general well-being, e.g.,
physical and mental performance
To stay healthy (health insurance in pill
form)
Multivitamin Usage
38 % of US population are
regular multivitamin users!
What shall we do with the
other 62 %?
Recommended Dietary
Allowances
RDA Definition: “Intake level of essential
nutrients judged to be adequate to meet the
needs of practically all healthy persons.”
RDAs prevent classical deficiency diseases:
• Vitamin C & Scurvy
• Thiamin & Beri-Beri
RDAs have a safety margin: Less than 2/3rds
of RDA = “nutrient deficiency”
RDA, RDI, DV…
confusing?
RDA: Recommended Dietary Allowances,
NRC Food and Nutrition Board 1989.
NRC Food and Nutrition Board 1998-?
RDI: Recommended Daily Intake,
FDA, for labeling, based on 1978 RDAs.
% DV: Daily Value, FDA, % of RDI present
in a serving of a food or supplement.
Why take multivitamins?
 In
a survey of 21,500 people*, not a single
person consumed a 100% of RDA for the
10 most important nutrients!
 Over
70% of people did not even meet
2/3rds of RDA for one or more
nutrients.**
* USDA National Food Consumption Survey 1977-78.
** USDA National Food Consumption Survey 1987-88.
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Percent of Adults Not Meeting RDA
90
80
70
60
50
Males
40
Females
30
20
10
0
Source: USDA 1994-96 CSFII
Eat More Fruits & Vegetables!
Eat Fruits & Vegetables!
 National
Cancer Institute: Eat 5-10
servings to prevent cancer!
 90% of Americans eat less than 5 servings
a day.*
 U.S. average is 3.2 servings/day.*
 Fruits & vegetables contain vitamins,
minerals, thousands of phytonutrients,
dietary fiber and potassium.
*NHANES II data
Are RDAs adequate?
 RDAs
do not consider optimum intakes.
• Vitamin E: 100-400 IU
• Vitamin C: 200-500 mg
• Chromium: 200 mcg
 Optimum
RDAs are under development
by the NRC Food and Nutrition Board
(NRC FNB)
Optimum Supplementation
Ensures RDA levels
+
Considers typical dietary intakes
+
Optimum nutrient levels for long-term health
+
Non-essential, beneficial nutrients
What is LifePak?
LifePak is a comprehensive
nutritional supplementation program
delivering the optimal amounts of all
essential vitamins, antioxidants,
minerals, and trace
elements, as well as
beneficial phytonutrients.
LifePak 5-in-1 Concept
LifePak is FIVE formulas in one:
1. high potency antioxidant formula
2. balanced B-vitamin formula
3. complete bone support formula
4. complete trace element supplement
5. phytonutrient formula
LifePak Advantages
LifePak is FIVE formulas in one:
1. high potency antioxidant formula
2. balanced B-vitamin formula
3. complete bone support formula
4. complete trace element supplement
5. phytonutrient formula
What are Free Radicals?
 Free
radicals are highly reactive, short-lived
compounds that can destroy the body’s fats,
proteins and nucleic acids (DNA).
 Free radicals are involved in the etiology of:
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cardiovascular disease
cancer
cataract, macular degeneration
aging process
What are Free Radicals?
There are many types of free radicals...
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HO• hydroxyl radical, 10-9 seconds
RO• alkoxyl radical, 10-6 seconds
ROO• peroxyl radical, 7 seconds
NO• nitric oxide radical, 1-10 seconds
O2-• superoxide anion radical, enzymic
…and reactive oxygen species (ROS):
• 1O2 singlet oxygen, 10-5 seconds
• ONOO- peroxinitrite, 0.05-1 seconds
• H2O2 hydrogen peroxide, enzymic
Free Radical Sources
 Environmental
pollution
 Radiation: UV light, X-ray, g-ray
 Smoking: 1016 free radicals/cigarette
 Normal oxidative metabolism of
carbohydrates, fats & proteins for energy
production.
Antioxidants
 Capture/neutralize
free radicals
• (e.g., vitamin E in cell membranes, etc.)
 Intrinsic Antioxidants:
• albumin, uric acid, a-ox enzymes (GPX, SOD,
catalase), and others.
 Extrinsic
(Dietary) Antioxidants:
• a-ox vitamins, trace element cofactors,
carotenoids, flavonoids, and others.
Antioxidant Effects
 Decrease
free radical damage (oxidation)
• especially in people with high oxidative stress:
» smokers, elderly, people in polluted urban areas
 Improve
cardiovascular health:
• Reduce LDL-Oxidation & atherosclerosis
 Slow
down aging process:
• Less DNA & protein damage
 Help
prevent cancer:
• Protect DNA; promote normal cell growth
Antioxidants
Many types of antioxidants must
work together (in synergy) to
afford effective protection from
free radical damage.
“Antioxidant defense system”
LifePak Antioxidants
 Vitamin
C, 500 mg
 Vitamin E, 300 IU, natural
 Selenium, Zinc, Copper, Manganese
 alpha-Lipoic acid
 Phytonutrients:
• Carotenoids
• Flavonoids
Objective of LifePak Studies
Does LifePak supplementation improve
antioxidant status and decrease LDLoxidation in healthy non-smokers
consuming typical U.S. diets?
LifePak Antioxidant Studies
 Two
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double-blind studies (FDA-GCP):
140-subject parallel design (Houston, TX)
46-subject cross-over design (Evansville, IN)
LifePak or placebo for 6 weeks
Both studies evaluated antioxidant status and
LDL oxidizability.
 FASEB
J. 13(4): A546 (cross-over study)
 other publications forthcoming.
LifePak Antioxidant Studies
Inclusion/Exclusion Criteria for Subjects:
 healthy non-smokers
 men & women, ages 18-65
 on typical U.S. Diets
< 5 servings of fruits & vegetables per day

no other dietary supplements or medications
Serum b-Carotene
(nmol/L)
1200
1000
PL
MVMS
(means +/- SD)
p < 0.001
800
600
716
400
200
331
335
299
0
Baseline
Endpoint
Serum a-Carotene
(nmol/L)
1000
800
PL
MVMS
(means +/- SD)
p < 0.001
600
592
400
200
122
0
77
Baseline
85
Endpoint
Serum Vitamin C
(mmol/L)
140
120
PL
MVMS
p < 0.001
(means +/- SD)
100
94.3
80
60
67.4
68.1
70.6
40
20
0
Baseline
Endpoint
Serum Vitamin E
(mmol/L)
50
PL
MVMS
p < 0.001
(means +/- SD)
40
36.9
30
20
19.9
20
20.6
10
0
Baseline
Endpoint
Serum Selenium
(mmol/L)
4
3
2
PL
MVMS
2.2
(means +/- SD)
2.1
p < 0.01
2.3
2.5
1
0
Baseline
Endpoint
LDL Oxidation
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LDL are prone to oxidation by free
radicals.
Oxidized LDL tend to adhere to artery
walls more than non-oxidized LDL.
Antioxidants can improve LDL’s
resistance against free-radical
oxidation
LDL Oxidizability
Blood Sample
Plasma
LDL isolation
LDL
LDL
Copper
Ion
Solution
LDL
LDL
Oxidation
LDL Oxidizability
Rate
Lag Time
Time
LDL Oxidizability, lag time
(min)
60
50
PL
MVMS
(means +/- SD)
p < 0.001
50.9
40
42.1
43.4
42
30
20
10
0
Baseline
Endpoint
LDL Oxidizability, Rate
(mmol/min x g protein)
20
18
16
PL
MVMS
(means +/- SD)
p < 0.001
14
12
12.7
12.5
10
8
12.9
11.4
6
4
2
0
Baseline
Endpoint
LP Studies: Conclusions
 LifePak
improved antioxidant status.
 LifePak
increased LDL’s resistance
against free-radical oxidation, and thus,
may have cardiovascular benefits.
 LifePak
is safe and well-tolerated.
LifePak Advantages
LifePak is FIVE formulas in one:
1. high potency antioxidant formula
2. balanced B-vitamin formula
3. complete bone support formula
4. complete trace element supplement
5. phytonutrient formula
LifePak B-Vitamins
 Balanced
accdg. to optimum requirements.
 Optimum amounts for normal
homocysteine metabolism.
• Homocysteine: Undesirable amino acid byproduct from methionine metabolism
• impairs vascular function, atherogenic
• independent risk factor for cardiovascular disease
• B12, Folate & B6 help control homocysteine.
LifePak B-Vitamins
Regular LifePak B-Vitamins:
Thiamin (vitamin B1)
Riboflavin (vitamin B2)
Niacin
Vitamin B6 (pyridoxine)
Folic Acid
Vitamin B12
Pantothenic Acid
Biotin
3 mg
3.4 mg
40 mg
10 mg
600 mcg
30 mcg
30 mg
300 mcg
200 % DV
200 % DV
200 % DV
500 % DV
150 % DV
500 % DV
300 % DV
100 % DV
LifePak Advantages
LifePak is FIVE formulas in one:
1. high potency antioxidant formula
2. balanced B-vitamin formula
3. complete bone support formula
4. complete trace element supplement
5. phytonutrient formula
Bone Nutrition: Calcium
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Calcium (Ca) is the major bone mineral, and
it helps prevent osteoporosis.
Calcium intake: 55% of men and 78% of
women do not meet the RDA!
Calcium RDA = RDI (DV): 1,000 mg/day
1 gl. of milk = 300 mg calcium = 30 % DV
LifePak has 500 mg Ca = 50 % DV
Bone Nutrition
Calcium alone is not the
answer!
LifePak Bone Nutrients
Magnesium: Like Ca, a structural component
 60 % of body’s Mg is in bone
 Mg supplementation increases BMD
 Mg also promotes heart rhythm, blood
pressure and muscle function (ATP action).
 Mg intake: 66% of men and 76% of women
do not meet the RDA!
 LifePak: 250 mg Mg = 62.5 % DV
LifePak Bone Nutrients
Vitamin D: Fat-soluble vitamin
 helps regulate Ca, Mg, and bone metabolism
 functions as a hormone
 Deficiency is common
 Experts recommend supplementation with
400 IU daily from multivitamins
 All LifePaks have 400 IU vitamin D
LifePak Bone Nutrients
Vitamin K: Fat-soluble vitamin
 promotes Ca incorporation into bone
Boron and Silicon: trace elements
 support normal bone metabolism
Soy Isoflavones (Phytoestrogens):
 promote bone mineralization
LifePak Bone
Nutrients
Calcium
500 mg 50 % DV
Magnesium
250 mg 62.5 % DV
Vitamin D
400 IU
100 % DV
Vitamin K
40 mcg 50 % DV
Boron
3 mg
n/a
Silicon
3 mg
n/a
Soy Isoflavones
10 mg
n/a
LifePak Advantages
LifePak is FIVE formulas in one:
1. high potency antioxidant formula
2. balanced B-vitamin formula
3. complete bone support formula
4. complete trace element supplement
5. phytonutrient formula
LifePak Trace Elements
Key Features:
 Highly
bioavailable (utilized by the body)
 Excellent
tolerance
 Complete
spectrum at optimum amounts
LifePak Trace
Elements
Top Quality Sources
(Amino Acid Chelates,
Albion Labs, etc.)
 Zinc AA Chelate
 Iron AA Chelate
 Copper AA Chelate
 Iodine (iodide)
 Vanadium (sulfate)
 Selenium (SeMet, selenite)
 Chromium AA Chelate
 Manganese AA Chelate
 Molybdenum AA
Chelate
 Silicon (metasilicate)
 Boron (citrate)
LifePak Trace Elements
Highlights:
 Chromium (200 mcg):
• normal insulin and blood glucose levels
• 90 % of US diets may be low in chromium
• effective in non-insulin-dependent diabetes
 Selenium
(100 mcg):
• essential cofactor for glutathione peroxidase, an
antioxidant enzyme
• may prevent prostate cancer
Chelates & Bioavailability
= the body’s ability to
utilize a nutrient = absorption + tissue
uptake + metabolic functions.
 Amino acid chelates tend to have the
highest bioavailability and solubility of all
mineral forms.
 Amino acid chelates are often better
tolerated than inorganic mineral salts.
 Bioavailability
Chelates & Bioavailability
Chelates  Amino Acid Chelates
• Pseudo-chelates: mixtures of mineral salts and
hydrolyzed proteins; “proteinates” etc.
• LifePak: covalently-bound, fully reacted amino
acid chelates (Albion Laboratories)
H 2C
NH2
O
M
O=C
C=O
O
H2N
CH2
LifePak Advantages
LifePak is FIVE formulas in one:
1. high potency antioxidant formula
2. balanced B-vitamin formula
3. complete bone support formula
4. complete trace element supplement
5. phytonutrient formula
Phytonutrients
A.k.a. phytochemicals or secondary
plant metabolites.
Non-essential plant compounds with
health benefits.
Over 12,000 phytonutrients have been
isolated from foods.
LifePak Phytonutrients
LifePak provides a broad spectrum of:
Carotenoids
Flavonoids
(Polyphenols)
LifePak Phytonutrients
Carotenoids:
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over 600 carotenoids present in nature
safe vitamin A sources (a- & b-carotene)
fat-soluble antioxidants (1O2 quenchers)
promote immune function (b-carotene)
prevent prostate cancer (lycopene)
prevent macular degeneration (lutein)
Phytonutrients
Beta-Carotene: Friend or Foe?
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
high-dose (20-30 mg) synthetic beta-carotene
may promote existing lung tumors (ATBC
study, CARET study).
Population studies: beta-carotene decreases risk
for most cancers, incl. lung cancer.
Other carotenoids have been ignored in
research. Most are more potent antioxidants.
Phytonutrients
Beta-Carotene: Friend or Foe?
Recommendations:
 Eat more fruits & vegetables!
 Pharmanex - IDN position:
Supplementation is beneficial:
 with a broad spectrum of dietary carotenoids
 at physiologic levels
 reflecting carotenoids from fruits & vegetables
LifePak
Phytonutrients
LifePak Carotenoids:
beta-Carotene (D.salina) 6 mg (10,000 IU)
lutein (Marigold extract) 2 mg
lycopene (Tomato extract) 1 mg
alpha-Carotene
2 mg
Zeaxanthin
beta-Cryptoxanthin
(extracts conform to Pharmanex 6S Process)
LifePak Phytonutrients
Flavonoids:
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O
over 5,000 flavonoids
known in nature, 600 present in our
diets.
water/alcohol soluble plant products
powerful antioxidants
many enhance microcirculation (blood flow)
many appear to prevent cancer
(epidemiological, animal studies)
LifePak Phytonutrients
LifePak Flavonoids (145 mg total):
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From 5 well-researched stdzd. extracts:
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OPC from grape seed extract
Hesperidin & Naringenin from citrus extract
Quercetin
Isoflavones (genistein, etc.) from soy extract
Curcumin (polyphenols) from turmeric extract
Amount  5-10 servings of fruits & veggies
All extracts conform to 6S Process
Synopsis: Health Benefits
LifePak: optimum supplementation for:
 addressing common nutrient deficiencies
 bone nutrition
 cardiovascular health
 glucose and insulin metabolism
 immune function
LifePak &
Cardiovascular Health
 Antioxidants: lower LDL-oxidizability
 Calcium & Magnesium: maintain normal
blood pressure & heart rhythm
 B-Vitamins: maintain normal blood homocysteine
 Flavonoids: promote normal platelet aggregation
and blood microcirculation
LifePak &
Insulin/Glucose Metabolism
 Vitamin
C, 500 mg:
• promotes normal sorbitol metabolism
 Vitamin
E, 300 IU:
• promotes normal platelet aggregation
• keeps protein glycosylation in balance
 Chromium,
200 mcg:
• essential for normal insulin function
LifePak & Immune Function
Promoting normal immune function
 Vitamins
C & E:
• promotes cell-mediated
specific and non-specific immunity
 beta-Carotene,
carotenoids:
• promotes natural killer cell activity
 Vitamin A,
vitamin B6 & zinc:
• essential for immune function
LifePak Women
LifePak Women
Young, Pre-Menopausal Women
Key Features:
 Bone
Nutrition: 1,000 mg calcium & 500 mg
magnesium (2x LifePak!), & extra silicon;
• National Insitutes of Health: 1,000 - 1,500 mg Ca/day
• About 80% of young women do not meet RDA (1,000 mg)
• FDA Health Claim: Calcium prevents osteoporosis
 Extra
Iron: 10 mg, amino acid chelate
• iron deficiency is more common in young women; over
70% do not meet RDA!
LifePak Women
Key Features, continued
 Folate
and Inositol: For women in their childbearing years;
• Folate prevents neural tube defects (FDA health claim)
 Extra
Vitamin B6: 20 mg
• 65 % of women don’t meet the RDA for vitamin B6
 Special
Phytonutrients:
• 25 mg soy isoflavones: same as in 25 grams soy protein
• gamma-linolenic acid-rich oils.
LifePak Prime
LifePak Prime
For Post-Menopausal Women &
Men Over Age 40
Key Features:
 Bone
Nutrition: 1,000 mg calcium & 500 mg
magnesium (2x LifePak!), & extra silicon
• NIH: 1,000 - 1,500 mg calcium per day
 Extra
Zinc: 20 mg amino acid chelate
• zinc promotes healthy immune function
• over 85% of the elderly do not meet the RDA
LifePak Prime
Key Features, continued:
 Glucosamine:
200 mg
• promotes joint structure & function
• 200 mg doubles average dietary intake
 Special Antioxidants:
glutathione, N-acetyl-
cysteine, coenzyme Q10
 Extra Phytonutrients: More curcumin, grape seed
OPCs; added stdzd. Ginkgo extract and Milk
Thistle extract.
LifePak PreNatal
LifePak PreNatal
For Pregnant & Lactating Women
Key Features:
 Optimum Antioxidants:
150 IU natural vitamin E
& 300 mg buffered vitamin C
• may prevent pre-eclampsia (gestational hypertension)
• pre-eclampsia affects 5-15 % of pregnant women
 Bone
Nutrition:
650 mg Calcium & 350 mg Magnesium
• pregnancy: fetal bone growth
• lactation: milk production
LifePak PreNatal
Key Features, continued:
 Folate
and Inositol: 800 mcg, 500 mg
• prevent neural tube defects
 Extra
Iron: 30 mg, Amino Acid Chelate
• best tolerated and most bioavailable form of iron
• higher demands due to fetal blood & muscle formation
• high risk for iron deficiency anemia
 Chromium:
180 mcg, Amino Acid Chelate
• promotes normal insulin and blood glucose metabolism
• benefits in gestational diabetes mellitus
LifePak PreNatal
Key Features, continued:
 Vitamin A:
5,000 IU is safe and effective
• Supplementation with more than 10,000 IU of preformed
vitamin A may increase the risk for fetal damage
(teratogenic effects).
 Carotenoids:
Natural beta-carotene (5,000 IU),
alpha-carotene,
lutein & lycopene.
TM
LifePak Teen
Optimum
Supplementation
for 9-18 year olds
THE PROBLEM:
THE SOLUTION:
Over 60% of
teen boys and
over 80% of
girls don’t meet
the RDA for
calcium or
magnesium*
LifePak Teen
Bone Nutrients:
500 mg Calcium
200 mg Magnesium
400 IU Vitamin D
40 mcg Vitamin K
3 mg Boron
3 mg Silicon
*USDA CSFII 1994-96 Survey Data
THE PROBLEM: THE SOLUTION:
Not enough
antioxidant
vitamins: Over
60% of teens
don’t get the
RDA for
vitamins A & E*
*USDA CSFII 1994-96 Survey Data
LifePak Teen
Antioxidants
5,000 IU Vitamin A
3 mg b-carotene
100 IU Vitamin E
200 mg Vitamin C
70 mcg Selenium
THE PROBLEM: THE SOLUTION:
Not enough
iron: 72.5% of
girls ages 1219 don’t meet
the RDA for
iron*
*USDA CSFII 1994-96 Survey Data
LifePak Teen
9 mg iron as amino
acid chelate;
50% of Daily Value
THE PROBLEM: THE SOLUTION:
Not enough
zinc: Over 65%
of teens don’t
meet the RDA
for zinc*
*USDA CSFII 1994-96 Survey Data
LifePak Teen
15 mg zinc as amino
acid chelate;
100% of Daily Value
LifePak Safety

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
All vitamin & mineral levels are below the
NOAEL (No Observed Adverse Effect
Level) established by the CRN (Council for
Responsible Nutrition, 1998).
Phytonutrients are added at levels that are
documented safe.
Clinical studies showed no adverse effects
to LifePak
LifePak Directions
One packet twice daily with meals
• meals enhance absorption (vitamins) and
improve tolerance (minerals)
• twice daily promotes steady nutrient delivery,
e.g., plasma levels of vitamin B6:
7:30 AM
6:30 PM
LifePak Precautions
“Pregnant & lactating women, diabetics,
hypoglycemics, and people with known
medical conditions should consult with a
physician before taking supplements”
LifePak Substantiation
Over 1,000 peer-reviewed scientific papers
on file documenting the efficacy and safety
of all nutrients in LifePak.
LifePak Substantiation
No other complete multi-nutrient
supplement has ever been subjected to two
well-designed double-blind clinical studies
to show antioxidant effects in healthy
people.
In other words...
LifePak is the best
multivitamin/mineral
supplement -worldwide!