Transcript Total IV volume: NS: 500 ml

GC
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1/2NS 1000 ml IVD 4-6 hrs for hydration
Furosemide 20 mg IVA 10 min at the last 200 ml 1/2NS of hydration
Dexamethasone 10 mg or Betamethasone 8 mg IVA 10 mins at 30 mins
before chemotherapy
Granisetron 3 mg or Tropisetron 5 mg or Ondansetron 16 mg or
Palonosetron 0.25 mg IVA 10 mins at 15 mins before chemotherapy
Aprepitant cap 80 mg PO QD x 3 days
Gemcitabine 1200 mg/m2 in NS 100 ml IVD for 30 mins
Cisplatin 75 mg/m2 in NS 500 ml IVD for 2 hr
1/2NS 500ml IVD 2 hrs
If I>O more than 1500 ml or body weight increase over 1 kg per day,
Furosemide 20 mg IVA 10 mins st
( Total IV volume: 1/2NS: 1500 ml, NS: 600 ml)
GCar
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NS 500 ml IVD keep line for chemotherapy
Dexamethasone 10 mg or Betamethasone 8mg IVA 10 mins at 30
mins before chemotherapy
Metoclopramide 20 mg IVA 15 mins + Biperiden 2 mg p.o OR
Granisetron 3 mg or Tropisetron 5 mg or Ondansetron 16 mg or
Palonosetron 0.25 mg IVA 10 mins at 15 mins before chemotherapy
Gemcitabine 1200 mg/m2 in NS 100 ml IVD for 30 mins
Carboplatin AUC =6 【dose=AUC X (CCr+25)】in NS 250 ml
IVD for 1 hr
Run out the remaining NS
(Total IV volume: NS: 850ml)
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NS 500 ml IVD keep line for chemotherapy
Dexamethsone 10 mg or Betamethasone 8mg IVA 10 mins at 30
mins before chemotherapy
Metoclopramide 20 mg IVA 15 mins + Biperiden 2 mg p.o OR
(自費) Granisetron 3 mg or Tropisetron 5 mg or Ondansetron 16 mg or
Palonosetron 0.25 mg IVA 10 mins at 15 mins before chemotherapy
Gemcitabine 1200 mg/m2 in NS 100 ml IVD for 30 mins
Run out the remaining NS
( Total IV volume: NS: 500 ml)
NC (Q3W)
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1/2NS 1000 ml IVD 4-6 hrs for hydration
Furosemide 20 mg IVA 10 mins at the last 200 ml 1/2NS of hydration
Dexamethsone 10 mg or Betamethasone 8mg IVA 10 mins at 30 mins
before chemotherapy
Granisetron 3 mg or Tropisetron 5 mg or Ondansetron 16 mg or
Palonosetron 0.25 mg IVA 10 mins at 15 mins before chemotherapy
Aprepitant cap 80 mg PO QD x 3 days
Vinorelbine 25 mg/m2 in NS 100 ml IVD for 10 mins
Cisplatin 75 mg/m2 in NS 500 ml IVD for 2 hr
1/2NS 500 ml IVD 2 hrs
If I>O more than 1500 ml or body weight increase over 1 kg per day,
Furosemide 20 mg IVA 10 mins st
( Total IV volume: 1/2NS: 1500 ml, NS: 600ml)
NCar
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NS 500 ml IVD keep line for chemotherapy
Dexamethsone 10 mg or Betamethasone 8mg IVA 10 mins at 30
mins before chemotherapy
Metoclopramide 20 mg IVA 15 mins + Biperiden 2 mg p.o OR
Granisetron 3 mg or Tropisetron 5 mg or Ondansetron 16 mg or
Palonosetron 0.25 mg IVA 10 mins at 15 mins before chemotherapy
Vinorelbine 25 mg/m2 in NS 100ml IVD for 10 mins
Carboplatin AUC = 6【dose=AUC X (CCr +25)】in NS 250 ml
IVD for 1 hr
Run out the remaining NS
(Total IV volume: NS: 850ml)
N
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NS 500 ml IVD keep line for chemotherapy
Dexamethsone 10 mg or Betamethasone 8mg IVA 10 mins at 30
mins before chemotherapy
Metoclopramide 20 mg IVA 15 mins + Biperiden 2 mg p.o OR
(自費) Granisetron 3 mg or Tropisetron 5 mg or Ondansetron 16
mg or Palonosetron 0.25 mg IVA 10 mins at 15 mins before
chemotherapy
Vinorelbine 25 mg/m2 in NS 100 ml IVD for 10 mins
Run out the remaining NS
( Total IV volume: NS: 500 ml)
Oral N+C
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Vinorelbine (oral): 75 mg/m2 (30mg #, 20mg #)
1/2NS 1000 ml IVD 4-6 hrs for hydration
Furosemide 20 mg IVA 10 mins at the last 200 ml 1/2NS of hydration
Dexamethsone 10 mg or Betamethasone 8mg IVA 10 mins at 30
mins before chemotherapy
Granisetron 3 mg or Tropisetron 5 mg or Ondansetron 16 mg or
Palonosetron 0.25 mg IVA 10 mins at 15 mins before chemotherapy
Aprepitant cap 80 mg PO QD x 3 days
Cisplatin 75 mg/m2 in 500 ml NS IVD for 2 hr
1/2NS 500ml IVD 2 hrs
If I>O more than 1500 ml or body weight increase over 1 kg per
day, Furosemide 20 mg IVA 10 mins st
( Total IV volume: 1/2NS: 1500ml, NS: 500ml)
Oral N+Carbo
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Vinorelbine (oral): 75 mg/m2 (30mg #, 20mg #)
NS 500 ml IVD keep line for chemotherapy
Dexamethsone 10 mg or Betamethasone 8mg IVA 10 mins at 30
mins before chemotherapy
Metoclopramide 20 mg IVA 15 mins + Biperiden 2 mg p.o OR
Granisetron 3 mg or Tropisetron 5 mg or Ondansetron 16 mg or
Palonosetron 0.25 mg IVA 10 mins at 15 mins before chemotherapy
Carboplatin AUC = 6【dose=AUC X (CCr +25)】in NS 250 ml
IVD for 1 hr
Run out the remaining NS
(Total IV volume: NS: 850ml)
Oral N (Oral dose= IV dose x 2.5 )
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Vinorelbine (oral): 75 mg/m2 (30mg
#, 20mg
#)
NC (Weekly)
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1/2NS 500 ml IVD for hydration
Dexamethsone 10 mg or Betamethasone 8mg IVA 10 mins at 30 mins
before chemotherapy
Granisetron 3 mg or Tropisetron 5 mg or Ondansetron 16 mg or
Palonosetron 0.25 mg IVA 10 mins at 15 mins before chemotherapy
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Vinorelbine 25 mg/m2 in 1/2NS 100 ml IVD for 10 mins
Cisplatin 40 mg/m2 in NS 500 ml IVD for 2 hr
1/2NS 500 ml IVD for 2 hrs
If I>O more than 1500 ml or body weight increase over 1 kg per day,
Furosemide 20 mg IVA 10 mins st
( Total IV volume: 1/2NS: 1000 ml, NS: 500ml)
Q3W TaC
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1/2NS 1000 ml IVD 4-6 hrs for hydration
Furosemide 20 mg IVA 10 mins at the last 200 ml 1/2NS of hydration
Dexamethsone 10 mg or Betamethasone 8mg IVA 10 mins at 30
mins before chemotherapy
4 Chlorampheniramine 5 mg IVA 10 mins at 30 mins before
chemotherapy
5 Ranitidine 50 mg or Famotidine 20 mg IVA 15 mins at 30 mins
before chemotherapy
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Granisetron 3 mg or Tropisetron 5 mg or Ondansetron 16 mg or
Palonosetron 0.25 mg IVA 10 mins at 15 mins before chemotherapy
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Aprepitant cap 80 mg PO QD x 3 days
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Paclitaxel 175 mg/m2 in D5W 250 ml glass bottle x2 IVD with 0.22
um microfilter and NTG tube for 3 hrs ( if it is the first time,
paclitaxel should be infused with EKG monitoring )
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Cisplatin 75 mg/m2 in NS 500ml IVD for 2 hr
10 1/2NS 500ml IVD 2 hrs
11 If I>O more than 1500 ml or body weight increase over 1 kg per day,
Furosemide 20 mg IVA 10 mins st
( Total IV volume: 1/2NS: 1500 ml, NS: 500 ml, D5W: 250 ml x2)
Q3W TaCarbo
1. NS 500 ml IVD keep line for chemotherapy
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Dexamethsone 10 mg or Betamethasone 8mg IVA 10 mins at 30
mins before chemotherapy
3 Chlorampheniramine 5 mg IVA 10 mins at 30 mins before
chemotherapy
4 Ranitidine 50 mg or Famotidine 20 mg IVA 15 mins at 30 mins
before chemotherapy
5 Metoclopramide 20 mg IVA 15 mins + Biperiden 2 mg p.o OR
Granisetron 3 mg or Tropisetron 5 mg or Ondansetron 16 mg or
Palonosetron 0.25 mg IVA 10 mins at 15 mins before chemotherapy
6. Paclitaxel 175 mg/m2 in D5W 250 ml glass bottle x2 IVD with
0.22 um microfilter and NTG tube for 3 hrs
( if it is the first time, paclitaxel should be infused with EKG monitoring )
7. Carboplatin AUC = 6【dose=AUC X (CCr +25)】in NS 250 ml
IVD for 1 hr
8. Run out the remaining NS
( Total IV volume: NS: 750 ml, D5W: 250 ml x2)
Weekly Taxel
1. NS 500 ml IVD keep line for chemotherapy
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Dexamethsone 10 mg or Betamethasone 8mg IVA 10 mins at 30
mins before chemotherapy
Chlorampheniramine 5 mg IVA 10 mins at 30 mins before
chemotherapy
Ranitidine 50 mg or Famotidine 20 mg IVA 15 mins at 30 mins
before chemotherapy
Metoclopramide 20 mg IVA 15 mins + Biperiden 2 mg p.o OR
(自費) Granisetron 3 mg or Tropisetron 5 mg or Ondansetron 16 mg or
Palonosetron 0.25 mg IVA 10 mins at 15 mins before chemotherapy
Paclitaxel 80 mg/m2 in D5W 250 ml glass bottle IVD with
0.22 um microfilter and NTG tube for 1 hr
( if it is the first time, paclitaxel should be infused with EKG monitoring )
Run out the remaining NS
( Total IV volume: NS: 500 ml, D5W: 250 ml)
Weekly TaC
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1/2NS 1000 ml IVD 4-6 hrs for hydration
Dexamethsone 10 mg or Betamethasone 8mg IVA 10 mins at 30
mins before chemotherapy
Chlorampheniramine 5 mg IVA 10 mins at 30 mins before
chemotherapy
Ranitidine 50 mg or Famotidine 20 mg IVA 15 mins at 30 mins
before chemotherapy
Metoclopramide 20 mg IVA 15 mins + Biperiden 2 mg p.o OR
(自費) Granisetron 3 mg or Tropisetron 5 mg or Ondansetron 16 mg or
Palonosetron 0.25 mg IVA 10 mins at 15 mins before chemotherapy
Paclitaxel 80 mg/m2 in D5W 250 ml glass bottle IVD with 0.22
um microfilter and NTG tube for 1 hr
( if it is the first time, paclitaxel should be infused with EKG monitoring )
Cisplatin 25 mg/m2 in NS 500ml IVD for 2 hr
1/2NS 500ml IVD 2 hrs
( Total IV volume: 1/2NS: 1500 ml, NS: 500 ml, D5W: 250 ml)
Taxotere+ Cisplatin, Q3W
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1/2NS 1000 ml IVD 4-6 hrs for hydration
Furosemide 20 mg IVA 10 mins at the last 200 ml 1/2NS of hydration
Dexamethsone 10 mg or Betamethasone 8mg IVA 10 mins at 30 mins
before chemotherapy
Granisetron 3 mg or Tropisetron 5 mg or Ondansetron 16 mg or
Palonosetron 0.25 mg IVA 10 mins at 15 mins before chemotherapy
Aprepitant cap 80 mg PO QD x 3 days
Taxotere 60 mg/m2 in NS 250 ml IVD for 1 hr
Cisplatin 75 mg/m2 in NS 500 ml IVD for 2 hr
1/2NS 500 ml IVD 2 hrs
If I>O more than 1500 ml or body weight increase over 1 kg per day,
Furosemide 20 mg IVA 10 mins st
( Total IV volume: 1/2NS: 1500 ml, NS: 750 ml)
Taxotere+ Carboplatin, Q3W
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NS 500 ml IVD keep line for chemotherapy
Dexamethasone 10 mg or Betamethasone 8mg IVA 10 mins at 30
mins before chemotherapy
Metoclopramide 20 mg IVA 15 mins + Biperiden 2 mg p.o OR
Granisetron 3 mg or Tropisetron 5 mg or Ondansetron 16 mg or
Palonosetron 0.25 mg IVA 10 mins at 15 mins before chemotherapy
Taxotere 60 mg/m2 in NS 250 ml IVD for 1 hr
Carboplatin AUC =6 【dose=AUC X (CCr+25)】in NS 250 ml
IVD for 1 hr
Run out the remaining NS
(Total IV volume: NS: 1000ml)
Weekly Taxotere alone, Q3W
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NS 500 ml IVD keep line for chemotherapy
Dexamethasone 10 mg or Betamethasone 8mg IVA 10 mins at 30
mins before chemotherapy
Metoclopramide 20 mg IVA 15 mins + Biperiden 2 mg p.o OR
(自費) Granisetron 3 mg or Tropisetron 5 mg or Ondansetron 16 mg
or Palonosetron 0.25 mg IVA 10 mins at 15 mins before
chemotherapy
Docetaxel 40 mg/m2 in NS 250 ml IVD for 1 hr
Run out the remaining NS
( Total IV volume: NS: 500ml)
Alimta, Q3W
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NS 500 ml IVD keep line for chemotherapy
Dexamethsone 10 mg or Betamethasone 8mg IVA 10 mins at 30
mins before chemotherapy
Metoclopramide 20 mg IVA 15 mins + Biperiden 2 mg p.o OR
(自費) Granisetron 3 mg or Tropisetron 5 mg or Ondansetron 16 mg
or Palonosetron 0.25 mg IVA 10 mins at 15 mins before
chemotherapy
Pemetrexed 500 mg/m2 in NS 100ml IVD for 10 mins st
Run out the remaining NS
( Total IV volume: NS: 500ml)
Cisplatin + VP-16 (EP)
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1. 1/2 NS 1000 ml IVD 4-6 hrs for hydration
2. Furosemide 20 mg IVA × 10 mins at the last 200 ml NS of hydration
Dexamethasone 10 mg or Betamethasone 8 mg IVA 10 mins at 30 mins
before chemotherapy
Granisetron 3 mg or Tropisetron 5 mg or Ondansetron 16 mg or
alonosetron 0.25 mg IVA × 10 mins at 15 mins before chemotherapy
Aprepitant cap 80 mg PO QD x 3 days
Cisplatin 75 mg/m2 in NS 500 ml IVD × 2 hr
Etoposide (VP-16) 75 mg/m2 in NS 500 ml IVD × 2 hrs
1/2NS 500 ml IVD 2 hrs
If I>O more than 1500 ml or body weight increase over 1 kg per day,
Furosemide 20 mg IVA 10 mins st
( Total IV volume: 1/2 NS: 1500 ml, NS: 1000 ml)
Carboplatin + VP-16 (CarE)
1. NS 500 ml IVD keep line for chemotherapy
2. Dexamethasone 10 mg or Betamethasone 8 mg IVA × 10 mins at 30
mins before chemotherapy
3. Metoclopramide 20 mg IVA × 15 mins at 15 mins before
chemotherapy
4. Carboplatin AUC =6 【dose=AUC X (CCr+25)】in NS 250 ml IVD
for 1 hr
5. Etoposide (VP-16) 75 mg/m2 in NS 500 ml IVD × 2hrs
6. Run out the remaining NS
( Total IV volume: NS: 1500ml)
VP-16 (E)
1. NS 500 ml IVD keep line for chemotherapy
2. Dexamethasone 10 mg or Betamethasone 8 mg IVA × 10 mins at 30
mins before chemotherapy
3. Metoclopramide 20 mg IVA 10 mins at 15 mins before
chemotherapy
4. Etoposide (VP-16) 75 mg/m2 in NS 500 ml IVD × 2 hrs
5. Lorazepam 1 mg p.o. hs
6. Run out the remaining NS
( Total IV volume: NS: 1000ml)
Oral VP-16 (Oral E)
• Oral Etoposide 50mg QD × 10 days
Ifosfamide (I)
1. NS 500 ml IVD keep line for chemotherapy
2. Dexamethasone 10 mg or Betamethasone 8 mg IVA × 10 mins at 30
mins before chemotherapy
3. Metoclopramide 20 mg IVA × 15 mins at 15 mins before
chemotherapy
4. Ifosfamide 1000 mg/m2 in NS 500 ml IVD × 2hrs
5. Uromitexan 400mg add in NS 100 ml for IVD× 30 mins q2h × 3 doses
(at 0,2,4 hrs after Ifosfamide)
6. Lorazepam 1 mg hs
( Total IV volume: NS: 2000ml)
Topotecan + Epirubicin (TE)
1. NS 500 ml IVD keep line for chemotherapy
2. Dexamethasone 10 mg or Betamethasone 8 mg IVA × 10 mins at 30
mins before chemotherapy
3. Metoclopramide 20 mg IVA × 15 mins at 15 mins before
chemotherapy
4. Topotecan 1.5 mg/m2 IVD in NS 100 ml × 30 mins
5. Epirubicin 30 mg/m2 in NS 500 ml IVD× 2 hrs
6. Run out the remaining NS
( Total IV volume: NS: 1000ml)
Topotecan (T)
1. NS 500 ml IVD keep line for chemotherapy
2. Dexamethasone 10 mg or Betamethasone 8 mg IVA × 10 mins at 30
mins before chemotherapy
3. Metoclopramide 20 mg IVA × 15 mins at 15 mins before
chemotherapy
4. Topotecan 1.5 mg/m2 IVD in NS 100 ml × 30 mins
5. Run out the remaining NS
( Total IV volume: NS: 500 ml)
Pemetrexed + Cisplatin (Q3W)
1. 1/2NS 1000 ml IVD 4-6 hrs for hydration
2. Furosemide 20 mg IVA 10 min at the last 200 ml 1/2NS of hydration
3. Dexamethasone 10 mg or Betamethasone 8 mg IVA 10 mins at 30 mins
before chemotherapy
4. Granisetron 3 mg or Tropisetron 5 mg or Ondansetron 16 mg or
Palonosetron 0.25 mg IVA 10 mins at 15 mins before chemotherapy
5. Aprepitant cap 80 mg PO QD x 3 days
6. Pemetrexed 500 mg/m2 in NS 100 ml IVD for 10 mins
7. Cisplatin 75 mg/m2 in NS 500 ml IVD for 2 hrs
8. 1/2 NS 500ml IVD 2 hrs
9. If I>O more than 1500 ml or body weight increase over 1 kg per day,
furosemide 20 mg IVA 10 mins st
(Total IV volume: 1/2NS: 1500 ml, NS: 600 ml)
Pemetrexed + Carboplatin (Q3W)
1. NS 500 ml IVD keep line for chemotherapy
2. Dexamethasone 10 mg or Betamethasone 8 mg IVA 10 mins
at 30 mins before chemotherapy
3. Metoclopramide 20 mg IVA 15 mins and biperiden 2 mg po st
before chemotherapy
4. Pemetrexed 500 mg/m2 in NS 100 ml IVD for 10 mins
5. Carboplatin AUC=6 in NS 250 ml IVD for 1 hr
6. Run out the remaining NS
(Total IV volume: NS 850 ml)
•
•
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•
•
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•
關Aloxi健保給付如下
7.2.1 serotonin antagonists（如ondansetron、granisetron、tropisetron、ramosetron、palonosetron (Aloxi)
等）(93/2/1、93/9/1、98/9 /1、99/5/1)
1.血液幹細胞移植患者接受高劑量化學治療時。
2.惡性腫瘤患者及風濕免疫疾病（如紅斑性狼瘡、類風濕性關節炎、貝西氏症、皮肌炎/多發性肌炎、
硬皮症、血管炎等）患者接受化學治療時，依下述情形使用：(98/9 /1、99/5/1)
(1)前述患者處方高致吐性藥品，可預防性使用ondansetron 8~32mg、granisetron 1~3mg、tropisetron
5mg、ramosetron 0.3mg一日劑量。必要時，其使用以不得超過5日為原則。若發生嚴重延遲性嘔吐，
得直接使用，每療程使用不得超過5日為原則。
(2)前述患者處方中致吐性藥品，可預防性使用ondansetron 8~32mg、granisetron 1~3mg、tropisetron
5mg、ramosetron 0.3mg一日劑量。若發生嚴重延遲性嘔吐，使用dexamethasone 及 metoclopramide 無
效之病例，每療程使用以不得超過5日為原則。病歷須有使用dexamethasone及 metoclopramide 無效
之紀錄。
(3) 血液腫瘤病患接受化學治療，須使用中、高致吐性抗癌藥品時，得依患者接受抗癌藥品實際使用
天數使用本類製劑。(93/9/1)
(4) Palonosetron限於中、高致吐化學治療之前使用。(99/5/1)
1.
高致吐性藥品：cisplatin (>50mg/m2/day)，carmustine (≧250mg/m2 /day)，cyclophosphamide
(>1500mg/m2/day)，methotrexate (≧1.2gm/m2/day)。
2.
中致吐性藥品：cisplatin (≧30mg/m2/day, ≦50mg/m2/day)，carmustine (<250mg/m2/day)，
Cyclophosphamide (≦1500mg/m2 /day)，doxorubicin (≧45mg/m2/day)，epirubicin (≧70mg/m2/day)，
CPT-11，idarubicin (≧10mg/m2/day)，daunorubicin (≧60mg/m2 /day)，dactinomycin (actinomycin-D)，
arsenic trioxide，melphalan (≧50mg/m2/day)，cytarabine，carboplatin，oxaliplatin，ifosfamide，
mitoxantrone，dacarbazine且其使用劑量為一般公認治療劑量或上述規定劑量時。
所以原則上Aloxi在carboplatin也有給付