Transcript Folie 1 - FLI

3D Structures of Biological Macromolecules
Exercise 3: Membrane Proteins
Jürgen Sühnel
[email protected]
Leibniz Institute for Age Research, Fritz Lipmann Institute,
Jena Centre for Bioinformatics
Jena / Germany
Supplementary Material: http://www.fli-leibniz.de/www_bioc/3D/
Cell Membrane
Membrane Structural Components
Lipids
Membrane Proteins
Cholesterol, a Constituent of the Cell Membrane
The First 3D Membrane Protein Structure
Membrane Protein Databases
www.mpdb.ul.ie/
Membrane Protein Databases
opm.phar.umich.edu/
Comparing Protein Structures
Transmembrane Protein (Halorhodopsin)
alpha-helical
Transmembrane Protein (Halorhodopsin)
alpha-helical
1e12
JenaLib
Transmembrane Protein (Outer Membrane Protein)
beta-barrel
Transmembrane Protein (Outer Membrane Protein)
beta-barrel
1qjp
JenaLib
1qjp
JenaLib
Transmembrane Helix Prediction Server
www.cbs.dtu.dk/services/TMHMM/
Transmembrane Helix Prediction Server
www.cbs.dtu.dk/services/TMHMM/
Transmembrane Helix Prediction Server (1e12)
www.cbs.dtu.dk/services/TMHMM/
Split Server Prediction (1e12)
split.pmfst.hr/split/4/
Prediction Comparison (1e12)
split.pmfst.hr/split/4/
www.cbs.dtu.dk/services/TMHMM/
Split Server Prediction (1qjp)
split.pmfst.hr/split/4/