Transcript 405213 LAB 1 - คณะแพทยศาสตร์ มหาวิทยาลัยนเรศวร

ปฏิบัตกิ าร วิชา พยาธิวิทยา ครั งที้ ท 1
ภาควิชาพยาธิวิทยาและนิตเิ วชศาสตร์
คณะแพทยศาสตร์ มหาวิทยาลัยนเรศวร
เนือ้ หา
• Cell adaptation, injury and death
• Inflammation and Repair
• Hemodynamic disorder
Cell adaptation, injury and death
Cell adaptation, injury and death
Reversible cell injury;
• Cloudy swelling of Hepatocytes (Micros)
• Fatty change of Liver (Gross&Micros)
• Hyaline change; Mallory bodies in hepatocytes
(Micros)
Cloudy swelling of Hepatocytes (Micros)
Fatty change of Liver (Gross&Micros)
Fatty change of Liver (Gross&Micros)
Hyaline change;
Mallory bodies in hepatocytes (Micros)
Cell adaptation, injury and death
Irreversible injury;
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Coagulative necrosis of Kidney (Renal infarct)
Coagulative necrosis of Spleen (Splenic infarct)
Liquefactive necrosis of Lung (Lung abscess)
Liquefactive necrosis of Brain (Brain infarct)
Caseous necrosis of Lymph nodes
Enzymatic fat necrosis in Acute pancreatitis
Coagulative necrosis of Kidney
(Gross&Micros)
Coagulative necrosis of Kidney (Gross)
Coagulative necrosis; Renal infarct
Coagulative necrosis; Splenic infarct
Liquefactive necrosis; Lung abscess
Liquefactive necrosis; Brain infarct
Liquefactive necrosis; Brain infarct
Caseous necrosis of Lymph nodes
(Gross & Micro)
Caseous necrosis; TB lymph nodes
Enzymatic fat necrosis in Acute pancreatitis
(Gross&Micros)
Cell adaptation, injury and death
Cellular adaptation;
• Hypertrophy ( Heart and Uterus)
• Testicular atrophy
• Prostatic hyperplasia
Cellular accumulation;
• Cholesterolosis of Gall bladder
Testicular atrophy (Gross)
Ventricular Hypertrophy (Gross&Micros)
Hypertrophy; Pregnant uterus
Prostatic hyperplasia (Gross&Micros)
Cholesterolosis of Gall bladder
(Gross&Micros)
Inflammation and Repair
Inflammatory cells;
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Neutrophils
Macrophages
Lymphocytes
Plasma cells
Neutrophils
Macrophages
Lymphocytes
Plasma cells
Inflammation and Repair
Acute inflammation;
• Acute appendicitis (Gross )
• Acute cholecystitis (Gross )
• Breast abscess (Gross )
Acute appendicitis (Gross )
Acute cholecystitis (Gross )
Breast abscess (Gross )
Inflammation and Repair
Chronic cholecystitis ( Micros)
Granulation tissue ( Micros)
Granulomatous inflammation ( Micros)
Keloid (Gross&Micros)
Scar contracture (Gross )
Chronic cholecystitis ( Micros)
Granulation tissue ( Micros)
Granulomatous inflammation ( Micros)
Keloid (Gross&Micros)
Hemodynamic disorders
Pitting edema
Pulmonary edema
Pulmonary edema
Hemorrhage
• Petechiae  1-2 mm
• Purpura  > 3 mm
• Ecchymoses  1-2 cm
• Hematoma
Petechial hemorrhage
Hematoma in Cerebral cortex
Shock
• Acute respiratory distress syndrome
(Shock lung) - ARDS
• Centrilobular hemorrhagic necrosis of
liver (Shock liver)
ARDS – Shock lung
ARDS – Shock lung
Hyaline membrane
Shock liver – Nutmeg liver
Shock liver – Nutmeg liver
Thrombosis and Embolism
• Thrombosis in Hemorrhoid
• Thrombotic embolism
• Tumor embolism
• Amniotic embolism
• Fat embolism
Thrombosis in Hemorrhoid
Thrombosis in Hemorrhoid
Thrombotic embolism in aorta
Tumor embolism
Amniotic embolism
Fetal squame cells
in pulmonary vessel
Fat embolism
Bone marrow
in vessel
Infarction
• Renal infarct
• Myocardial infarct
• Hemorrhagic necrosis of small bowel
– Gangrene bowel
• Gangrene of toe
Renal infarct
Renal infarct
Myocardial infarct
Gangrene bowel
Gangrene; Small intestine
Gangrene; Small intestine
Wet gangrene of toes
Dry gangrene of fingers
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